The basic objective of the study conducted by Weinstock et al., titled "Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial" was to determine whether application of high strength topical tretinoin (0.1%) will have chemo-prophylactic role in the prevention of common skin cancers.[1] Secondary objective was to determine its effect in terms of prevention of actinic keratoses and to stratify in whom this product could be useful.