The rds +/− mouse adRP model exhibits reduced electroretinogram (ERG) responses indicative of early-onset slow rod degeneration followed by late-onset slow cone degeneration [26], [40]. In order to assess functional rescue of this phenotype after treatment, full-field ERGs were obtained from nanoparticle-injected and control mice. Initial ERGs were obtained and analyzed at PI-30 (see Table 1). Average scotopic a-wave amplitudes, indicative of rod function, were increased with statistical significance after injection of either CBA-NMP or IRBP-NMP nanoparticles, compared to amplitudes from eyes injected with naked DNA or saline. In order to confirm that the naked DNA had no adverse effect, a subset of animals was injected with saline only. Scotopic a-wave amplitudes for saline injected animals were not significantly different from those injected with either CBA-NMP or IRBP-NMP naked DNA (p = 0.2634). Interestingly, nanoparticles led to an improvement in cone function. The magnitude of rescue varied considerably with both nanoparticles, most likely due to variations in particle uptake and/or relative activity of CBA vs. IRBP promoters in rods and cones. Several nanoparticle-injected animals exhibited significantly greater-than-average rescue; 6/15 (IRBP-NMP) and 5/19 (CBA-NMP) treated animals had 90% increase in scotopic a-wave amplitudes, compared to naked DNA-injected controls. Similarly, 4/15 (IRBP-NMP) and 6/19 (CBA-NMP) animals had at least a 70% increase in cone ERG amplitudes.