Brinzolamide
Brinzolamide, available as 1% ophthalmic suspension, has been able to lower IOP as well as dorzolamide. Its pH of 7.4 equivalent to that of human tears makes it better tolerated than dorzolamide (pH 5.5) by most patients.[4142]
A multicenter, double-masked, prospective, parallel-group study showed that brinzolamide 1.0% caused less ocular discomfort than dorzolamide 2.0%. The incidence of ocular discomfort (burning and stinging) on instillation of brinzolamide (twice daily, 1.8%; three times daily, 3.0%) was significantly less compared with the treatment with dorzolamide (16.4%).[43]