PMC:2664230 / 453-771 JSONTXT

Annnotations TAB JSON ListView MergeView

    bionlp-st-ge-2016-reference

    {"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T64","span":{"begin":130,"end":136},"obj":"Regulation"},{"id":"T65","span":{"begin":137,"end":142},"obj":"Protein"},{"id":"T66","span":{"begin":143,"end":153},"obj":"Gene_expression"},{"id":"T67","span":{"begin":154,"end":172},"obj":"Positive_regulation"}],"relations":[{"id":"R33","pred":"themeOf","subj":"T64","obj":"T67"},{"id":"R34","pred":"themeOf","subj":"T65","obj":"T66"},{"id":"R35","pred":"themeOf","subj":"T66","obj":"T64"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    pmc-enju-pas

    {"project":"pmc-enju-pas","denotations":[{"id":"T511","span":{"begin":0,"end":3},"obj":"NN"},{"id":"T512","span":{"begin":4,"end":15},"obj":"NN"},{"id":"T513","span":{"begin":16,"end":18},"obj":"VB"},{"id":"T514","span":{"begin":19,"end":22},"obj":"CD"},{"id":"T515","span":{"begin":23,"end":25},"obj":"IN"},{"id":"T516","span":{"begin":26,"end":29},"obj":"DT"},{"id":"T517","span":{"begin":30,"end":33},"obj":"JJ"},{"id":"T518","span":{"begin":34,"end":39},"obj":"NN"},{"id":"T519","span":{"begin":40,"end":42},"obj":"IN"},{"id":"T520","span":{"begin":43,"end":52},"obj":"JJ"},{"id":"T521","span":{"begin":53,"end":59},"obj":"NN"},{"id":"T522","span":{"begin":60,"end":63},"obj":"CC"},{"id":"T523","span":{"begin":64,"end":76},"obj":"NN"},{"id":"T524","span":{"begin":78,"end":81},"obj":"DT"},{"id":"T525","span":{"begin":82,"end":91},"obj":"NN"},{"id":"T526","span":{"begin":92,"end":94},"obj":"IN"},{"id":"T527","span":{"begin":95,"end":100},"obj":"WDT"},{"id":"T528","span":{"begin":101,"end":118},"obj":"NN"},{"id":"T529","span":{"begin":119,"end":129},"obj":"NN"},{"id":"T530","span":{"begin":130,"end":136},"obj":"VB"},{"id":"T531","span":{"begin":137,"end":142},"obj":"NN"},{"id":"T532","span":{"begin":143,"end":153},"obj":"NN"},{"id":"T533","span":{"begin":154,"end":156},"obj":"IN"},{"id":"T534","span":{"begin":157,"end":160},"obj":"DT"},{"id":"T535","span":{"begin":161,"end":169},"obj":"NN"},{"id":"T536","span":{"begin":170,"end":172},"obj":"IN"},{"id":"T537","span":{"begin":173,"end":176},"obj":"NN"},{"id":"T538","span":{"begin":177,"end":184},"obj":"VB"},{"id":"T539","span":{"begin":185,"end":192},"obj":"JJ"},{"id":"T540","span":{"begin":195,"end":202},"obj":"NN"},{"id":"T541","span":{"begin":203,"end":208},"obj":"JJ"},{"id":"T542","span":{"begin":209,"end":220},"obj":"JJ"},{"id":"T543","span":{"begin":221,"end":226},"obj":"NN"},{"id":"T544","span":{"begin":227,"end":231},"obj":"VB"},{"id":"T545","span":{"begin":232,"end":242},"obj":"VB"},{"id":"T546","span":{"begin":243,"end":247},"obj":"IN"},{"id":"T547","span":{"begin":248,"end":251},"obj":"NN"},{"id":"T548","span":{"begin":252,"end":253},"obj":"-LRB-"},{"id":"T549","span":{"begin":253,"end":254},"obj":"CD"},{"id":"T550","span":{"begin":255,"end":260},"obj":"NN"},{"id":"T551","span":{"begin":260,"end":261},"obj":"-RRB-"},{"id":"T552","span":{"begin":261,"end":262},"obj":"-COMMA-"},{"id":"T553","span":{"begin":263,"end":265},"obj":"IN"},{"id":"T554","span":{"begin":266,"end":269},"obj":"DT"},{"id":"T555","span":{"begin":270,"end":278},"obj":"NN"},{"id":"T556","span":{"begin":279,"end":282},"obj":"CC"},{"id":"T557","span":{"begin":283,"end":290},"obj":"NN"},{"id":"T558","span":{"begin":291,"end":293},"obj":"IN"},{"id":"T559","span":{"begin":294,"end":308},"obj":"NN"},{"id":"T560","span":{"begin":309,"end":310},"obj":"-LRB-"},{"id":"T561","span":{"begin":310,"end":313},"obj":"NN"},{"id":"T562","span":{"begin":313,"end":314},"obj":"-COLON-"},{"id":"T563","span":{"begin":315,"end":317},"obj":"CD"}],"relations":[{"id":"R405","pred":"arg1Of","subj":"T512","obj":"T511"},{"id":"R406","pred":"arg2Of","subj":"T514","obj":"T513"},{"id":"R407","pred":"arg1Of","subj":"T514","obj":"T515"},{"id":"R408","pred":"arg2Of","subj":"T518","obj":"T515"},{"id":"R409","pred":"arg1Of","subj":"T518","obj":"T516"},{"id":"R410","pred":"arg1Of","subj":"T518","obj":"T517"},{"id":"R411","pred":"arg1Of","subj":"T518","obj":"T519"},{"id":"R412","pred":"arg1Of","subj":"T521","obj":"T522"},{"id":"R413","pred":"arg2Of","subj":"T522","obj":"T519"},{"id":"R414","pred":"arg1Of","subj":"T522","obj":"T520"},{"id":"R415","pred":"arg2Of","subj":"T523","obj":"T522"},{"id":"R416","pred":"arg1Of","subj":"T525","obj":"T524"},{"id":"R417","pred":"arg2Of","subj":"T525","obj":"T526"},{"id":"R418","pred":"arg1Of","subj":"T525","obj":"T527"},{"id":"R419","pred":"arg1Of","subj":"T525","obj":"T538"},{"id":"R420","pred":"arg1Of","subj":"T525","obj":"T539"},{"id":"R421","pred":"arg1Of","subj":"T529","obj":"T528"},{"id":"R422","pred":"arg1Of","subj":"T529","obj":"T530"},{"id":"R423","pred":"arg1Of","subj":"T530","obj":"T526"},{"id":"R424","pred":"arg1Of","subj":"T530","obj":"T533"},{"id":"R425","pred":"arg2Of","subj":"T532","obj":"T530"},{"id":"R426","pred":"arg1Of","subj":"T532","obj":"T531"},{"id":"R427","pred":"arg2Of","subj":"T535","obj":"T533"},{"id":"R428","pred":"arg1Of","subj":"T535","obj":"T534"},{"id":"R429","pred":"arg1Of","subj":"T535","obj":"T536"},{"id":"R430","pred":"arg2Of","subj":"T537","obj":"T536"},{"id":"R431","pred":"arg2Of","subj":"T539","obj":"T538"},{"id":"R432","pred":"arg1Of","subj":"T543","obj":"T541"},{"id":"R433","pred":"arg1Of","subj":"T543","obj":"T542"},{"id":"R434","pred":"arg1Of","subj":"T543","obj":"T544"},{"id":"R435","pred":"arg2Of","subj":"T543","obj":"T545"},{"id":"R436","pred":"arg2Of","subj":"T545","obj":"T544"},{"id":"R437","pred":"arg1Of","subj":"T545","obj":"T546"},{"id":"R438","pred":"arg2Of","subj":"T547","obj":"T546"},{"id":"R439","pred":"arg1Of","subj":"T547","obj":"T548"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stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    bionlp-st-ge-2016-spacy-parsed

    {"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T192","span":{"begin":0,"end":3},"obj":"NNP"},{"id":"T193","span":{"begin":4,"end":15},"obj":"NN"},{"id":"T194","span":{"begin":16,"end":18},"obj":"VBZ"},{"id":"T195","span":{"begin":19,"end":22},"obj":"CD"},{"id":"T196","span":{"begin":23,"end":25},"obj":"IN"},{"id":"T197","span":{"begin":26,"end":29},"obj":"DT"},{"id":"T198","span":{"begin":30,"end":33},"obj":"JJ"},{"id":"T199","span":{"begin":34,"end":39},"obj":"NNS"},{"id":"T200","span":{"begin":40,"end":42},"obj":"IN"},{"id":"T201","span":{"begin":43,"end":52},"obj":"JJ"},{"id":"T202","span":{"begin":53,"end":59},"obj":"NN"},{"id":"T203","span":{"begin":60,"end":63},"obj":"CC"},{"id":"T204","span":{"begin":64,"end":76},"obj":"NN"},{"id":"T205","span":{"begin":76,"end":77},"obj":"."},{"id":"T206","span":{"begin":78,"end":81},"obj":"DT"},{"id":"T207","span":{"begin":82,"end":91},"obj":"NN"},{"id":"T208","span":{"begin":92,"end":94},"obj":"IN"},{"id":"T209","span":{"begin":95,"end":100},"obj":"WDT"},{"id":"T210","span":{"begin":101,"end":118},"obj":"NN"},{"id":"T211","span":{"begin":119,"end":129},"obj":"NN"},{"id":"T212","span":{"begin":130,"end":136},"obj":"VBZ"},{"id":"T213","span":{"begin":137,"end":142},"obj":"JJ"},{"id":"T214","span":{"begin":143,"end":153},"obj":"NN"},{"id":"T215","span":{"begin":154,"end":156},"obj":"IN"},{"id":"T216","span":{"begin":157,"end":160},"obj":"DT"},{"id":"T217","span":{"begin":161,"end":169},"obj":"NN"},{"id":"T218","span":{"begin":170,"end":172},"obj":"IN"},{"id":"T219","span":{"begin":173,"end":176},"obj":"NNP"},{"id":"T220","span":{"begin":177,"end":184},"obj":"VBZ"},{"id":"T221","span":{"begin":185,"end":192},"obj":"JJ"},{"id":"T222","span":{"begin":192,"end":193},"obj":"."},{"id":"T223","span":{"begin":195,"end":202},"obj":"NNP"},{"id":"T224","span":{"begin":203,"end":208},"obj":"NNP"},{"id":"T225","span":{"begin":209,"end":220},"obj":"NN"},{"id":"T226","span":{"begin":221,"end":226},"obj":"NNS"},{"id":"T227","span":{"begin":227,"end":231},"obj":"VBD"},{"id":"T228","span":{"begin":232,"end":242},"obj":"VBN"},{"id":"T229","span":{"begin":243,"end":247},"obj":"IN"},{"id":"T230","span":{"begin":248,"end":251},"obj":"NNP"},{"id":"T231","span":{"begin":252,"end":253},"obj":"-LRB-"},{"id":"T232","span":{"begin":253,"end":254},"obj":"CD"},{"id":"T233","span":{"begin":255,"end":257},"obj":"NN"},{"id":"T234","span":{"begin":257,"end":258},"obj":"NN"},{"id":"T235","span":{"begin":258,"end":260},"obj":"NNP"},{"id":"T236","span":{"begin":260,"end":261},"obj":"-RRB-"},{"id":"T237","span":{"begin":261,"end":262},"obj":","},{"id":"T238","span":{"begin":263,"end":265},"obj":"IN"},{"id":"T239","span":{"begin":266,"end":269},"obj":"DT"},{"id":"T240","span":{"begin":270,"end":278},"obj":"NN"},{"id":"T241","span":{"begin":279,"end":282},"obj":"CC"},{"id":"T242","span":{"begin":283,"end":290},"obj":"NN"},{"id":"T243","span":{"begin":291,"end":293},"obj":"IN"},{"id":"T244","span":{"begin":294,"end":308},"obj":"NNP"},{"id":"T245","span":{"begin":309,"end":310},"obj":"-LRB-"},{"id":"T246","span":{"begin":310,"end":313},"obj":"NNP"},{"id":"T247","span":{"begin":313,"end":314},"obj":":"},{"id":"T248","span":{"begin":315,"end":317},"obj":"CD"}],"relations":[{"id":"R90","pred":"compound","subj":"T192","obj":"T193"},{"id":"R92","pred":"ROOT","subj":"T194","obj":"T194"},{"id":"R93","pred":"attr","subj":"T195","obj":"T194"},{"id":"R94","pred":"prep","subj":"T196","obj":"T195"},{"id":"R95","pred":"det","subj":"T197","obj":"T199"},{"id":"R96","pred":"amod","subj":"T198","obj":"T199"},{"id":"R97","pred":"pobj","subj":"T199","obj":"T196"},{"id":"R98","pred":"prep","subj":"T200","obj":"T199"},{"id":"R99","pred":"amod","subj":"T201","obj":"T202"},{"id":"R103","pred":"punct","subj":"T205","obj":"T194"},{"id":"R104","pred":"det","subj":"T206","obj":"T207"},{"id":"R105","pred":"nsubj","subj":"T207","obj":"T220"},{"id":"R106","pred":"prep","subj":"T208","obj":"T212"},{"id":"R107","pred":"pobj","subj":"T209","obj":"T208"},{"id":"R108","pred":"amod","subj":"T210","obj":"T211"},{"id":"R109","pred":"nsubj","subj":"T211","obj":"T212"},{"id":"R110","pred":"relcl","subj":"T212","obj":"T207"},{"id":"R111","pred":"amod","subj":"T213","obj":"T214"},{"id":"R112","pred":"dobj","subj":"T214","obj":"T212"},{"id":"R113","pred":"prep","subj":"T215","obj":"T212"},{"id":"R114","pred":"det","subj":"T216","obj":"T217"},{"id":"R115","pred":"pobj","subj":"T217","obj":"T215"},{"id":"R116","pred":"prep","subj":"T218","obj":"T217"},{"id":"R117","pred":"pobj","subj":"T219","obj":"T218"},{"id":"R118","pred":"ROOT","subj":"T220","obj":"T220"},{"id":"R119","pred":"acomp","subj":"T221","obj":"T220"},{"id":"R120","pred":"punct","subj":"T222","obj":"T220"},{"id":"R121","pred":"compound","subj":"T223","obj":"T226"},{"id":"R122","pred":"compound","subj":"T224","obj":"T226"},{"id":"R123","pred":"compound","subj":"T225","obj":"T226"},{"id":"R124","pred":"nsubjpass","subj":"T226","obj":"T228"},{"id":"R125","pred":"auxpass","s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stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T828","span":{"begin":137,"end":153},"obj":"http://purl.obolibrary.org/obo/GO_0032680"},{"id":"T839","span":{"begin":101,"end":118},"obj":"http://purl.obolibrary.org/obo/GO_0008081"},{"id":"T856","span":{"begin":64,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    GO-MF

    {"project":"GO-MF","denotations":[{"id":"T866","span":{"begin":101,"end":118},"obj":"http://purl.obolibrary.org/obo/GO_0008081"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    GO-CC

    {"project":"GO-CC","denotations":[{"id":"T882","span":{"begin":221,"end":226},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    sentences

    {"project":"sentences","denotations":[{"id":"T116","span":{"begin":78,"end":193},"obj":"Sentence"},{"id":"T117","span":{"begin":195,"end":202},"obj":"Sentence"},{"id":"T8","span":{"begin":78,"end":193},"obj":"Sentence"},{"id":"T9","span":{"begin":195,"end":202},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    events-check-again

    {"project":"events-check-again","denotations":[{"id":"T894","span":{"begin":130,"end":136},"obj":"Regulation"},{"id":"T895","span":{"begin":137,"end":142},"obj":"Protein"},{"id":"T896","span":{"begin":143,"end":153},"obj":"Gene_expression"},{"id":"T897","span":{"begin":154,"end":172},"obj":"Positive_regulation"}],"relations":[{"id":"R654","pred":"themeOf","subj":"T894","obj":"T897"},{"id":"R655","pred":"themeOf","subj":"T895","obj":"T896"},{"id":"R656","pred":"themeOf","subj":"T896","obj":"T894"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    bionlp-st-ge-2016-reference-tees

    {"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T929","span":{"begin":4,"end":15},"obj":"Positive_regulation"},{"id":"T930","span":{"begin":137,"end":142},"obj":"Protein"},{"id":"T931","span":{"begin":143,"end":153},"obj":"Gene_expression"},{"id":"T932","span":{"begin":130,"end":136},"obj":"Regulation"}],"relations":[{"id":"R677","pred":"themeOf","subj":"T930","obj":"T931"},{"id":"R678","pred":"themeOf","subj":"T931","obj":"T932"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T764","span":{"begin":137,"end":140},"obj":"P01375"},{"id":"T765","span":{"begin":137,"end":142},"obj":"P01375"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}

    test2

    {"project":"test2","denotations":[{"id":"T38","span":{"begin":130,"end":136},"obj":"Regulation"},{"id":"T39","span":{"begin":137,"end":142},"obj":"Protein"},{"id":"T40","span":{"begin":143,"end":153},"obj":"Gene_expression"}],"relations":[{"id":"R23","pred":"themeOf","subj":"T39","obj":"T40"},{"id":"R24","pred":"themeOf","subj":"T40","obj":"T38"}],"text":"LPS stimulation is one of the key steps in bacterial sepsis and inflammation. The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.\n\nMETHODS\nHuman mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 "}