In comparison, the dynamic ensembles pdb:1xqq and pdb:2nr2 show a much higher level of conformational heterogeneity, by virtue of their refinement against not only backbone but also side chain (methyl group) relaxation-based order parameters. However, as discussed previously, these order parameters are insensitive to supra-τc motion. Predictably, the back-calculated order parameters from these ensembles do not reproduce very well those acquired from RDCs, which are smaller for the large majority of residues. The average order parameters  (σ = 0.27) and  (σ = 0.27) are both significantly larger than the average from the MFA  Agreement within error ranges only occur in 33% of the cases.