The simulation results showed (1) that both TAP and STAP interventions could be effective in suppressing an outbreak within an early period of 90 days but that STAP would be inferior to TAP in terms of the ripple effect of the administration of antiviral drugs and (2) school closure and restraint could bring about a delay in the peak of infection. The combination of three interventions—TAP, school closure, and restraint—would decrease the number of total patients to 0.02% of that with a no-intervention situation and would be highly effective in suppressing infection. In comparison, although the combination of TAP with only school closure or restraint would have some degree of effectiveness in reducing the number of patients, this strategy would be unable to shorten the epidemic period. The results of this study will be helpful in planning intervention strategies against a future influenza pandemic.