Table 1  Contacts deleted on mutation of core residues
Data calculated for the FADD DD NMR structure 1e41,21 using the program InsightII (Accelrys Inc.).
a Total contacts made by sidechain (excluding Cβ) to other sidechain heavy atoms within 6 Å is shown in black. Contacts made to other helices within each bundle shown in red for B1 (H1, H5 and H6) and blue for B2 (H2, H3 and H4). Thus, for example, V103 (H1) makes long-range contacts only within B1, whereas I104 (H1) makes the majority of its long-range contacts with residues in B2 (through the central core).
b Note that for non-conservative replacements, these contacts are simply those made by the WT sidechain.