PMC:2806624 / 22284-26995 JSON TXT

Annnotations TAB JSON ListView MergeView

2_test

Id	Subject	Object	Predicate	Lexical cue
19917773-16648838-59851500	464-468	16648838	denotes	2006

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T10677	0-4	NN	denotes	CBFβ
T10678	4-5	-COMMA-	denotes	,
T10679	6-11	NN	denotes	RUNX1
T10680	11-12	-COMMA-	denotes	,
T10681	13-16	CC	denotes	and
T10682	17-22	NN	denotes	RUNX3
T10683	23-26	VB	denotes	are
T10684	27-36	JJ	denotes	important
T10685	37-40	IN	denotes	for
T10686	41-44	DT	denotes	the
T10687	45-56	JJ	denotes	suppressive
T10688	57-65	NN	denotes	activity
T10689	66-68	IN	denotes	of
T10690	69-74	JJ	denotes	CD25+
T10691	75-81	JJ	denotes	Foxp3+
T10692	82-83	NN	denotes	T
T10693	84-87	NN	denotes	reg
T10694	88-93	NN	denotes	cells
T10695	94-98	RB	denotes	Even
T10696	99-105	IN	denotes	though
T10697	106-120	JJ	denotes	Cbfb-deficient
T10698	121-125	JJ	denotes	CD4+
T10699	126-127	NN	denotes	T
T10700	128-133	NN	denotes	cells
T10701	134-137	VB	denotes	had
T10702	138-146	VB	denotes	impaired
T10703	147-156	NN	denotes	induction
T10704	157-159	IN	denotes	of
T10705	160-165	NN	denotes	Foxp3
T10706	166-171	IN	denotes	after
T10707	172-183	NN	denotes	stimulation
T10708	184-188	IN	denotes	with
T10709	189-200	JJ	denotes	anti-CD3/28
T10710	201-205	NN	denotes	mAbs
T10711	206-209	CC	denotes	and
T10712	210-215	NN	denotes	TGF-β
T10713	215-216	-COMMA-	denotes	,
T10714	217-227	JJ	denotes	sufficient
T10715	228-235	NN	denotes	numbers
T10716	236-238	IN	denotes	of
T10717	239-245	JJ	denotes	Foxp3+
T10718	246-251	NN	denotes	cells
T10719	252-257	MD	denotes	could
T10720	258-260	VB	denotes	be
T10721	261-270	VB	denotes	generated
T10722	271-273	TO	denotes	to
T10723	274-280	VB	denotes	permit
T10724	281-289	NN	denotes	analysis
T10725	290-292	IN	denotes	of
T10726	293-298	PRP-DOLLAR-	denotes	their
T10727	299-310	JJ	denotes	suppressive
T10728	311-319	NN	denotes	activity
T10729	321-329	VB	denotes	Purified
T10730	330-335	JJ	denotes	naive
T10731	336-340	JJ	denotes	CD4+
T10732	341-342	NN	denotes	T
T10733	343-348	NN	denotes	cells
T10734	349-353	IN	denotes	from
T10735	354-361	NN	denotes	CbfbF/F
T10736	362-369	JJ	denotes	CD4-cre
T10737	370-373	CC	denotes	and
T10738	374-381	NN	denotes	control
T10739	382-389	JJ	denotes	CbfbF/+
T10740	390-397	JJ	denotes	CD4-cre
T10741	398-402	NN	denotes	mice
T10742	403-404	-LRB-	denotes	(
T10743	404-410	NN	denotes	Cd45.2
T10744	410-411	-RRB-	denotes	)
T10745	412-421	VB	denotes	harboring
T10746	422-423	DT	denotes	a
T10747	424-438	NN	denotes	Foxp3-ires-GFP
T10748	439-445	NN	denotes	allele
T10749	446-447	-LRB-	denotes	(
T10750	447-455	NNP	denotes	Bettelli
T10751	456-458	FW	denotes	et
T10752	459-462	FW	denotes	al.
T10753	462-463	-COMMA-	denotes	,
T10754	464-468	CD	denotes	2006
T10755	468-469	-RRB-	denotes	)
T10756	470-474	VB	denotes	were
T10757	475-485	VB	denotes	stimulated
T10758	486-488	FW	denotes	in
T10759	489-494	FW	denotes	vitro
T10760	495-499	IN	denotes	with
T10761	500-511	JJ	denotes	anti-CD3/28
T10762	512-516	NN	denotes	mAbs
T10763	516-517	-COMMA-	denotes	,
T10764	518-522	NN	denotes	IL-2
T10765	522-523	-COMMA-	denotes	,
T10766	524-527	CC	denotes	and
T10767	528-533	NN	denotes	TGF-β
T10768	535-540	IN	denotes	After
T10769	541-542	CD	denotes	3
T10770	543-544	NN	denotes	d
T10771	544-545	-COMMA-	denotes	,
T10772	546-557	JJ	denotes	Foxp3+-GFP+
T10773	558-563	NN	denotes	cells
T10774	564-568	VB	denotes	were
T10775	569-575	VB	denotes	sorted
T10776	576-578	IN	denotes	by
T10777	579-583	NN	denotes	flow
T10778	584-593	NN	denotes	cytometry
T10779	594-597	CC	denotes	and
T10780	598-603	VB	denotes	mixed
T10781	604-608	IN	denotes	with
T10782	609-621	JJ	denotes	CFSE-labeled
T10783	622-627	JJ	denotes	naive
T10784	628-635	JJ	denotes	CD45.1+
T10785	636-640	JJ	denotes	CD4+
T10786	641-646	NN	denotes	cells
T10787	647-649	IN	denotes	at
T10788	650-656	NN	denotes	ratios
T10789	657-659	IN	denotes	of
T10790	660-661	CD	denotes	1
T10791	661-662	-COLON-	denotes	:
T10792	662-663	CD	denotes	4
T10793	663-664	-COMMA-	denotes	,
T10794	665-666	CD	denotes	1
T10795	666-667	SYM	denotes	:
T10796	667-668	CD	denotes	2
T10797	668-669	-COMMA-	denotes	,
T10798	670-673	CC	denotes	and
T10799	674-675	CD	denotes	1
T10800	675-676	-COLON-	denotes	:
T10801	676-677	CD	denotes	1
T10802	679-682	DT	denotes	The
T10803	683-688	NN	denotes	cells
T10804	689-693	VB	denotes	were
T10805	694-698	RB	denotes	then
T10806	699-708	VB	denotes	incubated
T10807	709-713	IN	denotes	with
T10808	714-725	VB	denotes	inactivated
T10809	726-737	NN	denotes	splenocytes
T10810	738-741	CC	denotes	and
T10811	742-752	VB	denotes	stimulated
T10812	753-757	IN	denotes	with
T10813	758-766	JJ	denotes	anti-CD3
T10814	767-770	NN	denotes	mAb
T10815	771-774	IN	denotes	for
T10816	775-779	CD	denotes	four
T10817	780-784	JJ	denotes	more
T10818	785-789	NN	denotes	days
T10819	791-798	JJ	denotes	CD45.1+
T10820	799-804	NN	denotes	cells
T10821	805-809	VB	denotes	were
T10822	810-818	VB	denotes	analyzed
T10823	819-822	IN	denotes	for
T10824	823-827	NN	denotes	CFSE
T10825	828-836	NN	denotes	dilution
T10826	837-838	-LRB-	denotes	(
T10827	838-842	NN	denotes	Fig.
T10828	843-844	CD	denotes	6
T10829	845-846	NN	denotes	A
T10830	846-847	-RRB-	denotes	)
T10831	849-856	JJ	denotes	CbfbF/+
T10832	857-864	JJ	denotes	CD4-cre
T10833	865-869	JJ	denotes	CD4+
T10834	870-871	NN	denotes	T
T10835	872-877	NN	denotes	cells
T10836	878-887	VB	denotes	activated
T10837	888-890	IN	denotes	in
T10838	891-894	DT	denotes	the
T10839	895-903	NN	denotes	presence
T10840	904-906	IN	denotes	of
T10841	907-912	NN	denotes	TGF-β
T10842	913-919	VB	denotes	showed
T10843	920-921	DT	denotes	a
T10844	922-927	JJ	denotes	clear
T10845	928-939	NN	denotes	suppression
T10846	940-942	IN	denotes	of
T10847	943-944	NN	denotes	T
T10848	945-949	NN	denotes	cell
T10849	950-963	NN	denotes	proliferation
T10850	964-968	WDT	denotes	that
T10851	969-975	VB	denotes	became
T10852	976-980	RB	denotes	even
T10853	981-985	RB	denotes	more
T10854	986-994	JJ	denotes	apparent
T10855	995-999	WRB	denotes	when
T10856	1000-1002	DT	denotes	an
T10857	1003-1012	VB	denotes	increased
T10858	1013-1018	NN	denotes	ratio
T10859	1019-1021	IN	denotes	of
T10860	1022-1034	NN	denotes	FOXP3+/CD25−
T10861	1035-1040	NN	denotes	cells
T10862	1041-1044	VB	denotes	was
T10863	1045-1049	VB	denotes	used
T10864	1050-1051	-LRB-	denotes	(
T10865	1051-1055	NN	denotes	Fig.
T10866	1056-1057	CD	denotes	6
T10867	1058-1059	NN	denotes	B
T10868	1059-1060	-RRB-	denotes	)
T10869	1062-1065	DT	denotes	The
T10870	1066-1077	NN	denotes	suppression
T10871	1078-1081	VB	denotes	was
T10872	1082-1095	RB	denotes	significantly
T10873	1096-1103	VB	denotes	reduced
T10874	1104-1108	WRB	denotes	when
T10875	1109-1114	NN	denotes	cells
T10876	1115-1119	IN	denotes	from
T10877	1120-1127	NN	denotes	CbfbF/F
T10878	1128-1135	JJ	denotes	CD4-cre
T10879	1136-1140	NN	denotes	mice
T10880	1141-1145	VB	denotes	were
T10881	1146-1150	VB	denotes	used
T10882	1150-1151	-COMMA-	denotes	,
T10883	1152-1165	VB	denotes	demonstrating
T10884	1166-1170	IN	denotes	that
T10885	1171-1184	JJ	denotes	TGF-β–induced
T10886	1185-1189	NN	denotes	Runx
T10887	1190-1199	NN	denotes	complexes
T10888	1200-1203	VB	denotes	are
T10889	1204-1213	JJ	denotes	important
T10890	1214-1217	IN	denotes	for
T10891	1218-1221	DT	denotes	the
T10892	1222-1233	JJ	denotes	suppressive
T10893	1234-1242	NN	denotes	activity
T10894	1243-1245	IN	denotes	of
T10895	1246-1252	JJ	denotes	Foxp3+
T10896	1253-1254	NN	denotes	T
T10897	1255-1258	NN	denotes	reg
T10898	1259-1264	NN	denotes	cells
T10899	1265-1266	-LRB-	denotes	(
T10900	1266-1270	NN	denotes	Fig.
T10901	1271-1272	CD	denotes	6
T10902	1273-1274	NN	denotes	B
T10903	1274-1275	-RRB-	denotes	)
T10904	1277-1279	IN	denotes	As
T10905	1280-1281	DT	denotes	a
T10906	1282-1289	NN	denotes	control
T10907	1289-1290	-COMMA-	denotes	,
T10908	1291-1298	JJ	denotes	CbfbF/+
T10909	1299-1306	JJ	denotes	CD4-cre
T10910	1307-1311	JJ	denotes	CD4+
T10911	1312-1313	NN	denotes	T
T10912	1314-1319	NN	denotes	cells
T10913	1320-1329	VB	denotes	activated
T10914	1330-1332	IN	denotes	in
T10915	1333-1340	NN	denotes	absence
T10916	1341-1343	IN	denotes	of
T10917	1344-1349	NN	denotes	TGF-β
T10918	1350-1354	VB	denotes	were
T10919	1355-1360	VB	denotes	mixed
T10920	1361-1365	IN	denotes	with
T10921	1366-1378	JJ	denotes	CFSE-labeled
T10922	1379-1384	JJ	denotes	naive
T10923	1385-1392	JJ	denotes	CD45.1+
T10924	1393-1397	JJ	denotes	CD4+
T10925	1398-1403	NN	denotes	cells
T10926	1405-1407	DT	denotes	No
T10927	1408-1419	NN	denotes	suppression
T10928	1420-1425	MD	denotes	could
T10929	1426-1428	VB	denotes	be
T10930	1429-1437	VB	denotes	observed
T10931	1438-1440	IN	denotes	in
T10932	1441-1444	DT	denotes	all
T10933	1445-1452	NN	denotes	control
T10934	1453-1459	NN	denotes	groups
T10935	1460-1467	IN	denotes	without
T10936	1468-1473	NN	denotes	TGF-β
T10937	1474-1476	IN	denotes	at
T10938	1477-1480	DT	denotes	all
T10939	1481-1487	VB	denotes	tested
T10940	1488-1494	NN	denotes	ratios
T10941	1495-1496	-LRB-	denotes	(
T10942	1496-1500	NN	denotes	Fig.
T10943	1501-1502	CD	denotes	6
T10944	1503-1504	NN	denotes	C
T10945	1504-1505	-RRB-	denotes	)
T10946	1507-1510	DT	denotes	The
T10947	1511-1520	VB	denotes	decreased
T10948	1521-1532	NN	denotes	suppression
T10949	1533-1541	NN	denotes	capacity
T10950	1542-1544	IN	denotes	of
T10951	1545-1552	NN	denotes	CbfbF/F
T10952	1553-1560	JJ	denotes	CD4-cre
T10953	1561-1563	NN	denotes	iT
T10954	1564-1567	NN	denotes	reg
T10955	1568-1573	NN	denotes	cells
T10956	1574-1577	VB	denotes	was
T10957	1578-1586	JJ	denotes	unlikely
T10958	1587-1589	TO	denotes	to
T10959	1590-1592	VB	denotes	be
T10960	1593-1599	VB	denotes	caused
T10961	1600-1602	IN	denotes	by
T10962	1603-1612	VB	denotes	decreased
T10963	1613-1621	NN	denotes	survival
T10964	1622-1624	CC	denotes	or
T10965	1625-1638	NN	denotes	proliferation
T10966	1640-1646	JJ	denotes	Foxp3+
T10967	1647-1650	CC	denotes	and
T10968	1651-1657	NN	denotes	Foxp3−
T10969	1658-1663	NN	denotes	cells
T10970	1664-1673	VB	denotes	generated
T10971	1674-1678	IN	denotes	from
T10972	1679-1683	CC	denotes	both
T10973	1684-1691	NN	denotes	CbfbF/F
T10974	1692-1699	JJ	denotes	CD4-cre
T10975	1700-1703	CC	denotes	and
T10976	1704-1711	NN	denotes	control
T10977	1712-1717	NN	denotes	cells
T10978	1718-1721	DT	denotes	all
T10979	1722-1731	VB	denotes	displayed
T10980	1732-1739	JJ	denotes	similar
T10981	1740-1753	NN	denotes	proliferation
T10982	1754-1759	NN	denotes	rates
T10983	1760-1763	CC	denotes	and
T10984	1764-1768	NN	denotes	cell
T10985	1769-1774	NN	denotes	death
T10986	1775-1777	IN	denotes	as
T10987	1778-1786	VB	denotes	measured
T10988	1787-1789	IN	denotes	by
T10989	1790-1794	NN	denotes	CFSE
T10990	1795-1803	NN	denotes	dilution
T10991	1804-1807	CC	denotes	and
T10992	1808-1815	NN	denotes	annexin
T10993	1816-1817	NN	denotes	V
T10994	1818-1826	NN	denotes	staining
T10995	1826-1827	-COMMA-	denotes	,
T10996	1828-1840	RB	denotes	respectively
T10997	1841-1842	-LRB-	denotes	(
T10998	1842-1846	NNP	denotes	Fig.
T10999	1847-1849	NN	denotes	S7
T11000	1849-1850	-COMMA-	denotes	,
T11001	1851-1852	NN	denotes	A
T11002	1853-1856	CC	denotes	and
T11003	1857-1858	NN	denotes	B
T11004	1858-1859	-RRB-	denotes	)
T11005	3436-3438	IN	denotes	In
T11006	3439-3447	NN	denotes	addition
T11007	3447-3448	-COMMA-	denotes	,
T11008	3449-3451	PRP	denotes	we
T11009	3452-3458	VB	denotes	tested
T11010	3459-3462	DT	denotes	the
T11011	3463-3474	NN	denotes	requirement
T11012	3475-3477	IN	denotes	of
T11013	3478-3483	NN	denotes	RUNX1
T11014	3484-3487	CC	denotes	and
T11015	3488-3493	NN	denotes	RUNX3
T11016	3494-3497	IN	denotes	for
T11017	3498-3501	DT	denotes	the
T11018	3502-3513	NN	denotes	development
T11019	3514-3516	IN	denotes	of
T11020	3517-3520	DT	denotes	the
T11021	3521-3532	JJ	denotes	suppressive
T11022	3533-3541	NN	denotes	capacity
T11023	3542-3544	IN	denotes	in
T11024	3545-3550	JJ	denotes	human
T11025	3551-3553	NN	denotes	iT
T11026	3554-3557	NN	denotes	reg
T11027	3558-3563	NN	denotes	cells
T11028	3565-3567	PRP	denotes	We
T11029	3568-3576	VB	denotes	isolated
T11030	3577-3582	JJ	denotes	human
T11031	3583-3588	JJ	denotes	naive
T11032	3589-3593	JJ	denotes	CD4+
T11033	3594-3595	NN	denotes	T
T11034	3596-3601	NN	denotes	cells
T11035	3602-3605	CC	denotes	and
T11036	3606-3617	VB	denotes	transfected
T11037	3618-3622	PRP	denotes	them
T11038	3623-3627	IN	denotes	with
T11039	3628-3629	DT	denotes	a
T11040	3630-3641	NN	denotes	combination
T11041	3642-3644	IN	denotes	of
T11042	3645-3650	NN	denotes	RUNX1
T11043	3651-3654	CC	denotes	and
T11044	3655-3660	NN	denotes	RUNX3
T11045	3661-3666	NN	denotes	siRNA
T11046	3666-3667	-COMMA-	denotes	,
T11047	3668-3670	CC	denotes	or
T11048	3671-3675	IN	denotes	with
T11049	3676-3677	DT	denotes	a
T11050	3678-3687	VB	denotes	scrambled
T11051	3688-3695	NN	denotes	control
T11052	3696-3701	NN	denotes	siRNA
T11053	3703-3708	NN	denotes	Cells
T11054	3709-3713	VB	denotes	were
T11055	3714-3722	VB	denotes	cultured
T11056	3723-3728	IN	denotes	under
T11057	3729-3730	NN	denotes	T
T11058	3731-3734	NN	denotes	reg
T11059	3735-3745	NN	denotes	conditions
T11060	3745-3746	-COMMA-	denotes	,
T11061	3747-3750	CC	denotes	and
T11062	3751-3755	RB	denotes	then
T11063	3756-3761	VB	denotes	mixed
T11064	3762-3766	IN	denotes	with
T11065	3767-3779	JJ	denotes	CFSE-labeled
T11066	3780-3790	JJ	denotes	autologous
T11067	3791-3795	JJ	denotes	CD4+
T11068	3796-3797	NN	denotes	T
T11069	3798-3803	NN	denotes	cells
T11070	3804-3807	CC	denotes	and
T11071	3808-3818	VB	denotes	stimulated
T11072	3819-3823	IN	denotes	with
T11073	3824-3832	JJ	denotes	anti-CD3
T11074	3833-3836	NN	denotes	mAb
T11075	3838-3843	NN	denotes	Cells
T11076	3844-3846	IN	denotes	in
T11077	3847-3852	WDT	denotes	which
T11078	3853-3858	NN	denotes	RUNX1
T11079	3859-3862	CC	denotes	and
T11080	3863-3868	NN	denotes	RUNX3
T11081	3869-3873	VB	denotes	were
T11082	3874-3881	VB	denotes	knocked
T11083	3882-3886	RB	denotes	down
T11084	3887-3893	VB	denotes	showed
T11085	3894-3902	RB	denotes	markedly
T11086	3903-3908	JJ	denotes	lower
T11087	3909-3920	JJ	denotes	suppressive
T11088	3921-3929	NN	denotes	activity
T11089	3930-3938	VB	denotes	compared
T11090	3939-3943	IN	denotes	with
T11091	3944-3951	NN	denotes	control
T11092	3952-3954	NN	denotes	iT
T11093	3955-3958	NN	denotes	reg
T11094	3959-3964	NN	denotes	cells
T11095	3965-3967	IN	denotes	at
T11096	3968-3969	DT	denotes	a
T11097	3970-3971	NN	denotes	T
T11098	3972-3980	NN	denotes	reg/CD4+
T11099	3981-3982	NN	denotes	T
T11100	3983-3992	NN	denotes	responder
T11101	3993-3997	NN	denotes	cell
T11102	3998-4003	NN	denotes	ratio
T11103	4004-4006	IN	denotes	of
T11104	4007-4008	CD	denotes	1
T11105	4008-4009	SYM	denotes	:
T11106	4009-4011	CD	denotes	20
T11107	4011-4012	-COMMA-	denotes	,
T11108	4013-4016	CC	denotes	but
T11109	4017-4020	RB	denotes	not
T11110	4021-4025	WRB	denotes	when
T11111	4026-4029	DT	denotes	the
T11112	4030-4031	NN	denotes	T
T11113	4032-4040	NN	denotes	reg/CD4+
T11114	4041-4042	NN	denotes	T
T11115	4043-4052	NN	denotes	responder
T11116	4053-4057	NN	denotes	cell
T11117	4058-4063	NN	denotes	ratio
T11118	4064-4067	VB	denotes	was
T11119	4068-4077	VB	denotes	increased
T11120	4078-4080	TO	denotes	to
T11121	4081-4082	CD	denotes	1
T11122	4082-4083	SYM	denotes	:
T11123	4083-4084	CD	denotes	5
T11124	4085-4086	-LRB-	denotes	(
T11125	4086-4090	NN	denotes	Fig.
T11126	4091-4092	CD	denotes	6
T11127	4093-4094	NN	denotes	D
T11128	4094-4095	-RRB-	denotes	)
T11129	4097-4102	DT	denotes	These
T11130	4103-4110	NN	denotes	results
T11131	4111-4122	VB	denotes	demonstrate
T11132	4123-4126	DT	denotes	the
T11133	4127-4136	JJ	denotes	important
T11134	4137-4141	NN	denotes	role
T11135	4142-4144	IN	denotes	of
T11136	4145-4150	NN	denotes	RUNX1
T11137	4151-4154	CC	denotes	and
T11138	4155-4160	NN	denotes	RUNX3
T11139	4161-4164	RB	denotes	not
T11140	4165-4169	RB	denotes	only
T11141	4170-4173	IN	denotes	for
T11142	4174-4177	DT	denotes	the
T11143	4178-4187	NN	denotes	induction
T11144	4188-4190	IN	denotes	of
T11145	4191-4196	NN	denotes	FOXP3
T11146	4196-4197	-COMMA-	denotes	,
T11147	4198-4201	CC	denotes	but
T11148	4202-4206	RB	denotes	also
T11149	4207-4210	IN	denotes	for
T11150	4211-4214	DT	denotes	the
T11151	4215-4226	JJ	denotes	suppressive
T11152	4227-4235	NN	denotes	capacity
T11153	4236-4238	IN	denotes	of
T11154	4239-4241	NN	denotes	iT
T11155	4242-4245	NN	denotes	reg
T11156	4246-4251	NN	denotes	cells
T11157	4252-4256	CC	denotes	both
T11158	4257-4259	IN	denotes	in
T11159	4260-4266	NN	denotes	humans
T11160	4267-4270	CC	denotes	and
T11161	4271-4273	IN	denotes	in
T11162	4274-4278	NN	denotes	mice
T11163	4280-4283	DT	denotes	The
T11164	4284-4288	NN	denotes	data
T11165	4289-4296	VB	denotes	suggest
T11166	4297-4301	CC	denotes	both
T11167	4302-4310	NN	denotes	quantity
T11168	4311-4314	CC	denotes	and
T11169	4315-4322	NN	denotes	quality
T11170	4323-4325	IN	denotes	of
T11171	4326-4327	NN	denotes	T
T11172	4328-4331	NN	denotes	reg
T11173	4332-4337	NN	denotes	cells
T11174	4338-4341	VB	denotes	are
T11175	4342-4350	VB	denotes	hampered
T11176	4352-4359	VB	denotes	Reduced
T11177	4360-4369	JJ	denotes	intrinsic
T11178	4370-4381	JJ	denotes	suppressive
T11179	4382-4390	NN	denotes	capacity
T11180	4391-4393	IN	denotes	of
T11181	4394-4396	NN	denotes	iT
T11182	4397-4400	NN	denotes	reg
T11183	4401-4406	NN	denotes	cells
T11184	4407-4410	VB	denotes	was
T11185	4411-4423	VB	denotes	demonstrated
T11186	4424-4426	IN	denotes	in
T11187	4427-4431	NN	denotes	mice
T11188	4431-4432	-COMMA-	denotes	,
T11189	4433-4440	IN	denotes	because
T11190	4441-4451	JJ	denotes	Foxp3-GFP+
T11191	4452-4457	NN	denotes	cells
T11192	4458-4462	VB	denotes	were
T11193	4463-4467	NN	denotes	FACS
T11194	4468-4474	VB	denotes	sorted
T11195	4475-4478	CC	denotes	and
T11196	4479-4483	JJ	denotes	same
T11197	4484-4491	NN	denotes	numbers
T11198	4492-4494	IN	denotes	of
T11199	4495-4497	NN	denotes	iT
T11200	4498-4501	NN	denotes	reg
T11201	4502-4507	NN	denotes	cells
T11202	4508-4511	VB	denotes	are
T11203	4512-4520	VB	denotes	included
T11204	4521-4523	IN	denotes	in
T11205	4524-4531	NN	denotes	control
T11206	4532-4543	NN	denotes	experiments
T11207	4545-4547	IN	denotes	In
T11208	4548-4551	DT	denotes	the
T11209	4552-4563	NN	denotes	suppression
T11210	4564-4574	NN	denotes	experiment
T11211	4575-4579	IN	denotes	with
T11212	4580-4585	JJ	denotes	human
T11213	4586-4591	NN	denotes	cells
T11214	4591-4592	-COMMA-	denotes	,
T11215	4593-4600	VB	denotes	reduced
T11216	4601-4612	JJ	denotes	suppressive
T11217	4613-4621	NN	denotes	activity
T11218	4622-4625	VB	denotes	was
T11219	4626-4632	VB	denotes	caused
T11220	4633-4635	IN	denotes	by
T11221	4636-4643	VB	denotes	reduced
T11222	4644-4649	NN	denotes	FOXP3
T11223	4650-4660	NN	denotes	expression
T11224	4661-4663	IN	denotes	in
T11225	4664-4665	NN	denotes	T
T11226	4666-4671	NN	denotes	cells
T11227	4672-4674	IN	denotes	by
T11228	4675-4680	NN	denotes	siRNA
T11229	4681-4691	NN	denotes	inhibition
T11230	4692-4694	IN	denotes	of
T11231	4695-4700	NN	denotes	RUNX1
T11232	4701-4704	CC	denotes	and
T11233	4705-4710	NN	denotes	RUNX3
T32180	1872-1879	NN	denotes	CbfbF/F
T32181	1880-1887	JJ	denotes	CD4-cre
T32182	1888-1893	NN	denotes	mouse
T32183	1894-1899	NN	denotes	cells
T32184	1900-1903	CC	denotes	and
T32185	1904-1906	NN	denotes	iT
T32186	1907-1910	NN	denotes	reg
T32187	1911-1916	NN	denotes	cells
T32188	1917-1926	VB	denotes	generated
T32189	1927-1931	IN	denotes	from
T32190	1932-1937	JJ	denotes	human
T32191	1938-1943	JJ	denotes	naive
T32192	1944-1948	JJ	denotes	CD4+
T32193	1949-1950	NN	denotes	T
T32194	1951-1956	NN	denotes	cells
T32195	1957-1967	VB	denotes	undergoing
T32196	1968-1982	JJ	denotes	siRNA-mediated
T32197	1983-1988	NN	denotes	RUNX1
T32198	1989-1992	CC	denotes	and
T32199	1993-1998	NN	denotes	RUNX3
T32200	1999-2004	VB	denotes	knock
T32201	2005-2009	RB	denotes	down
T32202	2010-2014	VB	denotes	show
T32203	2015-2016	DT	denotes	a
T32204	2017-2027	JJ	denotes	diminished
T32205	2028-2039	JJ	denotes	suppressive
T32206	2040-2048	NN	denotes	activity
T32207	2050-2062	JJ	denotes	Experimental
T32208	2063-2068	NN	denotes	setup
T32209	2069-2070	-LRB-	denotes	(
T32210	2070-2071	NN	denotes	A
T32211	2071-2072	-RRB-	denotes	)
T32212	2073-2076	CC	denotes	and
T32213	2077-2084	NN	denotes	results
T32214	2085-2087	IN	denotes	of
T32215	2088-2091	DT	denotes	the
T32216	2092-2097	NN	denotes	mouse
T32217	2098-2109	NN	denotes	suppression
T32218	2110-2115	NN	denotes	assay
T32219	2116-2117	-LRB-	denotes	(
T32220	2117-2118	NN	denotes	B
T32221	2118-2119	-RRB-	denotes	)
T32222	2119-2120	-COMMA-	denotes	,
T32223	2121-2134	JJ	denotes	FACS-purified
T32224	2135-2140	JJ	denotes	naive
T32225	2141-2147	NN	denotes	CD4+8−
T32226	2148-2149	NN	denotes	T
T32227	2150-2155	NN	denotes	cells
T32228	2156-2160	IN	denotes	from
T32229	2161-2168	NN	denotes	CbfbF/F
T32230	2169-2176	JJ	denotes	CD4-cre
T32231	2177-2178	-LRB-	denotes	(
T32232	2178-2182	JJ	denotes	left
T32233	2182-2183	-RRB-	denotes	)
T32234	2184-2187	CC	denotes	and
T32235	2188-2195	NN	denotes	control
T32236	2196-2203	JJ	denotes	CbfbF/+
T32237	2204-2211	JJ	denotes	CD4-cre
T32238	2212-2216	NN	denotes	mice
T32239	2217-2218	-LRB-	denotes	(
T32240	2218-2224	NN	denotes	Cd45.2
T32241	2224-2225	-COLON-	denotes	;
T32242	2226-2231	NN	denotes	right
T32243	2231-2232	-RRB-	denotes	)
T32244	2233-2237	VB	denotes	were
T32245	2238-2247	VB	denotes	activated
T32246	2248-2250	FW	denotes	in
T32247	2251-2256	FW	denotes	vitro
T32248	2257-2261	IN	denotes	with
T32249	2262-2273	JJ	denotes	anti-CD3/28
T32250	2274-2277	NN	denotes	mAb
T32251	2277-2278	-COMMA-	denotes	,
T32252	2279-2281	CD	denotes	50
T32253	2282-2286	NN	denotes	U/ml
T32254	2287-2291	NN	denotes	IL-2
T32255	2291-2292	-COMMA-	denotes	,
T32256	2293-2296	CC	denotes	and
T32257	2297-2300	CD	denotes	2.5
T32258	2301-2306	NN	denotes	ng/ml
T32259	2307-2312	NN	denotes	TGF-β
T32260	2314-2319	IN	denotes	After
T32261	2320-2321	CD	denotes	3
T32262	2322-2323	NN	denotes	d
T32263	2323-2324	-COMMA-	denotes	,
T32264	2325-2335	JJ	denotes	Foxp3-GFP+
T32265	2336-2341	NN	denotes	cells
T32266	2342-2346	VB	denotes	were
T32267	2347-2358	JJ	denotes	FACS-sorted
T32268	2359-2362	CC	denotes	and
T32269	2363-2368	VB	denotes	mixed
T32270	2369-2373	IN	denotes	with
T32271	2374-2385	JJ	denotes	CFSE-loaded
T32272	2386-2391	JJ	denotes	naive
T32273	2392-2399	JJ	denotes	CD45.1+
T32274	2400-2404	JJ	denotes	CD4+
T32275	2405-2410	NN	denotes	cells
T32276	2411-2413	IN	denotes	at
T32277	2414-2417	DT	denotes	the
T32278	2418-2427	JJ	denotes	indicated
T32279	2428-2434	NN	denotes	ratios
T32280	2436-2441	DT	denotes	These
T32281	2442-2446	VB	denotes	were
T32282	2447-2451	RB	denotes	then
T32283	2452-2461	VB	denotes	incubated
T32284	2462-2466	IN	denotes	with
T32285	2467-2478	VB	denotes	inactivated
T32286	2479-2490	NN	denotes	splenocytes
T32287	2491-2494	CC	denotes	and
T32288	2495-2503	JJ	denotes	anti-CD3
T32289	2504-2507	NN	denotes	mAb
T32290	2509-2514	IN	denotes	After
T32291	2515-2516	DT	denotes	a
T32292	2517-2524	JJ	denotes	further
T32293	2525-2526	CD	denotes	4
T32294	2527-2528	NN	denotes	d
T32295	2528-2529	-COMMA-	denotes	,
T32296	2530-2537	JJ	denotes	CD45.1+
T32297	2538-2543	NN	denotes	cells
T32298	2544-2548	VB	denotes	were
T32299	2549-2557	VB	denotes	analyzed
T32300	2558-2561	IN	denotes	for
T32301	2562-2566	NNP	denotes	CFSE
T32302	2567-2576	NN	denotes	dilution.
T32303	2577-2578	-LRB-	denotes	(
T32304	2578-2579	NN	denotes	C
T32305	2579-2580	-RRB-	denotes	)
T32306	2581-2583	IN	denotes	As
T32307	2584-2585	DT	denotes	a
T32308	2586-2593	NN	denotes	control
T32309	2593-2594	-COMMA-	denotes	,
T32310	2595-2602	JJ	denotes	CbfbF/+
T32311	2603-2610	JJ	denotes	CD4-cre
T32312	2611-2615	JJ	denotes	CD4+
T32313	2616-2617	NN	denotes	T
T32314	2618-2623	NN	denotes	cells
T32315	2624-2633	VB	denotes	activated
T32316	2634-2636	IN	denotes	in
T32317	2637-2644	NN	denotes	absence
T32318	2645-2647	IN	denotes	of
T32319	2648-2653	NN	denotes	TGF-β
T32320	2654-2658	VB	denotes	were
T32321	2659-2664	VB	denotes	mixed
T32322	2665-2669	IN	denotes	with
T32323	2670-2681	JJ	denotes	CFSE-loaded
T32324	2682-2687	JJ	denotes	naive
T32325	2688-2695	JJ	denotes	CD45.1+
T32326	2696-2700	JJ	denotes	CD4+
T32327	2701-2706	NN	denotes	cells
T32328	2707-2709	IN	denotes	at
T32329	2710-2713	DT	denotes	the
T32330	2714-2723	JJ	denotes	indicated
T32331	2724-2730	NN	denotes	ratios
T32332	2732-2736	CD	denotes	Four
T32333	2737-2741	NN	denotes	days
T32334	2742-2747	RB	denotes	later
T32335	2748-2755	JJ	denotes	CD45.1+
T32336	2756-2761	NN	denotes	cells
T32337	2762-2766	VB	denotes	were
T32338	2767-2775	VB	denotes	analyzed
T32339	2776-2779	IN	denotes	for
T32340	2780-2784	NN	denotes	CFSE
T32341	2785-2793	NN	denotes	dilution
T32342	2795-2798	DT	denotes	The
T32343	2799-2805	JJ	denotes	median
T32344	2806-2814	NN	denotes	division
T32345	2815-2821	NN	denotes	number
T32346	2822-2823	-LRB-	denotes	(
T32347	2823-2825	IN	denotes	of
T32348	2826-2829	DT	denotes	the
T32349	2830-2835	JJ	denotes	naive
T32350	2836-2843	JJ	denotes	CD45.1+
T32351	2844-2848	JJ	denotes	CD4+
T32352	2849-2854	NN	denotes	cells
T32353	2855-2857	IN	denotes	in
T32354	2858-2861	DT	denotes	the
T32355	2862-2870	NN	denotes	cultures
T32356	2871-2881	VB	denotes	containing
T32357	2882-2892	JJ	denotes	Foxp3-GFP+
T32358	2893-2898	NN	denotes	cells
T32359	2898-2899	-RRB-	denotes	)
T32360	2900-2902	VB	denotes	is
T32361	2903-2912	VB	denotes	indicated
T32362	2913-2915	IN	denotes	in
T32363	2916-2920	DT	denotes	each
T32364	2921-2923	IN	denotes	of
T32365	2924-2927	DT	denotes	the
T32366	2928-2938	NN	denotes	histograms
T32367	2940-2943	CD	denotes	One
T32368	2944-2946	IN	denotes	of
T32369	2947-2952	CD	denotes	three
T32370	2953-2964	NN	denotes	experiments
T32371	2965-2967	VB	denotes	is
T32372	2968-2974	NN	denotes	shown.
T32373	2975-2976	-LRB-	denotes	(
T32374	2976-2977	NN	denotes	D
T32375	2977-2978	-RRB-	denotes	)
T32376	2979-2984	JJ	denotes	Human
T32377	2985-2990	JJ	denotes	naive
T32378	2991-2995	JJ	denotes	CD4+
T32379	2996-2997	NN	denotes	T
T32380	2998-3003	NN	denotes	cells
T32381	3003-3004	-COMMA-	denotes	,
T32382	3005-3016	VB	denotes	transfected
T32383	3017-3021	IN	denotes	with
T32384	3022-3027	NN	denotes	RUNX1
T32385	3028-3031	CC	denotes	and
T32386	3032-3037	NN	denotes	RUNX3
T32387	3038-3043	NN	denotes	siRNA
T32388	3044-3047	CC	denotes	and
T32389	3048-3056	VB	denotes	cultured
T32390	3057-3062	IN	denotes	under
T32391	3063-3065	PRP	denotes	iT
T32392	3066-3069	NN	denotes	reg
T32393	3070-3085	VB	denotes	differentiating
T32394	3086-3096	NN	denotes	conditions
T32395	3097-3101	VB	denotes	were
T32396	3102-3106	VB	denotes	used
T32397	3107-3109	IN	denotes	in
T32398	3110-3112	DT	denotes	an
T32399	3113-3115	FW	denotes	in
T32400	3116-3121	FW	denotes	vitro
T32401	3122-3133	NN	denotes	suppression
T32402	3134-3139	NN	denotes	assay
T32403	3139-3140	-COMMA-	denotes	,
T32404	3141-3149	VB	denotes	cultured
T32405	3150-3158	RB	denotes	together
T32406	3159-3163	IN	denotes	with
T32407	3164-3174	JJ	denotes	autologous
T32408	3175-3187	JJ	denotes	CFSE-labeled
T32409	3188-3192	JJ	denotes	CD4+
T32410	3193-3194	NN	denotes	T
T32411	3195-3200	NN	denotes	cells
T32412	3200-3201	-COMMA-	denotes	,
T32413	3202-3205	CC	denotes	and
T32414	3206-3216	VB	denotes	stimulated
T32415	3217-3221	IN	denotes	with
T32416	3222-3230	JJ	denotes	anti-CD3
T32417	3231-3234	NN	denotes	mAb
T32418	3236-3239	DT	denotes	The
T32419	3240-3244	NNP	denotes	CFSE
T32420	3245-3253	NN	denotes	dilution
T32421	3254-3256	IN	denotes	of
T32422	3257-3260	DT	denotes	the
T32423	3261-3265	JJ	denotes	CD4+
T32424	3266-3267	NN	denotes	T
T32425	3268-3272	NN	denotes	cell
T32426	3273-3282	NN	denotes	responder
T32427	3283-3288	NN	denotes	cells
T32428	3289-3292	VB	denotes	was
T32429	3293-3301	VB	denotes	analyzed
T32430	3302-3307	IN	denotes	after
T32431	3308-3309	CD	denotes	5
T32432	3310-3311	NN	denotes	d
T32433	3312-3314	IN	denotes	by
T32434	3315-3319	NN	denotes	flow
T32435	3320-3329	NN	denotes	cytometry
T32436	3331-3334	DT	denotes	The
T32437	3335-3336	NN	denotes	T
T32438	3337-3350	NN	denotes	reg/responder
T32439	3351-3355	JJ	denotes	CD4+
T32440	3356-3357	NN	denotes	T
T32441	3358-3362	NN	denotes	cell
T32442	3363-3369	NN	denotes	ratios
T32443	3370-3374	VB	denotes	used
T32444	3375-3379	VB	denotes	were
T32445	3380-3381	CD	denotes	1
T32446	3381-3382	SYM	denotes	:
T32447	3382-3384	CD	denotes	20
T32448	3384-3385	-COMMA-	denotes	,
T32449	3386-3387	CD	denotes	1
T32450	3387-3388	-COLON-	denotes	:
T32451	3388-3390	CD	denotes	10
T32452	3390-3391	-COMMA-	denotes	,
T32453	3392-3395	CC	denotes	and
T32454	3396-3397	CD	denotes	1
T32455	3397-3398	-COLON-	denotes	:
T32456	3398-3399	CD	denotes	5
T32457	3401-3404	CD	denotes	One
T32458	3405-3407	IN	denotes	of
T32459	3408-3411	CD	denotes	two
T32460	3412-3423	NN	denotes	experiments
T32461	3424-3426	VB	denotes	is
T32462	3427-3432	VB	denotes	shown
R8226	T10677	T10678	arg1Of	CBFβ,","
R8227	T10678	T10681	arg1Of	",",and
R8228	T10679	T10678	arg2Of	RUNX1,","
R8229	T10681	T10680	arg1Of	and,","
R8230	T10681	T10683	arg1Of	and,are
R8231	T10681	T10684	arg1Of	and,important
R8232	T10682	T10681	arg2Of	RUNX3,and
R8233	T10684	T10683	arg2Of	important,are
R8234	T10684	T10685	arg1Of	important,for
R8235	T10688	T10685	arg2Of	activity,for
R8236	T10688	T10686	arg1Of	activity,the
R8237	T10688	T10687	arg1Of	activity,suppressive
R8238	T10688	T10689	arg1Of	activity,of
R8239	T10694	T10689	arg2Of	cells,of
R8240	T10694	T10690	arg1Of	cells,CD25+
R8241	T10694	T10691	arg1Of	cells,Foxp3+
R8242	T10694	T10692	arg1Of	cells,T
R8243	T10694	T10693	arg1Of	cells,reg
R8244	T10696	T10695	arg1Of	though,Even
R8245	T10700	T10697	arg1Of	cells,Cbfb-deficient
R8246	T10700	T10698	arg1Of	cells,CD4+
R8247	T10700	T10699	arg1Of	cells,T
R8248	T10700	T10701	arg1Of	cells,had
R8249	T10700	T10702	arg1Of	cells,impaired
R8250	T10702	T10696	arg2Of	impaired,though
R8251	T10702	T10701	arg2Of	impaired,had
R8252	T10702	T10706	arg1Of	impaired,after
R8253	T10703	T10702	arg2Of	induction,impaired
R8254	T10703	T10704	arg1Of	induction,of
R8255	T10705	T10704	arg2Of	Foxp3,of
R8256	T10707	T10706	arg2Of	stimulation,after
R8257	T10707	T10708	arg1Of	stimulation,with
R8258	T10710	T10709	arg1Of	mAbs,anti-CD3/28
R8259	T10710	T10711	arg1Of	mAbs,and
R8260	T10711	T10708	arg2Of	and,with
R8261	T10712	T10711	arg2Of	TGF-β,and
R8262	T10715	T10714	arg1Of	numbers,sufficient
R8263	T10715	T10716	arg1Of	numbers,of
R8264	T10715	T10719	arg1Of	numbers,could
R8265	T10715	T10720	arg1Of	numbers,be
R8266	T10715	T10721	arg2Of	numbers,generated
R8267	T10718	T10716	arg2Of	cells,of
R8268	T10718	T10717	arg1Of	cells,Foxp3+
R8269	T10721	T10696	arg1Of	generated,though
R8270	T10721	T10713	arg1Of	generated,","
R8271	T10721	T10719	arg2Of	generated,could
R8272	T10721	T10720	arg2Of	generated,be
R8273	T10721	T10722	modOf	generated,to
R8274	T10723	T10722	arg1Of	permit,to
R8275	T10724	T10723	arg2Of	analysis,permit
R8276	T10724	T10725	arg1Of	analysis,of
R8277	T10728	T10725	arg2Of	activity,of
R8278	T10728	T10726	arg1Of	activity,their
R8279	T10728	T10727	arg1Of	activity,suppressive
R8280	T10733	T10729	arg2Of	cells,Purified
R8281	T10733	T10730	arg1Of	cells,naive
R8282	T10733	T10731	arg1Of	cells,CD4+
R8283	T10733	T10732	arg1Of	cells,T
R8284	T10733	T10734	arg1Of	cells,from
R8285	T10733	T10745	arg1Of	cells,harboring
R8286	T10733	T10756	arg1Of	cells,were
R8287	T10733	T10757	arg2Of	cells,stimulated
R8288	T10736	T10737	arg1Of	CD4-cre,and
R8289	T10737	T10735	arg1Of	and,CbfbF/F
R8290	T10738	T10737	arg2Of	control,and
R8291	T10741	T10734	arg2Of	mice,from
R8292	T10741	T10736	arg1Of	mice,CD4-cre
R8293	T10741	T10738	arg1Of	mice,control
R8294	T10741	T10739	arg1Of	mice,CbfbF/+
R8295	T10741	T10740	arg1Of	mice,CD4-cre
R8296	T10741	T10742	arg1Of	mice,(
R8297	T10743	T10742	arg2Of	Cd45.2,(
R8298	T10744	T10742	arg3Of	),(
R8299	T10745	T10749	arg1Of	harboring,(
R8300	T10748	T10745	arg2Of	allele,harboring
R8301	T10748	T10746	arg1Of	allele,a
R8302	T10748	T10747	arg1Of	allele,Foxp3-ires-GFP
R8303	T10750	T10749	arg2Of	Bettelli,(
R8304	T10750	T10751	arg1Of	Bettelli,et
R8305	T10750	T10752	arg1Of	Bettelli,al.
R8306	T10750	T10753	arg1Of	Bettelli,","
R8307	T10754	T10753	arg2Of	2006,","
R8308	T10755	T10749	arg3Of	),(
R8309	T10757	T10756	arg2Of	stimulated,were
R8310	T10757	T10759	arg1Of	stimulated,vitro
R8311	T10757	T10760	arg1Of	stimulated,with
R8312	T10759	T10758	arg1Of	vitro,in
R8313	T10762	T10761	arg1Of	mAbs,anti-CD3/28
R8314	T10762	T10763	arg1Of	mAbs,","
R8315	T10763	T10766	arg1Of	",",and
R8316	T10764	T10763	arg2Of	IL-2,","
R8317	T10766	T10760	arg2Of	and,with
R8318	T10766	T10765	arg1Of	and,","
R8319	T10767	T10766	arg2Of	TGF-β,and
R8320	T10770	T10768	arg2Of	d,After
R8321	T10770	T10769	arg1Of	d,3
R8322	T10773	T10772	arg1Of	cells,Foxp3+-GFP+
R8323	T10773	T10774	arg1Of	cells,were
R8324	T10773	T10775	arg2Of	cells,sorted
R8325	T10773	T10780	arg2Of	cells,mixed
R8326	T10775	T10779	arg1Of	sorted,and
R8327	T10778	T10775	arg1Of	cytometry,sorted
R8328	T10778	T10776	arg2Of	cytometry,by
R8329	T10778	T10777	arg1Of	cytometry,flow
R8330	T10779	T10768	arg1Of	and,After
R8331	T10779	T10771	arg1Of	and,","
R8332	T10779	T10774	arg2Of	and,were
R8333	T10780	T10779	arg2Of	mixed,and
R8334	T10780	T10781	arg1Of	mixed,with
R8335	T10786	T10781	arg2Of	cells,with
R8336	T10786	T10782	arg1Of	cells,CFSE-labeled
R8337	T10786	T10783	arg1Of	cells,naive
R8338	T10786	T10784	arg1Of	cells,CD45.1+
R8339	T10786	T10785	arg1Of	cells,CD4+
R8340	T10786	T10787	arg1Of	cells,at
R8341	T10788	T10787	arg2Of	ratios,at
R8342	T10788	T10789	arg1Of	ratios,of
R8343	T10790	T10791	arg1Of	1,:
R8344	T10791	T10798	arg1Of	:,and
R8345	T10792	T10793	arg1Of	4,","
R8346	T10794	T10793	arg2Of	1,","
R8347	T10796	T10791	arg2Of	2,:
R8348	T10796	T10792	arg1Of	2,4
R8349	T10796	T10794	arg1Of	2,1
R8350	T10796	T10795	arg1Of	2,:
R8351	T10798	T10797	arg1Of	and,","
R8352	T10798	T10800	arg1Of	and,:
R8353	T10799	T10798	arg2Of	1,and
R8354	T10800	T10789	arg2Of	:,of
R8355	T10801	T10800	arg2Of	1,:
R8356	T10803	T10802	arg1Of	cells,The
R8357	T10803	T10804	arg1Of	cells,were
R8358	T10803	T10806	arg2Of	cells,incubated
R8359	T10803	T10811	arg2Of	cells,stimulated
R8360	T10806	T10807	arg1Of	incubated,with
R8361	T10806	T10810	arg1Of	incubated,and
R8362	T10809	T10807	arg2Of	splenocytes,with
R8363	T10809	T10808	arg2Of	splenocytes,inactivated
R8364	T10810	T10804	arg2Of	and,were
R8365	T10810	T10805	arg1Of	and,then
R8366	T10811	T10810	arg2Of	stimulated,and
R8367	T10811	T10812	arg1Of	stimulated,with
R8368	T10811	T10815	arg1Of	stimulated,for
R8369	T10814	T10812	arg2Of	mAb,with
R8370	T10814	T10813	arg1Of	mAb,anti-CD3
R8371	T10818	T10815	arg2Of	days,for
R8372	T10818	T10816	arg1Of	days,four
R8373	T10818	T10817	arg1Of	days,more
R8374	T10820	T10819	arg1Of	cells,CD45.1+
R8375	T10820	T10821	arg1Of	cells,were
R8376	T10820	T10822	arg2Of	cells,analyzed
R8377	T10822	T10821	arg2Of	analyzed,were
R8378	T10822	T10823	arg1Of	analyzed,for
R8379	T10825	T10823	arg2Of	dilution,for
R8380	T10825	T10824	arg1Of	dilution,CFSE
R8381	T10825	T10826	arg1Of	dilution,(
R8382	T10829	T10826	arg2Of	A,(
R8383	T10829	T10827	arg1Of	A,Fig.
R8384	T10829	T10828	arg1Of	A,6
R8385	T10830	T10826	arg3Of	),(
R8386	T10835	T10831	arg1Of	cells,CbfbF/+
R8387	T10835	T10832	arg1Of	cells,CD4-cre
R8388	T10835	T10833	arg1Of	cells,CD4+
R8389	T10835	T10834	arg1Of	cells,T
R8390	T10835	T10836	arg2Of	cells,activated
R8391	T10835	T10842	arg1Of	cells,showed
R8392	T10836	T10837	arg1Of	activated,in
R8393	T10839	T10837	arg2Of	presence,in
R8394	T10839	T10838	arg1Of	presence,the
R8395	T10839	T10840	arg1Of	presence,of
R8396	T10841	T10840	arg2Of	TGF-β,of
R8397	T10845	T10842	arg2Of	suppression,showed
R8398	T10845	T10843	arg1Of	suppression,a
R8399	T10845	T10844	arg1Of	suppression,clear
R8400	T10845	T10846	arg1Of	suppression,of
R8401	T10845	T10850	arg1Of	suppression,that
R8402	T10845	T10851	arg1Of	suppression,became
R8403	T10845	T10854	arg1Of	suppression,apparent
R8404	T10849	T10846	arg2Of	proliferation,of
R8405	T10849	T10847	arg1Of	proliferation,T
R8406	T10849	T10848	arg1Of	proliferation,cell
R8407	T10851	T10855	arg1Of	became,when
R8408	T10853	T10852	arg1Of	more,even
R8409	T10854	T10851	arg2Of	apparent,became
R8410	T10854	T10853	arg1Of	apparent,more
R8411	T10858	T10856	arg1Of	ratio,an
R8412	T10858	T10857	arg2Of	ratio,increased
R8413	T10858	T10859	arg1Of	ratio,of
R8414	T10858	T10862	arg1Of	ratio,was
R8415	T10858	T10863	arg2Of	ratio,used
R8416	T10861	T10859	arg2Of	cells,of
R8417	T10861	T10860	arg1Of	cells,FOXP3+/CD25−
R8418	T10863	T10855	arg2Of	used,when
R8419	T10863	T10862	arg2Of	used,was
R8420	T10863	T10864	arg1Of	used,(
R8421	T10867	T10864	arg2Of	B,(
R8422	T10867	T10865	arg1Of	B,Fig.
R8423	T10867	T10866	arg1Of	B,6
R8424	T10868	T10864	arg3Of	),(
R8425	T10870	T10869	arg1Of	suppression,The
R8426	T10870	T10871	arg1Of	suppression,was
R8427	T10870	T10873	arg2Of	suppression,reduced
R8428	T10873	T10871	arg2Of	reduced,was
R8429	T10873	T10872	arg1Of	reduced,significantly
R8430	T10873	T10874	arg1Of	reduced,when
R8431	T10873	T10882	arg1Of	reduced,","
R8432	T10873	T10883	modOf	reduced,demonstrating
R8433	T10875	T10876	arg1Of	cells,from
R8434	T10875	T10880	arg1Of	cells,were
R8435	T10875	T10881	arg2Of	cells,used
R8436	T10879	T10876	arg2Of	mice,from
R8437	T10879	T10877	arg1Of	mice,CbfbF/F
R8438	T10879	T10878	arg1Of	mice,CD4-cre
R8439	T10881	T10874	arg2Of	used,when
R8440	T10881	T10880	arg2Of	used,were
R8441	T10887	T10885	arg1Of	complexes,TGF-β–induced
R8442	T10887	T10886	arg1Of	complexes,Runx
R8443	T10887	T10888	arg1Of	complexes,are
R8444	T10887	T10889	arg1Of	complexes,important
R8445	T10888	T10883	arg2Of	are,demonstrating
R8446	T10888	T10884	arg1Of	are,that
R8447	T10889	T10888	arg2Of	important,are
R8448	T10889	T10890	arg1Of	important,for
R8449	T10893	T10890	arg2Of	activity,for
R8450	T10893	T10891	arg1Of	activity,the
R8451	T10893	T10892	arg1Of	activity,suppressive
R8452	T10893	T10894	arg1Of	activity,of
R8453	T10898	T10894	arg2Of	cells,of
R8454	T10898	T10895	arg1Of	cells,Foxp3+
R8455	T10898	T10896	arg1Of	cells,T
R8456	T10898	T10897	arg1Of	cells,reg
R8457	T10898	T10899	arg1Of	cells,(
R8458	T10902	T10899	arg2Of	B,(
R8459	T10902	T10900	arg1Of	B,Fig.
R8460	T10902	T10901	arg1Of	B,6
R8461	T10903	T10899	arg3Of	),(
R8462	T10906	T10904	arg2Of	control,As
R8463	T10906	T10905	arg1Of	control,a
R8464	T10912	T10908	arg1Of	cells,CbfbF/+
R8465	T10912	T10909	arg1Of	cells,CD4-cre
R8466	T10912	T10910	arg1Of	cells,CD4+
R8467	T10912	T10911	arg1Of	cells,T
R8468	T10912	T10913	arg2Of	cells,activated
R8469	T10912	T10918	arg1Of	cells,were
R8470	T10912	T10919	arg2Of	cells,mixed
R8471	T10913	T10914	arg1Of	activated,in
R8472	T10915	T10914	arg2Of	absence,in
R8473	T10915	T10916	arg1Of	absence,of
R8474	T10917	T10916	arg2Of	TGF-β,of
R8475	T10919	T10904	arg1Of	mixed,As
R8476	T10919	T10907	arg1Of	mixed,","
R8477	T10919	T10918	arg2Of	mixed,were
R8478	T10919	T10920	arg1Of	mixed,with
R8479	T10925	T10920	arg2Of	cells,with
R8480	T10925	T10921	arg1Of	cells,CFSE-labeled
R8481	T10925	T10922	arg1Of	cells,naive
R8482	T10925	T10923	arg1Of	cells,CD45.1+
R8483	T10925	T10924	arg1Of	cells,CD4+
R8484	T10927	T10926	arg1Of	suppression,No
R8485	T10927	T10928	arg1Of	suppression,could
R8486	T10927	T10929	arg1Of	suppression,be
R8487	T10927	T10930	arg2Of	suppression,observed
R8488	T10930	T10928	arg2Of	observed,could
R8489	T10930	T10929	arg2Of	observed,be
R8490	T10930	T10931	arg1Of	observed,in
R8491	T10934	T10931	arg2Of	groups,in
R8492	T10934	T10932	arg1Of	groups,all
R8493	T10934	T10933	arg1Of	groups,control
R8494	T10934	T10935	arg1Of	groups,without
R8495	T10934	T10937	arg1Of	groups,at
R8496	T10936	T10935	arg2Of	TGF-β,without
R8497	T10940	T10937	arg2Of	ratios,at
R8498	T10940	T10938	arg1Of	ratios,all
R8499	T10940	T10939	arg2Of	ratios,tested
R8500	T10940	T10941	arg1Of	ratios,(
R8501	T10944	T10941	arg2Of	C,(
R8502	T10944	T10942	arg1Of	C,Fig.
R8503	T10944	T10943	arg1Of	C,6
R8504	T10945	T10941	arg3Of	),(
R8505	T10949	T10946	arg1Of	capacity,The
R8506	T10949	T10947	arg2Of	capacity,decreased
R8507	T10949	T10948	arg1Of	capacity,suppression
R8508	T10949	T10950	arg1Of	capacity,of
R8509	T10949	T10956	arg1Of	capacity,was
R8510	T10949	T10957	arg1Of	capacity,unlikely
R8511	T10949	T10959	arg1Of	capacity,be
R8512	T10949	T10960	arg2Of	capacity,caused
R8513	T10955	T10950	arg2Of	cells,of
R8514	T10955	T10951	arg1Of	cells,CbfbF/F
R8515	T10955	T10952	arg1Of	cells,CD4-cre
R8516	T10955	T10953	arg1Of	cells,iT
R8517	T10955	T10954	arg1Of	cells,reg
R8518	T10957	T10956	arg2Of	unlikely,was
R8519	T10960	T10957	arg2Of	caused,unlikely
R8520	T10960	T10958	arg1Of	caused,to
R8521	T10960	T10959	arg2Of	caused,be
R8522	T10963	T10964	arg1Of	survival,or
R8523	T10964	T10960	arg1Of	or,caused
R8524	T10964	T10961	arg2Of	or,by
R8525	T10964	T10962	arg2Of	or,decreased
R8526	T10965	T10964	arg2Of	proliferation,or
R8527	T10966	T10967	arg1Of	Foxp3+,and
R8528	T10968	T10967	arg2Of	Foxp3−,and
R8529	T10969	T10966	arg1Of	cells,Foxp3+
R8530	T10969	T10968	arg1Of	cells,Foxp3−
R8531	T10969	T10970	arg2Of	cells,generated
R8532	T10969	T10979	arg1Of	cells,displayed
R8533	T10970	T10971	arg1Of	generated,from
R8534	T10974	T10975	arg1Of	CD4-cre,and
R8535	T10975	T10973	arg1Of	and,CbfbF/F
R8536	T10976	T10975	arg2Of	control,and
R8537	T10977	T10971	arg2Of	cells,from
R8538	T10977	T10972	arg1Of	cells,both
R8539	T10977	T10974	arg1Of	cells,CD4-cre
R8540	T10977	T10976	arg1Of	cells,control
R8541	T10979	T10978	arg1Of	displayed,all
R8542	T10982	T10980	arg1Of	rates,similar
R8543	T10982	T10981	arg1Of	rates,proliferation
R8544	T10982	T10983	arg1Of	rates,and
R8545	T10983	T10979	arg2Of	and,displayed
R8546	T10983	T10986	arg1Of	and,as
R8547	T10983	T10995	arg1Of	and,","
R8548	T10983	T10996	arg1Of	and,respectively
R8549	T10983	T10997	arg1Of	and,(
R8550	T10985	T10983	arg2Of	death,and
R8551	T10985	T10984	arg1Of	death,cell
R8552	T10987	T10986	arg2Of	measured,as
R8553	T10987	T10988	arg1Of	measured,by
R8554	T10990	T10989	arg1Of	dilution,CFSE
R8555	T10990	T10991	arg1Of	dilution,and
R8556	T10991	T10988	arg2Of	and,by
R8557	T10994	T10991	arg2Of	staining,and
R8558	T10994	T10992	arg1Of	staining,annexin
R8559	T10994	T10993	arg1Of	staining,V
R8560	T10999	T11000	arg1Of	S7,","
R8561	T11000	T11002	arg1Of	",",and
R8562	T11001	T11000	arg2Of	A,","
R8563	T11002	T10997	arg2Of	and,(
R8564	T11002	T10998	arg1Of	and,Fig.
R8565	T11003	T11002	arg2Of	B,and
R8566	T11004	T10997	arg3Of	),(
R8567	T11006	T11005	arg2Of	addition,In
R8568	T11008	T11009	arg1Of	we,tested
R8569	T11009	T11005	arg1Of	tested,In
R8570	T11009	T11007	arg1Of	tested,","
R8571	T11011	T11009	arg2Of	requirement,tested
R8572	T11011	T11010	arg1Of	requirement,the
R8573	T11011	T11012	arg1Of	requirement,of
R8574	T11011	T11016	arg1Of	requirement,for
R8575	T11013	T11014	arg1Of	RUNX1,and
R8576	T11014	T11012	arg2Of	and,of
R8577	T11015	T11014	arg2Of	RUNX3,and
R8578	T11018	T11016	arg2Of	development,for
R8579	T11018	T11017	arg1Of	development,the
R8580	T11018	T11019	arg1Of	development,of
R8581	T11018	T11023	arg1Of	development,in
R8582	T11022	T11019	arg2Of	capacity,of
R8583	T11022	T11020	arg1Of	capacity,the
R8584	T11022	T11021	arg1Of	capacity,suppressive
R8585	T11027	T11023	arg2Of	cells,in
R8586	T11027	T11024	arg1Of	cells,human
R8587	T11027	T11025	arg1Of	cells,iT
R8588	T11027	T11026	arg1Of	cells,reg
R8589	T11028	T11029	arg1Of	We,isolated
R8590	T11029	T11036	modOf	isolated,transfected
R8591	T11029	T11038	arg1Of	isolated,with
R8592	T11029	T11048	arg1Of	isolated,with
R8593	T11034	T11030	arg1Of	cells,human
R8594	T11034	T11031	arg1Of	cells,naive
R8595	T11034	T11032	arg1Of	cells,CD4+
R8596	T11034	T11033	arg1Of	cells,T
R8597	T11034	T11035	arg1Of	cells,and
R8598	T11034	T11036	arg2Of	cells,transfected
R8599	T11037	T11029	arg2Of	them,isolated
R8600	T11038	T11047	arg1Of	with,or
R8601	T11040	T11038	arg2Of	combination,with
R8602	T11040	T11039	arg1Of	combination,a
R8603	T11040	T11041	arg1Of	combination,of
R8604	T11042	T11043	arg1Of	RUNX1,and
R8605	T11044	T11043	arg2Of	RUNX3,and
R8606	T11045	T11041	arg2Of	siRNA,of
R8607	T11045	T11042	arg1Of	siRNA,RUNX1
R8608	T11045	T11044	arg1Of	siRNA,RUNX3
R8609	T11047	T11046	arg1Of	or,","
R8610	T11048	T11047	arg2Of	with,or
R8611	T11052	T11048	arg2Of	siRNA,with
R8612	T11052	T11049	arg1Of	siRNA,a
R8613	T11052	T11050	arg2Of	siRNA,scrambled
R8614	T11052	T11051	arg1Of	siRNA,control
R8615	T11053	T11054	arg1Of	Cells,were
R8616	T11053	T11055	arg2Of	Cells,cultured
R8617	T11053	T11063	arg2Of	Cells,mixed
R8618	T11053	T11071	arg2Of	Cells,stimulated
R8619	T11055	T11056	arg1Of	cultured,under
R8620	T11055	T11061	arg1Of	cultured,and
R8621	T11059	T11056	arg2Of	conditions,under
R8622	T11059	T11057	arg1Of	conditions,T
R8623	T11059	T11058	arg1Of	conditions,reg
R8624	T11061	T11054	arg2Of	and,were
R8625	T11061	T11060	arg1Of	and,","
R8626	T11063	T11064	arg1Of	mixed,with
R8627	T11063	T11070	arg1Of	mixed,and
R8628	T11069	T11064	arg2Of	cells,with
R8629	T11069	T11065	arg1Of	cells,CFSE-labeled
R8630	T11069	T11066	arg1Of	cells,autologous
R8631	T11069	T11067	arg1Of	cells,CD4+
R8632	T11069	T11068	arg1Of	cells,T
R8633	T11070	T11061	arg2Of	and,and
R8634	T11070	T11062	arg1Of	and,then
R8635	T11071	T11070	arg2Of	stimulated,and
R8636	T11071	T11072	arg1Of	stimulated,with
R8637	T11074	T11072	arg2Of	mAb,with
R8638	T11074	T11073	arg1Of	mAb,anti-CD3
R8639	T11075	T11076	arg2Of	Cells,in
R8640	T11075	T11077	arg1Of	Cells,which
R8641	T11075	T11084	arg1Of	Cells,showed
R8642	T11078	T11079	arg1Of	RUNX1,and
R8643	T11079	T11081	arg1Of	and,were
R8644	T11079	T11082	arg2Of	and,knocked
R8645	T11080	T11079	arg2Of	RUNX3,and
R8646	T11082	T11076	arg1Of	knocked,in
R8647	T11082	T11081	arg2Of	knocked,were
R8648	T11082	T11083	arg1Of	knocked,down
R8649	T11084	T11089	arg1Of	showed,compared
R8650	T11085	T11086	arg1Of	markedly,lower
R8651	T11087	T11085	arg1Of	suppressive,markedly
R8652	T11088	T11084	arg2Of	activity,showed
R8653	T11088	T11087	arg1Of	activity,suppressive
R8654	T11090	T11089	arg2Of	with,compared
R8655	T11094	T11091	arg1Of	cells,control
R8656	T11094	T11092	arg1Of	cells,iT
R8657	T11094	T11093	arg1Of	cells,reg
R8658	T11094	T11095	arg1Of	cells,at
R8659	T11094	T11108	arg1Of	cells,but
R8660	T11102	T11095	arg2Of	ratio,at
R8661	T11102	T11096	arg1Of	ratio,a
R8662	T11102	T11097	arg1Of	ratio,T
R8663	T11102	T11098	arg1Of	ratio,reg/CD4+
R8664	T11102	T11099	arg1Of	ratio,T
R8665	T11102	T11100	arg1Of	ratio,responder
R8666	T11102	T11101	arg1Of	ratio,cell
R8667	T11102	T11103	arg1Of	ratio,of
R8668	T11106	T11103	arg2Of	20,of
R8669	T11106	T11104	arg1Of	20,1
R8670	T11106	T11105	arg1Of	20,:
R8671	T11108	T11090	arg2Of	but,with
R8672	T11108	T11107	arg1Of	but,","
R8673	T11108	T11109	arg1Of	but,not
R8674	T11110	T11108	arg2Of	when,but
R8675	T11117	T11111	arg1Of	ratio,the
R8676	T11117	T11112	arg1Of	ratio,T
R8677	T11117	T11113	arg1Of	ratio,reg/CD4+
R8678	T11117	T11114	arg1Of	ratio,T
R8679	T11117	T11115	arg1Of	ratio,responder
R8680	T11117	T11116	arg1Of	ratio,cell
R8681	T11117	T11118	arg1Of	ratio,was
R8682	T11117	T11119	arg2Of	ratio,increased
R8683	T11119	T11110	arg1Of	increased,when
R8684	T11119	T11118	arg2Of	increased,was
R8685	T11119	T11120	arg1Of	increased,to
R8686	T11123	T11120	arg2Of	5,to
R8687	T11123	T11121	arg1Of	5,1
R8688	T11123	T11122	arg1Of	5,:
R8689	T11123	T11124	arg1Of	5,(
R8690	T11127	T11124	arg2Of	D,(
R8691	T11127	T11125	arg1Of	D,Fig.
R8692	T11127	T11126	arg1Of	D,6
R8693	T11128	T11124	arg3Of	),(
R8694	T11130	T11129	arg1Of	results,These
R8695	T11130	T11131	arg1Of	results,demonstrate
R8696	T11131	T11141	arg1Of	demonstrate,for
R8697	T11131	T11149	arg1Of	demonstrate,for
R8698	T11134	T11131	arg2Of	role,demonstrate
R8699	T11134	T11132	arg1Of	role,the
R8700	T11134	T11133	arg1Of	role,important
R8701	T11134	T11135	arg1Of	role,of
R8702	T11136	T11137	arg1Of	RUNX1,and
R8703	T11137	T11135	arg2Of	and,of
R8704	T11138	T11137	arg2Of	RUNX3,and
R8705	T11140	T11139	arg1Of	only,not
R8706	T11141	T11147	arg1Of	for,but
R8707	T11143	T11141	arg2Of	induction,for
R8708	T11143	T11142	arg1Of	induction,the
R8709	T11143	T11144	arg1Of	induction,of
R8710	T11145	T11144	arg2Of	FOXP3,of
R8711	T11147	T11140	arg1Of	but,only
R8712	T11147	T11146	arg1Of	but,","
R8713	T11147	T11148	arg1Of	but,also
R8714	T11149	T11147	arg2Of	for,but
R8715	T11152	T11149	arg2Of	capacity,for
R8716	T11152	T11150	arg1Of	capacity,the
R8717	T11152	T11151	arg1Of	capacity,suppressive
R8718	T11152	T11153	arg1Of	capacity,of
R8719	T11152	T11158	arg1Of	capacity,in
R8720	T11152	T11161	arg1Of	capacity,in
R8721	T11156	T11153	arg2Of	cells,of
R8722	T11156	T11154	arg1Of	cells,iT
R8723	T11156	T11155	arg1Of	cells,reg
R8724	T11158	T11160	arg1Of	in,and
R8725	T11159	T11158	arg2Of	humans,in
R8726	T11160	T11157	arg1Of	and,both
R8727	T11161	T11160	arg2Of	in,and
R8728	T11162	T11161	arg2Of	mice,in
R8729	T11164	T11163	arg1Of	data,The
R8730	T11164	T11165	arg1Of	data,suggest
R8731	T11167	T11168	arg1Of	quantity,and
R8732	T11168	T11166	arg1Of	and,both
R8733	T11168	T11170	arg1Of	and,of
R8734	T11168	T11174	arg1Of	and,are
R8735	T11168	T11175	arg2Of	and,hampered
R8736	T11169	T11168	arg2Of	quality,and
R8737	T11173	T11170	arg2Of	cells,of
R8738	T11173	T11171	arg1Of	cells,T
R8739	T11173	T11172	arg1Of	cells,reg
R8740	T11175	T11165	arg2Of	hampered,suggest
R8741	T11175	T11174	arg2Of	hampered,are
R8742	T11179	T11176	arg2Of	capacity,Reduced
R8743	T11179	T11177	arg1Of	capacity,intrinsic
R8744	T11179	T11178	arg1Of	capacity,suppressive
R8745	T11179	T11180	arg1Of	capacity,of
R8746	T11179	T11184	arg1Of	capacity,was
R8747	T11179	T11185	arg2Of	capacity,demonstrated
R8748	T11183	T11180	arg2Of	cells,of
R8749	T11183	T11181	arg1Of	cells,iT
R8750	T11183	T11182	arg1Of	cells,reg
R8751	T11185	T11184	arg2Of	demonstrated,was
R8752	T11185	T11186	arg1Of	demonstrated,in
R8753	T11185	T11188	arg1Of	demonstrated,","
R8754	T11187	T11186	arg2Of	mice,in
R8755	T11189	T11185	arg3Of	because,demonstrated
R8756	T11191	T11190	arg1Of	cells,Foxp3-GFP+
R8757	T11191	T11192	arg1Of	cells,were
R8758	T11192	T11195	arg1Of	were,and
R8759	T11193	T11192	arg2Of	FACS,were
R8760	T11193	T11194	arg2Of	FACS,sorted
R8761	T11195	T11189	arg2Of	and,because
R8762	T11197	T11196	arg1Of	numbers,same
R8763	T11197	T11198	arg1Of	numbers,of
R8764	T11197	T11202	arg1Of	numbers,are
R8765	T11197	T11203	arg2Of	numbers,included
R8766	T11201	T11198	arg2Of	cells,of
R8767	T11201	T11199	arg1Of	cells,iT
R8768	T11201	T11200	arg1Of	cells,reg
R8769	T11203	T11195	arg2Of	included,and
R8770	T11203	T11202	arg2Of	included,are
R8771	T11203	T11204	arg1Of	included,in
R8772	T11206	T11204	arg2Of	experiments,in
R8773	T11206	T11205	arg1Of	experiments,control
R8774	T11210	T11207	arg2Of	experiment,In
R8775	T11210	T11208	arg1Of	experiment,the
R8776	T11210	T11209	arg1Of	experiment,suppression
R8777	T11210	T11211	arg1Of	experiment,with
R8778	T11213	T11211	arg2Of	cells,with
R8779	T11213	T11212	arg1Of	cells,human
R8780	T11217	T11215	arg2Of	activity,reduced
R8781	T11217	T11216	arg1Of	activity,suppressive
R8782	T11217	T11218	arg1Of	activity,was
R8783	T11217	T11219	arg2Of	activity,caused
R8784	T11219	T11207	arg1Of	caused,In
R8785	T11219	T11214	arg1Of	caused,","
R8786	T11219	T11218	arg2Of	caused,was
R8787	T11219	T11220	arg1Of	caused,by
R8788	T11223	T11220	arg2Of	expression,by
R8789	T11223	T11221	arg2Of	expression,reduced
R8790	T11223	T11222	arg1Of	expression,FOXP3
R8791	T11223	T11224	arg1Of	expression,in
R8792	T11226	T11224	arg2Of	cells,in
R8793	T11226	T11225	arg1Of	cells,T
R8794	T11229	T11219	arg1Of	inhibition,caused
R8795	T11229	T11227	arg2Of	inhibition,by
R8796	T11229	T11228	arg1Of	inhibition,siRNA
R8797	T11229	T11230	arg1Of	inhibition,of
R8798	T11231	T11232	arg1Of	RUNX1,and
R8799	T11232	T11230	arg2Of	and,of
R8800	T11233	T11232	arg2Of	RUNX3,and
R24572	T32183	T32180	arg1Of	cells,CbfbF/F
R24573	T32183	T32181	arg1Of	cells,CD4-cre
R24574	T32183	T32182	arg1Of	cells,mouse
R24575	T32183	T32184	arg1Of	cells,and
R24576	T32184	T32202	arg2Of	and,show
R24577	T32187	T32184	arg2Of	cells,and
R24578	T32187	T32185	arg1Of	cells,iT
R24579	T32187	T32186	arg1Of	cells,reg
R24580	T32187	T32188	arg2Of	cells,generated
R24581	T32191	T32189	arg1Of	naive,from
R24582	T32191	T32190	arg1Of	naive,human
R24583	T32192	T32191	arg1Of	CD4+,naive
R24584	T32192	T32201	arg2Of	CD4+,down
R24585	T32192	T32202	arg1Of	CD4+,show
R24586	T32194	T32193	arg1Of	cells,T
R24587	T32194	T32195	arg1Of	cells,undergoing
R24588	T32194	T32200	arg1Of	cells,knock
R24589	T32197	T32198	arg1Of	RUNX1,and
R24590	T32198	T32195	arg2Of	and,undergoing
R24591	T32198	T32196	arg1Of	and,siRNA-mediated
R24592	T32199	T32198	arg2Of	RUNX3,and
R24593	T32200	T32201	arg1Of	knock,down
R24594	T32206	T32202	arg3Of	activity,show
R24595	T32206	T32203	arg1Of	activity,a
R24596	T32206	T32204	arg1Of	activity,diminished
R24597	T32206	T32205	arg1Of	activity,suppressive
R24598	T32208	T32207	arg1Of	setup,Experimental
R24599	T32208	T32209	arg1Of	setup,(
R24600	T32208	T32212	arg1Of	setup,and
R24601	T32210	T32209	arg2Of	A,(
R24602	T32211	T32209	arg3Of	),(
R24603	T32212	T32234	arg1Of	and,and
R24604	T32213	T32214	arg1Of	results,of
R24605	T32213	T32222	arg1Of	results,","
R24606	T32218	T32214	arg2Of	assay,of
R24607	T32218	T32215	arg1Of	assay,the
R24608	T32218	T32216	arg1Of	assay,mouse
R24609	T32218	T32217	arg1Of	assay,suppression
R24610	T32218	T32219	arg1Of	assay,(
R24611	T32220	T32219	arg2Of	B,(
R24612	T32221	T32219	arg3Of	),(
R24613	T32222	T32212	arg2Of	",",and
R24614	T32222	T32230	arg1Of	",",CD4-cre
R24615	T32227	T32222	arg2Of	cells,","
R24616	T32227	T32223	arg1Of	cells,FACS-purified
R24617	T32227	T32224	arg1Of	cells,naive
R24618	T32227	T32225	arg1Of	cells,CD4+8−
R24619	T32227	T32226	arg1Of	cells,T
R24620	T32227	T32228	arg1Of	cells,from
R24621	T32229	T32228	arg2Of	CbfbF/F,from
R24622	T32230	T32231	arg1Of	CD4-cre,(
R24623	T32232	T32231	arg2Of	left,(
R24624	T32233	T32231	arg3Of	),(
R24625	T32234	T32244	arg1Of	and,were
R24626	T32234	T32245	arg2Of	and,activated
R24627	T32238	T32234	arg2Of	mice,and
R24628	T32238	T32235	arg1Of	mice,control
R24629	T32238	T32236	arg1Of	mice,CbfbF/+
R24630	T32238	T32237	arg1Of	mice,CD4-cre
R24631	T32238	T32239	arg1Of	mice,(
R24632	T32240	T32239	arg2Of	Cd45.2,(
R24633	T32240	T32241	arg1Of	Cd45.2,;
R24634	T32242	T32241	arg2Of	right,;
R24635	T32243	T32239	arg3Of	),(
R24636	T32245	T32244	arg2Of	activated,were
R24637	T32245	T32247	arg1Of	activated,vitro
R24638	T32245	T32248	arg1Of	activated,with
R24639	T32247	T32246	arg1Of	vitro,in
R24640	T32250	T32249	arg1Of	mAb,anti-CD3/28
R24641	T32250	T32251	arg1Of	mAb,","
R24642	T32251	T32256	arg1Of	",",and
R24643	T32254	T32251	arg2Of	IL-2,","
R24644	T32254	T32252	arg1Of	IL-2,50
R24645	T32254	T32253	arg1Of	IL-2,U/ml
R24646	T32256	T32248	arg2Of	and,with
R24647	T32256	T32255	arg1Of	and,","
R24648	T32257	T32258	arg1Of	2.5,ng/ml
R24649	T32259	T32256	arg2Of	TGF-β,and
R24650	T32259	T32257	arg1Of	TGF-β,2.5
R24651	T32262	T32260	arg2Of	d,After
R24652	T32262	T32261	arg1Of	d,3
R24653	T32265	T32264	arg1Of	cells,Foxp3-GFP+
R24654	T32265	T32266	arg1Of	cells,were
R24655	T32265	T32267	arg1Of	cells,FACS-sorted
R24656	T32265	T32269	arg2Of	cells,mixed
R24657	T32266	T32260	arg1Of	were,After
R24658	T32266	T32263	arg1Of	were,","
R24659	T32267	T32268	arg1Of	FACS-sorted,and
R24660	T32268	T32266	arg2Of	and,were
R24661	T32269	T32268	arg2Of	mixed,and
R24662	T32269	T32270	arg1Of	mixed,with
R24663	T32269	T32276	arg1Of	mixed,at
R24664	T32275	T32270	arg2Of	cells,with
R24665	T32275	T32271	arg1Of	cells,CFSE-loaded
R24666	T32275	T32272	arg1Of	cells,naive
R24667	T32275	T32273	arg1Of	cells,CD45.1+
R24668	T32275	T32274	arg1Of	cells,CD4+
R24669	T32279	T32276	arg2Of	ratios,at
R24670	T32279	T32277	arg1Of	ratios,the
R24671	T32279	T32278	arg1Of	ratios,indicated
R24672	T32280	T32281	arg1Of	These,were
R24673	T32280	T32283	arg2Of	These,incubated
R24674	T32283	T32281	arg2Of	incubated,were
R24675	T32283	T32282	arg1Of	incubated,then
R24676	T32283	T32284	arg1Of	incubated,with
R24677	T32286	T32285	arg2Of	splenocytes,inactivated
R24678	T32286	T32287	arg1Of	splenocytes,and
R24679	T32287	T32284	arg2Of	and,with
R24680	T32289	T32287	arg2Of	mAb,and
R24681	T32289	T32288	arg1Of	mAb,anti-CD3
R24682	T32294	T32290	arg2Of	d,After
R24683	T32294	T32291	arg1Of	d,a
R24684	T32294	T32292	arg1Of	d,further
R24685	T32294	T32293	arg1Of	d,4
R24686	T32297	T32296	arg1Of	cells,CD45.1+
R24687	T32297	T32298	arg1Of	cells,were
R24688	T32297	T32299	arg2Of	cells,analyzed
R24689	T32299	T32290	arg1Of	analyzed,After
R24690	T32299	T32295	arg1Of	analyzed,","
R24691	T32299	T32298	arg2Of	analyzed,were
R24692	T32299	T32300	arg1Of	analyzed,for
R24693	T32299	T32306	arg1Of	analyzed,As
R24694	T32302	T32300	arg2Of	dilution.,for
R24695	T32302	T32301	arg1Of	dilution.,CFSE
R24696	T32302	T32303	arg1Of	dilution.,(
R24697	T32304	T32303	arg2Of	C,(
R24698	T32305	T32303	arg3Of	),(
R24699	T32308	T32306	arg2Of	control,As
R24700	T32308	T32307	arg1Of	control,a
R24701	T32308	T32320	modOf	control,were
R24702	T32314	T32310	arg1Of	cells,CbfbF/+
R24703	T32314	T32311	arg1Of	cells,CD4-cre
R24704	T32314	T32312	arg1Of	cells,CD4+
R24705	T32314	T32313	arg1Of	cells,T
R24706	T32314	T32315	arg2Of	cells,activated
R24707	T32314	T32320	arg1Of	cells,were
R24708	T32314	T32321	arg2Of	cells,mixed
R24709	T32315	T32316	arg1Of	activated,in
R24710	T32317	T32316	arg2Of	absence,in
R24711	T32317	T32318	arg1Of	absence,of
R24712	T32319	T32318	arg2Of	TGF-β,of
R24713	T32321	T32309	arg1Of	mixed,","
R24714	T32321	T32320	arg2Of	mixed,were
R24715	T32321	T32322	arg1Of	mixed,with
R24716	T32327	T32322	arg2Of	cells,with
R24717	T32327	T32323	arg1Of	cells,CFSE-loaded
R24718	T32327	T32324	arg1Of	cells,naive
R24719	T32327	T32325	arg1Of	cells,CD45.1+
R24720	T32327	T32326	arg1Of	cells,CD4+
R24721	T32327	T32328	arg1Of	cells,at
R24722	T32331	T32328	arg2Of	ratios,at
R24723	T32331	T32329	arg1Of	ratios,the
R24724	T32331	T32330	arg1Of	ratios,indicated
R24725	T32333	T32332	arg1Of	days,Four
R24726	T32334	T32333	arg1Of	later,days
R24727	T32336	T32335	arg1Of	cells,CD45.1+
R24728	T32336	T32337	arg1Of	cells,were
R24729	T32336	T32338	arg2Of	cells,analyzed
R24730	T32338	T32334	arg1Of	analyzed,later
R24731	T32338	T32337	arg2Of	analyzed,were
R24732	T32338	T32339	arg1Of	analyzed,for
R24733	T32341	T32339	arg2Of	dilution,for
R24734	T32341	T32340	arg1Of	dilution,CFSE
R24735	T32345	T32342	arg1Of	number,The
R24736	T32345	T32343	arg1Of	number,median
R24737	T32345	T32344	arg1Of	number,division
R24738	T32345	T32346	arg1Of	number,(
R24739	T32345	T32360	arg1Of	number,is
R24740	T32345	T32361	arg2Of	number,indicated
R24741	T32347	T32346	arg2Of	of,(
R24742	T32352	T32347	arg2Of	cells,of
R24743	T32352	T32348	arg1Of	cells,the
R24744	T32352	T32349	arg1Of	cells,naive
R24745	T32352	T32350	arg1Of	cells,CD45.1+
R24746	T32352	T32351	arg1Of	cells,CD4+
R24747	T32352	T32353	arg1Of	cells,in
R24748	T32355	T32353	arg2Of	cultures,in
R24749	T32355	T32354	arg1Of	cultures,the
R24750	T32355	T32356	arg1Of	cultures,containing
R24751	T32358	T32356	arg2Of	cells,containing
R24752	T32358	T32357	arg1Of	cells,Foxp3-GFP+
R24753	T32359	T32346	arg3Of	),(
R24754	T32361	T32360	arg2Of	indicated,is
R24755	T32361	T32362	arg1Of	indicated,in
R24756	T32363	T32362	arg2Of	each,in
R24757	T32363	T32364	arg1Of	each,of
R24758	T32366	T32364	arg2Of	histograms,of
R24759	T32366	T32365	arg1Of	histograms,the
R24760	T32367	T32368	arg1Of	One,of
R24761	T32367	T32371	arg1Of	One,is
R24762	T32370	T32368	arg2Of	experiments,of
R24763	T32370	T32369	arg1Of	experiments,three
R24764	T32374	T32373	arg2Of	D,(
R24765	T32375	T32373	arg3Of	),(
R24766	T32376	T32372	arg1Of	Human,shown.
R24767	T32376	T32373	arg1Of	Human,(
R24768	T32380	T32376	arg1Of	cells,Human
R24769	T32380	T32377	arg1Of	cells,naive
R24770	T32380	T32378	arg1Of	cells,CD4+
R24771	T32380	T32379	arg1Of	cells,T
R24772	T32380	T32381	arg1Of	cells,","
R24773	T32380	T32382	arg2Of	cells,transfected
R24774	T32380	T32389	arg2Of	cells,cultured
R24775	T32380	T32395	arg1Of	cells,were
R24776	T32380	T32396	arg2Of	cells,used
R24777	T32380	T32414	arg2Of	cells,stimulated
R24778	T32382	T32383	arg1Of	transfected,with
R24779	T32382	T32388	arg1Of	transfected,and
R24780	T32384	T32385	arg1Of	RUNX1,and
R24781	T32385	T32383	arg2Of	and,with
R24782	T32387	T32385	arg2Of	siRNA,and
R24783	T32387	T32386	arg1Of	siRNA,RUNX3
R24784	T32389	T32388	arg2Of	cultured,and
R24785	T32389	T32390	arg1Of	cultured,under
R24786	T32394	T32390	arg2Of	conditions,under
R24787	T32394	T32391	arg1Of	conditions,iT
R24788	T32394	T32392	arg1Of	conditions,reg
R24789	T32394	T32393	arg1Of	conditions,differentiating
R24790	T32396	T32397	arg1Of	used,in
R24791	T32396	T32413	arg1Of	used,and
R24792	T32400	T32399	arg1Of	vitro,in
R24793	T32402	T32397	arg2Of	assay,in
R24794	T32402	T32398	arg1Of	assay,an
R24795	T32402	T32400	arg1Of	assay,vitro
R24796	T32402	T32401	arg1Of	assay,suppression
R24797	T32402	T32403	arg1Of	assay,","
R24798	T32402	T32404	arg2Of	assay,cultured
R24799	T32404	T32405	arg1Of	cultured,together
R24800	T32404	T32406	arg1Of	cultured,with
R24801	T32411	T32406	arg2Of	cells,with
R24802	T32411	T32407	arg1Of	cells,autologous
R24803	T32411	T32408	arg1Of	cells,CFSE-labeled
R24804	T32411	T32409	arg1Of	cells,CD4+
R24805	T32411	T32410	arg1Of	cells,T
R24806	T32413	T32371	arg2Of	and,is
R24807	T32413	T32395	arg2Of	and,were
R24808	T32413	T32412	arg1Of	and,","
R24809	T32414	T32413	arg2Of	stimulated,and
R24810	T32414	T32415	arg1Of	stimulated,with
R24811	T32417	T32415	arg2Of	mAb,with
R24812	T32417	T32416	arg1Of	mAb,anti-CD3
R24813	T32420	T32418	arg1Of	dilution,The
R24814	T32420	T32419	arg1Of	dilution,CFSE
R24815	T32420	T32421	arg1Of	dilution,of
R24816	T32420	T32428	arg1Of	dilution,was
R24817	T32420	T32429	arg2Of	dilution,analyzed
R24818	T32427	T32421	arg2Of	cells,of
R24819	T32427	T32422	arg1Of	cells,the
R24820	T32427	T32423	arg1Of	cells,CD4+
R24821	T32427	T32424	arg1Of	cells,T
R24822	T32427	T32425	arg1Of	cells,cell
R24823	T32427	T32426	arg1Of	cells,responder
R24824	T32429	T32428	arg2Of	analyzed,was
R24825	T32429	T32430	arg1Of	analyzed,after
R24826	T32432	T32430	arg2Of	d,after
R24827	T32432	T32431	arg1Of	d,5
R24828	T32432	T32433	arg1Of	d,by
R24829	T32435	T32433	arg2Of	cytometry,by
R24830	T32435	T32434	arg1Of	cytometry,flow
R24831	T32442	T32436	arg1Of	ratios,The
R24832	T32442	T32437	arg1Of	ratios,T
R24833	T32442	T32438	arg1Of	ratios,reg/responder
R24834	T32442	T32439	arg1Of	ratios,CD4+
R24835	T32442	T32440	arg1Of	ratios,T
R24836	T32442	T32441	arg1Of	ratios,cell
R24837	T32442	T32443	arg2Of	ratios,used
R24838	T32442	T32444	arg1Of	ratios,were
R24839	T32447	T32448	arg1Of	20,","
R24840	T32448	T32450	arg1Of	",",:
R24841	T32449	T32448	arg2Of	1,","
R24842	T32450	T32445	arg1Of	:,1
R24843	T32450	T32446	arg1Of	:,:
R24844	T32450	T32453	arg1Of	:,and
R24845	T32451	T32450	arg2Of	10,:
R24846	T32453	T32444	arg2Of	and,were
R24847	T32453	T32452	arg1Of	and,","
R24848	T32454	T32455	arg1Of	1,:
R24849	T32455	T32453	arg2Of	:,and
R24850	T32456	T32455	arg2Of	5,:
R24851	T32457	T32458	arg1Of	One,of
R24852	T32457	T32461	arg1Of	One,is
R24853	T32457	T32462	arg2Of	One,shown
R24854	T32460	T32458	arg2Of	experiments,of
R24855	T32460	T32459	arg1Of	experiments,two
R24856	T32462	T32461	arg2Of	shown,is

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T11340	0-4	NNP	denotes	CBFβ
T11341	4-5	,	denotes	,
T11342	6-11	NNP	denotes	RUNX1
T11343	11-12	,	denotes	,
T11344	13-16	CC	denotes	and
T11345	17-22	NNP	denotes	RUNX3
T11346	23-26	VBP	denotes	are
T11347	27-36	JJ	denotes	important
T11348	37-40	IN	denotes	for
T11349	41-44	DT	denotes	the
T11350	45-56	JJ	denotes	suppressive
T11351	57-65	NN	denotes	activity
T11352	66-68	IN	denotes	of
T11353	69-73	NNP	denotes	CD25
T11354	73-74	NNP	denotes	+
T11355	75-80	NNP	denotes	Foxp3
T11356	80-81	VBD	denotes	+
T11357	82-83	NNP	denotes	T
T11358	84-87	NN	denotes	reg
T11359	88-93	NNS	denotes	cells
T11360	94-98	RB	denotes	Even
T11361	99-105	IN	denotes	though
T11362	106-120	JJ	denotes	Cbfb-deficient
T11363	121-124	NNP	denotes	CD4
T11364	124-125	CD	denotes	+
T11365	126-127	NNP	denotes	T
T11366	128-133	NNS	denotes	cells
T11367	134-137	VBD	denotes	had
T11368	138-146	VBN	denotes	impaired
T11369	147-156	NN	denotes	induction
T11370	157-159	IN	denotes	of
T11371	160-165	JJ	denotes	Foxp3
T11372	166-171	IN	denotes	after
T11373	172-183	NN	denotes	stimulation
T11374	184-188	IN	denotes	with
T11375	189-197	JJ	denotes	anti-CD3
T11376	197-198	NN	denotes	/
T11377	198-200	CD	denotes	28
T11378	201-205	NNS	denotes	mAbs
T11379	206-209	CC	denotes	and
T11380	210-215	NNP	denotes	TGF-β
T11381	215-216	,	denotes	,
T11382	217-227	JJ	denotes	sufficient
T11383	228-235	NNS	denotes	numbers
T11384	236-238	IN	denotes	of
T11385	239-244	JJ	denotes	Foxp3
T11386	244-245	NN	denotes	+
T11387	246-251	NNS	denotes	cells
T11388	252-257	MD	denotes	could
T11389	258-260	VB	denotes	be
T11390	261-270	VBN	denotes	generated
T11391	271-273	TO	denotes	to
T11392	274-280	VB	denotes	permit
T11393	281-289	NN	denotes	analysis
T11394	290-292	IN	denotes	of
T11395	293-298	PRP$	denotes	their
T11396	299-310	JJ	denotes	suppressive
T11397	311-319	NN	denotes	activity
T11398	319-320	.	denotes	.
T11399	321-329	NNP	denotes	Purified
T11400	330-335	JJ	denotes	naive
T11401	336-339	NNP	denotes	CD4
T11402	339-340	CD	denotes	+
T11403	341-342	NNP	denotes	T
T11404	343-348	NNS	denotes	cells
T11405	349-353	IN	denotes	from
T11406	354-361	NNP	denotes	CbfbF/F
T11407	362-369	NNP	denotes	CD4-cre
T11408	370-373	CC	denotes	and
T11409	374-381	NN	denotes	control
T11410	382-387	NNP	denotes	CbfbF
T11411	387-388	NNP	denotes	/
T11412	388-389	VBD	denotes	+
T11413	390-397	JJ	denotes	CD4-cre
T11414	398-402	NNS	denotes	mice
T11415	403-404	-LRB-	denotes	(
T11416	404-408	NNS	denotes	Cd45
T11417	408-410	CD	denotes	.2
T11418	410-411	-RRB-	denotes	)
T11419	412-421	VBG	denotes	harboring
T11420	422-423	DT	denotes	a
T11421	424-438	JJ	denotes	Foxp3-ires-GFP
T11422	439-445	NN	denotes	allele
T11423	446-447	-LRB-	denotes	(
T11424	447-455	NNP	denotes	Bettelli
T11425	456-458	FW	denotes	et
T11426	459-462	FW	denotes	al.
T11427	462-463	,	denotes	,
T11428	464-468	CD	denotes	2006
T11429	468-469	-RRB-	denotes	)
T11430	470-474	VBD	denotes	were
T11431	475-485	VBN	denotes	stimulated
T11432	486-488	IN	denotes	in
T11433	489-494	NN	denotes	vitro
T11434	495-499	IN	denotes	with
T11435	500-508	JJ	denotes	anti-CD3
T11436	508-509	NN	denotes	/
T11437	509-511	CD	denotes	28
T11438	512-516	NNS	denotes	mAbs
T11439	516-517	,	denotes	,
T11440	518-522	NN	denotes	IL-2
T11441	522-523	,	denotes	,
T11442	524-527	CC	denotes	and
T11443	528-533	NNP	denotes	TGF-β
T11444	533-534	.	denotes	.
T11445	535-540	IN	denotes	After
T11446	541-542	CD	denotes	3
T11447	543-544	LS	denotes	d
T11448	544-545	,	denotes	,
T11449	546-551	JJ	denotes	Foxp3
T11450	551-552	SYM	denotes	+
T11451	552-553	:	denotes	-
T11452	553-556	NNP	denotes	GFP
T11453	556-557	CD	denotes	+
T11454	558-563	NNS	denotes	cells
T11455	564-568	VBD	denotes	were
T11456	569-575	VBN	denotes	sorted
T11457	576-578	IN	denotes	by
T11458	579-583	NN	denotes	flow
T11459	584-593	NN	denotes	cytometry
T11460	594-597	CC	denotes	and
T11461	598-603	JJ	denotes	mixed
T11462	604-608	IN	denotes	with
T11463	609-621	JJ	denotes	CFSE-labeled
T11464	622-627	JJ	denotes	naive
T11465	628-632	NNS	denotes	CD45
T11466	632-634	CD	denotes	.1
T11467	634-635	CD	denotes	+
T11468	636-639	NNP	denotes	CD4
T11469	639-640	NN	denotes	+
T11470	641-646	NNS	denotes	cells
T11471	647-649	IN	denotes	at
T11472	650-656	NNS	denotes	ratios
T11473	657-659	IN	denotes	of
T11474	660-663	CD	denotes	1:4
T11475	663-664	,	denotes	,
T11476	665-668	CD	denotes	1:2
T11477	668-669	,	denotes	,
T11478	670-673	CC	denotes	and
T11479	674-677	CD	denotes	1:1
T11480	677-678	.	denotes	.
T11481	679-682	DT	denotes	The
T11482	683-688	NNS	denotes	cells
T11483	689-693	VBD	denotes	were
T11484	694-698	RB	denotes	then
T11485	699-708	VBN	denotes	incubated
T11486	709-713	IN	denotes	with
T11487	714-725	JJ	denotes	inactivated
T11488	726-737	NNS	denotes	splenocytes
T11489	738-741	CC	denotes	and
T11490	742-752	VBN	denotes	stimulated
T11491	753-757	IN	denotes	with
T11492	758-766	JJ	denotes	anti-CD3
T11493	767-770	NNP	denotes	mAb
T11494	771-774	IN	denotes	for
T11495	775-779	CD	denotes	four
T11496	780-784	JJR	denotes	more
T11497	785-789	NNS	denotes	days
T11498	789-790	.	denotes	.
T11499	791-795	CD	denotes	CD45
T11500	795-797	CD	denotes	.1
T11501	797-798	NN	denotes	+
T11502	799-804	NNS	denotes	cells
T11503	805-809	VBD	denotes	were
T11504	810-818	VBN	denotes	analyzed
T11505	819-822	IN	denotes	for
T11506	823-827	NNP	denotes	CFSE
T11507	828-836	NN	denotes	dilution
T11508	837-838	-LRB-	denotes	(
T11509	838-842	FW	denotes	Fig.
T11510	843-844	CD	denotes	6
T11511	845-846	NN	denotes	A
T11512	846-847	-RRB-	denotes	)
T11513	847-848	.	denotes	.
T11514	849-854	NNP	denotes	CbfbF
T11515	854-855	NNP	denotes	/
T11516	855-856	NNP	denotes	+
T11517	857-864	NNP	denotes	CD4-cre
T11518	865-868	NNP	denotes	CD4
T11519	868-869	VBD	denotes	+
T11520	870-871	NNP	denotes	T
T11521	872-877	NNS	denotes	cells
T11522	878-887	VBN	denotes	activated
T11523	888-890	IN	denotes	in
T11524	891-894	DT	denotes	the
T11525	895-903	NN	denotes	presence
T11526	904-906	IN	denotes	of
T11527	907-912	JJ	denotes	TGF-β
T11528	913-919	VBD	denotes	showed
T11529	920-921	DT	denotes	a
T11530	922-927	JJ	denotes	clear
T11531	928-939	NN	denotes	suppression
T11532	940-942	IN	denotes	of
T11533	943-944	NNP	denotes	T
T11534	945-949	NN	denotes	cell
T11535	950-963	NN	denotes	proliferation
T11536	964-968	WDT	denotes	that
T11537	969-975	VBD	denotes	became
T11538	976-980	RB	denotes	even
T11539	981-985	RBR	denotes	more
T11540	986-994	JJ	denotes	apparent
T11541	995-999	WRB	denotes	when
T11542	1000-1002	DT	denotes	an
T11543	1003-1012	VBN	denotes	increased
T11544	1013-1018	NN	denotes	ratio
T11545	1019-1021	IN	denotes	of
T11546	1022-1027	CD	denotes	FOXP3
T11547	1027-1028	CD	denotes	+
T11548	1028-1029	NN	denotes	/
T11549	1029-1033	NNS	denotes	CD25
T11550	1033-1034	VBP	denotes	−
T11551	1035-1040	NNS	denotes	cells
T11552	1041-1044	VBD	denotes	was
T11553	1045-1049	VBN	denotes	used
T11554	1050-1051	-LRB-	denotes	(
T11555	1051-1055	NNP	denotes	Fig.
T11556	1056-1057	CD	denotes	6
T11557	1058-1059	NNP	denotes	B
T11558	1059-1060	-RRB-	denotes	)
T11559	1060-1061	.	denotes	.
T11560	1062-1065	DT	denotes	The
T11561	1066-1077	NN	denotes	suppression
T11562	1078-1081	VBD	denotes	was
T11563	1082-1095	RB	denotes	significantly
T11564	1096-1103	VBN	denotes	reduced
T11565	1104-1108	WRB	denotes	when
T11566	1109-1114	NNS	denotes	cells
T11567	1115-1119	IN	denotes	from
T11568	1120-1127	NNP	denotes	CbfbF/F
T11569	1128-1135	NNP	denotes	CD4-cre
T11570	1136-1140	NNS	denotes	mice
T11571	1141-1145	VBD	denotes	were
T11572	1146-1150	VBN	denotes	used
T11573	1150-1151	,	denotes	,
T11574	1152-1165	VBG	denotes	demonstrating
T11575	1166-1170	IN	denotes	that
T11576	1171-1176	NNP	denotes	TGF-β
T11577	1177-1184	VBD	denotes	induced
T11578	1185-1189	NNP	denotes	Runx
T11579	1190-1199	NNS	denotes	complexes
T11580	1200-1203	VBP	denotes	are
T11581	1204-1213	JJ	denotes	important
T11582	1214-1217	IN	denotes	for
T11583	1218-1221	DT	denotes	the
T11584	1222-1233	JJ	denotes	suppressive
T11585	1234-1242	NN	denotes	activity
T11586	1243-1245	IN	denotes	of
T11587	1246-1251	JJ	denotes	Foxp3
T11588	1251-1252	NN	denotes	+
T11589	1253-1254	NNP	denotes	T
T11590	1255-1258	NN	denotes	reg
T11591	1259-1264	NNS	denotes	cells
T11592	1265-1266	-LRB-	denotes	(
T11593	1266-1270	NNP	denotes	Fig.
T11594	1271-1272	CD	denotes	6
T11595	1273-1274	NNP	denotes	B
T11596	1274-1275	-RRB-	denotes	)
T11597	1275-1276	.	denotes	.
T11598	1277-1279	IN	denotes	As
T11599	1280-1281	DT	denotes	a
T11600	1282-1289	NN	denotes	control
T11601	1289-1290	,	denotes	,
T11602	1291-1296	NNP	denotes	CbfbF
T11603	1296-1297	NNP	denotes	/
T11604	1297-1298	NNP	denotes	+
T11605	1299-1306	NNP	denotes	CD4-cre
T11606	1307-1310	NNP	denotes	CD4
T11607	1310-1311	VBD	denotes	+
T11608	1312-1313	NNP	denotes	T
T11609	1314-1319	NNS	denotes	cells
T11610	1320-1329	VBN	denotes	activated
T11611	1330-1332	IN	denotes	in
T11612	1333-1340	NN	denotes	absence
T11613	1341-1343	IN	denotes	of
T11614	1344-1349	NNP	denotes	TGF-β
T11615	1350-1354	VBD	denotes	were
T11616	1355-1360	VBN	denotes	mixed
T11617	1361-1365	IN	denotes	with
T11618	1366-1378	JJ	denotes	CFSE-labeled
T11619	1379-1384	JJ	denotes	naive
T11620	1385-1389	NNS	denotes	CD45
T11621	1389-1391	CD	denotes	.1
T11622	1391-1392	CD	denotes	+
T11623	1393-1396	NNP	denotes	CD4
T11624	1396-1397	NN	denotes	+
T11625	1398-1403	NNS	denotes	cells
T11626	1403-1404	.	denotes	.
T11627	1405-1407	DT	denotes	No
T11628	1408-1419	NN	denotes	suppression
T11629	1420-1425	MD	denotes	could
T11630	1426-1428	VB	denotes	be
T11631	1429-1437	VBN	denotes	observed
T11632	1438-1440	IN	denotes	in
T11633	1441-1444	DT	denotes	all
T11634	1445-1452	NN	denotes	control
T11635	1453-1459	NNS	denotes	groups
T11636	1460-1467	IN	denotes	without
T11637	1468-1473	NNP	denotes	TGF-β
T11638	1474-1476	IN	denotes	at
T11639	1477-1480	DT	denotes	all
T11640	1481-1487	VBN	denotes	tested
T11641	1488-1494	NNS	denotes	ratios
T11642	1495-1496	-LRB-	denotes	(
T11643	1496-1500	NN	denotes	Fig.
T11644	1501-1502	CD	denotes	6
T11645	1503-1504	NNP	denotes	C
T11646	1504-1505	-RRB-	denotes	)
T11647	1505-1506	.	denotes	.
T11648	1507-1510	DT	denotes	The
T11649	1511-1520	VBN	denotes	decreased
T11650	1521-1532	NN	denotes	suppression
T11651	1533-1541	NN	denotes	capacity
T11652	1542-1544	IN	denotes	of
T11653	1545-1552	NNP	denotes	CbfbF/F
T11654	1553-1560	NNP	denotes	CD4-cre
T11655	1561-1563	NNP	denotes	iT
T11656	1564-1567	NN	denotes	reg
T11657	1568-1573	NNS	denotes	cells
T11658	1574-1577	VBD	denotes	was
T11659	1578-1586	JJ	denotes	unlikely
T11660	1587-1589	TO	denotes	to
T11661	1590-1592	VB	denotes	be
T11662	1593-1599	VBN	denotes	caused
T11663	1600-1602	IN	denotes	by
T11664	1603-1612	VBN	denotes	decreased
T11665	1613-1621	NN	denotes	survival
T11666	1622-1624	CC	denotes	or
T11667	1625-1638	NN	denotes	proliferation
T11668	1638-1639	.	denotes	.
T11669	1640-1645	CD	denotes	Foxp3
T11670	1645-1646	NN	denotes	+
T11671	1647-1650	CC	denotes	and
T11672	1651-1656	JJ	denotes	Foxp3
T11673	1656-1657	NN	denotes	−
T11674	1658-1663	NNS	denotes	cells
T11675	1664-1673	VBD	denotes	generated
T11676	1674-1678	IN	denotes	from
T11677	1679-1683	DT	denotes	both
T11678	1684-1691	NNP	denotes	CbfbF/F
T11679	1692-1699	NNP	denotes	CD4-cre
T11680	1700-1703	CC	denotes	and
T11681	1704-1711	VB	denotes	control
T11682	1712-1717	NNS	denotes	cells
T11683	1718-1721	DT	denotes	all
T11684	1722-1731	VBD	denotes	displayed
T11685	1732-1739	JJ	denotes	similar
T11686	1740-1753	NN	denotes	proliferation
T11687	1754-1759	NNS	denotes	rates
T11688	1760-1763	CC	denotes	and
T11689	1764-1768	NN	denotes	cell
T11690	1769-1774	NN	denotes	death
T11691	1775-1777	IN	denotes	as
T11692	1778-1786	VBN	denotes	measured
T11693	1787-1789	IN	denotes	by
T11694	1790-1794	NNP	denotes	CFSE
T11695	1795-1803	NN	denotes	dilution
T11696	1804-1807	CC	denotes	and
T11697	1808-1815	NN	denotes	annexin
T11698	1816-1817	NNP	denotes	V
T11699	1818-1826	NN	denotes	staining
T11700	1826-1827	,	denotes	,
T11701	1828-1840	RB	denotes	respectively
T11702	1841-1842	-LRB-	denotes	(
T11703	1842-1845	NNP	denotes	Fig
T11704	1845-1846	.	denotes	.
T11705	1847-1849	CD	denotes	S7
T11706	1849-1850	,	denotes	,
T11707	1851-1852	DT	denotes	A
T11708	1853-1856	CC	denotes	and
T11709	1857-1858	NNP	denotes	B
T11710	1858-1859	-RRB-	denotes	)
T11711	1859-1860	.	denotes	.
T11712	3436-3438	IN	denotes	In
T11713	3439-3447	NN	denotes	addition
T11714	3447-3448	,	denotes	,
T11715	3449-3451	PRP	denotes	we
T11716	3452-3458	VBD	denotes	tested
T11717	3459-3462	DT	denotes	the
T11718	3463-3474	NN	denotes	requirement
T11719	3475-3477	IN	denotes	of
T11720	3478-3483	NNP	denotes	RUNX1
T11721	3484-3487	CC	denotes	and
T11722	3488-3493	NNP	denotes	RUNX3
T11723	3494-3497	IN	denotes	for
T11724	3498-3501	DT	denotes	the
T11725	3502-3513	NN	denotes	development
T11726	3514-3516	IN	denotes	of
T11727	3517-3520	DT	denotes	the
T11728	3521-3532	JJ	denotes	suppressive
T11729	3533-3541	NN	denotes	capacity
T11730	3542-3544	IN	denotes	in
T11731	3545-3550	JJ	denotes	human
T11732	3551-3553	NNP	denotes	iT
T11733	3554-3557	NN	denotes	reg
T11734	3558-3563	NNS	denotes	cells
T11735	3563-3564	.	denotes	.
T11736	3565-3567	PRP	denotes	We
T11737	3568-3576	VBD	denotes	isolated
T11738	3577-3582	JJ	denotes	human
T11739	3583-3588	JJ	denotes	naive
T11740	3589-3592	NNP	denotes	CD4
T11741	3592-3593	CD	denotes	+
T11742	3594-3595	NNP	denotes	T
T11743	3596-3601	NNS	denotes	cells
T11744	3602-3605	CC	denotes	and
T11745	3606-3617	VBD	denotes	transfected
T11746	3618-3622	PRP	denotes	them
T11747	3623-3627	IN	denotes	with
T11748	3628-3629	DT	denotes	a
T11749	3630-3641	NN	denotes	combination
T11750	3642-3644	IN	denotes	of
T11751	3645-3650	NNP	denotes	RUNX1
T11752	3651-3654	CC	denotes	and
T11753	3655-3660	NNP	denotes	RUNX3
T11754	3661-3666	NNP	denotes	siRNA
T11755	3666-3667	,	denotes	,
T11756	3668-3670	CC	denotes	or
T11757	3671-3675	IN	denotes	with
T11758	3676-3677	DT	denotes	a
T11759	3678-3687	VBN	denotes	scrambled
T11760	3688-3695	NN	denotes	control
T11761	3696-3701	NNP	denotes	siRNA
T11762	3701-3702	.	denotes	.
T11763	3703-3708	NNS	denotes	Cells
T11764	3709-3713	VBD	denotes	were
T11765	3714-3722	VBN	denotes	cultured
T11766	3723-3728	IN	denotes	under
T11767	3729-3730	NNP	denotes	T
T11768	3731-3734	NN	denotes	reg
T11769	3735-3745	NNS	denotes	conditions
T11770	3745-3746	,	denotes	,
T11771	3747-3750	CC	denotes	and
T11772	3751-3755	RB	denotes	then
T11773	3756-3761	JJ	denotes	mixed
T11774	3762-3766	IN	denotes	with
T11775	3767-3779	JJ	denotes	CFSE-labeled
T11776	3780-3790	JJ	denotes	autologous
T11777	3791-3794	NNP	denotes	CD4
T11778	3794-3795	CD	denotes	+
T11779	3796-3797	NNP	denotes	T
T11780	3798-3803	NNS	denotes	cells
T11781	3804-3807	CC	denotes	and
T11782	3808-3818	VBN	denotes	stimulated
T11783	3819-3823	IN	denotes	with
T11784	3824-3832	JJ	denotes	anti-CD3
T11785	3833-3836	NNP	denotes	mAb
T11786	3836-3837	.	denotes	.
T11787	3838-3843	NNS	denotes	Cells
T11788	3844-3846	IN	denotes	in
T11789	3847-3852	WDT	denotes	which
T11790	3853-3858	NNP	denotes	RUNX1
T11791	3859-3862	CC	denotes	and
T11792	3863-3868	NNP	denotes	RUNX3
T11793	3869-3873	VBD	denotes	were
T11794	3874-3881	VBN	denotes	knocked
T11795	3882-3886	RP	denotes	down
T11796	3887-3893	VBD	denotes	showed
T11797	3894-3902	RB	denotes	markedly
T11798	3903-3908	JJR	denotes	lower
T11799	3909-3920	JJ	denotes	suppressive
T11800	3921-3929	NN	denotes	activity
T11801	3930-3938	VBN	denotes	compared
T11802	3939-3943	IN	denotes	with
T11803	3944-3951	NN	denotes	control
T11804	3952-3954	NNP	denotes	iT
T11805	3955-3958	NN	denotes	reg
T11806	3959-3964	NNS	denotes	cells
T11807	3965-3967	IN	denotes	at
T11808	3968-3969	DT	denotes	a
T11809	3970-3971	NNP	denotes	T
T11810	3972-3979	NNP	denotes	reg/CD4
T11811	3979-3980	VBD	denotes	+
T11812	3981-3982	NNP	denotes	T
T11813	3983-3992	NN	denotes	responder
T11814	3993-3997	NN	denotes	cell
T11815	3998-4003	NN	denotes	ratio
T11816	4004-4006	IN	denotes	of
T11817	4007-4011	CD	denotes	1:20
T11818	4011-4012	,	denotes	,
T11819	4013-4016	CC	denotes	but
T11820	4017-4020	RB	denotes	not
T11821	4021-4025	WRB	denotes	when
T11822	4026-4029	DT	denotes	the
T11823	4030-4031	NNP	denotes	T
T11824	4032-4039	NNP	denotes	reg/CD4
T11825	4039-4040	VBD	denotes	+
T11826	4041-4042	NNP	denotes	T
T11827	4043-4052	NN	denotes	responder
T11828	4053-4057	NN	denotes	cell
T11829	4058-4063	NN	denotes	ratio
T11830	4064-4067	VBD	denotes	was
T11831	4068-4077	VBN	denotes	increased
T11832	4078-4080	TO	denotes	to
T11833	4081-4084	CD	denotes	1:5
T11834	4085-4086	-LRB-	denotes	(
T11835	4086-4090	NN	denotes	Fig.
T11836	4091-4092	CD	denotes	6
T11837	4093-4094	NNP	denotes	D
T11838	4094-4095	-RRB-	denotes	)
T11839	4095-4096	.	denotes	.
T11840	4097-4102	DT	denotes	These
T11841	4103-4110	NNS	denotes	results
T11842	4111-4122	VBP	denotes	demonstrate
T11843	4123-4126	DT	denotes	the
T11844	4127-4136	JJ	denotes	important
T11845	4137-4141	NN	denotes	role
T11846	4142-4144	IN	denotes	of
T11847	4145-4150	NNP	denotes	RUNX1
T11848	4151-4154	CC	denotes	and
T11849	4155-4160	NNP	denotes	RUNX3
T11850	4161-4164	RB	denotes	not
T11851	4165-4169	RB	denotes	only
T11852	4170-4173	IN	denotes	for
T11853	4174-4177	DT	denotes	the
T11854	4178-4187	NN	denotes	induction
T11855	4188-4190	IN	denotes	of
T11856	4191-4196	CD	denotes	FOXP3
T11857	4196-4197	,	denotes	,
T11858	4198-4201	CC	denotes	but
T11859	4202-4206	RB	denotes	also
T11860	4207-4210	IN	denotes	for
T11861	4211-4214	DT	denotes	the
T11862	4215-4226	JJ	denotes	suppressive
T11863	4227-4235	NN	denotes	capacity
T11864	4236-4238	IN	denotes	of
T11865	4239-4241	NNP	denotes	iT
T11866	4242-4245	NN	denotes	reg
T11867	4246-4251	NNS	denotes	cells
T11868	4252-4256	DT	denotes	both
T11869	4257-4259	IN	denotes	in
T11870	4260-4266	NNS	denotes	humans
T11871	4267-4270	CC	denotes	and
T11872	4271-4273	IN	denotes	in
T11873	4274-4278	NNS	denotes	mice
T11874	4278-4279	.	denotes	.
T11875	4280-4283	DT	denotes	The
T11876	4284-4288	NNS	denotes	data
T11877	4289-4296	VBP	denotes	suggest
T11878	4297-4301	DT	denotes	both
T11879	4302-4310	NN	denotes	quantity
T11880	4311-4314	CC	denotes	and
T11881	4315-4322	NN	denotes	quality
T11882	4323-4325	IN	denotes	of
T11883	4326-4327	NNP	denotes	T
T11884	4328-4331	NN	denotes	reg
T11885	4332-4337	NNS	denotes	cells
T11886	4338-4341	VBP	denotes	are
T11887	4342-4350	VBN	denotes	hampered
T11888	4350-4351	.	denotes	.
T11889	4352-4359	VBN	denotes	Reduced
T11890	4360-4369	JJ	denotes	intrinsic
T11891	4370-4381	JJ	denotes	suppressive
T11892	4382-4390	NN	denotes	capacity
T11893	4391-4393	IN	denotes	of
T11894	4394-4396	NNP	denotes	iT
T11895	4397-4400	NN	denotes	reg
T11896	4401-4406	NNS	denotes	cells
T11897	4407-4410	VBD	denotes	was
T11898	4411-4423	VBN	denotes	demonstrated
T11899	4424-4426	IN	denotes	in
T11900	4427-4431	NNS	denotes	mice
T11901	4431-4432	,	denotes	,
T11902	4433-4440	IN	denotes	because
T11903	4441-4450	JJ	denotes	Foxp3-GFP
T11904	4450-4451	NN	denotes	+
T11905	4452-4457	NNS	denotes	cells
T11906	4458-4462	VBD	denotes	were
T11907	4463-4467	NNP	denotes	FACS
T11908	4468-4474	VBD	denotes	sorted
T11909	4475-4478	CC	denotes	and
T11910	4479-4483	JJ	denotes	same
T11911	4484-4491	NNS	denotes	numbers
T11912	4492-4494	IN	denotes	of
T11913	4495-4497	NNP	denotes	iT
T11914	4498-4501	NN	denotes	reg
T11915	4502-4507	NNS	denotes	cells
T11916	4508-4511	VBP	denotes	are
T11917	4512-4520	VBN	denotes	included
T11918	4521-4523	IN	denotes	in
T11919	4524-4531	NN	denotes	control
T11920	4532-4543	NNS	denotes	experiments
T11921	4543-4544	.	denotes	.
T11922	4545-4547	IN	denotes	In
T11923	4548-4551	DT	denotes	the
T11924	4552-4563	NN	denotes	suppression
T11925	4564-4574	NN	denotes	experiment
T11926	4575-4579	IN	denotes	with
T11927	4580-4585	JJ	denotes	human
T11928	4586-4591	NNS	denotes	cells
T11929	4591-4592	,	denotes	,
T11930	4593-4600	VBN	denotes	reduced
T11931	4601-4612	JJ	denotes	suppressive
T11932	4613-4621	NN	denotes	activity
T11933	4622-4625	VBD	denotes	was
T11934	4626-4632	VBN	denotes	caused
T11935	4633-4635	IN	denotes	by
T11936	4636-4643	JJ	denotes	reduced
T11937	4644-4649	CD	denotes	FOXP3
T11938	4650-4660	NN	denotes	expression
T11939	4661-4663	IN	denotes	in
T11940	4664-4665	NNP	denotes	T
T11941	4666-4671	NNS	denotes	cells
T11942	4672-4674	IN	denotes	by
T11943	4675-4680	NNP	denotes	siRNA
T11944	4681-4691	NN	denotes	inhibition
T11945	4692-4694	IN	denotes	of
T11946	4695-4700	NNP	denotes	RUNX1
T11947	4701-4704	CC	denotes	and
T11948	4705-4710	NNP	denotes	RUNX3
T11949	4710-4711	.	denotes	.
T32521	1872-1879	NNP	denotes	CbfbF/F
T32522	1880-1887	NNP	denotes	CD4-cre
T32523	1888-1893	NN	denotes	mouse
T32524	1894-1899	NNS	denotes	cells
T32525	1900-1903	CC	denotes	and
T32526	1904-1906	NNP	denotes	iT
T32527	1907-1910	NN	denotes	reg
T32528	1911-1916	NNS	denotes	cells
T32529	1917-1926	VBD	denotes	generated
T32530	1927-1931	IN	denotes	from
T32531	1932-1937	JJ	denotes	human
T32532	1938-1943	JJ	denotes	naive
T32533	1944-1947	NNP	denotes	CD4
T32534	1947-1948	CD	denotes	+
T32535	1949-1950	NNP	denotes	T
T32536	1951-1956	NNS	denotes	cells
T32537	1957-1967	VBG	denotes	undergoing
T32538	1968-1982	JJ	denotes	siRNA-mediated
T32539	1983-1988	NNP	denotes	RUNX1
T32540	1989-1992	CC	denotes	and
T32541	1993-1998	NNP	denotes	RUNX3
T32542	1999-2004	VBP	denotes	knock
T32543	2005-2009	RP	denotes	down
T32544	2010-2014	NN	denotes	show
T32545	2015-2016	DT	denotes	a
T32546	2017-2027	JJ	denotes	diminished
T32547	2028-2039	JJ	denotes	suppressive
T32548	2040-2048	NN	denotes	activity
T32549	2048-2049	.	denotes	.
T32550	2050-2062	JJ	denotes	Experimental
T32551	2063-2068	NN	denotes	setup
T32552	2069-2070	-LRB-	denotes	(
T32553	2070-2071	NNP	denotes	A
T32554	2071-2072	-RRB-	denotes	)
T32555	2073-2076	CC	denotes	and
T32556	2077-2084	NNS	denotes	results
T32557	2085-2087	IN	denotes	of
T32558	2088-2091	DT	denotes	the
T32559	2092-2097	NN	denotes	mouse
T32560	2098-2109	NN	denotes	suppression
T32561	2110-2115	NN	denotes	assay
T32562	2116-2117	-LRB-	denotes	(
T32563	2117-2118	NNP	denotes	B
T32564	2118-2119	-RRB-	denotes	)
T32565	2119-2120	,	denotes	,
T32566	2121-2134	JJ	denotes	FACS-purified
T32567	2135-2140	JJ	denotes	naive
T32568	2141-2144	NNP	denotes	CD4
T32569	2144-2146	CD	denotes	+8
T32570	2146-2147	CD	denotes	−
T32571	2148-2149	NNP	denotes	T
T32572	2150-2155	NNS	denotes	cells
T32573	2156-2160	IN	denotes	from
T32574	2161-2168	NNP	denotes	CbfbF/F
T32575	2169-2176	NNP	denotes	CD4-cre
T32576	2177-2178	-LRB-	denotes	(
T32577	2178-2182	VBN	denotes	left
T32578	2182-2183	-RRB-	denotes	)
T32579	2184-2187	CC	denotes	and
T32580	2188-2195	VB	denotes	control
T32581	2196-2201	NNP	denotes	CbfbF
T32582	2201-2202	NNP	denotes	/
T32583	2202-2203	VBD	denotes	+
T32584	2204-2211	JJ	denotes	CD4-cre
T32585	2212-2216	NNS	denotes	mice
T32586	2217-2218	-LRB-	denotes	(
T32587	2218-2222	NNS	denotes	Cd45
T32588	2222-2224	CD	denotes	.2
T32589	2224-2225	:	denotes	;
T32590	2226-2231	NN	denotes	right
T32591	2231-2232	-RRB-	denotes	)
T32592	2233-2237	VBD	denotes	were
T32593	2238-2247	VBN	denotes	activated
T32594	2248-2250	IN	denotes	in
T32595	2251-2256	NN	denotes	vitro
T32596	2257-2261	IN	denotes	with
T32597	2262-2270	JJ	denotes	anti-CD3
T32598	2270-2271	NN	denotes	/
T32599	2271-2273	CD	denotes	28
T32600	2274-2277	NNP	denotes	mAb
T32601	2277-2278	,	denotes	,
T32602	2279-2281	CD	denotes	50
T32603	2282-2286	NNP	denotes	U/ml
T32604	2287-2291	NNP	denotes	IL-2
T32605	2291-2292	,	denotes	,
T32606	2293-2296	CC	denotes	and
T32607	2297-2300	CD	denotes	2.5
T32608	2301-2306	JJ	denotes	ng/ml
T32609	2307-2312	NN	denotes	TGF-β
T32610	2312-2313	.	denotes	.
T32611	2314-2319	IN	denotes	After
T32612	2320-2321	CD	denotes	3
T32613	2322-2323	LS	denotes	d
T32614	2323-2324	,	denotes	,
T32615	2325-2334	JJ	denotes	Foxp3-GFP
T32616	2334-2335	NN	denotes	+
T32617	2336-2341	NNS	denotes	cells
T32618	2342-2346	VBD	denotes	were
T32619	2347-2358	JJ	denotes	FACS-sorted
T32620	2359-2362	CC	denotes	and
T32621	2363-2368	JJ	denotes	mixed
T32622	2369-2373	IN	denotes	with
T32623	2374-2385	JJ	denotes	CFSE-loaded
T32624	2386-2391	JJ	denotes	naive
T32625	2392-2396	NNS	denotes	CD45
T32626	2396-2398	CD	denotes	.1
T32627	2398-2399	CD	denotes	+
T32628	2400-2403	NNP	denotes	CD4
T32629	2403-2404	NN	denotes	+
T32630	2405-2410	NNS	denotes	cells
T32631	2411-2413	IN	denotes	at
T32632	2414-2417	DT	denotes	the
T32633	2418-2427	JJ	denotes	indicated
T32634	2428-2434	NNS	denotes	ratios
T32635	2434-2435	.	denotes	.
T32636	2436-2441	DT	denotes	These
T32637	2442-2446	VBD	denotes	were
T32638	2447-2451	RB	denotes	then
T32639	2452-2461	VBN	denotes	incubated
T32640	2462-2466	IN	denotes	with
T32641	2467-2478	JJ	denotes	inactivated
T32642	2479-2490	NNS	denotes	splenocytes
T32643	2491-2494	CC	denotes	and
T32644	2495-2503	JJ	denotes	anti-CD3
T32645	2504-2507	NN	denotes	mAb
T32646	2507-2508	.	denotes	.
T32647	2509-2514	IN	denotes	After
T32648	2515-2516	DT	denotes	a
T32649	2517-2524	JJ	denotes	further
T32650	2525-2526	CD	denotes	4
T32651	2527-2528	LS	denotes	d
T32652	2528-2529	,	denotes	,
T32653	2530-2534	NNP	denotes	CD45
T32654	2534-2536	CD	denotes	.1
T32655	2536-2537	NN	denotes	+
T32656	2538-2543	NNS	denotes	cells
T32657	2544-2548	VBD	denotes	were
T32658	2549-2557	VBN	denotes	analyzed
T32659	2558-2561	IN	denotes	for
T32660	2562-2566	NNP	denotes	CFSE
T32661	2567-2575	NN	denotes	dilution
T32662	2575-2576	.	denotes	.
T32663	2577-2578	-LRB-	denotes	(
T32664	2578-2579	$	denotes	C
T32665	2579-2580	-RRB-	denotes	)
T32666	2581-2583	IN	denotes	As
T32667	2584-2585	DT	denotes	a
T32668	2586-2593	NN	denotes	control
T32669	2593-2594	,	denotes	,
T32670	2595-2600	NNP	denotes	CbfbF
T32671	2600-2601	NNP	denotes	/
T32672	2601-2602	NNP	denotes	+
T32673	2603-2610	NNP	denotes	CD4-cre
T32674	2611-2614	NNP	denotes	CD4
T32675	2614-2615	VBD	denotes	+
T32676	2616-2617	NNP	denotes	T
T32677	2618-2623	NNS	denotes	cells
T32678	2624-2633	VBN	denotes	activated
T32679	2634-2636	IN	denotes	in
T32680	2637-2644	NN	denotes	absence
T32681	2645-2647	IN	denotes	of
T32682	2648-2653	NNP	denotes	TGF-β
T32683	2654-2658	VBD	denotes	were
T32684	2659-2664	VBN	denotes	mixed
T32685	2665-2669	IN	denotes	with
T32686	2670-2681	JJ	denotes	CFSE-loaded
T32687	2682-2687	JJ	denotes	naive
T32688	2688-2692	NNS	denotes	CD45
T32689	2692-2694	CD	denotes	.1
T32690	2694-2695	CD	denotes	+
T32691	2696-2699	NNP	denotes	CD4
T32692	2699-2700	NN	denotes	+
T32693	2701-2706	NNS	denotes	cells
T32694	2707-2709	IN	denotes	at
T32695	2710-2713	DT	denotes	the
T32696	2714-2723	JJ	denotes	indicated
T32697	2724-2730	NNS	denotes	ratios
T32698	2730-2731	.	denotes	.
T32699	2732-2736	CD	denotes	Four
T32700	2737-2741	NNS	denotes	days
T32701	2742-2747	RB	denotes	later
T32702	2748-2752	CD	denotes	CD45
T32703	2752-2754	CD	denotes	.1
T32704	2754-2755	NN	denotes	+
T32705	2756-2761	NNS	denotes	cells
T32706	2762-2766	VBD	denotes	were
T32707	2767-2775	VBN	denotes	analyzed
T32708	2776-2779	IN	denotes	for
T32709	2780-2784	NNP	denotes	CFSE
T32710	2785-2793	NN	denotes	dilution
T32711	2793-2794	.	denotes	.
T32712	2795-2798	DT	denotes	The
T32713	2799-2805	NN	denotes	median
T32714	2806-2814	NN	denotes	division
T32715	2815-2821	NN	denotes	number
T32716	2822-2823	-LRB-	denotes	(
T32717	2823-2825	IN	denotes	of
T32718	2826-2829	DT	denotes	the
T32719	2830-2835	JJ	denotes	naive
T32720	2836-2840	NNP	denotes	CD45
T32721	2840-2842	CD	denotes	.1
T32722	2842-2843	CD	denotes	+
T32723	2844-2847	NNP	denotes	CD4
T32724	2847-2848	NN	denotes	+
T32725	2849-2854	NNS	denotes	cells
T32726	2855-2857	IN	denotes	in
T32727	2858-2861	DT	denotes	the
T32728	2862-2870	NNS	denotes	cultures
T32729	2871-2881	VBG	denotes	containing
T32730	2882-2891	JJ	denotes	Foxp3-GFP
T32731	2891-2892	NN	denotes	+
T32732	2893-2898	NNS	denotes	cells
T32733	2898-2899	-RRB-	denotes	)
T32734	2900-2902	VBZ	denotes	is
T32735	2903-2912	VBN	denotes	indicated
T32736	2913-2915	IN	denotes	in
T32737	2916-2920	DT	denotes	each
T32738	2921-2923	IN	denotes	of
T32739	2924-2927	DT	denotes	the
T32740	2928-2938	NNS	denotes	histograms
T32741	2938-2939	.	denotes	.
T32742	2940-2943	CD	denotes	One
T32743	2944-2946	IN	denotes	of
T32744	2947-2952	CD	denotes	three
T32745	2953-2964	NNS	denotes	experiments
T32746	2965-2967	VBZ	denotes	is
T32747	2968-2973	VBN	denotes	shown
T32748	2973-2974	.	denotes	.
T32749	2975-2976	-LRB-	denotes	(
T32750	2976-2977	NNP	denotes	D
T32751	2977-2978	-RRB-	denotes	)
T32752	2979-2984	NNP	denotes	Human
T32753	2985-2990	JJ	denotes	naive
T32754	2991-2994	NNP	denotes	CD4
T32755	2994-2995	CD	denotes	+
T32756	2996-2997	NNP	denotes	T
T32757	2998-3003	NNS	denotes	cells
T32758	3003-3004	,	denotes	,
T32759	3005-3016	VBN	denotes	transfected
T32760	3017-3021	IN	denotes	with
T32761	3022-3027	NNP	denotes	RUNX1
T32762	3028-3031	CC	denotes	and
T32763	3032-3037	NNP	denotes	RUNX3
T32764	3038-3043	NNP	denotes	siRNA
T32765	3044-3047	CC	denotes	and
T32766	3048-3056	VBN	denotes	cultured
T32767	3057-3062	IN	denotes	under
T32768	3063-3065	NNP	denotes	iT
T32769	3066-3069	NN	denotes	reg
T32770	3070-3085	NN	denotes	differentiating
T32771	3086-3096	NNS	denotes	conditions
T32772	3097-3101	VBD	denotes	were
T32773	3102-3106	VBN	denotes	used
T32774	3107-3109	IN	denotes	in
T32775	3110-3112	DT	denotes	an
T32776	3113-3115	IN	denotes	in
T32777	3116-3121	NN	denotes	vitro
T32778	3122-3133	NN	denotes	suppression
T32779	3134-3139	NN	denotes	assay
T32780	3139-3140	,	denotes	,
T32781	3141-3149	VBN	denotes	cultured
T32782	3150-3158	RB	denotes	together
T32783	3159-3163	IN	denotes	with
T32784	3164-3174	JJ	denotes	autologous
T32785	3175-3187	JJ	denotes	CFSE-labeled
T32786	3188-3191	NNP	denotes	CD4
T32787	3191-3192	CD	denotes	+
T32788	3193-3194	NNP	denotes	T
T32789	3195-3200	NNS	denotes	cells
T32790	3200-3201	,	denotes	,
T32791	3202-3205	CC	denotes	and
T32792	3206-3216	VBN	denotes	stimulated
T32793	3217-3221	IN	denotes	with
T32794	3222-3230	JJ	denotes	anti-CD3
T32795	3231-3234	NNP	denotes	mAb
T32796	3234-3235	.	denotes	.
T32797	3236-3239	DT	denotes	The
T32798	3240-3244	NNP	denotes	CFSE
T32799	3245-3253	NN	denotes	dilution
T32800	3254-3256	IN	denotes	of
T32801	3257-3260	DT	denotes	the
T32802	3261-3264	NNP	denotes	CD4
T32803	3264-3265	CD	denotes	+
T32804	3266-3267	NNP	denotes	T
T32805	3268-3272	NN	denotes	cell
T32806	3273-3282	NN	denotes	responder
T32807	3283-3288	NNS	denotes	cells
T32808	3289-3292	VBD	denotes	was
T32809	3293-3301	VBN	denotes	analyzed
T32810	3302-3307	IN	denotes	after
T32811	3308-3309	CD	denotes	5
T32812	3310-3311	LS	denotes	d
T32813	3312-3314	IN	denotes	by
T32814	3315-3319	NN	denotes	flow
T32815	3320-3329	NN	denotes	cytometry
T32816	3329-3330	.	denotes	.
T32817	3331-3334	DT	denotes	The
T32818	3335-3336	NNP	denotes	T
T32819	3337-3350	NN	denotes	reg/responder
T32820	3351-3354	NNP	denotes	CD4
T32821	3354-3355	NNP	denotes	+
T32822	3356-3357	NNP	denotes	T
T32823	3358-3362	NN	denotes	cell
T32824	3363-3369	NNS	denotes	ratios
T32825	3370-3374	VBN	denotes	used
T32826	3375-3379	VBD	denotes	were
T32827	3380-3384	CD	denotes	1:20
T32828	3384-3385	,	denotes	,
T32829	3386-3390	CD	denotes	1:10
T32830	3390-3391	,	denotes	,
T32831	3392-3395	CC	denotes	and
T32832	3396-3399	CD	denotes	1:5
T32833	3399-3400	.	denotes	.
T32834	3401-3404	CD	denotes	One
T32835	3405-3407	IN	denotes	of
T32836	3408-3411	CD	denotes	two
T32837	3412-3423	NNS	denotes	experiments
T32838	3424-3426	VBZ	denotes	is
T32839	3427-3432	VBN	denotes	shown
T32840	3432-3433	.	denotes	.
R8801	T11340	T11346	nsubj	CBFβ,are
R8802	T11341	T11340	punct	",",CBFβ
R8803	T11342	T11340	conj	RUNX1,CBFβ
R8804	T11343	T11342	punct	",",RUNX1
R8805	T11344	T11342	cc	and,RUNX1
R8806	T11345	T11342	conj	RUNX3,RUNX1
R8807	T11346	T11346	ROOT	are,are
R8808	T11347	T11346	acomp	important,are
R8809	T11348	T11347	prep	for,important
R8810	T11349	T11351	det	the,activity
R8811	T11350	T11351	amod	suppressive,activity
R8812	T11351	T11348	pobj	activity,for
R8813	T11352	T11351	prep	of,activity
R8814	T11353	T11355	compound	CD25,Foxp3
R8815	T11354	T11355	compound	+,Foxp3
R8816	T11355	T11352	pobj	Foxp3,of
R8817	T11356	T11359	amod	+,cells
R8818	T11357	T11358	compound	T,reg
R8819	T11358	T11359	compound	reg,cells
R8820	T11359	T11351	conj	cells,activity
R8821	T11360	T11368	advmod	Even,impaired
R8822	T11361	T11368	mark	though,impaired
R8823	T11362	T11366	amod	Cbfb-deficient,cells
R8824	T11363	T11366	compound	CD4,cells
R8825	T11364	T11366	nummod	+,cells
R8826	T11365	T11366	compound	T,cells
R8827	T11366	T11368	nsubj	cells,impaired
R8828	T11367	T11368	aux	had,impaired
R8829	T11368	T11390	advcl	impaired,generated
R8830	T11369	T11368	dobj	induction,impaired
R8831	T11370	T11369	prep	of,induction
R8832	T11371	T11370	pobj	Foxp3,of
R8833	T11372	T11368	prep	after,impaired
R8834	T11373	T11372	pobj	stimulation,after
R8835	T11374	T11373	prep	with,stimulation
R8836	T11375	T11378	amod	anti-CD3,mAbs
R8837	T11376	T11378	nmod	/,mAbs
R8838	T11377	T11376	nummod	28,/
R8839	T11378	T11374	pobj	mAbs,with
R8840	T11379	T11378	cc	and,mAbs
R8841	T11380	T11378	conj	TGF-β,mAbs
R8842	T11381	T11380	punct	",",TGF-β
R8843	T11382	T11383	amod	sufficient,numbers
R8844	T11383	T11380	appos	numbers,TGF-β
R8845	T11384	T11383	prep	of,numbers
R8846	T11385	T11387	amod	Foxp3,cells
R8847	T11386	T11387	compound	+,cells
R8848	T11387	T11384	pobj	cells,of
R8849	T11388	T11390	aux	could,generated
R8850	T11389	T11390	auxpass	be,generated
R8851	T11390	T11346	conj	generated,are
R8852	T11391	T11392	aux	to,permit
R8853	T11392	T11390	xcomp	permit,generated
R8854	T11393	T11392	dobj	analysis,permit
R8855	T11394	T11393	prep	of,analysis
R8856	T11395	T11397	poss	their,activity
R8857	T11396	T11397	amod	suppressive,activity
R8858	T11397	T11394	pobj	activity,of
R8859	T11398	T11390	punct	.,generated
R8860	T11399	T11404	amod	Purified,cells
R8861	T11400	T11404	amod	naive,cells
R8862	T11401	T11404	compound	CD4,cells
R8863	T11402	T11404	nummod	+,cells
R8864	T11403	T11404	compound	T,cells
R8865	T11404	T11412	nsubj	cells,+
R8866	T11405	T11404	prep	from,cells
R8867	T11406	T11407	compound	CbfbF/F,CD4-cre
R8868	T11407	T11405	pobj	CD4-cre,from
R8869	T11408	T11407	cc	and,CD4-cre
R8870	T11409	T11411	compound	control,/
R8871	T11410	T11411	compound	CbfbF,/
R8872	T11411	T11407	conj	/,CD4-cre
R8873	T11412	T11412	ROOT	+,+
R8874	T11413	T11414	amod	CD4-cre,mice
R8875	T11414	T11412	dobj	mice,+
R8876	T11415	T11419	punct	(,harboring
R8877	T11416	T11416	ROOT	Cd45,Cd45
R8878	T11417	T11416	nummod	.2,Cd45
R8879	T11418	T11416	punct	),Cd45
R8880	T11419	T11412	parataxis	harboring,+
R8881	T11420	T11422	det	a,allele
R8882	T11421	T11422	amod	Foxp3-ires-GFP,allele
R8883	T11422	T11419	dobj	allele,harboring
R8884	T11423	T11422	punct	(,allele
R8885	T11424	T11426	compound	Bettelli,al.
R8886	T11425	T11426	nmod	et,al.
R8887	T11426	T11422	appos	al.,allele
R8888	T11427	T11426	punct	",",al.
R8889	T11428	T11426	npadvmod	2006,al.
R8890	T11429	T11422	punct	),allele
R8891	T11430	T11431	auxpass	were,stimulated
R8892	T11431	T11412	conj	stimulated,+
R8893	T11432	T11431	prep	in,stimulated
R8894	T11433	T11432	pobj	vitro,in
R8895	T11434	T11433	prep	with,vitro
R8896	T11435	T11436	amod	anti-CD3,/
R8897	T11436	T11434	pobj	/,with
R8898	T11437	T11436	nummod	28,/
R8899	T11438	T11436	appos	mAbs,/
R8900	T11439	T11438	punct	",",mAbs
R8901	T11440	T11438	conj	IL-2,mAbs
R8902	T11441	T11440	punct	",",IL-2
R8903	T11442	T11440	cc	and,IL-2
R8904	T11443	T11440	conj	TGF-β,IL-2
R8905	T11444	T11412	punct	.,+
R8906	T11445	T11456	prep	After,sorted
R8907	T11446	T11447	nummod	3,d
R8908	T11447	T11445	pobj	d,After
R8909	T11448	T11456	punct	",",sorted
R8910	T11449	T11452	nmod	Foxp3,GFP
R8911	T11450	T11452	punct	+,GFP
R8912	T11451	T11452	punct	-,GFP
R8913	T11452	T11454	nmod	GFP,cells
R8914	T11453	T11454	nummod	+,cells
R8915	T11454	T11456	nsubjpass	cells,sorted
R8916	T11455	T11456	auxpass	were,sorted
R8917	T11456	T11456	ROOT	sorted,sorted
R8918	T11457	T11456	agent	by,sorted
R8919	T11458	T11459	compound	flow,cytometry
R8920	T11459	T11457	pobj	cytometry,by
R8921	T11460	T11459	cc	and,cytometry
R8922	T11461	T11459	conj	mixed,cytometry
R8923	T11462	T11461	prep	with,mixed
R8924	T11463	T11465	amod	CFSE-labeled,CD45
R8925	T11464	T11465	amod	naive,CD45
R8926	T11465	T11462	pobj	CD45,with
R8927	T11466	T11470	nummod	.1,cells
R8928	T11467	T11470	nummod	+,cells
R8929	T11468	T11470	compound	CD4,cells
R8930	T11469	T11470	compound	+,cells
R8931	T11470	T11456	dobj	cells,sorted
R8932	T11471	T11456	prep	at,sorted
R8933	T11472	T11471	pobj	ratios,at
R8934	T11473	T11472	prep	of,ratios
R8935	T11474	T11473	pobj	1:4,of
R8936	T11475	T11472	punct	",",ratios
R8937	T11476	T11472	appos	1:2,ratios
R8938	T11477	T11472	punct	",",ratios
R8939	T11478	T11472	cc	and,ratios
R8940	T11479	T11472	conj	1:1,ratios
R8941	T11480	T11456	punct	.,sorted
R8942	T11481	T11482	det	The,cells
R8943	T11482	T11485	nsubjpass	cells,incubated
R8944	T11483	T11485	auxpass	were,incubated
R8945	T11484	T11485	advmod	then,incubated
R8946	T11485	T11485	ROOT	incubated,incubated
R8947	T11486	T11485	prep	with,incubated
R8948	T11487	T11488	amod	inactivated,splenocytes
R8949	T11488	T11486	pobj	splenocytes,with
R8950	T11489	T11485	cc	and,incubated
R8951	T11490	T11485	conj	stimulated,incubated
R8952	T11491	T11490	prep	with,stimulated
R8953	T11492	T11493	compound	anti-CD3,mAb
R8954	T11493	T11491	pobj	mAb,with
R8955	T11494	T11490	prep	for,stimulated
R8956	T11495	T11497	nummod	four,days
R8957	T11496	T11495	amod	more,four
R8958	T11497	T11494	pobj	days,for
R8959	T11498	T11485	punct	.,incubated
R8960	T11499	T11502	nummod	CD45,cells
R8961	T11500	T11502	nummod	.1,cells
R8962	T11501	T11502	compound	+,cells
R8963	T11502	T11504	nsubjpass	cells,analyzed
R8964	T11503	T11504	auxpass	were,analyzed
R8965	T11504	T11504	ROOT	analyzed,analyzed
R8966	T11505	T11504	prep	for,analyzed
R8967	T11506	T11507	compound	CFSE,dilution
R8968	T11507	T11505	pobj	dilution,for
R8969	T11508	T11509	punct	(,Fig.
R8970	T11509	T11511	nmod	Fig.,A
R8971	T11510	T11511	nummod	6,A
R8972	T11511	T11507	appos	A,dilution
R8973	T11512	T11504	punct	),analyzed
R8974	T11513	T11504	punct	.,analyzed
R8975	T11514	T11518	compound	CbfbF,CD4
R8976	T11515	T11518	compound	/,CD4
R8977	T11516	T11518	compound	+,CD4
R8978	T11517	T11518	compound	CD4-cre,CD4
R8979	T11518	T11528	nsubj	CD4,showed
R8980	T11519	T11528	amod	+,showed
R8981	T11520	T11521	compound	T,cells
R8982	T11521	T11519	dobj	cells,+
R8983	T11522	T11521	acl	activated,cells
R8984	T11523	T11522	prep	in,activated
R8985	T11524	T11525	det	the,presence
R8986	T11525	T11523	pobj	presence,in
R8987	T11526	T11525	prep	of,presence
R8988	T11527	T11526	pobj	TGF-β,of
R8989	T11528	T11528	ROOT	showed,showed
R8990	T11529	T11531	det	a,suppression
R8991	T11530	T11531	amod	clear,suppression
R8992	T11531	T11528	dobj	suppression,showed
R8993	T11532	T11531	prep	of,suppression
R8994	T11533	T11535	compound	T,proliferation
R8995	T11534	T11535	compound	cell,proliferation
R8996	T11535	T11532	pobj	proliferation,of
R8997	T11536	T11537	nsubj	that,became
R8998	T11537	T11535	relcl	became,proliferation
R8999	T11538	T11539	advmod	even,more
R9000	T11539	T11540	advmod	more,apparent
R9001	T11540	T11537	acomp	apparent,became
R9002	T11541	T11553	advmod	when,used
R9003	T11542	T11544	det	an,ratio
R9004	T11543	T11544	amod	increased,ratio
R9005	T11544	T11553	nsubjpass	ratio,used
R9006	T11545	T11544	prep	of,ratio
R9007	T11546	T11549	nummod	FOXP3,CD25
R9008	T11547	T11549	nummod	+,CD25
R9009	T11548	T11549	compound	/,CD25
R9010	T11549	T11545	pobj	CD25,of
R9011	T11550	T11551	amod	−,cells
R9012	T11551	T11544	conj	cells,ratio
R9013	T11552	T11553	auxpass	was,used
R9014	T11553	T11537	advcl	used,became
R9015	T11554	T11557	punct	(,B
R9016	T11555	T11557	nmod	Fig.,B
R9017	T11556	T11557	nummod	6,B
R9018	T11557	T11553	oprd	B,used
R9019	T11558	T11557	punct	),B
R9020	T11559	T11528	punct	.,showed
R9021	T11560	T11561	det	The,suppression
R9022	T11561	T11564	nsubjpass	suppression,reduced
R9023	T11562	T11564	auxpass	was,reduced
R9024	T11563	T11564	advmod	significantly,reduced
R9025	T11564	T11564	ROOT	reduced,reduced
R9026	T11565	T11572	advmod	when,used
R9027	T11566	T11572	nsubjpass	cells,used
R9028	T11567	T11566	prep	from,cells
R9029	T11568	T11569	compound	CbfbF/F,CD4-cre
R9030	T11569	T11570	compound	CD4-cre,mice
R9031	T11570	T11567	pobj	mice,from
R9032	T11571	T11572	auxpass	were,used
R9033	T11572	T11564	advcl	used,reduced
R9034	T11573	T11564	punct	",",reduced
R9035	T11574	T11564	advcl	demonstrating,reduced
R9036	T11575	T11577	mark	that,induced
R9037	T11576	T11577	nsubj	TGF-β,induced
R9038	T11577	T11574	ccomp	induced,demonstrating
R9039	T11578	T11579	compound	Runx,complexes
R9040	T11579	T11580	nsubj	complexes,are
R9041	T11580	T11564	conj	are,reduced
R9042	T11581	T11580	acomp	important,are
R9043	T11582	T11581	prep	for,important
R9044	T11583	T11585	det	the,activity
R9045	T11584	T11585	amod	suppressive,activity
R9046	T11585	T11582	pobj	activity,for
R9047	T11586	T11585	prep	of,activity
R9048	T11587	T11591	amod	Foxp3,cells
R9049	T11588	T11591	compound	+,cells
R9050	T11589	T11591	compound	T,cells
R9051	T11590	T11591	compound	reg,cells
R9052	T11591	T11586	pobj	cells,of
R9053	T11592	T11595	punct	(,B
R9054	T11593	T11595	nmod	Fig.,B
R9055	T11594	T11595	nummod	6,B
R9056	T11595	T11591	appos	B,cells
R9057	T11596	T11591	punct	),cells
R9058	T11597	T11580	punct	.,are
R9059	T11598	T11607	prep	As,+
R9060	T11599	T11600	det	a,control
R9061	T11600	T11598	pobj	control,As
R9062	T11601	T11607	punct	",",+
R9063	T11602	T11606	compound	CbfbF,CD4
R9064	T11603	T11606	compound	/,CD4
R9065	T11604	T11606	compound	+,CD4
R9066	T11605	T11606	compound	CD4-cre,CD4
R9067	T11606	T11607	nsubj	CD4,+
R9068	T11607	T11607	ROOT	+,+
R9069	T11608	T11609	compound	T,cells
R9070	T11609	T11615	nsubj	cells,were
R9071	T11610	T11609	acl	activated,cells
R9072	T11611	T11610	prep	in,activated
R9073	T11612	T11611	pobj	absence,in
R9074	T11613	T11612	prep	of,absence
R9075	T11614	T11613	pobj	TGF-β,of
R9076	T11615	T11607	ccomp	were,+
R9077	T11616	T11615	acomp	mixed,were
R9078	T11617	T11616	prep	with,mixed
R9079	T11618	T11620	amod	CFSE-labeled,CD45
R9080	T11619	T11620	amod	naive,CD45
R9081	T11620	T11617	pobj	CD45,with
R9082	T11621	T11625	nummod	.1,cells
R9083	T11622	T11625	nummod	+,cells
R9084	T11623	T11625	compound	CD4,cells
R9085	T11624	T11625	compound	+,cells
R9086	T11625	T11620	appos	cells,CD45
R9087	T11626	T11607	punct	.,+
R9088	T11627	T11628	det	No,suppression
R9089	T11628	T11631	nsubjpass	suppression,observed
R9090	T11629	T11631	aux	could,observed
R9091	T11630	T11631	auxpass	be,observed
R9092	T11631	T11631	ROOT	observed,observed
R9093	T11632	T11631	prep	in,observed
R9094	T11633	T11635	det	all,groups
R9095	T11634	T11635	compound	control,groups
R9096	T11635	T11632	pobj	groups,in
R9097	T11636	T11631	prep	without,observed
R9098	T11637	T11636	pobj	TGF-β,without
R9099	T11638	T11631	prep	at,observed
R9100	T11639	T11641	det	all,ratios
R9101	T11640	T11641	amod	tested,ratios
R9102	T11641	T11638	pobj	ratios,at
R9103	T11642	T11641	punct	(,ratios
R9104	T11643	T11641	appos	Fig.,ratios
R9105	T11644	T11643	nummod	6,Fig.
R9106	T11645	T11643	npadvmod	C,Fig.
R9107	T11646	T11643	punct	),Fig.
R9108	T11647	T11631	punct	.,observed
R9109	T11648	T11651	det	The,capacity
R9110	T11649	T11651	amod	decreased,capacity
R9111	T11650	T11651	compound	suppression,capacity
R9112	T11651	T11658	nsubj	capacity,was
R9113	T11652	T11651	prep	of,capacity
R9114	T11653	T11657	compound	CbfbF/F,cells
R9115	T11654	T11657	compound	CD4-cre,cells
R9116	T11655	T11657	compound	iT,cells
R9117	T11656	T11657	compound	reg,cells
R9118	T11657	T11652	pobj	cells,of
R9119	T11658	T11658	ROOT	was,was
R9120	T11659	T11658	acomp	unlikely,was
R9121	T11660	T11662	aux	to,caused
R9122	T11661	T11662	auxpass	be,caused
R9123	T11662	T11659	xcomp	caused,unlikely
R9124	T11663	T11662	agent	by,caused
R9125	T11664	T11665	amod	decreased,survival
R9126	T11665	T11663	pobj	survival,by
R9127	T11666	T11665	cc	or,survival
R9128	T11667	T11665	conj	proliferation,survival
R9129	T11668	T11658	punct	.,was
R9130	T11669	T11674	nummod	Foxp3,cells
R9131	T11670	T11674	nmod	+,cells
R9132	T11671	T11670	cc	and,+
R9133	T11672	T11674	amod	Foxp3,cells
R9134	T11673	T11674	compound	−,cells
R9135	T11674	T11684	nsubj	cells,displayed
R9136	T11675	T11674	acl	generated,cells
R9137	T11676	T11675	prep	from,generated
R9138	T11677	T11679	det	both,CD4-cre
R9139	T11678	T11679	compound	CbfbF/F,CD4-cre
R9140	T11679	T11676	pobj	CD4-cre,from
R9141	T11680	T11679	cc	and,CD4-cre
R9142	T11681	T11682	compound	control,cells
R9143	T11682	T11675	dobj	cells,generated
R9144	T11683	T11674	appos	all,cells
R9145	T11684	T11684	ROOT	displayed,displayed
R9146	T11685	T11687	amod	similar,rates
R9147	T11686	T11687	compound	proliferation,rates
R9148	T11687	T11684	dobj	rates,displayed
R9149	T11688	T11687	cc	and,rates
R9150	T11689	T11690	compound	cell,death
R9151	T11690	T11687	conj	death,rates
R9152	T11691	T11692	mark	as,measured
R9153	T11692	T11684	advcl	measured,displayed
R9154	T11693	T11692	agent	by,measured
R9155	T11694	T11695	compound	CFSE,dilution
R9156	T11695	T11693	pobj	dilution,by
R9157	T11696	T11695	cc	and,dilution
R9158	T11697	T11698	compound	annexin,V
R9159	T11698	T11699	compound	V,staining
R9160	T11699	T11695	conj	staining,dilution
R9161	T11700	T11699	punct	",",staining
R9162	T11701	T11692	advmod	respectively,measured
R9163	T11702	T11703	punct	(,Fig
R9164	T11703	T11684	npadvmod	Fig,displayed
R9165	T11704	T11684	punct	.,displayed
R9166	T11705	T11705	ROOT	S7,S7
R9167	T11706	T11705	punct	",",S7
R9168	T11707	T11705	appos	A,S7
R9169	T11708	T11707	cc	and,A
R9170	T11709	T11707	conj	B,A
R9171	T11710	T11709	punct	),B
R9172	T11711	T11705	punct	.,S7
R9173	T11712	T11716	prep	In,tested
R9174	T11713	T11712	pobj	addition,In
R9175	T11714	T11716	punct	",",tested
R9176	T11715	T11716	nsubj	we,tested
R9177	T11716	T11716	ROOT	tested,tested
R9178	T11717	T11718	det	the,requirement
R9179	T11718	T11716	dobj	requirement,tested
R9180	T11719	T11718	prep	of,requirement
R9181	T11720	T11719	pobj	RUNX1,of
R9182	T11721	T11720	cc	and,RUNX1
R9183	T11722	T11720	conj	RUNX3,RUNX1
R9184	T11723	T11718	prep	for,requirement
R9185	T11724	T11725	det	the,development
R9186	T11725	T11723	pobj	development,for
R9187	T11726	T11725	prep	of,development
R9188	T11727	T11729	det	the,capacity
R9189	T11728	T11729	amod	suppressive,capacity
R9190	T11729	T11726	pobj	capacity,of
R9191	T11730	T11729	prep	in,capacity
R9192	T11731	T11734	amod	human,cells
R9193	T11732	T11733	compound	iT,reg
R9194	T11733	T11734	compound	reg,cells
R9195	T11734	T11730	pobj	cells,in
R9196	T11735	T11716	punct	.,tested
R9197	T11736	T11737	nsubj	We,isolated
R9198	T11737	T11737	ROOT	isolated,isolated
R9199	T11738	T11739	npadvmod	human,naive
R9200	T11739	T11743	amod	naive,cells
R9201	T11740	T11743	compound	CD4,cells
R9202	T11741	T11743	nummod	+,cells
R9203	T11742	T11743	compound	T,cells
R9204	T11743	T11737	dobj	cells,isolated
R9205	T11744	T11737	cc	and,isolated
R9206	T11745	T11737	conj	transfected,isolated
R9207	T11746	T11745	dobj	them,transfected
R9208	T11747	T11745	prep	with,transfected
R9209	T11748	T11749	det	a,combination
R9210	T11749	T11747	pobj	combination,with
R9211	T11750	T11749	prep	of,combination
R9212	T11751	T11750	pobj	RUNX1,of
R9213	T11752	T11751	cc	and,RUNX1
R9214	T11753	T11754	compound	RUNX3,siRNA
R9215	T11754	T11751	conj	siRNA,RUNX1
R9216	T11755	T11754	punct	",",siRNA
R9217	T11756	T11747	cc	or,with
R9218	T11757	T11747	conj	with,with
R9219	T11758	T11760	det	a,control
R9220	T11759	T11760	amod	scrambled,control
R9221	T11760	T11757	pobj	control,with
R9222	T11761	T11760	appos	siRNA,control
R9223	T11762	T11737	punct	.,isolated
R9224	T11763	T11765	nsubjpass	Cells,cultured
R9225	T11764	T11765	auxpass	were,cultured
R9226	T11765	T11765	ROOT	cultured,cultured
R9227	T11766	T11765	prep	under,cultured
R9228	T11767	T11769	compound	T,conditions
R9229	T11768	T11769	compound	reg,conditions
R9230	T11769	T11766	pobj	conditions,under
R9231	T11770	T11765	punct	",",cultured
R9232	T11771	T11765	cc	and,cultured
R9233	T11772	T11773	advmod	then,mixed
R9234	T11773	T11765	conj	mixed,cultured
R9235	T11774	T11773	prep	with,mixed
R9236	T11775	T11780	amod	CFSE-labeled,cells
R9237	T11776	T11780	amod	autologous,cells
R9238	T11777	T11780	nmod	CD4,cells
R9239	T11778	T11780	nummod	+,cells
R9240	T11779	T11780	compound	T,cells
R9241	T11780	T11774	pobj	cells,with
R9242	T11781	T11773	cc	and,mixed
R9243	T11782	T11773	conj	stimulated,mixed
R9244	T11783	T11782	prep	with,stimulated
R9245	T11784	T11785	compound	anti-CD3,mAb
R9246	T11785	T11783	pobj	mAb,with
R9247	T11786	T11765	punct	.,cultured
R9248	T11787	T11796	nsubj	Cells,showed
R9249	T11788	T11794	prep	in,knocked
R9250	T11789	T11788	pobj	which,in
R9251	T11790	T11794	nsubjpass	RUNX1,knocked
R9252	T11791	T11790	cc	and,RUNX1
R9253	T11792	T11790	conj	RUNX3,RUNX1
R9254	T11793	T11794	auxpass	were,knocked
R9255	T11794	T11787	relcl	knocked,Cells
R9256	T11795	T11794	prt	down,knocked
R9257	T11796	T11796	ROOT	showed,showed
R9258	T11797	T11798	advmod	markedly,lower
R9259	T11798	T11800	amod	lower,activity
R9260	T11799	T11800	compound	suppressive,activity
R9261	T11800	T11796	dobj	activity,showed
R9262	T11801	T11796	prep	compared,showed
R9263	T11802	T11801	prep	with,compared
R9264	T11803	T11802	pobj	control,with
R9265	T11804	T11806	compound	iT,cells
R9266	T11805	T11806	compound	reg,cells
R9267	T11806	T11803	dobj	cells,control
R9268	T11807	T11803	prep	at,control
R9269	T11808	T11810	det	a,reg/CD4
R9270	T11809	T11810	compound	T,reg/CD4
R9271	T11810	T11807	pobj	reg/CD4,at
R9272	T11811	T11815	amod	+,ratio
R9273	T11812	T11815	nmod	T,ratio
R9274	T11813	T11815	nmod	responder,ratio
R9275	T11814	T11815	compound	cell,ratio
R9276	T11815	T11831	nsubj	ratio,increased
R9277	T11816	T11815	prep	of,ratio
R9278	T11817	T11816	pobj	1:20,of
R9279	T11818	T11815	punct	",",ratio
R9280	T11819	T11815	cc	but,ratio
R9281	T11820	T11831	neg	not,increased
R9282	T11821	T11825	advmod	when,+
R9283	T11822	T11824	det	the,reg/CD4
R9284	T11823	T11824	compound	T,reg/CD4
R9285	T11824	T11825	nsubj	reg/CD4,+
R9286	T11825	T11831	advcl	+,increased
R9287	T11826	T11829	compound	T,ratio
R9288	T11827	T11829	compound	responder,ratio
R9289	T11828	T11829	compound	cell,ratio
R9290	T11829	T11831	nsubjpass	ratio,increased
R9291	T11830	T11831	auxpass	was,increased
R9292	T11831	T11796	conj	increased,showed
R9293	T11832	T11831	prep	to,increased
R9294	T11833	T11832	pobj	1:5,to
R9295	T11834	T11837	punct	(,D
R9296	T11835	T11837	nmod	Fig.,D
R9297	T11836	T11835	nummod	6,Fig.
R9298	T11837	T11833	appos	D,1:5
R9299	T11838	T11833	punct	),1:5
R9300	T11839	T11831	punct	.,increased
R9301	T11840	T11841	det	These,results
R9302	T11841	T11842	nsubj	results,demonstrate
R9303	T11842	T11842	ROOT	demonstrate,demonstrate
R9304	T11843	T11845	det	the,role
R9305	T11844	T11845	amod	important,role
R9306	T11845	T11842	dobj	role,demonstrate
R9307	T11846	T11845	prep	of,role
R9308	T11847	T11846	pobj	RUNX1,of
R9309	T11848	T11847	cc	and,RUNX1
R9310	T11849	T11847	conj	RUNX3,RUNX1
R9311	T11850	T11852	preconj	not,for
R9312	T11851	T11850	advmod	only,not
R9313	T11852	T11842	prep	for,demonstrate
R9314	T11853	T11854	det	the,induction
R9315	T11854	T11852	pobj	induction,for
R9316	T11855	T11854	prep	of,induction
R9317	T11856	T11855	pobj	FOXP3,of
R9318	T11857	T11852	punct	",",for
R9319	T11858	T11852	cc	but,for
R9320	T11859	T11858	advmod	also,but
R9321	T11860	T11852	conj	for,for
R9322	T11861	T11863	det	the,capacity
R9323	T11862	T11863	amod	suppressive,capacity
R9324	T11863	T11860	pobj	capacity,for
R9325	T11864	T11863	prep	of,capacity
R9326	T11865	T11866	compound	iT,reg
R9327	T11866	T11867	compound	reg,cells
R9328	T11867	T11864	pobj	cells,of
R9329	T11868	T11869	advmod	both,in
R9330	T11869	T11863	prep	in,capacity
R9331	T11870	T11869	pobj	humans,in
R9332	T11871	T11869	cc	and,in
R9333	T11872	T11869	conj	in,in
R9334	T11873	T11872	pobj	mice,in
R9335	T11874	T11842	punct	.,demonstrate
R9336	T11875	T11876	det	The,data
R9337	T11876	T11877	nsubj	data,suggest
R9338	T11877	T11877	ROOT	suggest,suggest
R9339	T11878	T11879	det	both,quantity
R9340	T11879	T11877	dobj	quantity,suggest
R9341	T11880	T11879	cc	and,quantity
R9342	T11881	T11879	conj	quality,quantity
R9343	T11882	T11881	prep	of,quality
R9344	T11883	T11885	compound	T,cells
R9345	T11884	T11885	compound	reg,cells
R9346	T11885	T11882	pobj	cells,of
R9347	T11886	T11887	auxpass	are,hampered
R9348	T11887	T11877	ccomp	hampered,suggest
R9349	T11888	T11877	punct	.,suggest
R9350	T11889	T11892	amod	Reduced,capacity
R9351	T11890	T11892	amod	intrinsic,capacity
R9352	T11891	T11892	amod	suppressive,capacity
R9353	T11892	T11898	nsubjpass	capacity,demonstrated
R9354	T11893	T11892	prep	of,capacity
R9355	T11894	T11896	compound	iT,cells
R9356	T11895	T11896	compound	reg,cells
R9357	T11896	T11893	pobj	cells,of
R9358	T11897	T11898	auxpass	was,demonstrated
R9359	T11898	T11898	ROOT	demonstrated,demonstrated
R9360	T11899	T11898	prep	in,demonstrated
R9361	T11900	T11899	pobj	mice,in
R9362	T11901	T11898	punct	",",demonstrated
R9363	T11902	T11906	mark	because,were
R9364	T11903	T11905	amod	Foxp3-GFP,cells
R9365	T11904	T11905	compound	+,cells
R9366	T11905	T11906	nsubj	cells,were
R9367	T11906	T11898	advcl	were,demonstrated
R9368	T11907	T11908	nsubj	FACS,sorted
R9369	T11908	T11898	conj	sorted,demonstrated
R9370	T11909	T11908	cc	and,sorted
R9371	T11910	T11911	amod	same,numbers
R9372	T11911	T11917	nsubjpass	numbers,included
R9373	T11912	T11911	prep	of,numbers
R9374	T11913	T11914	compound	iT,reg
R9375	T11914	T11915	compound	reg,cells
R9376	T11915	T11912	pobj	cells,of
R9377	T11916	T11917	auxpass	are,included
R9378	T11917	T11908	conj	included,sorted
R9379	T11918	T11917	prep	in,included
R9380	T11919	T11920	compound	control,experiments
R9381	T11920	T11918	pobj	experiments,in
R9382	T11921	T11917	punct	.,included
R9383	T11922	T11934	prep	In,caused
R9384	T11923	T11925	det	the,experiment
R9385	T11924	T11925	compound	suppression,experiment
R9386	T11925	T11922	pobj	experiment,In
R9387	T11926	T11925	prep	with,experiment
R9388	T11927	T11928	amod	human,cells
R9389	T11928	T11926	pobj	cells,with
R9390	T11929	T11934	punct	",",caused
R9391	T11930	T11932	amod	reduced,activity
R9392	T11931	T11932	amod	suppressive,activity
R9393	T11932	T11934	nsubjpass	activity,caused
R9394	T11933	T11934	auxpass	was,caused
R9395	T11934	T11934	ROOT	caused,caused
R9396	T11935	T11934	agent	by,caused
R9397	T11936	T11938	amod	reduced,expression
R9398	T11937	T11938	nummod	FOXP3,expression
R9399	T11938	T11935	pobj	expression,by
R9400	T11939	T11938	prep	in,expression
R9401	T11940	T11941	compound	T,cells
R9402	T11941	T11939	pobj	cells,in
R9403	T11942	T11938	prep	by,expression
R9404	T11943	T11944	compound	siRNA,inhibition
R9405	T11944	T11942	pobj	inhibition,by
R9406	T11945	T11944	prep	of,inhibition
R9407	T11946	T11945	pobj	RUNX1,of
R9408	T11947	T11946	cc	and,RUNX1
R9409	T11948	T11946	conj	RUNX3,RUNX1
R9410	T11949	T11934	punct	.,caused
R24857	T32521	T32524	compound	CbfbF/F,cells
R24858	T32522	T32524	compound	CD4-cre,cells
R24859	T32523	T32524	compound	mouse,cells
R24860	T32524	T32529	nsubj	cells,generated
R24861	T32525	T32524	cc	and,cells
R24862	T32526	T32528	compound	iT,cells
R24863	T32527	T32528	compound	reg,cells
R24864	T32528	T32524	conj	cells,cells
R24865	T32529	T32529	ROOT	generated,generated
R24866	T32530	T32529	prep	from,generated
R24867	T32531	T32532	npadvmod	human,naive
R24868	T32532	T32536	amod	naive,cells
R24869	T32533	T32536	nmod	CD4,cells
R24870	T32534	T32536	nummod	+,cells
R24871	T32535	T32536	compound	T,cells
R24872	T32536	T32530	pobj	cells,from
R24873	T32537	T32536	acl	undergoing,cells
R24874	T32538	T32539	compound	siRNA-mediated,RUNX1
R24875	T32539	T32537	dobj	RUNX1,undergoing
R24876	T32540	T32539	cc	and,RUNX1
R24877	T32541	T32539	conj	RUNX3,RUNX1
R24878	T32542	T32529	conj	knock,generated
R24879	T32543	T32542	prt	down,knock
R24880	T32544	T32529	advcl	show,generated
R24881	T32545	T32548	det	a,activity
R24882	T32546	T32548	amod	diminished,activity
R24883	T32547	T32548	amod	suppressive,activity
R24884	T32548	T32544	dobj	activity,show
R24885	T32549	T32529	punct	.,generated
R24886	T32550	T32551	amod	Experimental,setup
R24887	T32551	T32551	ROOT	setup,setup
R24888	T32552	T32553	punct	(,A
R24889	T32553	T32551	appos	A,setup
R24890	T32554	T32553	punct	),A
R24891	T32555	T32551	cc	and,setup
R24892	T32556	T32551	conj	results,setup
R24893	T32557	T32556	prep	of,results
R24894	T32558	T32561	det	the,assay
R24895	T32559	T32560	compound	mouse,suppression
R24896	T32560	T32561	compound	suppression,assay
R24897	T32561	T32557	pobj	assay,of
R24898	T32562	T32563	punct	(,B
R24899	T32563	T32561	appos	B,assay
R24900	T32564	T32561	punct	),assay
R24901	T32565	T32556	punct	",",results
R24902	T32566	T32567	npadvmod	FACS-purified,naive
R24903	T32567	T32572	amod	naive,cells
R24904	T32568	T32572	nmod	CD4,cells
R24905	T32569	T32568	nummod	+8,CD4
R24906	T32570	T32572	nummod	−,cells
R24907	T32571	T32572	compound	T,cells
R24908	T32572	T32551	conj	cells,setup
R24909	T32573	T32572	prep	from,cells
R24910	T32574	T32575	compound	CbfbF/F,CD4-cre
R24911	T32575	T32573	pobj	CD4-cre,from
R24912	T32576	T32577	punct	(,left
R24913	T32577	T32575	parataxis	left,CD4-cre
R24914	T32578	T32577	punct	),left
R24915	T32579	T32575	cc	and,CD4-cre
R24916	T32580	T32582	compound	control,/
R24917	T32581	T32582	compound	CbfbF,/
R24918	T32582	T32583	nsubj	/,+
R24919	T32583	T32583	ROOT	+,+
R24920	T32584	T32585	amod	CD4-cre,mice
R24921	T32585	T32583	dobj	mice,+
R24922	T32586	T32593	punct	(,activated
R24923	T32587	T32593	ccomp	Cd45,activated
R24924	T32588	T32587	nummod	.2,Cd45
R24925	T32589	T32593	punct	;,activated
R24926	T32590	T32593	nsubjpass	right,activated
R24927	T32591	T32590	punct	),right
R24928	T32592	T32593	auxpass	were,activated
R24929	T32593	T32583	parataxis	activated,+
R24930	T32594	T32593	prep	in,activated
R24931	T32595	T32594	pobj	vitro,in
R24932	T32596	T32595	prep	with,vitro
R24933	T32597	T32600	amod	anti-CD3,mAb
R24934	T32598	T32600	nmod	/,mAb
R24935	T32599	T32598	nummod	28,/
R24936	T32600	T32596	pobj	mAb,with
R24937	T32601	T32600	punct	",",mAb
R24938	T32602	T32604	nummod	50,IL-2
R24939	T32603	T32604	compound	U/ml,IL-2
R24940	T32604	T32600	conj	IL-2,mAb
R24941	T32605	T32604	punct	",",IL-2
R24942	T32606	T32604	cc	and,IL-2
R24943	T32607	T32609	nummod	2.5,TGF-β
R24944	T32608	T32609	amod	ng/ml,TGF-β
R24945	T32609	T32604	conj	TGF-β,IL-2
R24946	T32610	T32583	punct	.,+
R24947	T32611	T32618	prep	After,were
R24948	T32612	T32613	nummod	3,d
R24949	T32613	T32611	pobj	d,After
R24950	T32614	T32618	punct	",",were
R24951	T32615	T32617	amod	Foxp3-GFP,cells
R24952	T32616	T32617	compound	+,cells
R24953	T32617	T32618	nsubj	cells,were
R24954	T32618	T32618	ROOT	were,were
R24955	T32619	T32618	acomp	FACS-sorted,were
R24956	T32620	T32619	cc	and,FACS-sorted
R24957	T32621	T32619	conj	mixed,FACS-sorted
R24958	T32622	T32621	prep	with,mixed
R24959	T32623	T32625	amod	CFSE-loaded,CD45
R24960	T32624	T32625	amod	naive,CD45
R24961	T32625	T32622	pobj	CD45,with
R24962	T32626	T32630	nummod	.1,cells
R24963	T32627	T32630	nummod	+,cells
R24964	T32628	T32630	compound	CD4,cells
R24965	T32629	T32630	compound	+,cells
R24966	T32630	T32618	attr	cells,were
R24967	T32631	T32618	prep	at,were
R24968	T32632	T32634	det	the,ratios
R24969	T32633	T32634	amod	indicated,ratios
R24970	T32634	T32631	pobj	ratios,at
R24971	T32635	T32618	punct	.,were
R24972	T32636	T32639	nsubjpass	These,incubated
R24973	T32637	T32639	auxpass	were,incubated
R24974	T32638	T32639	advmod	then,incubated
R24975	T32639	T32639	ROOT	incubated,incubated
R24976	T32640	T32639	prep	with,incubated
R24977	T32641	T32642	amod	inactivated,splenocytes
R24978	T32642	T32640	pobj	splenocytes,with
R24979	T32643	T32642	cc	and,splenocytes
R24980	T32644	T32645	amod	anti-CD3,mAb
R24981	T32645	T32642	conj	mAb,splenocytes
R24982	T32646	T32639	punct	.,incubated
R24983	T32647	T32658	prep	After,analyzed
R24984	T32648	T32651	det	a,d
R24985	T32649	T32651	amod	further,d
R24986	T32650	T32651	nummod	4,d
R24987	T32651	T32647	pobj	d,After
R24988	T32652	T32658	punct	",",analyzed
R24989	T32653	T32658	nsubjpass	CD45,analyzed
R24990	T32654	T32656	nummod	.1,cells
R24991	T32655	T32656	compound	+,cells
R24992	T32656	T32658	nsubjpass	cells,analyzed
R24993	T32657	T32658	auxpass	were,analyzed
R24994	T32658	T32658	ROOT	analyzed,analyzed
R24995	T32659	T32658	prep	for,analyzed
R24996	T32660	T32661	compound	CFSE,dilution
R24997	T32661	T32659	pobj	dilution,for
R24998	T32662	T32658	punct	.,analyzed
R24999	T32663	T32664	punct	(,C
R25000	T32664	T32664	ROOT	C,C
R25001	T32665	T32664	punct	),C
R25002	T32666	T32675	prep	As,+
R25003	T32667	T32668	det	a,control
R25004	T32668	T32666	pobj	control,As
R25005	T32669	T32675	punct	",",+
R25006	T32670	T32674	compound	CbfbF,CD4
R25007	T32671	T32674	compound	/,CD4
R25008	T32672	T32674	compound	+,CD4
R25009	T32673	T32674	compound	CD4-cre,CD4
R25010	T32674	T32675	nsubj	CD4,+
R25011	T32675	T32675	ROOT	+,+
R25012	T32676	T32677	compound	T,cells
R25013	T32677	T32683	nsubj	cells,were
R25014	T32678	T32677	acl	activated,cells
R25015	T32679	T32678	prep	in,activated
R25016	T32680	T32679	pobj	absence,in
R25017	T32681	T32680	prep	of,absence
R25018	T32682	T32681	pobj	TGF-β,of
R25019	T32683	T32675	ccomp	were,+
R25020	T32684	T32683	acomp	mixed,were
R25021	T32685	T32684	prep	with,mixed
R25022	T32686	T32688	amod	CFSE-loaded,CD45
R25023	T32687	T32688	amod	naive,CD45
R25024	T32688	T32685	pobj	CD45,with
R25025	T32689	T32693	nummod	.1,cells
R25026	T32690	T32693	nummod	+,cells
R25027	T32691	T32693	compound	CD4,cells
R25028	T32692	T32693	compound	+,cells
R25029	T32693	T32683	attr	cells,were
R25030	T32694	T32683	prep	at,were
R25031	T32695	T32697	det	the,ratios
R25032	T32696	T32697	amod	indicated,ratios
R25033	T32697	T32694	pobj	ratios,at
R25034	T32698	T32675	punct	.,+
R25035	T32699	T32700	nummod	Four,days
R25036	T32700	T32701	npadvmod	days,later
R25037	T32701	T32707	advmod	later,analyzed
R25038	T32702	T32705	nummod	CD45,cells
R25039	T32703	T32705	nummod	.1,cells
R25040	T32704	T32705	compound	+,cells
R25041	T32705	T32707	nsubjpass	cells,analyzed
R25042	T32706	T32707	auxpass	were,analyzed
R25043	T32707	T32707	ROOT	analyzed,analyzed
R25044	T32708	T32707	prep	for,analyzed
R25045	T32709	T32710	compound	CFSE,dilution
R25046	T32710	T32708	pobj	dilution,for
R25047	T32711	T32707	punct	.,analyzed
R25048	T32712	T32715	det	The,number
R25049	T32713	T32715	compound	median,number
R25050	T32714	T32715	compound	division,number
R25051	T32715	T32735	nsubjpass	number,indicated
R25052	T32716	T32715	punct	(,number
R25053	T32717	T32715	prep	of,number
R25054	T32718	T32725	det	the,cells
R25055	T32719	T32725	amod	naive,cells
R25056	T32720	T32725	nmod	CD45,cells
R25057	T32721	T32720	nummod	.1,CD45
R25058	T32722	T32725	nummod	+,cells
R25059	T32723	T32725	compound	CD4,cells
R25060	T32724	T32725	compound	+,cells
R25061	T32725	T32717	pobj	cells,of
R25062	T32726	T32725	prep	in,cells
R25063	T32727	T32728	det	the,cultures
R25064	T32728	T32726	pobj	cultures,in
R25065	T32729	T32728	acl	containing,cultures
R25066	T32730	T32732	amod	Foxp3-GFP,cells
R25067	T32731	T32732	compound	+,cells
R25068	T32732	T32729	dobj	cells,containing
R25069	T32733	T32715	punct	),number
R25070	T32734	T32735	auxpass	is,indicated
R25071	T32735	T32735	ROOT	indicated,indicated
R25072	T32736	T32735	prep	in,indicated
R25073	T32737	T32736	pobj	each,in
R25074	T32738	T32737	prep	of,each
R25075	T32739	T32740	det	the,histograms
R25076	T32740	T32738	pobj	histograms,of
R25077	T32741	T32735	punct	.,indicated
R25078	T32742	T32747	nsubjpass	One,shown
R25079	T32743	T32742	prep	of,One
R25080	T32744	T32745	nummod	three,experiments
R25081	T32745	T32743	pobj	experiments,of
R25082	T32746	T32747	auxpass	is,shown
R25083	T32747	T32747	ROOT	shown,shown
R25084	T32748	T32747	punct	.,shown
R25085	T32749	T32752	punct	(,Human
R25086	T32750	T32752	nmod	D,Human
R25087	T32751	T32752	punct	),Human
R25088	T32752	T32753	npadvmod	Human,naive
R25089	T32753	T32757	amod	naive,cells
R25090	T32754	T32757	compound	CD4,cells
R25091	T32755	T32757	nummod	+,cells
R25092	T32756	T32757	compound	T,cells
R25093	T32757	T32773	nsubjpass	cells,used
R25094	T32758	T32757	punct	",",cells
R25095	T32759	T32757	acl	transfected,cells
R25096	T32760	T32759	prep	with,transfected
R25097	T32761	T32760	pobj	RUNX1,with
R25098	T32762	T32761	cc	and,RUNX1
R25099	T32763	T32764	compound	RUNX3,siRNA
R25100	T32764	T32761	conj	siRNA,RUNX1
R25101	T32765	T32759	cc	and,transfected
R25102	T32766	T32759	conj	cultured,transfected
R25103	T32767	T32766	prep	under,cultured
R25104	T32768	T32769	compound	iT,reg
R25105	T32769	T32771	compound	reg,conditions
R25106	T32770	T32771	compound	differentiating,conditions
R25107	T32771	T32767	pobj	conditions,under
R25108	T32772	T32773	auxpass	were,used
R25109	T32773	T32773	ROOT	used,used
R25110	T32774	T32773	prep	in,used
R25111	T32775	T32779	det	an,assay
R25112	T32776	T32779	nmod	in,assay
R25113	T32777	T32778	amod	vitro,suppression
R25114	T32778	T32779	compound	suppression,assay
R25115	T32779	T32774	pobj	assay,in
R25117	T32781	T32773	conj	cultured,used
R25118	T32782	T32781	advmod	together,cultured
R25119	T32783	T32781	prep	with,cultured
R25120	T32784	T32789	amod	autologous,cells
R25121	T32785	T32789	amod	CFSE-labeled,cells
R25122	T32786	T32789	nmod	CD4,cells
R25123	T32787	T32789	nummod	+,cells
R25124	T32788	T32789	compound	T,cells
R25125	T32789	T32783	pobj	cells,with
R25126	T32790	T32781	punct	",",cultured
R25127	T32791	T32781	cc	and,cultured
R25128	T32792	T32781	conj	stimulated,cultured
R25129	T32793	T32792	prep	with,stimulated
R25130	T32794	T32795	compound	anti-CD3,mAb
R25131	T32795	T32793	pobj	mAb,with
R25132	T32796	T32773	punct	.,used
R25133	T32797	T32799	det	The,dilution
R25134	T32798	T32799	compound	CFSE,dilution
R25135	T32799	T32809	nsubjpass	dilution,analyzed
R25136	T32800	T32799	prep	of,dilution
R25137	T32801	T32807	det	the,cells
R25138	T32802	T32807	compound	CD4,cells
R25139	T32803	T32807	nummod	+,cells
R25140	T32804	T32805	compound	T,cell
R25141	T32805	T32806	compound	cell,responder
R25142	T32806	T32807	compound	responder,cells
R25143	T32807	T32800	pobj	cells,of
R25144	T32808	T32809	auxpass	was,analyzed
R25145	T32809	T32809	ROOT	analyzed,analyzed
R25146	T32810	T32809	prep	after,analyzed
R25147	T32811	T32812	nummod	5,d
R25148	T32812	T32810	pobj	d,after
R25149	T32813	T32809	agent	by,analyzed
R25150	T32814	T32815	compound	flow,cytometry
R25151	T32815	T32813	pobj	cytometry,by
R25152	T32816	T32809	punct	.,analyzed
R25153	T32817	T32819	det	The,reg/responder
R25154	T32818	T32819	compound	T,reg/responder
R25155	T32819	T32824	compound	reg/responder,ratios
R25156	T32820	T32824	compound	CD4,ratios
R25157	T32821	T32824	compound	+,ratios
R25158	T32822	T32823	compound	T,cell
R25159	T32823	T32824	compound	cell,ratios
R25160	T32824	T32826	nsubj	ratios,were
R25161	T32825	T32824	acl	used,ratios
R25162	T32826	T32826	ROOT	were,were
R25163	T32827	T32826	attr	1:20,were
R25164	T32828	T32827	punct	",",1:20
R25165	T32829	T32827	conj	1:10,1:20
R25166	T32830	T32826	punct	",",were
R25167	T32831	T32826	cc	and,were
R25168	T32832	T32826	conj	1:5,were
R25169	T32833	T32826	punct	.,were
R25170	T32834	T32839	nsubjpass	One,shown
R25171	T32835	T32834	prep	of,One
R25172	T32836	T32837	nummod	two,experiments
R25173	T32837	T32835	pobj	experiments,of
R25174	T32838	T32839	auxpass	is,shown
R25175	T32839	T32839	ROOT	shown,shown
R25176	T32840	T32839	punct	.,shown
R25116	T32780	T32773	punct	",",used

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T12037	872-887	http://purl.obolibrary.org/obo/GO_0001775	denotes	cells activated
T12038	1314-1329	http://purl.obolibrary.org/obo/GO_0001775	denotes	cells activated
T12039	945-963	http://purl.obolibrary.org/obo/GO_0008283	denotes	cell proliferation
T12040	1764-1774	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T12041	1769-1774	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T12042	3502-3513	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T32885	2618-2633	http://purl.obolibrary.org/obo/GO_0001775	denotes	cells activated

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T12043	518-522	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2
T32886	2287-2291	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T12044	88-93	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12045	128-133	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12046	246-251	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12047	343-348	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12048	558-563	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12049	641-646	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12050	683-688	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12051	799-804	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12052	872-877	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12053	1035-1040	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12054	1109-1114	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12055	1259-1264	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12056	1314-1319	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12057	1398-1403	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12058	1568-1573	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12059	1658-1663	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12060	1712-1717	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12061	3558-3563	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12062	3596-3601	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12063	3798-3803	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12064	3959-3964	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12065	4246-4251	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12066	4332-4337	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12067	4401-4406	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12068	4452-4457	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12069	4502-4507	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12070	4586-4591	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12071	4666-4671	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32887	1894-1899	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32888	1911-1916	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32889	1951-1956	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32890	2150-2155	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32891	2336-2341	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32892	2405-2410	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32893	2538-2543	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32894	2618-2623	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32895	2701-2706	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32896	2756-2761	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32897	2849-2854	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32898	2893-2898	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32899	2998-3003	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32900	3195-3200	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32901	3283-3288	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T32902	3358-3362	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell

sentences

Id	Subject	Object	Predicate	Lexical cue
T10570	0-93	Sentence	denotes	CBFβ, RUNX1, and RUNX3 are important for the suppressive activity of CD25+ Foxp3+ T reg cells
T10571	94-320	Sentence	denotes	Even though Cbfb-deficient CD4+ T cells had impaired induction of Foxp3 after stimulation with anti-CD3/28 mAbs and TGF-β, sufficient numbers of Foxp3+ cells could be generated to permit analysis of their suppressive activity.
T10572	321-534	Sentence	denotes	Purified naive CD4+ T cells from CbfbF/F CD4-cre and control CbfbF/+ CD4-cre mice (Cd45.2) harboring a Foxp3-ires-GFP allele (Bettelli et al., 2006) were stimulated in vitro with anti-CD3/28 mAbs, IL-2, and TGF-β.
T10573	535-678	Sentence	denotes	After 3 d, Foxp3+-GFP+ cells were sorted by flow cytometry and mixed with CFSE-labeled naive CD45.1+ CD4+ cells at ratios of 1:4, 1:2, and 1:1.
T10574	679-790	Sentence	denotes	The cells were then incubated with inactivated splenocytes and stimulated with anti-CD3 mAb for four more days.
T10575	791-848	Sentence	denotes	CD45.1+ cells were analyzed for CFSE dilution (Fig. 6 A).
T10576	849-1061	Sentence	denotes	CbfbF/+ CD4-cre CD4+ T cells activated in the presence of TGF-β showed a clear suppression of T cell proliferation that became even more apparent when an increased ratio of FOXP3+/CD25− cells was used (Fig. 6 B).
T10577	1062-1276	Sentence	denotes	The suppression was significantly reduced when cells from CbfbF/F CD4-cre mice were used, demonstrating that TGF-β–induced Runx complexes are important for the suppressive activity of Foxp3+ T reg cells (Fig. 6 B).
T10578	1277-1404	Sentence	denotes	As a control, CbfbF/+ CD4-cre CD4+ T cells activated in absence of TGF-β were mixed with CFSE-labeled naive CD45.1+ CD4+ cells.
T10579	1405-1506	Sentence	denotes	No suppression could be observed in all control groups without TGF-β at all tested ratios (Fig. 6 C).
T10580	1507-1639	Sentence	denotes	The decreased suppression capacity of CbfbF/F CD4-cre iT reg cells was unlikely to be caused by decreased survival or proliferation.
T10581	1640-1860	Sentence	denotes	Foxp3+ and Foxp3− cells generated from both CbfbF/F CD4-cre and control cells all displayed similar proliferation rates and cell death as measured by CFSE dilution and annexin V staining, respectively (Fig. S7, A and B).
T10582	3436-3564	Sentence	denotes	In addition, we tested the requirement of RUNX1 and RUNX3 for the development of the suppressive capacity in human iT reg cells.
T10583	3565-3702	Sentence	denotes	We isolated human naive CD4+ T cells and transfected them with a combination of RUNX1 and RUNX3 siRNA, or with a scrambled control siRNA.
T10584	3703-3837	Sentence	denotes	Cells were cultured under T reg conditions, and then mixed with CFSE-labeled autologous CD4+ T cells and stimulated with anti-CD3 mAb.
T10585	3838-4096	Sentence	denotes	Cells in which RUNX1 and RUNX3 were knocked down showed markedly lower suppressive activity compared with control iT reg cells at a T reg/CD4+ T responder cell ratio of 1:20, but not when the T reg/CD4+ T responder cell ratio was increased to 1:5 (Fig. 6 D).
T10586	4097-4279	Sentence	denotes	These results demonstrate the important role of RUNX1 and RUNX3 not only for the induction of FOXP3, but also for the suppressive capacity of iT reg cells both in humans and in mice.
T10587	4280-4351	Sentence	denotes	The data suggest both quantity and quality of T reg cells are hampered.
T10588	4352-4544	Sentence	denotes	Reduced intrinsic suppressive capacity of iT reg cells was demonstrated in mice, because Foxp3-GFP+ cells were FACS sorted and same numbers of iT reg cells are included in control experiments.
T10589	4545-4711	Sentence	denotes	In the suppression experiment with human cells, reduced suppressive activity was caused by reduced FOXP3 expression in T cells by siRNA inhibition of RUNX1 and RUNX3.
T32169	1872-2049	Sentence	denotes	CbfbF/F CD4-cre mouse cells and iT reg cells generated from human naive CD4+ T cells undergoing siRNA-mediated RUNX1 and RUNX3 knock down show a diminished suppressive activity.
T32170	2050-2313	Sentence	denotes	Experimental setup (A) and results of the mouse suppression assay (B), FACS-purified naive CD4+8− T cells from CbfbF/F CD4-cre (left) and control CbfbF/+ CD4-cre mice (Cd45.2; right) were activated in vitro with anti-CD3/28 mAb, 50 U/ml IL-2, and 2.5 ng/ml TGF-β.
T32171	2314-2435	Sentence	denotes	After 3 d, Foxp3-GFP+ cells were FACS-sorted and mixed with CFSE-loaded naive CD45.1+ CD4+ cells at the indicated ratios.
T32172	2436-2508	Sentence	denotes	These were then incubated with inactivated splenocytes and anti-CD3 mAb.
T32173	2509-2731	Sentence	denotes	After a further 4 d, CD45.1+ cells were analyzed for CFSE dilution. (C) As a control, CbfbF/+ CD4-cre CD4+ T cells activated in absence of TGF-β were mixed with CFSE-loaded naive CD45.1+ CD4+ cells at the indicated ratios.
T32174	2732-2794	Sentence	denotes	Four days later CD45.1+ cells were analyzed for CFSE dilution.
T32175	2795-2939	Sentence	denotes	The median division number (of the naive CD45.1+ CD4+ cells in the cultures containing Foxp3-GFP+ cells) is indicated in each of the histograms.
T32176	2940-3235	Sentence	denotes	One of three experiments is shown. (D) Human naive CD4+ T cells, transfected with RUNX1 and RUNX3 siRNA and cultured under iT reg differentiating conditions were used in an in vitro suppression assay, cultured together with autologous CFSE-labeled CD4+ T cells, and stimulated with anti-CD3 mAb.
T32177	3236-3330	Sentence	denotes	The CFSE dilution of the CD4+ T cell responder cells was analyzed after 5 d by flow cytometry.
T32178	3331-3400	Sentence	denotes	The T reg/responder CD4+ T cell ratios used were 1:20, 1:10, and 1:5.
T32179	3401-3433	Sentence	denotes	One of two experiments is shown.
T149	0-93	Sentence	denotes	CBFβ, RUNX1, and RUNX3 are important for the suppressive activity of CD25+ Foxp3+ T reg cells
T150	94-320	Sentence	denotes	Even though Cbfb-deficient CD4+ T cells had impaired induction of Foxp3 after stimulation with anti-CD3/28 mAbs and TGF-β, sufficient numbers of Foxp3+ cells could be generated to permit analysis of their suppressive activity.
T151	321-534	Sentence	denotes	Purified naive CD4+ T cells from CbfbF/F CD4-cre and control CbfbF/+ CD4-cre mice (Cd45.2) harboring a Foxp3-ires-GFP allele (Bettelli et al., 2006) were stimulated in vitro with anti-CD3/28 mAbs, IL-2, and TGF-β.
T152	535-678	Sentence	denotes	After 3 d, Foxp3+-GFP+ cells were sorted by flow cytometry and mixed with CFSE-labeled naive CD45.1+ CD4+ cells at ratios of 1:4, 1:2, and 1:1.
T153	679-790	Sentence	denotes	The cells were then incubated with inactivated splenocytes and stimulated with anti-CD3 mAb for four more days.
T154	791-848	Sentence	denotes	CD45.1+ cells were analyzed for CFSE dilution (Fig. 6 A).
T155	849-1061	Sentence	denotes	CbfbF/+ CD4-cre CD4+ T cells activated in the presence of TGF-β showed a clear suppression of T cell proliferation that became even more apparent when an increased ratio of FOXP3+/CD25− cells was used (Fig. 6 B).
T156	1062-1276	Sentence	denotes	The suppression was significantly reduced when cells from CbfbF/F CD4-cre mice were used, demonstrating that TGF-β–induced Runx complexes are important for the suppressive activity of Foxp3+ T reg cells (Fig. 6 B).
T157	1277-1404	Sentence	denotes	As a control, CbfbF/+ CD4-cre CD4+ T cells activated in absence of TGF-β were mixed with CFSE-labeled naive CD45.1+ CD4+ cells.
T158	1405-1506	Sentence	denotes	No suppression could be observed in all control groups without TGF-β at all tested ratios (Fig. 6 C).
T159	1507-1639	Sentence	denotes	The decreased suppression capacity of CbfbF/F CD4-cre iT reg cells was unlikely to be caused by decreased survival or proliferation.
T160	1640-1860	Sentence	denotes	Foxp3+ and Foxp3− cells generated from both CbfbF/F CD4-cre and control cells all displayed similar proliferation rates and cell death as measured by CFSE dilution and annexin V staining, respectively (Fig. S7, A and B).
T161	1861-1870	Sentence	denotes	Figure 6.
T162	1872-2049	Sentence	denotes	CbfbF/F CD4-cre mouse cells and iT reg cells generated from human naive CD4+ T cells undergoing siRNA-mediated RUNX1 and RUNX3 knock down show a diminished suppressive activity.
T163	2050-2313	Sentence	denotes	Experimental setup (A) and results of the mouse suppression assay (B), FACS-purified naive CD4+8− T cells from CbfbF/F CD4-cre (left) and control CbfbF/+ CD4-cre mice (Cd45.2; right) were activated in vitro with anti-CD3/28 mAb, 50 U/ml IL-2, and 2.5 ng/ml TGF-β.
T164	2314-2435	Sentence	denotes	After 3 d, Foxp3-GFP+ cells were FACS-sorted and mixed with CFSE-loaded naive CD45.1+ CD4+ cells at the indicated ratios.
T165	2436-2508	Sentence	denotes	These were then incubated with inactivated splenocytes and anti-CD3 mAb.
T166	2509-2731	Sentence	denotes	After a further 4 d, CD45.1+ cells were analyzed for CFSE dilution. (C) As a control, CbfbF/+ CD4-cre CD4+ T cells activated in absence of TGF-β were mixed with CFSE-loaded naive CD45.1+ CD4+ cells at the indicated ratios.
T167	2732-2794	Sentence	denotes	Four days later CD45.1+ cells were analyzed for CFSE dilution.
T168	2795-2939	Sentence	denotes	The median division number (of the naive CD45.1+ CD4+ cells in the cultures containing Foxp3-GFP+ cells) is indicated in each of the histograms.
T169	2940-3235	Sentence	denotes	One of three experiments is shown. (D) Human naive CD4+ T cells, transfected with RUNX1 and RUNX3 siRNA and cultured under iT reg differentiating conditions were used in an in vitro suppression assay, cultured together with autologous CFSE-labeled CD4+ T cells, and stimulated with anti-CD3 mAb.
T170	3236-3330	Sentence	denotes	The CFSE dilution of the CD4+ T cell responder cells was analyzed after 5 d by flow cytometry.
T171	3331-3400	Sentence	denotes	The T reg/responder CD4+ T cell ratios used were 1:20, 1:10, and 1:5.
T172	3401-3433	Sentence	denotes	One of two experiments is shown.
T173	3436-3564	Sentence	denotes	In addition, we tested the requirement of RUNX1 and RUNX3 for the development of the suppressive capacity in human iT reg cells.
T174	3565-3702	Sentence	denotes	We isolated human naive CD4+ T cells and transfected them with a combination of RUNX1 and RUNX3 siRNA, or with a scrambled control siRNA.
T175	3703-3837	Sentence	denotes	Cells were cultured under T reg conditions, and then mixed with CFSE-labeled autologous CD4+ T cells and stimulated with anti-CD3 mAb.
T176	3838-4096	Sentence	denotes	Cells in which RUNX1 and RUNX3 were knocked down showed markedly lower suppressive activity compared with control iT reg cells at a T reg/CD4+ T responder cell ratio of 1:20, but not when the T reg/CD4+ T responder cell ratio was increased to 1:5 (Fig. 6 D).
T177	4097-4279	Sentence	denotes	These results demonstrate the important role of RUNX1 and RUNX3 not only for the induction of FOXP3, but also for the suppressive capacity of iT reg cells both in humans and in mice.
T178	4280-4351	Sentence	denotes	The data suggest both quantity and quality of T reg cells are hampered.
T179	4352-4544	Sentence	denotes	Reduced intrinsic suppressive capacity of iT reg cells was demonstrated in mice, because Foxp3-GFP+ cells were FACS sorted and same numbers of iT reg cells are included in control experiments.
T180	4545-4711	Sentence	denotes	In the suppression experiment with human cells, reduced suppressive activity was caused by reduced FOXP3 expression in T cells by siRNA inhibition of RUNX1 and RUNX3.

events-check-again

Id	Subject	Object	Predicate	Lexical cue
T12072	0-4	Protein	denotes	CBFβ
T12073	6-11	Protein	denotes	RUNX1
T12074	17-22	Protein	denotes	RUNX3
T12075	69-73	Protein	denotes	CD25
T12076	75-80	Protein	denotes	Foxp3
T12077	106-110	Protein	denotes	Cbfb
T12078	111-120	Negative_regulation	denotes	deficient
T12079	121-124	Protein	denotes	CD4
T12080	138-146	Negative_regulation	denotes	impaired
T12081	147-156	Positive_regulation	denotes	induction
T12082	160-165	Protein	denotes	Foxp3
T12083	194-197	Protein	denotes	CD3
T12084	198-200	Protein	denotes	28
T12085	210-215	Protein	denotes	TGF-β
T12086	239-244	Protein	denotes	Foxp3
T12087	336-339	Protein	denotes	CD4
T12088	354-358	Protein	denotes	Cbfb
T12089	362-369	Protein	denotes	CD4-cre
T12090	382-386	Protein	denotes	Cbfb
T12091	390-397	Protein	denotes	CD4-cre
T12092	404-410	Protein	denotes	Cd45.2
T12093	424-429	Protein	denotes	Foxp3
T12094	435-438	Protein	denotes	GFP
T12095	505-508	Protein	denotes	CD3
T12096	509-511	Protein	denotes	28
T12097	518-522	Protein	denotes	IL-2
T12098	528-533	Protein	denotes	TGF-β
T12099	546-551	Protein	denotes	Foxp3
T12100	553-556	Protein	denotes	GFP
T12101	628-634	Protein	denotes	CD45.1
T12102	636-639	Protein	denotes	CD4
T12103	763-766	Protein	denotes	CD3
T12104	791-797	Protein	denotes	CD45.1
T12105	849-853	Protein	denotes	Cbfb
T12106	857-864	Protein	denotes	CD4-cre
T12107	865-868	Protein	denotes	CD4
T12108	907-912	Protein	denotes	TGF-β
T12109	1022-1027	Protein	denotes	FOXP3
T12110	1029-1033	Protein	denotes	CD25
T12111	1120-1124	Protein	denotes	Cbfb
T12112	1128-1135	Protein	denotes	CD4-cre
T12113	1171-1176	Protein	denotes	TGF-β
T12114	1246-1251	Protein	denotes	Foxp3
T12115	1291-1295	Protein	denotes	Cbfb
T12116	1299-1306	Protein	denotes	CD4-cre
T12117	1307-1310	Protein	denotes	CD4
T12118	1344-1349	Protein	denotes	TGF-β
T12119	1385-1391	Protein	denotes	CD45.1
T12120	1393-1396	Protein	denotes	CD4
T12121	1468-1473	Protein	denotes	TGF-β
T12122	1545-1549	Protein	denotes	Cbfb
T12123	1553-1560	Protein	denotes	CD4-cre
T12124	1640-1645	Protein	denotes	Foxp3
T12125	1651-1656	Protein	denotes	Foxp3
T12126	1684-1688	Protein	denotes	Cbfb
T12127	1692-1699	Protein	denotes	CD4-cre
T12128	1808-1817	Protein	denotes	annexin V
T12129	3478-3483	Protein	denotes	RUNX1
T12130	3488-3493	Protein	denotes	RUNX3
T12131	3589-3592	Protein	denotes	CD4
T12132	3645-3650	Protein	denotes	RUNX1
T12133	3655-3660	Protein	denotes	RUNX3
T12134	3661-3666	Negative_regulation	denotes	siRNA
T12135	3661-3666	Negative_regulation	denotes	siRNA
T12136	3791-3794	Protein	denotes	CD4
T12137	3829-3832	Protein	denotes	CD3
T12138	3853-3858	Protein	denotes	RUNX1
T12139	3863-3868	Protein	denotes	RUNX3
T12140	3874-3886	Negative_regulation	denotes	knocked down
T12141	3874-3886	Negative_regulation	denotes	knocked down
T12142	3976-3979	Protein	denotes	CD4
T12143	4036-4039	Protein	denotes	CD4
T12144	4127-4136	Positive_regulation	denotes	important
T12145	4127-4136	Positive_regulation	denotes	important
T12146	4145-4150	Protein	denotes	RUNX1
T12147	4155-4160	Protein	denotes	RUNX3
T12148	4178-4187	Gene_expression	denotes	induction
T12149	4191-4196	Protein	denotes	FOXP3
T12150	4441-4450	Protein	denotes	Foxp3-GFP
T12151	4636-4643	Negative_regulation	denotes	reduced
T12152	4636-4643	Negative_regulation	denotes	reduced
T12153	4644-4649	Protein	denotes	FOXP3
T12154	4650-4660	Gene_expression	denotes	expression
T12155	4681-4691	Negative_regulation	denotes	inhibition
T12156	4681-4691	Negative_regulation	denotes	inhibition
T12157	4695-4700	Protein	denotes	RUNX1
T12158	4705-4710	Protein	denotes	RUNX3
T32903	1872-1876	Protein	denotes	Cbfb
T32904	1880-1887	Protein	denotes	CD4-cre
T32905	1944-1947	Protein	denotes	CD4
T32906	1974-1982	Positive_regulation	denotes	mediated
T32907	1974-1982	Positive_regulation	denotes	mediated
T32908	1983-1988	Protein	denotes	RUNX1
T32909	1993-1998	Protein	denotes	RUNX3
T32910	1999-2009	Negative_regulation	denotes	knock down
T32911	1999-2009	Negative_regulation	denotes	knock down
T32912	2141-2144	Protein	denotes	CD4
T32913	2145-2146	Protein	denotes	8
T32914	2161-2165	Protein	denotes	Cbfb
T32915	2169-2176	Protein	denotes	CD4-cre
T32916	2196-2200	Protein	denotes	Cbfb
T32917	2204-2211	Protein	denotes	CD4-cre
T32918	2218-2224	Protein	denotes	Cd45.2
T32919	2267-2270	Protein	denotes	CD3
T32920	2271-2273	Protein	denotes	28
T32921	2287-2291	Protein	denotes	IL-2
T32922	2307-2312	Protein	denotes	TGF-β
T32923	2325-2334	Protein	denotes	Foxp3-GFP
T32924	2392-2398	Protein	denotes	CD45.1
T32925	2400-2403	Protein	denotes	CD4
T32926	2500-2503	Protein	denotes	CD3
T32927	2530-2536	Protein	denotes	CD45.1
T32928	2595-2599	Protein	denotes	Cbfb
T32929	2603-2610	Protein	denotes	CD4-cre
T32930	2611-2614	Protein	denotes	CD4
T32931	2648-2653	Protein	denotes	TGF-β
T32932	2688-2694	Protein	denotes	CD45.1
T32933	2696-2699	Protein	denotes	CD4
T32934	2748-2754	Protein	denotes	CD45.1
T32935	2836-2842	Protein	denotes	CD45.1
T32936	2844-2847	Protein	denotes	CD4
T32937	2882-2891	Protein	denotes	Foxp3-GFP
T32938	2991-2994	Protein	denotes	CD4
T32939	3022-3027	Protein	denotes	RUNX1
T32940	3032-3037	Protein	denotes	RUNX3
T32941	3038-3043	Negative_regulation	denotes	siRNA
T32942	3038-3043	Negative_regulation	denotes	siRNA
T32943	3188-3191	Protein	denotes	CD4
T32944	3227-3230	Protein	denotes	CD3
T32945	3261-3264	Protein	denotes	CD4
T32946	3351-3354	Protein	denotes	CD4
R9431	T12077	T12078	themeOf	Cbfb,deficient
R9432	T12078	T12080	causeOf	deficient,impaired
R9433	T12081	T12080	themeOf	induction,impaired
R9434	T12082	T12081	themeOf	Foxp3,induction
R9435	T12132	T12134	themeOf	RUNX1,siRNA
R9436	T12133	T12135	themeOf	RUNX3,siRNA
R9437	T12138	T12140	themeOf	RUNX1,knocked down
R9438	T12139	T12141	themeOf	RUNX3,knocked down
R9439	T12146	T12145	causeOf	RUNX1,important
R9440	T12147	T12144	causeOf	RUNX3,important
R9441	T12148	T12144	themeOf	induction,important
R9442	T12148	T12145	themeOf	induction,important
R9443	T12149	T12148	themeOf	FOXP3,induction
R9444	T12153	T12154	themeOf	FOXP3,expression
R9445	T12154	T12151	themeOf	expression,reduced
R9446	T12154	T12152	themeOf	expression,reduced
R9447	T12155	T12151	causeOf	inhibition,reduced
R9448	T12156	T12152	causeOf	inhibition,reduced
R9449	T12157	T12155	themeOf	RUNX1,inhibition
R9450	T12158	T12156	themeOf	RUNX3,inhibition
R25183	T32908	T32911	themeOf	RUNX1,knock down
R25184	T32909	T32910	themeOf	RUNX3,knock down
R25185	T32910	T32906	themeOf	knock down,mediated
R25186	T32911	T32907	themeOf	knock down,mediated
R25187	T32939	T32941	themeOf	RUNX1,siRNA
R25188	T32940	T32942	themeOf	RUNX3,siRNA

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T32991	1872-1883	Protein	denotes	CbfbF/F CD4
T32992	1884-1887	Protein	denotes	cre
T32993	1904-1910	Protein	denotes	iT reg
T32994	1944-1948	Protein	denotes	CD4+
T32995	1983-1988	Protein	denotes	RUNX1
T32996	1993-1998	Protein	denotes	RUNX3
T32997	2005-2009	Negative_regulation	denotes	down
T32998	2005-2009	Negative_regulation	denotes	down
T32999	2141-2145	Protein	denotes	CD4+
T33000	2161-2172	Protein	denotes	CbfbF/F CD4
T33001	2173-2176	Protein	denotes	cre
T33002	2196-2211	Protein	denotes	CbfbF/+ CD4-cre
T33003	2325-2330	Protein	denotes	Foxp3
T33004	2331-2334	Protein	denotes	GFP
T33005	2392-2403	Protein	denotes	CD45.1+ CD4
T33006	2495-2507	Protein	denotes	anti-CD3 mAb
T33007	2595-2610	Protein	denotes	CbfbF/+ CD4-cre
T33008	2611-2615	Protein	denotes	CD4+
T33009	2688-2699	Protein	denotes	CD45.1+ CD4
T33010	2836-2847	Protein	denotes	CD45.1+ CD4
T33011	2991-2995	Protein	denotes	CD4+
T33012	3022-3027	Protein	denotes	RUNX1
T33013	3032-3043	Protein	denotes	RUNX3 siRNA
T33014	3188-3192	Protein	denotes	CD4+
T33015	3222-3234	Protein	denotes	anti-CD3 mAb
T33016	3261-3265	Protein	denotes	CD4+
T33017	3335-3350	Protein	denotes	T reg/responder
T33018	3351-3354	Protein	denotes	CD4
R25195	T32995	T32997	themeOf	RUNX1,down
R25196	T32996	T32998	themeOf	RUNX3,down

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue
T10590	111-120	Negative_regulation	denotes	deficient
T10591	4127-4136	Positive_regulation	denotes	important
T10592	4636-4643	Negative_regulation	denotes	reduced
T10593	4650-4660	Gene_expression	denotes	expression
T10594	4681-4691	Negative_regulation	denotes	inhibition
T10595	4636-4643	Negative_regulation	denotes	reduced
T10596	4681-4691	Negative_regulation	denotes	inhibition
T10597	138-146	Negative_regulation	denotes	impaired
T10598	147-156	Positive_regulation	denotes	induction
T10599	3661-3666	Negative_regulation	denotes	siRNA
T10600	3661-3666	Negative_regulation	denotes	siRNA
T10601	3874-3886	Negative_regulation	denotes	knocked down
T10602	3874-3886	Negative_regulation	denotes	knocked down
T10603	4127-4136	Positive_regulation	denotes	important
T10604	4178-4187	Gene_expression	denotes	induction
T10605	0-4	Protein	denotes	CBFβ
T10606	198-200	Protein	denotes	28
T10607	210-215	Protein	denotes	TGF-β
T10608	239-244	Protein	denotes	Foxp3
T10609	336-339	Protein	denotes	CD4
T10610	354-358	Protein	denotes	Cbfb
T10611	362-369	Protein	denotes	CD4-cre
T10612	382-386	Protein	denotes	Cbfb
T10613	390-397	Protein	denotes	CD4-cre
T10614	404-410	Protein	denotes	Cd45.2
T10615	424-429	Protein	denotes	Foxp3
T10616	6-11	Protein	denotes	RUNX1
T10617	435-438	Protein	denotes	GFP
T10618	505-508	Protein	denotes	CD3
T10619	509-511	Protein	denotes	28
T10620	518-522	Protein	denotes	IL-2
T10621	528-533	Protein	denotes	TGF-β
T10622	546-551	Protein	denotes	Foxp3
T10623	553-556	Protein	denotes	GFP
T10624	628-634	Protein	denotes	CD45.1
T10625	636-639	Protein	denotes	CD4
T10626	763-766	Protein	denotes	CD3
T10627	17-22	Protein	denotes	RUNX3
T10628	791-797	Protein	denotes	CD45.1
T10629	849-853	Protein	denotes	Cbfb
T10630	857-864	Protein	denotes	CD4-cre
T10631	865-868	Protein	denotes	CD4
T10632	907-912	Protein	denotes	TGF-β
T10633	1022-1027	Protein	denotes	FOXP3
T10634	1029-1033	Protein	denotes	CD25
T10635	1120-1124	Protein	denotes	Cbfb
T10636	1128-1135	Protein	denotes	CD4-cre
T10637	69-73	Protein	denotes	CD25
T10638	1246-1251	Protein	denotes	Foxp3
T10639	1291-1295	Protein	denotes	Cbfb
T10640	1299-1306	Protein	denotes	CD4-cre
T10641	1307-1310	Protein	denotes	CD4
T10642	1344-1349	Protein	denotes	TGF-β
T10643	1385-1391	Protein	denotes	CD45.1
T10644	1393-1396	Protein	denotes	CD4
T10645	1468-1473	Protein	denotes	TGF-β
T10646	1545-1549	Protein	denotes	Cbfb
T10647	1553-1560	Protein	denotes	CD4-cre
T10648	75-80	Protein	denotes	Foxp3
T10649	1640-1645	Protein	denotes	Foxp3
T10650	1651-1656	Protein	denotes	Foxp3
T10651	1684-1688	Protein	denotes	Cbfb
T10652	1692-1699	Protein	denotes	CD4-cre
T10653	1808-1817	Protein	denotes	annexin V
T10654	3478-3483	Protein	denotes	RUNX1
T10655	3488-3493	Protein	denotes	RUNX3
T10656	3589-3592	Protein	denotes	CD4
T10657	3645-3650	Protein	denotes	RUNX1
T10658	3655-3660	Protein	denotes	RUNX3
T10659	106-110	Protein	denotes	Cbfb
T10660	3791-3794	Protein	denotes	CD4
T10661	3829-3832	Protein	denotes	CD3
T10662	3853-3858	Protein	denotes	RUNX1
T10663	3863-3868	Protein	denotes	RUNX3
T10664	3976-3979	Protein	denotes	CD4
T10665	4036-4039	Protein	denotes	CD4
T10666	4145-4150	Protein	denotes	RUNX1
T10667	4155-4160	Protein	denotes	RUNX3
T10668	4191-4196	Protein	denotes	FOXP3
T10669	4441-4450	Protein	denotes	Foxp3-GFP
T10670	121-124	Protein	denotes	CD4
T10671	4644-4649	Protein	denotes	FOXP3
T10672	4695-4700	Protein	denotes	RUNX1
T32125	1872-1876	Protein	denotes	Cbfb
T32126	1880-1887	Protein	denotes	CD4-cre
T32127	1944-1947	Protein	denotes	CD4
T32128	1974-1982	Positive_regulation	denotes	mediated
T32129	1974-1982	Positive_regulation	denotes	mediated
T32130	1983-1988	Protein	denotes	RUNX1
T32131	1993-1998	Protein	denotes	RUNX3
T32132	1999-2009	Negative_regulation	denotes	knock down
T32133	1999-2009	Negative_regulation	denotes	knock down
T32134	2141-2144	Protein	denotes	CD4
T32135	2145-2146	Protein	denotes	8
T32136	2161-2165	Protein	denotes	Cbfb
T32137	2169-2176	Protein	denotes	CD4-cre
T32138	2196-2200	Protein	denotes	Cbfb
T32139	2204-2211	Protein	denotes	CD4-cre
T32140	2218-2224	Protein	denotes	Cd45.2
T32141	2267-2270	Protein	denotes	CD3
T32142	2271-2273	Protein	denotes	28
T32143	2287-2291	Protein	denotes	IL-2
T32144	2307-2312	Protein	denotes	TGF-β
T32145	2325-2334	Protein	denotes	Foxp3-GFP
T32146	2392-2398	Protein	denotes	CD45.1
T32147	2400-2403	Protein	denotes	CD4
T32148	2500-2503	Protein	denotes	CD3
T32149	2530-2536	Protein	denotes	CD45.1
T32150	2595-2599	Protein	denotes	Cbfb
T32151	2603-2610	Protein	denotes	CD4-cre
T32152	2611-2614	Protein	denotes	CD4
T32153	2648-2653	Protein	denotes	TGF-β
T32154	2688-2694	Protein	denotes	CD45.1
T32155	2696-2699	Protein	denotes	CD4
T32156	2748-2754	Protein	denotes	CD45.1
T32157	2836-2842	Protein	denotes	CD45.1
T32158	2844-2847	Protein	denotes	CD4
T32159	2882-2891	Protein	denotes	Foxp3-GFP
T32160	2991-2994	Protein	denotes	CD4
T32161	3022-3027	Protein	denotes	RUNX1
T32162	3032-3037	Protein	denotes	RUNX3
T32163	3038-3043	Negative_regulation	denotes	siRNA
T32164	3038-3043	Negative_regulation	denotes	siRNA
T32165	3188-3191	Protein	denotes	CD4
T32166	3227-3230	Protein	denotes	CD3
T32167	3261-3264	Protein	denotes	CD4
T32168	3351-3354	Protein	denotes	CD4
T10673	4705-4710	Protein	denotes	RUNX3
T10674	160-165	Protein	denotes	Foxp3
T10675	194-197	Protein	denotes	CD3
T10676	1171-1176	Protein	denotes	TGF-β
R8206	T10590	T10597	causeOf	deficient,impaired
R8207	T10593	T10595	themeOf	expression,reduced
R8209	T10594	T10592	causeOf	inhibition,reduced
R8210	T10596	T10595	causeOf	inhibition,reduced
R8211	T10598	T10597	themeOf	induction,impaired
R8212	T10604	T10603	themeOf	induction,important
R8213	T10604	T10591	themeOf	induction,important
R8214	T10657	T10599	themeOf	RUNX1,siRNA
R8215	T10658	T10600	themeOf	RUNX3,siRNA
R8216	T10659	T10590	themeOf	Cbfb,deficient
R8217	T10662	T10601	themeOf	RUNX1,knocked down
R8218	T10663	T10602	themeOf	RUNX3,knocked down
R8219	T10666	T10603	causeOf	RUNX1,important
R8220	T10667	T10591	causeOf	RUNX3,important
R8221	T10668	T10604	themeOf	FOXP3,induction
R8222	T10671	T10593	themeOf	FOXP3,expression
R8223	T10672	T10594	themeOf	RUNX1,inhibition
R8224	T10673	T10596	themeOf	RUNX3,inhibition
R8225	T10674	T10598	themeOf	Foxp3,induction
R24566	T32130	T32133	themeOf	RUNX1,knock down
R24567	T32131	T32132	themeOf	RUNX3,knock down
R24568	T32132	T32128	themeOf	knock down,mediated
R24569	T32133	T32129	themeOf	knock down,mediated
R24570	T32161	T32163	themeOf	RUNX1,siRNA
R24571	T32162	T32164	themeOf	RUNX3,siRNA
R8208	T10593	T10592	themeOf	expression,reduced

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T11234	0-4	Q13951	denotes	CBFβ
T11235	6-11	Q01196	denotes	RUNX1
T11236	17-22	Q13761	denotes	RUNX3
T11237	69-73	P01589	denotes	CD25
T11238	75-80	Q9BZS1	denotes	Foxp3
T11239	106-110	Q13951	denotes	Cbfb
T11240	121-124	P01730	denotes	CD4
T11241	160-165	Q9BZS1	denotes	Foxp3
T11242	194-197	P04234	denotes	CD3
T11243	194-197	P07766	denotes	CD3
T11244	194-197	P20963	denotes	CD3
T11245	194-197	P09693	denotes	CD3
T11246	210-215	P01137	denotes	TGF-β
T11247	239-244	Q9BZS1	denotes	Foxp3
T11248	336-339	P01730	denotes	CD4
T11249	362-365	P01730	denotes	CD4
T11250	366-369	P06956	denotes	cre
T11251	390-393	P01730	denotes	CD4
T11252	394-397	P06956	denotes	cre
T11253	404-408	P08575	denotes	Cd45
T11254	424-429	Q9BZS1	denotes	Foxp3
T11255	435-438	Q9U6Y4	denotes	GFP
T11256	505-508	P07766	denotes	CD3
T11257	505-508	P20963	denotes	CD3
T11258	505-508	P04234	denotes	CD3
T11259	505-508	P09693	denotes	CD3
T11260	518-522	P60568	denotes	IL-2
T11261	528-533	P01137	denotes	TGF-β
T11262	546-551	Q9BZS1	denotes	Foxp3
T11263	553-556	Q9U6Y4	denotes	GFP
T11264	628-632	P08575	denotes	CD45
T11265	636-639	P01730	denotes	CD4
T11266	763-766	P20963	denotes	CD3
T11267	763-766	P07766	denotes	CD3
T11268	763-766	P04234	denotes	CD3
T11269	763-766	P09693	denotes	CD3
T11270	791-795	P08575	denotes	CD45
T11271	857-860	P01730	denotes	CD4
T11272	861-864	P06956	denotes	cre
T11273	865-868	P01730	denotes	CD4
T11274	907-912	P01137	denotes	TGF-β
T11275	1022-1027	Q9BZS1	denotes	FOXP3
T11276	1029-1033	P01589	denotes	CD25
T11277	1128-1131	P01730	denotes	CD4
T11278	1132-1135	P06956	denotes	cre
T11279	1171-1176	P01137	denotes	TGF-β
T11280	1185-1189	Q13761	denotes	Runx
T11281	1185-1189	Q13950	denotes	Runx
T11282	1185-1189	Q01196	denotes	Runx
T11283	1246-1251	Q9BZS1	denotes	Foxp3
T11284	1299-1302	P01730	denotes	CD4
T11285	1303-1306	P06956	denotes	cre
T11286	1307-1310	P01730	denotes	CD4
T11287	1344-1349	P01137	denotes	TGF-β
T11288	1385-1389	P08575	denotes	CD45
T11289	1393-1396	P01730	denotes	CD4
T11290	1468-1473	P01137	denotes	TGF-β
T11291	1553-1556	P01730	denotes	CD4
T11292	1557-1560	P06956	denotes	cre
T11293	1640-1645	Q9BZS1	denotes	Foxp3
T11294	1651-1656	Q9BZS1	denotes	Foxp3
T11295	1692-1695	P01730	denotes	CD4
T11296	1696-1699	P06956	denotes	cre
T11297	1808-1817	P08758	denotes	annexin V
T11298	3478-3483	Q01196	denotes	RUNX1
T11299	3488-3493	Q13761	denotes	RUNX3
T11300	3589-3592	P01730	denotes	CD4
T11301	3645-3650	Q01196	denotes	RUNX1
T11302	3655-3660	Q13761	denotes	RUNX3
T11303	3791-3794	P01730	denotes	CD4
T11304	3829-3832	P20963	denotes	CD3
T11305	3829-3832	P09693	denotes	CD3
T11306	3829-3832	P07766	denotes	CD3
T11307	3829-3832	P04234	denotes	CD3
T11308	3853-3858	Q01196	denotes	RUNX1
T11309	3863-3868	Q13761	denotes	RUNX3
T11310	3976-3979	P01730	denotes	CD4
T11311	4036-4039	P01730	denotes	CD4
T11312	4145-4150	Q01196	denotes	RUNX1
T11313	4155-4160	Q13761	denotes	RUNX3
T11314	4191-4196	Q9BZS1	denotes	FOXP3
T11315	4441-4446	Q9BZS1	denotes	Foxp3
T11316	4447-4450	Q9U6Y4	denotes	GFP
T11317	4644-4649	Q9BZS1	denotes	FOXP3
T11318	4695-4700	Q01196	denotes	RUNX1
T11319	4705-4710	Q13761	denotes	RUNX3
T32463	1880-1883	P01730	denotes	CD4
T32464	1884-1887	P06956	denotes	cre
T32465	1944-1947	P01730	denotes	CD4
T32466	1983-1988	Q01196	denotes	RUNX1
T32467	1993-1998	Q13761	denotes	RUNX3
T32468	2141-2144	P01730	denotes	CD4
T32469	2169-2172	P01730	denotes	CD4
T32470	2173-2176	P06956	denotes	cre
T32471	2204-2207	P01730	denotes	CD4
T32472	2208-2211	P06956	denotes	cre
T32473	2218-2222	P08575	denotes	Cd45
T32474	2267-2270	P20963	denotes	CD3
T32475	2267-2270	P07766	denotes	CD3
T32476	2267-2270	P09693	denotes	CD3
T32477	2267-2270	P04234	denotes	CD3
T32478	2287-2291	P60568	denotes	IL-2
T32479	2307-2312	P01137	denotes	TGF-β
T32480	2325-2330	Q9BZS1	denotes	Foxp3
T32481	2331-2334	Q9U6Y4	denotes	GFP
T32482	2392-2396	P08575	denotes	CD45
T32483	2400-2403	P01730	denotes	CD4
T32484	2500-2503	P09693	denotes	CD3
T32485	2500-2503	P04234	denotes	CD3
T32486	2500-2503	P20963	denotes	CD3
T32487	2500-2503	P07766	denotes	CD3
T32488	2530-2534	P08575	denotes	CD45
T32489	2603-2606	P01730	denotes	CD4
T32490	2607-2610	P06956	denotes	cre
T32491	2611-2614	P01730	denotes	CD4
T32492	2648-2653	P01137	denotes	TGF-β
T32493	2688-2692	P08575	denotes	CD45
T32494	2696-2699	P01730	denotes	CD4
T32495	2748-2752	P08575	denotes	CD45
T32496	2836-2840	P08575	denotes	CD45
T32497	2844-2847	P01730	denotes	CD4
T32498	2882-2887	Q9BZS1	denotes	Foxp3
T32499	2888-2891	Q9U6Y4	denotes	GFP
T32500	2991-2994	P01730	denotes	CD4
T32501	3022-3027	Q01196	denotes	RUNX1
T32502	3032-3037	Q13761	denotes	RUNX3
T32503	3188-3191	P01730	denotes	CD4
T32504	3227-3230	P07766	denotes	CD3
T32505	3227-3230	P20963	denotes	CD3
T32506	3227-3230	P09693	denotes	CD3
T32507	3227-3230	P04234	denotes	CD3
T32508	3261-3264	P01730	denotes	CD4
T32509	3351-3354	P01730	denotes	CD4

test2

Id	Subject	Object	Predicate	Lexical cue
T10483	0-4	Protein	denotes	CBFβ
T10484	6-11	Protein	denotes	RUNX1
T10485	17-22	Protein	denotes	RUNX3
T10486	69-73	Protein	denotes	CD25
T10487	75-80	Protein	denotes	Foxp3
T10488	106-110	Protein	denotes	Cbfb
T10489	111-120	Negative_regulation	denotes	deficient
T10490	121-124	Protein	denotes	CD4
T10491	138-146	Negative_regulation	denotes	impaired
T10492	147-156	Positive_regulation	denotes	induction
T10493	160-165	Protein	denotes	Foxp3
T10494	194-197	Protein	denotes	CD3
T10495	198-200	Protein	denotes	28
T10496	210-215	Protein	denotes	TGF-β
T10497	239-244	Protein	denotes	Foxp3
T10498	336-339	Protein	denotes	CD4
T10499	354-359	Protein	denotes	CbfbF
T10500	362-369	Protein	denotes	CD4-cre
T10501	382-387	Protein	denotes	CbfbF
T10502	390-397	Protein	denotes	CD4-cre
T10503	404-410	Protein	denotes	Cd45.2
T10504	424-429	Protein	denotes	Foxp3
T10505	435-438	Protein	denotes	GFP
T10506	505-508	Protein	denotes	CD3
T10507	509-511	Protein	denotes	28
T10508	518-522	Protein	denotes	IL-2
T10509	528-533	Protein	denotes	TGF-β
T10510	546-551	Protein	denotes	Foxp3
T10511	553-556	Protein	denotes	GFP
T10512	628-634	Protein	denotes	CD45.1
T10513	636-639	Protein	denotes	CD4
T10514	763-766	Protein	denotes	CD3
T10515	791-797	Protein	denotes	CD45.1
T10516	849-854	Protein	denotes	CbfbF
T10517	857-864	Protein	denotes	CD4-cre
T10518	865-868	Protein	denotes	CD4
T10519	907-912	Protein	denotes	TGF-β
T10520	1022-1027	Protein	denotes	FOXP3
T10521	1029-1033	Protein	denotes	CD25
T10522	1096-1103	Negative_regulation	denotes	reduced
T10523	1120-1125	Protein	denotes	CbfbF
T10524	1128-1135	Protein	denotes	CD4-cre
T10525	1171-1176	Protein	denotes	TGF-β
T10526	1177-1184	Positive_regulation	denotes	induced
T10527	1246-1251	Protein	denotes	Foxp3
T10528	1291-1296	Protein	denotes	CbfbF
T10529	1299-1306	Protein	denotes	CD4-cre
T10530	1307-1310	Protein	denotes	CD4
T10531	1344-1349	Protein	denotes	TGF-β
T10532	1385-1391	Protein	denotes	CD45.1
T10533	1393-1396	Protein	denotes	CD4
T10534	1468-1473	Protein	denotes	TGF-β
T10535	1545-1550	Protein	denotes	CbfbF
T10536	1553-1560	Protein	denotes	CD4-cre
T10537	1640-1645	Protein	denotes	Foxp3
T10538	1651-1656	Protein	denotes	Foxp3
T10539	1684-1689	Protein	denotes	CbfbF
T10540	1692-1699	Protein	denotes	CD4-cre
T10541	1808-1817	Protein	denotes	annexin V
T10542	1818-1826	Gene_expression	denotes	staining
T10543	3463-3474	Positive_regulation	denotes	requirement
T10544	3478-3483	Protein	denotes	RUNX1
T10545	3488-3493	Protein	denotes	RUNX3
T10546	3589-3592	Protein	denotes	CD4
T10547	3645-3650	Protein	denotes	RUNX1
T10548	3655-3660	Protein	denotes	RUNX3
T10549	3661-3666	Negative_regulation	denotes	siRNA
T10550	3791-3794	Protein	denotes	CD4
T10551	3829-3832	Protein	denotes	CD3
T10552	3853-3858	Protein	denotes	RUNX1
T10553	3863-3868	Protein	denotes	RUNX3
T10554	3874-3886	Negative_regulation	denotes	knocked down
T10555	3976-3979	Protein	denotes	CD4
T10556	4036-4039	Protein	denotes	CD4
T10557	4068-4077	Positive_regulation	denotes	increased
T10558	4137-4141	Regulation	denotes	role
T10559	4145-4150	Protein	denotes	RUNX1
T10560	4155-4160	Protein	denotes	RUNX3
T10561	4178-4187	Positive_regulation	denotes	induction
T10562	4191-4196	Protein	denotes	FOXP3
T10563	4441-4450	Protein	denotes	Foxp3-GFP
T10564	4636-4643	Negative_regulation	denotes	reduced
T10565	4644-4649	Protein	denotes	FOXP3
T10566	4650-4660	Gene_expression	denotes	expression
T10567	4681-4691	Negative_regulation	denotes	inhibition
T10568	4695-4700	Protein	denotes	RUNX1
T10569	4705-4710	Protein	denotes	RUNX3
T32084	1872-1877	Protein	denotes	CbfbF
T32085	1880-1887	Protein	denotes	CD4-cre
T32086	1944-1947	Protein	denotes	CD4
T32087	1974-1982	Positive_regulation	denotes	mediated
T32088	1983-1988	Protein	denotes	RUNX1
T32089	1993-1998	Protein	denotes	RUNX3
T32090	1999-2009	Negative_regulation	denotes	knock down
T32091	2141-2144	Protein	denotes	CD4
T32092	2145-2146	Protein	denotes	8
T32093	2161-2166	Protein	denotes	CbfbF
T32094	2169-2176	Protein	denotes	CD4-cre
T32095	2196-2201	Protein	denotes	CbfbF
T32096	2204-2211	Protein	denotes	CD4-cre
T32097	2218-2224	Protein	denotes	Cd45.2
T32098	2267-2270	Protein	denotes	CD3
T32099	2271-2273	Protein	denotes	28
T32100	2287-2291	Protein	denotes	IL-2
T32101	2307-2312	Protein	denotes	TGF-β
T32102	2325-2334	Protein	denotes	Foxp3-GFP
T32103	2392-2398	Protein	denotes	CD45.1
T32104	2400-2403	Protein	denotes	CD4
T32105	2500-2503	Protein	denotes	CD3
T32106	2530-2536	Protein	denotes	CD45.1
T32107	2595-2600	Protein	denotes	CbfbF
T32108	2603-2610	Protein	denotes	CD4-cre
T32109	2611-2614	Protein	denotes	CD4
T32110	2648-2653	Protein	denotes	TGF-β
T32111	2688-2694	Protein	denotes	CD45.1
T32112	2696-2699	Protein	denotes	CD4
T32113	2748-2754	Protein	denotes	CD45.1
T32114	2836-2842	Protein	denotes	CD45.1
T32115	2844-2847	Protein	denotes	CD4
T32116	2882-2891	Protein	denotes	Foxp3-GFP
T32117	2991-2994	Protein	denotes	CD4
T32118	3022-3027	Protein	denotes	RUNX1
T32119	3032-3037	Protein	denotes	RUNX3
T32120	3038-3043	Negative_regulation	denotes	siRNA
T32121	3188-3191	Protein	denotes	CD4
T32122	3227-3230	Protein	denotes	CD3
T32123	3261-3264	Protein	denotes	CD4
T32124	3351-3354	Protein	denotes	CD4
R8186	T10488	T10489	themeOf	Cbfb,deficient
R8187	T10489	T10491	causeOf	deficient,impaired
R8188	T10492	T10491	themeOf	induction,impaired
R8189	T10493	T10492	themeOf	Foxp3,induction
R8190	T10525	T10526	causeOf	TGF-β,induced
R8191	T10541	T10542	themeOf	annexin V,staining
R8192	T10544	T10543	causeOf	RUNX1,requirement
R8193	T10545	T10543	causeOf	RUNX3,requirement
R8194	T10547	T10549	themeOf	RUNX1,siRNA
R8195	T10548	T10549	themeOf	RUNX3,siRNA
R8196	T10552	T10554	themeOf	RUNX1,knocked down
R8197	T10553	T10554	themeOf	RUNX3,knocked down
R8198	T10559	T10558	causeOf	RUNX1,role
R8199	T10560	T10558	causeOf	RUNX3,role
R8200	T10562	T10561	themeOf	FOXP3,induction
R8201	T10565	T10566	themeOf	FOXP3,expression
R8202	T10566	T10564	themeOf	expression,reduced
R8203	T10567	T10564	causeOf	inhibition,reduced
R8204	T10568	T10567	themeOf	RUNX1,inhibition
R8205	T10569	T10567	themeOf	RUNX3,inhibition
R24561	T32088	T32090	themeOf	RUNX1,knock down
R24562	T32089	T32090	themeOf	RUNX3,knock down
R24563	T32090	T32087	themeOf	knock down,mediated
R24564	T32118	T32120	themeOf	RUNX1,siRNA
R24565	T32119	T32120	themeOf	RUNX3,siRNA

PMC:2806624 / 22284-26995 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:2806624 / 22284-26995 JSON TXT