Table 3 Summary of currently available animal models for studying severe seasonal influenza pneumonia. Virus Animal Model References Influenza A H3N2 strains Mouse (BALB/c) Reviewed by Sidwell and Smee (2000) A/Shangdong/09/93 A/Victoria/3/79 Influenza B strains B/HongKong/5/72 B/Lee/40 B/Sichuan/379/99 BALB/c Smee et al. (2006) Influenza A H1N1 strains BALB/c Smee et al. (2008) A/WSN/33 (H1N1) virus containing the HA gene of A/New Caledonia/20/99 A/New Caledonia/20/99 BALB/c Smee et al. (2006) Influenza A strains A/Charlottesville/31/95 (H1N1) Ferret Smee et al. (2008) A/USSR/90/77 (H1N1) Ferret Svitek et al. (2008) A/Port Chalmers/1/73 (H3N2) Influenza A H3N2 A/Wuhan/359/95 Cotton Rat Ottolini et al. (2005), Review by Eichelberger (2007)