School closure School closure is regarded as an important intervention measure because an influenza epidemic can be spread widely among children at school [5]. In this model, when a person is diagnosed with a novel influenza at a medical institution in a ward, school closure will be implemented from the day following the diagnosis for all schools in this ward. The “Guidelines for the Prevention and Control of Pandemic Influenza” [25] states that a judgment based on the epidemiological investigation will end the period of school closure; however, in our model, school closure was assumed to be continued until no patients were detected in the ward.