Table 7  Representative examples of ENZ type presenting different structural features
#  O  Rule description  Subtype  Conf  Supp  C  G  K  U  S  I
28  24  If NoHelix  ENZ_A, ENZ_B, ENZ_C  0.508  0.069  -  0.058  1  1  1  0.606
29  1  If SCOPClass = 7 AND NoHelix  ENZ_A, ENZ_B  1.000  0.032  1  0.315  1  1  1  0.764
30  17  If 461.83 ≤ df-ASA < 681.42 AND NoHelix  ENZ_A, ENZ_B  0.593  0.037  -  0.085  1  1  1  0.619
31  39  If 461.83 ≤ df-ASA < 681.42  ENZ_A, ENZ_B  0.477  0.111  1  0.076  -  -  -  0.416
32  16  If NoHelix AND nFrag < 4.75  ENZ_A  0.612  0.032  -  0.076  1  1  1  0.620
33  19  If 4.75 ≤ nSSE < 6.62 AND NoHelix  ENZ_A  0.588  0.032  -  0.072  1  1  1  0.538
34  51  If 461.83 ≤ df-ASA < 681.42 AND 4.75 ≤ nSSE < 6.62  ENZ_A  0.417  0.032  -  0.018  -  1  -  0.367
35  77  If 44.38 ≤ nAtom < 84.76 AND 461.83 ≤ df-ASA < 681.42  ENZ_A  0.396  0.058  -  0.023  -  -  -  0.159
36  34  If 9.58 ≤ nAA < 18.16 AND 44.38 ≤ nAtom < 84.76 AND 461.83 ≤ df-ASA < 681.42  ENZ_A  0.500  0.032  -  0.045  1  1  -  0.515
37  60  If 18.16 ≤ nAA < 26.74 AND 44.38 ≤ nAtom < 84.76  ENZ_A  0.357  0.032  -  0.015  -  1  -  0.351
38  10  If 84.76 ≤ nAtom < 125.14 AND 461.83 ≤ df-ASA <681.42  ENZ_B  0.617  0.053  1  0.145  1  1  -  0.636
39  13  If 12.66 ≤ sRatio < 15.06 AND 461.83 ≤ df-ASA < 681.42  ENZ_B  0.600  0.032  1  0.113  1  1  -  0.624
40  14  If 461.83 ≤ df-ASA < 681.42 AND 10.38 ≤ nSSE < 12.25 AND SCOPClass = 2  ENZ_B  0.857  0.032  -  0.230  1  1  -  0.624
41  27  If SCOPClass = 2 AND 461.83 ≤ df-ASA < 681.42 AND 84.76 ≤ nAtom < 125.14  ENZ_B  0.789  0.032  -  0.176  1  1  -  0.599
42  35  If 10.38 ≤ nSSE < 12.25 AND 12.25 ≤ nFrag < 16  ENZ_B  0.500  0.032  -  0.043  1  1  -  0.515
43  73  If 84.76 ≤ nAtom < 125.14 AND SCOPClass = 2  ENZ_B  0.408  0.042  -  0.043  -  -  -  0.164
44  114  If 84.76 ≤ nAtom < 125.14 AND 26.74 ≤ nAA < 35.32  ENZ_B  0.307  0.037  -  0.024  -  -  -  0.123
45  109  If 681.42 ≤ df-ASA < 901.01  ENZ_C  0.317  0.048  -  0.013  -  -  -  0.126
46  137  If 84.76 ≤ nAtom < 125.14 AND 681.42 ≤ df-ASA < 901.01  ENZ_C  0.252  0.032  -  0.009  -  -  -  0.098
47  146  If SCOPClass = 4  ENZ_C  0.221  0.042  -  0.011  -  -  -  0.091
48  101  If 35.32 901.01 nAA < 43.9 AND 125.14 ≤ nAtom < 165.52  ENZ_D  0.323  0.032  -  0.041  -  -  -  0.132
49  130  If SCOPClass = 3  ENZ_D  0.238  0.069  -  0.016  -  -  -  0.108
50  141  If 901.01 ≤ df-ASA < 1120.6  ENZ_D  0.207  0.032  -  0.050  -  -  -  0.096
51  54  If 1120.6 ≤ df-ASA < 1340.19  ENZ_E  0.392  0.042  -  0.018  -  1  -  0.363
Abbreviation of column names is the same as that of Table 6.
The ENZ subtypes are defined in Figure 4. Note that ENZ_B includes both inhibitors and enzymes while the others are exclusively formed by inhibitors (e.g. ENZ_A, ENZ_C and ENZ_E) or enzymes (e.g. ENZ_D).