The specific combination of the three interventions TAP, school closure, and restraint was shown to be the most effective of all the combined interventions (scenarios 1–5) in terms of suppressing infection. It resulted in a average decrease in total patients to 0.02% of that of the baseline scenario because of concomitantly preventing the spread of infection at an early stage by prophylaxis and decreasing infection risk by school closure and restraint. On the other hand, the combination of prophylaxis with antiviral drugs (TAP/STAP) with either school closure or restraint would reduce the amount of patients to some extent but would not be able to shorten the epidemic period because the influenza infection would be spread among people, unlike the combination of prophylaxis with both school closure and restraint.