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PMC:2664230 / 145-2097 JSONTXT

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bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T64 438-444 Regulation denotes alters
T65 445-450 Protein denotes TNF-α
T66 451-461 Gene_expression denotes production
T67 462-480 Positive_regulation denotes in the presence of
T68 694-708 Phosphorylation denotes phosphorylated
T69 721-726 Protein denotes I-κBα
T70 746-749 Protein denotes p65
T71 915-920 Protein denotes TNF-α
T72 1135-1141 Negative_regulation denotes reduce
T73 1135-1141 Negative_regulation denotes reduce
T74 1154-1159 Protein denotes I-κBα
T75 1160-1175 Phosphorylation denotes phosphorylation
T76 1185-1188 Protein denotes p65
T77 1189-1204 Phosphorylation denotes phosphorylation
T78 1379-1387 Localization denotes secreted
T79 1406-1411 Protein denotes TNF-α
T80 1419-1427 Regulation denotes presence
T81 1432-1439 Regulation denotes absence true
T57 59-65 Regulation denotes effect true
T58 149-176 Protein denotes tumor necrosis factor-alpha
T59 178-183 Protein denotes TNF-α
T60 185-195 Gene_expression denotes production
T61 278-288 Gene_expression denotes production
T62 292-297 Protein denotes TNF-α
T63 298-307 Positive_regulation denotes following
R33 T64 T67 themeOf alters,in the presence of
R34 T65 T66 themeOf TNF-α,production
R35 T66 T64 themeOf production,alters
R36 T69 T68 themeOf I-κBα,phosphorylated
R37 T74 T75 themeOf I-κBα,phosphorylation
R38 T75 T73 themeOf phosphorylation,reduce
R39 T76 T77 themeOf p65,phosphorylation
R40 T77 T72 themeOf phosphorylation,reduce
R41 T78 T80 themeOf secreted,presence
R42 T78 T81 themeOf secreted,absence
R43 T79 T78 themeOf TNF-α,secreted
R750 T58 T60 themeOf tumor necrosis factor-alpha,production
R751 T60 T57 themeOf production,effect
R752 T61 T63 themeOf production,following
R753 T62 T61 themeOf TNF-α,production

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T469 0-9 NN denotes OBJECTIVE
T470 10-13 DT denotes The
T471 14-23 NN denotes objective
T472 24-26 IN denotes of
T473 27-31 DT denotes this
T474 32-37 NN denotes study
T475 38-41 VB denotes was
T476 42-44 TO denotes to
T477 45-54 VB denotes determine
T478 55-58 DT denotes the
T479 59-65 NN denotes effect
T480 66-68 IN denotes of
T481 69-80 JJ denotes nonspecific
T482 81-98 NN denotes phosphodiesterase
T483 99-109 NN denotes inhibition
T484 110-112 IN denotes on
T485 113-126 NN denotes transcription
T486 127-133 NN denotes factor
T487 134-144 NN denotes activation
T488 145-148 CC denotes and
T489 149-154 NN denotes tumor
T490 155-163 NN denotes necrosis
T491 164-176 NN denotes factor-alpha
T492 177-178 -LRB- denotes (
T493 178-183 NN denotes TNF-α
T494 183-184 -RRB- denotes )
T495 185-195 NN denotes production
T496 196-198 IN denotes in
T497 199-217 NN denotes lipopolysaccharide
T498 218-219 -LRB- denotes (
T499 219-222 NN denotes LPS
T500 222-223 -RRB- denotes )
T501 223-234 JJ denotes -stimulated
T502 235-240 JJ denotes human
T503 241-252 JJ denotes mononuclear
T504 253-258 NN denotes cells
T505 261-273 NN denotes INTRODUCTION
T506 274-277 DT denotes The
T507 278-288 NN denotes production
T508 289-291 IN denotes of
T509 292-297 NN denotes TNF-α
T510 298-307 VB denotes following
T511 308-311 NN denotes LPS
T512 312-323 NN denotes stimulation
T513 324-326 VB denotes is
T514 327-330 CD denotes one
T515 331-333 IN denotes of
T516 334-337 DT denotes the
T517 338-341 JJ denotes key
T518 342-347 NN denotes steps
T519 348-350 IN denotes in
T520 351-360 JJ denotes bacterial
T521 361-367 NN denotes sepsis
T522 368-371 CC denotes and
T523 372-384 NN denotes inflammation
T524 386-389 DT denotes The
T525 390-399 NN denotes mechanism
T526 400-402 IN denotes by
T527 403-408 WDT denotes which
T528 409-426 NN denotes phosphodiesterase
T529 427-437 NN denotes inhibition
T530 438-444 VB denotes alters
T531 445-450 NN denotes TNF-α
T532 451-461 NN denotes production
T533 462-464 IN denotes in
T534 465-468 DT denotes the
T535 469-477 NN denotes presence
T536 478-480 IN denotes of
T537 481-484 NN denotes LPS
T538 485-492 VB denotes remains
T539 493-500 JJ denotes unclear
T540 503-510 NN denotes METHODS
T541 511-516 JJ denotes Human
T542 517-528 JJ denotes mononuclear
T543 529-534 NN denotes cells
T544 535-539 VB denotes were
T545 540-550 VB denotes stimulated
T546 551-555 IN denotes with
T547 556-559 NN denotes LPS
T548 560-561 -LRB- denotes (
T549 561-562 CD denotes 1
T550 563-568 NN denotes μg/mL
T551 568-569 -RRB- denotes )
T552 569-570 -COMMA- denotes ,
T553 571-573 IN denotes in
T554 574-577 DT denotes the
T555 578-586 NN denotes presence
T556 587-590 CC denotes and
T557 591-598 NN denotes absence
T558 599-601 IN denotes of
T559 602-616 NN denotes Pentoxifylline
T560 617-618 -LRB- denotes (
T561 618-621 NN denotes PTX
T562 621-622 -COLON- denotes ;
T563 623-625 CD denotes 20
T564 626-628 NN denotes mM
T565 628-629 -RRB- denotes )
T566 629-630 -COMMA- denotes ,
T567 631-632 DT denotes a
T568 633-644 JJ denotes nonspecific
T569 645-662 NN denotes phosphodiesterase
T570 663-672 NN denotes inhibitor
T571 674-681 JJ denotes Western
T572 682-690 NN denotes blotting
T573 691-693 IN denotes of
T574 694-708 VB denotes phosphorylated
T575 709-720 JJ denotes cytoplasmic
T576 721-726 NN denotes I-κBα
T577 726-727 -COMMA- denotes ,
T578 728-735 JJ denotes nuclear
T579 736-745 NN denotes factor-κB
T580 746-749 NN denotes p65
T581 750-751 -LRB- denotes (
T582 751-756 NN denotes NF-κB
T583 756-757 -RRB- denotes )
T584 757-758 -COMMA- denotes ,
T585 759-762 CC denotes and
T586 763-770 JJ denotes nuclear
T587 771-784 JJ denotes cAMP-response
T588 785-792 NN denotes element
T589 793-800 NN denotes binding
T590 801-808 NN denotes protein
T591 809-810 -LRB- denotes (
T592 810-814 NN denotes CREB
T593 814-815 -RRB- denotes )
T594 816-819 VB denotes was
T595 820-829 VB denotes performed
T596 831-834 NN denotes DNA
T597 835-842 NN denotes binding
T598 843-845 IN denotes of
T599 846-851 NN denotes NF-κB
T600 852-855 CC denotes and
T601 856-860 NN denotes CREB
T602 861-864 VB denotes was
T603 865-873 VB denotes verified
T604 874-876 IN denotes by
T605 877-892 JJ denotes electrophoretic
T606 893-901 NN denotes mobility
T607 902-907 NN denotes shift
T608 908-913 NN denotes assay
T609 915-920 NN denotes TNF-α
T610 921-927 NN denotes levels
T611 928-932 VB denotes were
T612 933-943 VB denotes determined
T613 944-946 IN denotes in
T614 947-950 DT denotes the
T615 951-962 NN denotes supernatant
T616 963-965 IN denotes of
T617 966-976 VB denotes stimulated
T618 977-982 NN denotes cells
T619 983-985 IN denotes in
T620 986-989 DT denotes the
T621 990-998 NN denotes presence
T622 999-1002 CC denotes and
T623 1003-1010 NN denotes absence
T624 1011-1018 NN denotes Protein
T625 1019-1025 NN denotes kinase
T626 1026-1027 NN denotes A
T627 1028-1038 NN denotes inhibition
T628 1039-1041 IN denotes by
T629 1042-1044 DT denotes an
T630 1045-1058 JJ denotes enzyme-linked
T631 1059-1072 JJ denotes immunosorbent
T632 1073-1078 NN denotes assay
T633 1079-1080 -LRB- denotes (
T634 1080-1085 NN denotes ELISA
T635 1085-1086 -RRB- denotes )
T636 1089-1096 NN denotes RESULTS
T637 1097-1100 NN denotes PTX
T638 1101-1104 VB denotes was
T639 1105-1117 VB denotes demonstrated
T640 1118-1120 TO denotes to
T641 1121-1134 RB denotes significantly
T642 1135-1141 VB denotes reduce
T643 1142-1153 JJ denotes cytoplasmic
T644 1154-1159 NN denotes I-κBα
T645 1160-1175 NN denotes phosphorylation
T646 1175-1176 -COMMA- denotes ,
T647 1177-1184 JJ denotes nuclear
T648 1185-1188 NN denotes p65
T649 1189-1204 NN denotes phosphorylation
T650 1204-1205 -COMMA- denotes ,
T651 1206-1209 CC denotes and
T652 1210-1213 DT denotes the
T653 1214-1217 NN denotes DNA
T654 1218-1225 NN denotes binding
T655 1226-1234 NN denotes activity
T656 1235-1237 IN denotes of
T657 1238-1243 NN denotes NF-κB
T658 1245-1247 IN denotes In
T659 1248-1256 NN denotes contrast
T660 1256-1257 -COMMA- denotes ,
T661 1258-1261 NN denotes PTX
T662 1262-1270 RB denotes markedly
T663 1271-1279 VB denotes enhanced
T664 1280-1283 DT denotes the
T665 1284-1299 NN denotes phosphorylation
T666 1300-1303 CC denotes and
T667 1304-1307 NN denotes DNA
T668 1308-1315 NN denotes binding
T669 1316-1324 NN denotes activity
T670 1325-1327 IN denotes of
T671 1328-1332 NN denotes CREB
T672 1334-1339 NN denotes Cells
T673 1340-1353 RB denotes concomitantly
T674 1354-1361 VB denotes treated
T675 1362-1366 IN denotes with
T676 1367-1370 NN denotes PTX
T677 1371-1374 CC denotes and
T678 1375-1378 NN denotes LPS
T679 1379-1387 VB denotes secreted
T680 1388-1395 JJ denotes similar
T681 1396-1402 NN denotes levels
T682 1403-1405 IN denotes of
T683 1406-1411 NN denotes TNF-α
T684 1412-1414 IN denotes in
T685 1415-1418 DT denotes the
T686 1419-1427 NN denotes presence
T687 1428-1431 CC denotes and
T688 1432-1439 NN denotes absence
T689 1440-1447 NN denotes Protein
T690 1448-1454 NN denotes kinase
T691 1455-1456 NN denotes A
T692 1457-1467 NN denotes inhibition
T693 1470-1480 NN denotes DISCUSSION
T694 1481-1484 DT denotes The
T695 1485-1494 VB denotes increased
T696 1495-1500 NN denotes level
T697 1501-1503 IN denotes of
T698 1504-1508 NN denotes cAMP
T699 1509-1513 WDT denotes that
T700 1514-1521 VB denotes results
T701 1522-1526 IN denotes from
T702 1527-1544 NN denotes phosphodiesterase
T703 1545-1555 NN denotes inhibition
T704 1556-1563 VB denotes affects
T705 1564-1575 JJ denotes cytoplasmic
T706 1576-1579 CC denotes and
T707 1580-1587 JJ denotes nuclear
T708 1588-1594 NN denotes events
T709 1594-1595 -COMMA- denotes ,
T710 1596-1605 VB denotes resulting
T711 1606-1608 IN denotes in
T712 1609-1612 DT denotes the
T713 1613-1624 NN denotes attenuation
T714 1625-1627 IN denotes of
T715 1628-1633 NN denotes NF-κB
T716 1634-1637 CC denotes and
T717 1638-1641 DT denotes the
T718 1642-1652 NN denotes activation
T719 1653-1655 IN denotes of
T720 1656-1660 NN denotes CREB
T721 1661-1676 JJ denotes transcriptional
T722 1677-1680 NN denotes DNA
T723 1681-1688 NN denotes binding
T724 1689-1696 IN denotes through
T725 1697-1705 NN denotes pathways
T726 1706-1710 WDT denotes that
T727 1711-1714 VB denotes are
T728 1715-1724 RB denotes partially
T729 1725-1732 NN denotes Protein
T730 1733-1739 NN denotes kinase
T731 1740-1753 JJ denotes A-independent
T732 1756-1766 NN denotes CONCLUSION
T733 1767-1779 JJ denotes PTX-mediated
T734 1780-1797 NN denotes phosphodiesterase
T735 1798-1808 NN denotes inhibition
T736 1809-1815 VB denotes occurs
T737 1816-1825 RB denotes partially
T738 1826-1833 IN denotes through
T739 1834-1835 DT denotes a
T740 1836-1843 NN denotes Protein
T741 1844-1850 NN denotes kinase
T742 1851-1864 JJ denotes A-independent
T743 1865-1872 NN denotes pathway
T744 1873-1876 CC denotes and
T745 1877-1880 MD denotes may
T746 1881-1886 VB denotes serve
T747 1887-1889 IN denotes as
T748 1890-1891 DT denotes a
T749 1892-1898 JJ denotes useful
T750 1899-1903 NN denotes tool
T751 1904-1906 IN denotes in
T752 1907-1910 DT denotes the
T753 1911-1922 NN denotes attenuation
T754 1923-1925 IN denotes of
T755 1926-1937 JJ denotes LPS-induced
T756 1938-1950 NN denotes inflammation
T2791 27-31 DT denotes this
T2792 32-37 NN denotes study
T2793 38-41 VB denotes was
R365 T471 T470 arg1Of objective,The
R366 T471 T472 arg1Of objective,of
R367 T471 T475 arg1Of objective,was
R368 T474 T472 arg2Of study,of
R369 T474 T473 arg1Of study,this
R370 T477 T475 arg2Of determine,was
R371 T477 T476 arg1Of determine,to
R372 T479 T477 arg2Of effect,determine
R373 T479 T478 arg1Of effect,the
R374 T479 T480 arg1Of effect,of
R375 T479 T484 arg1Of effect,on
R376 T483 T480 arg2Of inhibition,of
R377 T483 T481 arg1Of inhibition,nonspecific
R378 T483 T482 arg1Of inhibition,phosphodiesterase
R379 T487 T485 arg1Of activation,transcription
R380 T487 T486 arg1Of activation,factor
R381 T487 T488 arg1Of activation,and
R382 T488 T484 arg2Of and,on
R383 T488 T496 arg1Of and,in
R384 T491 T489 arg1Of factor-alpha,tumor
R385 T491 T490 arg1Of factor-alpha,necrosis
R386 T491 T492 arg1Of factor-alpha,(
R387 T493 T492 arg2Of TNF-α,(
R388 T494 T492 arg3Of ),(
R389 T495 T488 arg2Of production,and
R390 T495 T491 arg1Of production,factor-alpha
R391 T499 T498 arg2Of LPS,(
R392 T500 T498 arg3Of ),(
R393 T501 T497 arg1Of -stimulated,lipopolysaccharide
R394 T501 T498 arg1Of -stimulated,(
R395 T504 T496 arg2Of cells,in
R396 T504 T501 arg1Of cells,-stimulated
R397 T504 T502 arg1Of cells,human
R398 T504 T503 arg1Of cells,mononuclear
R399 T507 T506 arg1Of production,The
R400 T507 T508 arg1Of production,of
R401 T507 T510 arg1Of production,following
R402 T507 T513 arg1Of production,is
R403 T509 T508 arg2Of TNF-α,of
R404 T512 T510 arg2Of stimulation,following
R405 T512 T511 arg1Of stimulation,LPS
R406 T514 T513 arg2Of one,is
R407 T514 T515 arg1Of one,of
R408 T518 T515 arg2Of steps,of
R409 T518 T516 arg1Of steps,the
R410 T518 T517 arg1Of steps,key
R411 T518 T519 arg1Of steps,in
R412 T521 T522 arg1Of sepsis,and
R413 T522 T519 arg2Of and,in
R414 T522 T520 arg1Of and,bacterial
R415 T523 T522 arg2Of inflammation,and
R416 T525 T524 arg1Of mechanism,The
R417 T525 T526 arg2Of mechanism,by
R418 T525 T527 arg1Of mechanism,which
R419 T525 T538 arg1Of mechanism,remains
R420 T525 T539 arg1Of mechanism,unclear
R421 T529 T528 arg1Of inhibition,phosphodiesterase
R422 T529 T530 arg1Of inhibition,alters
R423 T530 T526 arg1Of alters,by
R424 T530 T533 arg1Of alters,in
R425 T532 T530 arg2Of production,alters
R426 T532 T531 arg1Of production,TNF-α
R427 T535 T533 arg2Of presence,in
R428 T535 T534 arg1Of presence,the
R429 T535 T536 arg1Of presence,of
R430 T537 T536 arg2Of LPS,of
R431 T539 T538 arg2Of unclear,remains
R432 T543 T541 arg1Of cells,Human
R433 T543 T542 arg1Of cells,mononuclear
R434 T543 T544 arg1Of cells,were
R435 T543 T545 arg2Of cells,stimulated
R436 T545 T544 arg2Of stimulated,were
R437 T545 T546 arg1Of stimulated,with
R438 T547 T546 arg2Of LPS,with
R439 T547 T548 arg1Of LPS,(
R440 T547 T552 arg1Of LPS,","
R441 T547 T553 arg1Of LPS,in
R442 T547 T566 arg1Of LPS,","
R443 T550 T548 arg2Of μg/mL,(
R444 T550 T549 arg1Of μg/mL,1
R445 T551 T548 arg3Of ),(
R446 T555 T556 arg1Of presence,and
R447 T556 T553 arg2Of and,in
R448 T556 T554 arg1Of and,the
R449 T556 T558 arg1Of and,of
R450 T557 T556 arg2Of absence,and
R451 T559 T558 arg2Of Pentoxifylline,of
R452 T559 T560 arg1Of Pentoxifylline,(
R453 T561 T562 arg1Of PTX,;
R454 T562 T560 arg2Of ;,(
R455 T564 T562 arg2Of mM,;
R456 T564 T563 arg1Of mM,20
R457 T565 T560 arg3Of ),(
R458 T570 T566 arg2Of inhibitor,","
R459 T570 T567 arg1Of inhibitor,a
R460 T570 T568 arg1Of inhibitor,nonspecific
R461 T570 T569 arg1Of inhibitor,phosphodiesterase
R462 T572 T571 arg1Of blotting,Western
R463 T572 T573 arg1Of blotting,of
R464 T572 T594 arg1Of blotting,was
R465 T572 T595 arg2Of blotting,performed
R466 T576 T574 arg2Of I-κBα,phosphorylated
R467 T576 T575 arg1Of I-κBα,cytoplasmic
R468 T576 T577 arg1Of I-κBα,","
R469 T577 T585 arg1Of ",",and
R470 T580 T577 arg2Of p65,","
R471 T580 T578 arg1Of p65,nuclear
R472 T580 T579 arg1Of p65,factor-κB
R473 T580 T581 arg1Of p65,(
R474 T582 T581 arg2Of NF-κB,(
R475 T583 T581 arg3Of ),(
R476 T585 T573 arg2Of and,of
R477 T585 T584 arg1Of and,","
R478 T590 T585 arg2Of protein,and
R479 T590 T586 arg1Of protein,nuclear
R480 T590 T587 arg1Of protein,cAMP-response
R481 T590 T588 arg1Of protein,element
R482 T590 T589 arg1Of protein,binding
R483 T590 T591 arg1Of protein,(
R484 T592 T591 arg2Of CREB,(
R485 T593 T591 arg3Of ),(
R486 T595 T594 arg2Of performed,was
R487 T597 T596 arg1Of binding,DNA
R488 T597 T598 arg1Of binding,of
R489 T597 T602 arg1Of binding,was
R490 T597 T603 arg2Of binding,verified
R491 T599 T600 arg1Of NF-κB,and
R492 T600 T598 arg2Of and,of
R493 T601 T600 arg2Of CREB,and
R494 T603 T602 arg2Of verified,was
R495 T608 T603 arg1Of assay,verified
R496 T608 T604 arg2Of assay,by
R497 T608 T605 arg1Of assay,electrophoretic
R498 T608 T606 arg1Of assay,mobility
R499 T608 T607 arg1Of assay,shift
R500 T610 T609 arg1Of levels,TNF-α
R501 T610 T611 arg1Of levels,were
R502 T610 T612 arg2Of levels,determined
R503 T612 T611 arg2Of determined,were
R504 T612 T613 arg1Of determined,in
R505 T612 T619 arg1Of determined,in
R506 T615 T613 arg2Of supernatant,in
R507 T615 T614 arg1Of supernatant,the
R508 T615 T616 arg1Of supernatant,of
R509 T618 T616 arg2Of cells,of
R510 T618 T617 arg2Of cells,stimulated
R511 T621 T622 arg1Of presence,and
R512 T623 T622 arg2Of absence,and
R513 T627 T619 arg2Of inhibition,in
R514 T627 T620 arg1Of inhibition,the
R515 T627 T621 arg1Of inhibition,presence
R516 T627 T623 arg1Of inhibition,absence
R517 T627 T624 arg1Of inhibition,Protein
R518 T627 T625 arg1Of inhibition,kinase
R519 T627 T626 arg1Of inhibition,A
R520 T627 T628 arg1Of inhibition,by
R521 T632 T628 arg2Of assay,by
R522 T632 T629 arg1Of assay,an
R523 T632 T630 arg1Of assay,enzyme-linked
R524 T632 T631 arg1Of assay,immunosorbent
R525 T632 T633 arg1Of assay,(
R526 T634 T633 arg2Of ELISA,(
R527 T635 T633 arg3Of ),(
R528 T637 T638 arg1Of PTX,was
R529 T637 T639 arg2Of PTX,demonstrated
R530 T637 T642 arg1Of PTX,reduce
R531 T639 T638 arg2Of demonstrated,was
R532 T642 T639 arg3Of reduce,demonstrated
R533 T642 T640 arg1Of reduce,to
R534 T642 T641 arg1Of reduce,significantly
R535 T645 T643 arg1Of phosphorylation,cytoplasmic
R536 T645 T644 arg1Of phosphorylation,I-κBα
R537 T645 T646 arg1Of phosphorylation,","
R538 T646 T651 arg1Of ",",and
R539 T649 T646 arg2Of phosphorylation,","
R540 T649 T647 arg1Of phosphorylation,nuclear
R541 T649 T648 arg1Of phosphorylation,p65
R542 T651 T642 arg2Of and,reduce
R543 T651 T650 arg1Of and,","
R544 T655 T651 arg2Of activity,and
R545 T655 T652 arg1Of activity,the
R546 T655 T653 arg1Of activity,DNA
R547 T655 T654 arg1Of activity,binding
R548 T655 T656 arg1Of activity,of
R549 T657 T656 arg2Of NF-κB,of
R550 T659 T658 arg2Of contrast,In
R551 T661 T663 arg1Of PTX,enhanced
R552 T663 T658 arg1Of enhanced,In
R553 T663 T660 arg1Of enhanced,","
R554 T663 T662 arg1Of enhanced,markedly
R555 T665 T666 arg1Of phosphorylation,and
R556 T666 T663 arg2Of and,enhanced
R557 T666 T664 arg1Of and,the
R558 T666 T670 arg1Of and,of
R559 T669 T666 arg2Of activity,and
R560 T669 T667 arg1Of activity,DNA
R561 T669 T668 arg1Of activity,binding
R562 T671 T670 arg2Of CREB,of
R563 T672 T674 arg2Of Cells,treated
R564 T672 T679 arg1Of Cells,secreted
R565 T674 T673 arg1Of treated,concomitantly
R566 T674 T675 arg1Of treated,with
R567 T676 T677 arg1Of PTX,and
R568 T677 T675 arg2Of and,with
R569 T678 T677 arg2Of LPS,and
R570 T681 T679 arg2Of levels,secreted
R571 T681 T680 arg1Of levels,similar
R572 T681 T682 arg1Of levels,of
R573 T681 T684 arg1Of levels,in
R574 T683 T682 arg2Of TNF-α,of
R575 T686 T687 arg1Of presence,and
R576 T688 T687 arg2Of absence,and
R577 T692 T684 arg2Of inhibition,in
R578 T692 T685 arg1Of inhibition,the
R579 T692 T686 arg1Of inhibition,presence
R580 T692 T688 arg1Of inhibition,absence
R581 T692 T689 arg1Of inhibition,Protein
R582 T692 T690 arg1Of inhibition,kinase
R583 T692 T691 arg1Of inhibition,A
R584 T696 T694 arg1Of level,The
R585 T696 T695 arg2Of level,increased
R586 T696 T697 arg1Of level,of
R587 T696 T699 arg1Of level,that
R588 T696 T700 arg1Of level,results
R589 T696 T704 arg1Of level,affects
R590 T698 T697 arg2Of cAMP,of
R591 T700 T701 arg1Of results,from
R592 T703 T701 arg2Of inhibition,from
R593 T703 T702 arg1Of inhibition,phosphodiesterase
R594 T704 T709 arg1Of affects,","
R595 T704 T710 modOf affects,resulting
R596 T705 T706 arg1Of cytoplasmic,and
R597 T707 T706 arg2Of nuclear,and
R598 T708 T704 arg2Of events,affects
R599 T708 T705 arg1Of events,cytoplasmic
R600 T708 T707 arg1Of events,nuclear
R601 T710 T711 arg1Of resulting,in
R602 T710 T724 arg1Of resulting,through
R603 T713 T712 arg1Of attenuation,the
R604 T713 T714 arg1Of attenuation,of
R605 T713 T716 arg1Of attenuation,and
R606 T715 T714 arg2Of NF-κB,of
R607 T716 T711 arg2Of and,in
R608 T718 T716 arg2Of activation,and
R609 T718 T717 arg1Of activation,the
R610 T718 T719 arg1Of activation,of
R611 T723 T719 arg2Of binding,of
R612 T723 T720 arg1Of binding,CREB
R613 T723 T721 arg1Of binding,transcriptional
R614 T723 T722 arg1Of binding,DNA
R615 T725 T724 arg2Of pathways,through
R616 T725 T726 arg1Of pathways,that
R617 T725 T727 arg1Of pathways,are
R618 T725 T731 arg1Of pathways,A-independent
R619 T727 T728 arg1Of are,partially
R620 T731 T727 arg2Of A-independent,are
R621 T731 T729 arg1Of A-independent,Protein
R622 T731 T730 arg1Of A-independent,kinase
R623 T735 T733 arg1Of inhibition,PTX-mediated
R624 T735 T734 arg1Of inhibition,phosphodiesterase
R625 T735 T736 arg1Of inhibition,occurs
R626 T735 T745 arg1Of inhibition,may
R627 T735 T746 arg1Of inhibition,serve
R628 T736 T737 arg1Of occurs,partially
R629 T736 T738 arg1Of occurs,through
R630 T736 T744 arg1Of occurs,and
R631 T743 T738 arg2Of pathway,through
R632 T743 T739 arg1Of pathway,a
R633 T743 T740 arg1Of pathway,Protein
R634 T743 T741 arg1Of pathway,kinase
R635 T743 T742 arg1Of pathway,A-independent
R636 T746 T744 arg2Of serve,and
R637 T746 T745 arg2Of serve,may
R638 T746 T747 arg1Of serve,as
R639 T750 T747 arg2Of tool,as
R640 T750 T748 arg1Of tool,a
R641 T750 T749 arg1Of tool,useful
R642 T750 T751 arg1Of tool,in
R643 T753 T751 arg2Of attenuation,in
R644 T753 T752 arg1Of attenuation,the
R645 T753 T754 arg1Of attenuation,of
R646 T756 T754 arg2Of inflammation,of
R647 T756 T755 arg1Of inflammation,LPS-induced
R2218 T2792 T2791 arg1Of study,this
R2219 T2792 T2793 arg1Of study,was

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T162 99-109 NN denotes inhibition
T163 110-112 IN denotes on
T164 113-126 NN denotes transcription
T165 127-133 NN denotes factor
T166 134-144 NN denotes activation
T167 145-148 CC denotes and
T168 149-154 NN denotes tumor
T169 155-163 NN denotes necrosis
T170 164-176 NN denotes factor-alpha
T171 177-178 -LRB- denotes (
T172 178-183 NNP denotes TNF-α
T173 183-184 -RRB- denotes )
T174 185-195 NN denotes production
T175 196-198 IN denotes in
T176 199-217 NN denotes lipopolysaccharide
T177 218-219 -LRB- denotes (
T178 219-222 NNP denotes LPS
T179 222-223 -RRB- denotes )
T180 223-224 : denotes -
T181 224-234 VBN denotes stimulated
T182 235-240 JJ denotes human
T183 241-252 NN denotes mononuclear
T184 253-258 NNS denotes cells
T185 258-259 . denotes .
T186 261-273 NNP denotes INTRODUCTION
T187 274-277 DT denotes The
T188 278-288 NN denotes production
T189 289-291 IN denotes of
T190 292-297 NNP denotes TNF-α
T191 298-307 VBG denotes following
T192 308-311 NNP denotes LPS
T193 312-323 NN denotes stimulation
T194 324-326 VBZ denotes is
T195 327-330 CD denotes one
T196 331-333 IN denotes of
T197 334-337 DT denotes the
T198 338-341 JJ denotes key
T199 342-347 NNS denotes steps
T200 348-350 IN denotes in
T201 351-360 JJ denotes bacterial
T202 361-367 NN denotes sepsis
T203 368-371 CC denotes and
T204 372-384 NN denotes inflammation
T205 384-385 . denotes .
T206 386-389 DT denotes The
T207 390-399 NN denotes mechanism
T208 400-402 IN denotes by
T209 403-408 WDT denotes which
T210 409-426 NN denotes phosphodiesterase
T211 427-437 NN denotes inhibition
T212 438-444 VBZ denotes alters
T213 445-450 JJ denotes TNF-α
T214 451-461 NN denotes production
T215 462-464 IN denotes in
T216 465-468 DT denotes the
T217 469-477 NN denotes presence
T218 478-480 IN denotes of
T219 481-484 NNP denotes LPS
T220 485-492 VBZ denotes remains
T221 493-500 JJ denotes unclear
T222 500-501 . denotes .
T223 503-510 NNP denotes METHODS
T224 511-516 NNP denotes Human
T225 517-528 NN denotes mononuclear
T226 529-534 NNS denotes cells
T227 535-539 VBD denotes were
T228 540-550 VBN denotes stimulated
T229 551-555 IN denotes with
T230 556-559 NNP denotes LPS
T231 560-561 -LRB- denotes (
T232 561-562 CD denotes 1
T233 563-565 NN denotes μg
T234 565-566 NN denotes /
T235 566-568 NNP denotes mL
T236 568-569 -RRB- denotes )
T237 569-570 , denotes ,
T238 571-573 IN denotes in
T239 574-577 DT denotes the
T240 578-586 NN denotes presence
T241 587-590 CC denotes and
T242 591-598 NN denotes absence
T243 599-601 IN denotes of
T244 602-616 NNP denotes Pentoxifylline
T245 617-618 -LRB- denotes (
T246 618-621 NNP denotes PTX
T247 621-622 : denotes ;
T248 623-625 CD denotes 20
T249 626-628 NNP denotes mM
T250 628-629 -RRB- denotes )
T251 629-630 , denotes ,
T252 631-632 DT denotes a
T253 633-644 JJ denotes nonspecific
T254 645-662 NN denotes phosphodiesterase
T255 663-672 NN denotes inhibitor
T256 672-673 . denotes .
T257 674-681 JJ denotes Western
T258 682-690 VBG denotes blotting
T259 691-693 IN denotes of
T260 694-708 VBN denotes phosphorylated
T261 709-720 JJ denotes cytoplasmic
T262 721-726 NNP denotes I-κBα
T263 726-727 , denotes ,
T264 728-735 JJ denotes nuclear
T265 736-745 NNP denotes factor-κB
T266 746-749 NNS denotes p65
T267 750-751 -LRB- denotes (
T268 751-756 NN denotes NF-κB
T269 756-757 -RRB- denotes )
T270 757-758 , denotes ,
T271 759-762 CC denotes and
T272 763-770 JJ denotes nuclear
T273 771-784 JJ denotes cAMP-response
T274 785-792 NN denotes element
T275 793-800 JJ denotes binding
T276 801-808 NN denotes protein
T277 809-810 -LRB- denotes (
T278 810-814 NNP denotes CREB
T279 814-815 -RRB- denotes )
T280 816-819 VBD denotes was
T281 820-829 VBN denotes performed
T282 829-830 . denotes .
T283 831-834 NNP denotes DNA
T284 835-842 JJ denotes binding
T285 843-845 IN denotes of
T286 846-851 NNP denotes NF-κB
T287 852-855 CC denotes and
T288 856-860 NNP denotes CREB
T289 861-864 VBD denotes was
T290 865-873 VBN denotes verified
T291 874-876 IN denotes by
T292 877-892 JJ denotes electrophoretic
T293 893-901 NN denotes mobility
T294 902-907 NN denotes shift
T295 908-913 NN denotes assay
T296 913-914 . denotes .
T297 915-920 JJ denotes TNF-α
T298 921-927 NNS denotes levels
T299 928-932 VBD denotes were
T300 933-943 VBN denotes determined
T301 944-946 IN denotes in
T302 947-950 DT denotes the
T303 951-962 NN denotes supernatant
T304 963-965 IN denotes of
T305 966-976 VBN denotes stimulated
T306 977-982 NNS denotes cells
T307 983-985 IN denotes in
T308 986-989 DT denotes the
T309 990-998 NN denotes presence
T310 999-1002 CC denotes and
T311 1003-1010 NN denotes absence
T312 1011-1018 NNP denotes Protein
T313 1019-1025 NN denotes kinase
T314 1026-1027 DT denotes A
T315 1028-1038 NN denotes inhibition
T316 1039-1041 IN denotes by
T317 1042-1044 DT denotes an
T318 1045-1058 JJ denotes enzyme-linked
T319 1059-1072 JJ denotes immunosorbent
T320 1073-1078 NN denotes assay
T321 1079-1080 -LRB- denotes (
T322 1080-1085 NNP denotes ELISA
T323 1085-1086 -RRB- denotes )
T324 1086-1087 . denotes .
T325 1089-1096 NNS denotes RESULTS
T326 1097-1100 VBP denotes PTX
T327 1101-1104 VBD denotes was
T328 1105-1117 VBN denotes demonstrated
T329 1118-1120 TO denotes to
T330 1121-1134 RB denotes significantly
T331 1135-1141 VB denotes reduce
T332 1142-1153 JJ denotes cytoplasmic
T333 1154-1159 JJ denotes I-κBα
T334 1160-1175 NN denotes phosphorylation
T335 1175-1176 , denotes ,
T336 1177-1184 JJ denotes nuclear
T337 1185-1188 NNS denotes p65
T338 1189-1204 NN denotes phosphorylation
T339 1204-1205 , denotes ,
T340 1206-1209 CC denotes and
T341 1210-1213 DT denotes the
T342 1214-1217 NNP denotes DNA
T343 1218-1225 JJ denotes binding
T344 1226-1234 NN denotes activity
T345 1235-1237 IN denotes of
T346 1238-1243 NN denotes NF-κB
T347 1243-1244 . denotes .
T348 1245-1247 IN denotes In
T349 1248-1256 NN denotes contrast
T350 1256-1257 , denotes ,
T351 1258-1261 NNP denotes PTX
T352 1262-1270 RB denotes markedly
T353 1271-1279 VBD denotes enhanced
T354 1280-1283 DT denotes the
T355 1284-1299 NN denotes phosphorylation
T356 1300-1303 CC denotes and
T357 1304-1307 NN denotes DNA
T358 1308-1315 JJ denotes binding
T359 1316-1324 NN denotes activity
T360 1325-1327 IN denotes of
T361 1328-1332 NNP denotes CREB
T362 1332-1333 . denotes .
T363 1334-1339 NNS denotes Cells
T364 1340-1353 RB denotes concomitantly
T365 1354-1361 VBN denotes treated
T366 1362-1366 IN denotes with
T367 1367-1370 NNP denotes PTX
T368 1371-1374 CC denotes and
T369 1375-1378 NNP denotes LPS
T370 1379-1387 VBD denotes secreted
T371 1388-1395 JJ denotes similar
T372 1396-1402 NNS denotes levels
T373 1403-1405 IN denotes of
T374 1406-1411 NNP denotes TNF-α
T375 1412-1414 IN denotes in
T376 1415-1418 DT denotes the
T377 1419-1427 NN denotes presence
T378 1428-1431 CC denotes and
T379 1432-1439 NN denotes absence
T380 1440-1447 NNP denotes Protein
T381 1448-1454 NN denotes kinase
T382 1455-1456 DT denotes A
T383 1457-1467 NN denotes inhibition
T384 1467-1468 . denotes .
T385 1470-1480 NNP denotes DISCUSSION
T386 1481-1484 NNP denotes The
T387 1485-1494 VBD denotes increased
T388 1495-1500 NN denotes level
T389 1501-1503 IN denotes of
T390 1504-1508 NNP denotes cAMP
T391 1509-1513 WDT denotes that
T392 1514-1521 VBZ denotes results
T393 1522-1526 IN denotes from
T394 1527-1544 NN denotes phosphodiesterase
T395 1545-1555 NN denotes inhibition
T396 1556-1563 VBZ denotes affects
T397 1564-1575 JJ denotes cytoplasmic
T398 1576-1579 CC denotes and
T399 1580-1587 JJ denotes nuclear
T400 1588-1594 NNS denotes events
T401 1594-1595 , denotes ,
T402 1596-1605 VBG denotes resulting
T403 1606-1608 IN denotes in
T404 1609-1612 DT denotes the
T405 1613-1624 NN denotes attenuation
T406 1625-1627 IN denotes of
T407 1628-1633 NNP denotes NF-κB
T408 1634-1637 CC denotes and
T409 1638-1641 DT denotes the
T410 1642-1652 NN denotes activation
T411 1653-1655 IN denotes of
T412 1656-1660 NNP denotes CREB
T413 1661-1676 JJ denotes transcriptional
T414 1677-1680 NNP denotes DNA
T415 1681-1688 JJ denotes binding
T416 1689-1696 IN denotes through
T417 1697-1705 NNS denotes pathways
T418 1706-1710 WDT denotes that
T419 1711-1714 VBP denotes are
T420 1715-1724 RB denotes partially
T421 1725-1732 NNP denotes Protein
T422 1733-1739 NN denotes kinase
T423 1740-1753 NN denotes A-independent
T424 1753-1754 . denotes .
T425 1756-1766 NNP denotes CONCLUSION
T426 1767-1779 JJ denotes PTX-mediated
T427 1780-1797 NN denotes phosphodiesterase
T428 1798-1808 NN denotes inhibition
T429 1809-1815 VBZ denotes occurs
T430 1816-1825 RB denotes partially
T431 1826-1833 IN denotes through
T432 1834-1835 DT denotes a
T433 1836-1843 NNP denotes Protein
T434 1844-1850 NN denotes kinase
T435 1851-1864 JJ denotes A-independent
T436 1865-1872 NN denotes pathway
T437 1873-1876 CC denotes and
T438 1877-1880 MD denotes may
T439 1881-1886 VB denotes serve
T440 1887-1889 IN denotes as
T441 1890-1891 DT denotes a
T442 1892-1898 JJ denotes useful
T443 1899-1903 NN denotes tool
T444 1904-1906 IN denotes in
T445 1907-1910 DT denotes the
T446 1911-1922 NN denotes attenuation
T447 1923-1925 IN denotes of
T448 1926-1937 JJ denotes LPS-induced
T449 1938-1950 NN denotes inflammation
T450 1950-1951 . denotes .
T2464 27-31 DT denotes this
T2465 32-37 NN denotes study
T2466 38-41 VBD denotes was
T148 0-9 NNP denotes OBJECTIVE
T149 10-13 DT denotes The
T150 14-23 NN denotes objective
T151 24-26 IN denotes of
T152 27-31 DT denotes this
T153 32-37 NN denotes study
T154 38-41 VBD denotes was
T155 42-44 TO denotes to
T156 45-54 VB denotes determine
T157 55-58 DT denotes the
T158 59-65 NN denotes effect
T159 66-68 IN denotes of
T160 69-80 JJ denotes nonspecific
T161 81-98 NN denotes phosphodiesterase
R78 T180 T162 punct -,inhibition
R79 T181 T154 conj stimulated,was
R80 T182 T184 amod human,cells
R81 T183 T184 compound mononuclear,cells
R82 T184 T181 dobj cells,stimulated
R83 T185 T154 punct .,was
R84 T186 T194 advmod INTRODUCTION,is
R85 T187 T188 det The,production
R86 T188 T194 nsubj production,is
R87 T189 T188 prep of,production
R88 T190 T189 pobj TNF-α,of
R89 T191 T188 prep following,production
R90 T192 T193 compound LPS,stimulation
R91 T193 T191 pobj stimulation,following
R92 T194 T194 ROOT is,is
R93 T195 T194 attr one,is
R94 T196 T195 prep of,one
R95 T197 T199 det the,steps
R96 T198 T199 amod key,steps
R97 T199 T196 pobj steps,of
R98 T200 T199 prep in,steps
R99 T201 T202 amod bacterial,sepsis
R103 T205 T194 punct .,is
R104 T206 T207 det The,mechanism
R105 T207 T220 nsubj mechanism,remains
R106 T208 T212 prep by,alters
R107 T209 T208 pobj which,by
R108 T210 T211 amod phosphodiesterase,inhibition
R109 T211 T212 nsubj inhibition,alters
R110 T212 T207 relcl alters,mechanism
R111 T213 T214 amod TNF-α,production
R112 T214 T212 dobj production,alters
R113 T215 T212 prep in,alters
R114 T216 T217 det the,presence
R115 T217 T215 pobj presence,in
R116 T218 T217 prep of,presence
R117 T219 T218 pobj LPS,of
R118 T220 T220 ROOT remains,remains
R119 T221 T220 acomp unclear,remains
R120 T222 T220 punct .,remains
R121 T223 T226 compound METHODS,cells
R122 T224 T226 compound Human,cells
R123 T225 T226 compound mononuclear,cells
R124 T226 T228 nsubjpass cells,stimulated
R125 T227 T228 auxpass were,stimulated
R126 T228 T249 ccomp stimulated,mM
R127 T229 T228 prep with,stimulated
R128 T230 T229 pobj LPS,with
R129 T231 T235 punct (,mL
R130 T232 T233 nummod 1,μg
R131 T233 T235 compound μg,mL
R132 T234 T235 compound /,mL
R133 T235 T230 appos mL,LPS
R134 T236 T235 punct ),mL
R135 T237 T230 punct ",",LPS
R136 T238 T228 prep in,stimulated
R137 T239 T240 det the,presence
R138 T240 T238 pobj presence,in
R139 T241 T240 cc and,presence
R140 T242 T240 conj absence,presence
R141 T243 T242 prep of,absence
R142 T244 T243 pobj Pentoxifylline,of
R143 T245 T246 punct (,PTX
R144 T246 T244 appos PTX,Pentoxifylline
R145 T247 T249 punct ;,mM
R146 T248 T249 nummod 20,mM
R147 T249 T249 ROOT mM,mM
R148 T250 T249 punct ),mM
R149 T251 T249 punct ",",mM
R150 T252 T255 det a,inhibitor
R151 T253 T255 amod nonspecific,inhibitor
R152 T254 T255 compound phosphodiesterase,inhibitor
R153 T255 T249 appos inhibitor,mM
R154 T256 T249 punct .,mM
R155 T257 T258 amod Western,blotting
R156 T258 T281 nsubjpass blotting,performed
R157 T259 T258 prep of,blotting
R158 T260 T262 amod phosphorylated,I-κBα
R159 T261 T262 compound cytoplasmic,I-κBα
R160 T262 T259 pobj I-κBα,of
R161 T263 T262 punct ",",I-κBα
R162 T264 T266 amod nuclear,p65
R163 T265 T266 compound factor-κB,p65
R164 T266 T262 appos p65,I-κBα
R165 T267 T266 punct (,p65
R166 T268 T266 appos NF-κB,p65
R167 T269 T266 punct ),p65
R168 T270 T266 punct ",",p65
R169 T271 T266 cc and,p65
R170 T272 T274 amod nuclear,element
R171 T273 T274 amod cAMP-response,element
R172 T274 T276 compound element,protein
R173 T275 T276 amod binding,protein
R174 T276 T266 conj protein,p65
R175 T277 T278 punct (,CREB
R176 T278 T276 appos CREB,protein
R177 T279 T276 punct ),protein
R178 T280 T281 auxpass was,performed
R179 T281 T281 ROOT performed,performed
R180 T282 T281 punct .,performed
R181 T283 T284 npadvmod DNA,binding
R182 T284 T290 nsubjpass binding,verified
R183 T285 T284 prep of,binding
R184 T286 T285 pobj NF-κB,of
R185 T287 T286 cc and,NF-κB
R186 T288 T286 conj CREB,NF-κB
R187 T289 T290 auxpass was,verified
R188 T290 T290 ROOT verified,verified
R189 T291 T290 agent by,verified
R190 T292 T295 amod electrophoretic,assay
R191 T293 T294 compound mobility,shift
R192 T294 T295 compound shift,assay
R193 T295 T291 pobj assay,by
R194 T296 T290 punct .,verified
R195 T297 T298 amod TNF-α,levels
R196 T298 T300 nsubjpass levels,determined
R197 T299 T300 auxpass were,determined
R198 T300 T300 ROOT determined,determined
R199 T301 T300 prep in,determined
R200 T302 T303 det the,supernatant
R201 T303 T301 pobj supernatant,in
R202 T304 T303 prep of,supernatant
R203 T305 T306 amod stimulated,cells
R204 T306 T304 pobj cells,of
R205 T307 T303 prep in,supernatant
R206 T308 T309 det the,presence
R207 T309 T307 pobj presence,in
R208 T310 T309 cc and,presence
R209 T311 T309 conj absence,presence
R210 T312 T313 compound Protein,kinase
R211 T313 T313 ROOT kinase,kinase
R212 T314 T315 det A,inhibition
R213 T315 T315 ROOT inhibition,inhibition
R214 T316 T315 prep by,inhibition
R215 T317 T320 det an,assay
R216 T318 T320 nmod enzyme-linked,assay
R217 T319 T320 compound immunosorbent,assay
R218 T320 T316 pobj assay,by
R219 T321 T320 punct (,assay
R220 T322 T320 appos ELISA,assay
R221 T323 T320 punct ),assay
R222 T324 T315 punct .,inhibition
R223 T325 T326 compound RESULTS,PTX
R224 T326 T328 nsubjpass PTX,demonstrated
R225 T327 T328 auxpass was,demonstrated
R226 T328 T328 ROOT demonstrated,demonstrated
R227 T329 T331 aux to,reduce
R228 T330 T331 advmod significantly,reduce
R229 T331 T328 xcomp reduce,demonstrated
R230 T332 T334 amod cytoplasmic,phosphorylation
R231 T333 T334 amod I-κBα,phosphorylation
R232 T334 T331 dobj phosphorylation,reduce
R233 T335 T334 punct ",",phosphorylation
R234 T336 T337 amod nuclear,p65
R235 T337 T338 compound p65,phosphorylation
R236 T338 T334 appos phosphorylation,phosphorylation
R237 T339 T338 punct ",",phosphorylation
R238 T340 T338 cc and,phosphorylation
R239 T341 T344 det the,activity
R240 T342 T344 nmod DNA,activity
R241 T343 T344 amod binding,activity
R242 T344 T338 conj activity,phosphorylation
R243 T345 T344 prep of,activity
R244 T346 T345 pobj NF-κB,of
R245 T347 T328 punct .,demonstrated
R246 T348 T353 prep In,enhanced
R247 T349 T348 pobj contrast,In
R248 T350 T353 punct ",",enhanced
R249 T351 T353 nsubj PTX,enhanced
R250 T352 T353 advmod markedly,enhanced
R251 T353 T353 ROOT enhanced,enhanced
R252 T354 T355 det the,phosphorylation
R253 T355 T353 dobj phosphorylation,enhanced
R254 T356 T355 cc and,phosphorylation
R255 T357 T359 amod DNA,activity
R256 T358 T359 amod binding,activity
R257 T359 T355 conj activity,phosphorylation
R258 T360 T355 prep of,phosphorylation
R259 T361 T360 pobj CREB,of
R260 T362 T353 punct .,enhanced
R261 T363 T370 nsubj Cells,secreted
R262 T364 T365 advmod concomitantly,treated
R263 T365 T363 acl treated,Cells
R264 T366 T365 prep with,treated
R265 T367 T366 pobj PTX,with
R266 T368 T367 cc and,PTX
R267 T369 T367 conj LPS,PTX
R268 T370 T370 ROOT secreted,secreted
R269 T371 T372 amod similar,levels
R270 T372 T370 dobj levels,secreted
R271 T373 T372 prep of,levels
R272 T374 T373 pobj TNF-α,of
R273 T375 T370 prep in,secreted
R274 T376 T377 det the,presence
R275 T377 T375 pobj presence,in
R276 T378 T377 cc and,presence
R277 T379 T377 conj absence,presence
R278 T380 T381 compound Protein,kinase
R279 T381 T381 ROOT kinase,kinase
R280 T382 T383 det A,inhibition
R281 T383 T383 ROOT inhibition,inhibition
R282 T384 T383 punct .,inhibition
R283 T385 T396 nsubj DISCUSSION,affects
R284 T386 T388 det The,level
R285 T387 T388 amod increased,level
R286 T388 T396 nsubj level,affects
R287 T389 T388 prep of,level
R288 T390 T389 pobj cAMP,of
R289 T391 T392 nsubj that,results
R290 T392 T388 relcl results,level
R291 T393 T392 prep from,results
R292 T394 T395 amod phosphodiesterase,inhibition
R293 T395 T393 pobj inhibition,from
R294 T396 T396 ROOT affects,affects
R295 T397 T400 amod cytoplasmic,events
R296 T398 T397 cc and,cytoplasmic
R297 T399 T397 conj nuclear,cytoplasmic
R298 T400 T396 dobj events,affects
R299 T401 T396 punct ",",affects
R300 T402 T396 advcl resulting,affects
R301 T403 T402 prep in,resulting
R302 T404 T405 det the,attenuation
R303 T405 T403 pobj attenuation,in
R304 T406 T405 prep of,attenuation
R305 T407 T406 pobj NF-κB,of
R306 T408 T405 cc and,attenuation
R307 T409 T410 det the,activation
R308 T410 T405 conj activation,attenuation
R309 T411 T410 prep of,activation
R310 T412 T414 compound CREB,DNA
R311 T413 T414 compound transcriptional,DNA
R312 T414 T411 pobj DNA,of
R313 T415 T410 amod binding,activation
R314 T416 T415 prep through,binding
R315 T417 T416 pobj pathways,through
R316 T418 T419 nsubj that,are
R317 T419 T417 relcl are,pathways
R318 T420 T419 advmod partially,are
R319 T421 T423 compound Protein,A-independent
R320 T422 T423 compound kinase,A-independent
R321 T423 T419 attr A-independent,are
R322 T424 T396 punct .,affects
R323 T425 T428 nmod CONCLUSION,inhibition
R324 T426 T428 amod PTX-mediated,inhibition
R325 T427 T428 compound phosphodiesterase,inhibition
R326 T428 T429 nsubj inhibition,occurs
R327 T429 T429 ROOT occurs,occurs
R328 T430 T431 advmod partially,through
R329 T431 T429 prep through,occurs
R330 T432 T436 det a,pathway
R331 T433 T436 nmod Protein,pathway
R332 T434 T436 nmod kinase,pathway
R333 T435 T436 compound A-independent,pathway
R334 T436 T431 pobj pathway,through
R335 T437 T429 cc and,occurs
R336 T438 T439 aux may,serve
R337 T439 T429 conj serve,occurs
R338 T440 T439 prep as,serve
R348 T450 T429 punct .,occurs
R774 T149 T150 det The,objective
R775 T150 T154 nsubj objective,was
R776 T151 T150 prep of,objective
R777 T152 T153 det this,study
R778 T153 T151 pobj study,of
R779 T154 T154 ROOT was,was
R780 T155 T156 aux to,determine
R781 T156 T154 xcomp determine,was
R782 T157 T158 det the,effect
R783 T158 T156 dobj effect,determine
R784 T159 T158 prep of,effect
R785 T160 T162 amod nonspecific,inhibition
R786 T161 T162 compound phosphodiesterase,inhibition
R1891 T2464 T2465 det this,study
R100 T202 T200 pobj sepsis,in
R101 T203 T202 cc and,sepsis
R102 T204 T202 conj inflammation,sepsis
R339 T441 T443 det a,tool
R340 T442 T443 amod useful,tool
R341 T443 T440 pobj tool,as
R342 T444 T443 prep in,tool
R343 T445 T446 det the,attenuation
R344 T446 T444 pobj attenuation,in
R345 T447 T446 prep of,attenuation
R346 T448 T449 amod LPS-induced,inflammation
R347 T449 T447 pobj inflammation,of
R60 T162 T159 pobj inhibition,of
R61 T163 T162 prep on,inhibition
R62 T164 T165 compound transcription,factor
R63 T165 T166 compound factor,activation
R64 T166 T163 pobj activation,on
R65 T167 T166 cc and,activation
R66 T168 T169 compound tumor,necrosis
R67 T169 T170 compound necrosis,factor-alpha
R68 T170 T166 conj factor-alpha,activation
R69 T171 T172 punct (,TNF-α
R70 T172 T170 appos TNF-α,factor-alpha
R71 T173 T170 punct ),factor-alpha
R72 T174 T166 conj production,activation
R73 T175 T174 prep in,production
R74 T176 T175 pobj lipopolysaccharide,in
R75 T177 T178 punct (,LPS
R76 T178 T176 appos LPS,lipopolysaccharide
R77 T179 T176 punct ),lipopolysaccharide

GO-BP

Id Subject Object Predicate Lexical cue
T826 178-195 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α) production
T827 278-297 http://purl.obolibrary.org/obo/GO_0032680 denotes production of TNF-α
T828 445-461 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T834 178-195 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α) production
T835 278-297 http://purl.obolibrary.org/obo/GO_0032640 denotes production of TNF-α
T836 278-295 http://purl.obolibrary.org/obo/GO_0032640 denotes production of TNF
T838 81-98 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T839 409-426 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T840 645-662 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T841 1527-1544 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T842 1780-1797 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T843 99-133 http://purl.obolibrary.org/obo/GO_1901484 denotes inhibition on transcription factor
T844 99-133 http://purl.obolibrary.org/obo/GO_0043433 denotes inhibition on transcription factor
T845 99-133 http://purl.obolibrary.org/obo/GO_0032792 denotes inhibition on transcription factor
T846 113-126 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T847 1661-1676 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T848 113-144 http://purl.obolibrary.org/obo/GO_0051091 denotes transcription factor activation
T849 113-144 http://purl.obolibrary.org/obo/GO_0032793 denotes transcription factor activation
T850 1642-1660 http://purl.obolibrary.org/obo/GO_0032793 denotes activation of CREB
T851 113-144 http://purl.obolibrary.org/obo/GO_1901485 denotes transcription factor activation
T852 155-163 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T853 155-163 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T854 155-163 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T855 155-163 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T856 372-384 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T857 1938-1950 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T858 645-672 http://purl.obolibrary.org/obo/GO_0051344 denotes phosphodiesterase inhibitor
T859 771-784 http://purl.obolibrary.org/obo/GO_0051591 denotes cAMP-response
T860 1160-1175 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T861 1189-1204 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T862 1284-1299 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T863 1628-1652 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB and the activation

GO-MF

Id Subject Object Predicate Lexical cue
T865 81-98 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T866 409-426 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T867 645-662 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T868 1527-1544 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T869 1780-1797 http://purl.obolibrary.org/obo/GO_0008081 denotes phosphodiesterase
T870 793-800 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T871 835-842 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T872 1218-1225 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T873 1308-1315 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T874 1681-1688 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T875 793-808 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T876 831-842 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T877 1214-1225 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T878 1304-1315 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T879 1677-1688 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T880 835-851 http://purl.obolibrary.org/obo/GO_0051059 denotes binding of NF-κB

GO-CC

Id Subject Object Predicate Lexical cue
T881 253-258 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T882 529-534 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T883 977-982 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T112 0-9 Sentence denotes OBJECTIVE
T113 10-259 Sentence denotes The objective of this study was to determine the effect of nonspecific phosphodiesterase inhibition on transcription factor activation and tumor necrosis factor-alpha (TNF-α) production in lipopolysaccharide (LPS)-stimulated human mononuclear cells.
T114 261-273 Sentence denotes INTRODUCTION
T115 274-385 Sentence denotes The production of TNF-α following LPS stimulation is one of the key steps in bacterial sepsis and inflammation.
T116 386-501 Sentence denotes The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.
T117 503-510 Sentence denotes METHODS
T118 511-673 Sentence denotes Human mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 mM), a nonspecific phosphodiesterase inhibitor.
T119 674-830 Sentence denotes Western blotting of phosphorylated cytoplasmic I-κBα, nuclear factor-κB p65 (NF-κB), and nuclear cAMP-response element binding protein (CREB) was performed.
T120 831-914 Sentence denotes DNA binding of NF-κB and CREB was verified by electrophoretic mobility shift assay.
T121 915-1087 Sentence denotes TNF-α levels were determined in the supernatant of stimulated cells in the presence and absence Protein kinase A inhibition by an enzyme-linked immunosorbent assay (ELISA).
T122 1089-1096 Sentence denotes RESULTS
T123 1097-1244 Sentence denotes PTX was demonstrated to significantly reduce cytoplasmic I-κBα phosphorylation, nuclear p65 phosphorylation, and the DNA binding activity of NF-κB.
T124 1245-1333 Sentence denotes In contrast, PTX markedly enhanced the phosphorylation and DNA binding activity of CREB.
T125 1334-1468 Sentence denotes Cells concomitantly treated with PTX and LPS secreted similar levels of TNF-α in the presence and absence Protein kinase A inhibition.
T126 1470-1480 Sentence denotes DISCUSSION
T127 1481-1754 Sentence denotes The increased level of cAMP that results from phosphodiesterase inhibition affects cytoplasmic and nuclear events, resulting in the attenuation of NF-κB and the activation of CREB transcriptional DNA binding through pathways that are partially Protein kinase A-independent.
T128 1756-1766 Sentence denotes CONCLUSION
T129 1767-1951 Sentence denotes PTX-mediated phosphodiesterase inhibition occurs partially through a Protein kinase A-independent pathway and may serve as a useful tool in the attenuation of LPS-induced inflammation.
T4 0-9 Sentence denotes OBJECTIVE
T5 10-259 Sentence denotes The objective of this study was to determine the effect of nonspecific phosphodiesterase inhibition on transcription factor activation and tumor necrosis factor-alpha (TNF-α) production in lipopolysaccharide (LPS)-stimulated human mononuclear cells.
T6 261-273 Sentence denotes INTRODUCTION
T7 274-385 Sentence denotes The production of TNF-α following LPS stimulation is one of the key steps in bacterial sepsis and inflammation.
T8 386-501 Sentence denotes The mechanism by which phosphodiesterase inhibition alters TNF-α production in the presence of LPS remains unclear.
T9 503-510 Sentence denotes METHODS
T10 511-673 Sentence denotes Human mononuclear cells were stimulated with LPS (1 μg/mL), in the presence and absence of Pentoxifylline (PTX; 20 mM), a nonspecific phosphodiesterase inhibitor.
T11 674-830 Sentence denotes Western blotting of phosphorylated cytoplasmic I-κBα, nuclear factor-κB p65 (NF-κB), and nuclear cAMP-response element binding protein (CREB) was performed.
T12 831-914 Sentence denotes DNA binding of NF-κB and CREB was verified by electrophoretic mobility shift assay.
T13 915-1087 Sentence denotes TNF-α levels were determined in the supernatant of stimulated cells in the presence and absence Protein kinase A inhibition by an enzyme-linked immunosorbent assay (ELISA).
T14 1089-1096 Sentence denotes RESULTS
T15 1097-1244 Sentence denotes PTX was demonstrated to significantly reduce cytoplasmic I-κBα phosphorylation, nuclear p65 phosphorylation, and the DNA binding activity of NF-κB.
T16 1245-1333 Sentence denotes In contrast, PTX markedly enhanced the phosphorylation and DNA binding activity of CREB.
T17 1334-1468 Sentence denotes Cells concomitantly treated with PTX and LPS secreted similar levels of TNF-α in the presence and absence Protein kinase A inhibition.
T18 1470-1480 Sentence denotes DISCUSSION
T19 1481-1754 Sentence denotes The increased level of cAMP that results from phosphodiesterase inhibition affects cytoplasmic and nuclear events, resulting in the attenuation of NF-κB and the activation of CREB transcriptional DNA binding through pathways that are partially Protein kinase A-independent.
T20 1756-1766 Sentence denotes CONCLUSION
T21 1767-1951 Sentence denotes PTX-mediated phosphodiesterase inhibition occurs partially through a Protein kinase A-independent pathway and may serve as a useful tool in the attenuation of LPS-induced inflammation.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T887 59-65 Regulation denotes effect true
T888 149-176 Protein denotes tumor necrosis factor-alpha
T889 178-183 Protein denotes TNF-α
T890 185-195 Gene_expression denotes production
T891 278-288 Gene_expression denotes production
T892 292-297 Protein denotes TNF-α
T893 298-307 Positive_regulation denotes following
T894 438-444 Regulation denotes alters
T895 445-450 Protein denotes TNF-α
T896 451-461 Gene_expression denotes production
T897 462-480 Positive_regulation denotes in the presence of
T898 694-708 Phosphorylation denotes phosphorylated
T899 721-726 Protein denotes I-κBα
T900 746-749 Protein denotes p65
T901 915-920 Protein denotes TNF-α
T902 1135-1141 Negative_regulation denotes reduce
T903 1135-1141 Negative_regulation denotes reduce
T904 1154-1159 Protein denotes I-κBα
T905 1160-1175 Phosphorylation denotes phosphorylation
T906 1185-1188 Protein denotes p65
T907 1189-1204 Phosphorylation denotes phosphorylation
T908 1379-1387 Localization denotes secreted
T909 1406-1411 Protein denotes TNF-α
T910 1419-1427 Regulation denotes presence
T911 1432-1439 Regulation denotes absence true
R650 T888 T890 themeOf tumor necrosis factor-alpha,production
R651 T890 T887 themeOf production,effect
R652 T891 T893 themeOf production,following
R653 T892 T891 themeOf TNF-α,production
R654 T894 T897 themeOf alters,in the presence of
R655 T895 T896 themeOf TNF-α,production
R656 T896 T894 themeOf production,alters
R657 T899 T898 themeOf I-κBα,phosphorylated
R658 T904 T905 themeOf I-κBα,phosphorylation
R659 T905 T903 themeOf phosphorylation,reduce
R660 T906 T907 themeOf p65,phosphorylation
R661 T907 T902 themeOf phosphorylation,reduce
R662 T908 T910 themeOf secreted,presence
R663 T908 T911 themeOf secreted,absence
R664 T909 T908 themeOf TNF-α,secreted

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T919 149-176 Protein denotes tumor necrosis factor-alpha
T920 178-183 Protein denotes TNF-α
T921 185-195 Gene_expression denotes production
T922 185-195 Gene_expression denotes production
T923 134-144 Positive_regulation denotes activation
T924 134-144 Positive_regulation denotes activation
T925 59-65 Regulation denotes effect
T926 59-65 Regulation denotes effect
T927 292-297 Protein denotes TNF-α
T928 278-288 Gene_expression denotes production
T929 312-323 Positive_regulation denotes stimulation
T930 445-450 Protein denotes TNF-α
T931 451-461 Gene_expression denotes production
T932 438-444 Regulation denotes alters
T933 694-726 Protein denotes phosphorylated cytoplasmic I-κBα
T934 728-745 Protein denotes nuclear factor-κB
T935 746-749 Protein denotes p65
T936 751-756 Protein denotes NF-κB
T937 763-808 Protein denotes nuclear cAMP-response element binding protein
T938 810-814 Protein denotes CREB
T939 846-851 Protein denotes NF-κB
T940 856-860 Protein denotes CREB
T941 835-842 Binding denotes binding
T942 835-842 Binding denotes binding
T943 915-920 Protein denotes TNF-α
T944 1011-1027 Protein denotes Protein kinase A
T945 1028-1038 Negative_regulation denotes inhibition
T946 1097-1100 Protein denotes PTX
T947 1142-1155 Protein denotes cytoplasmic I
T948 1156-1159 Protein denotes κBα
T949 1185-1188 Protein denotes p65
T950 1238-1243 Protein denotes NF-κB
T951 1160-1175 Phosphorylation denotes phosphorylation
T952 1160-1175 Phosphorylation denotes phosphorylation
T953 1177-1184 Entity denotes nuclear
T954 1189-1204 Phosphorylation denotes phosphorylation
T955 1218-1225 Binding denotes binding
T956 1135-1141 Negative_regulation denotes reduce
T957 1258-1261 Protein denotes PTX
T958 1328-1332 Protein denotes CREB
T959 1284-1299 Phosphorylation denotes phosphorylation
T960 1271-1279 Positive_regulation denotes enhanced
T961 1367-1370 Protein denotes PTX
T962 1406-1411 Protein denotes TNF-α
T963 1440-1456 Protein denotes Protein kinase A
T964 1379-1387 Localization denotes secreted
T965 1379-1387 Localization denotes secreted
T966 1457-1467 Negative_regulation denotes inhibition
T967 1628-1633 Protein denotes NF-κB
T968 1656-1660 Protein denotes CREB
T969 1681-1688 Binding denotes binding
T970 1642-1652 Positive_regulation denotes activation
T971 1767-1770 Protein denotes PTX
T972 1836-1852 Protein denotes Protein kinase A
R669 T919 T921 themeOf tumor necrosis factor-alpha,production
R670 T920 T922 themeOf TNF-α,production
R671 T921 T923 themeOf production,activation
R672 T922 T924 themeOf production,activation
R673 T923 T925 themeOf activation,effect
R674 T924 T926 themeOf activation,effect
R675 T927 T928 themeOf TNF-α,production
R676 T928 T929 themeOf production,stimulation
R677 T930 T931 themeOf TNF-α,production
R678 T931 T932 themeOf production,alters
R679 T939 T941 themeOf NF-κB,binding
R680 T940 T942 themeOf CREB,binding
R681 T944 T945 themeOf Protein kinase A,inhibition
R682 T946 T956 causeOf PTX,reduce
R683 T947 T951 themeOf cytoplasmic I,phosphorylation
R684 T948 T952 themeOf κBα,phosphorylation
R685 T949 T954 themeOf p65,phosphorylation
R686 T950 T955 themeOf NF-κB,binding
R687 T953 T954 Site nuclear,phosphorylation
R688 T954 T956 themeOf phosphorylation,reduce
R689 T957 T960 causeOf PTX,enhanced
R690 T958 T959 themeOf CREB,phosphorylation
R691 T959 T960 themeOf phosphorylation,enhanced
R692 T961 T964 themeOf PTX,secreted
R693 T962 T965 themeOf TNF-α,secreted
R694 T963 T966 themeOf Protein kinase A,inhibition
R695 T967 T969 themeOf NF-κB,binding
R696 T969 T970 themeOf binding,activation

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T759 149-170 P01375 denotes tumor necrosis factor
T760 178-181 P01375 denotes TNF
T761 178-183 P01375 denotes TNF-α
T762 292-295 P01375 denotes TNF
T763 292-297 P01375 denotes TNF-α
T764 445-448 P01375 denotes TNF
T765 445-450 P01375 denotes TNF-α
T766 746-749 P21579 denotes p65
T767 746-749 Q04206 denotes p65
T768 771-808 O43889 denotes cAMP-response element binding protein
T769 771-808 P15336 denotes cAMP-response element binding protein
T770 771-808 P18848 denotes cAMP-response element binding protein
T771 771-808 Q8TEY5 denotes cAMP-response element binding protein
T772 771-808 Q02930 denotes cAMP-response element binding protein
T773 771-808 P16220 denotes cAMP-response element binding protein
T774 810-814 P16220 denotes CREB
T775 810-814 O43889 denotes CREB
T776 810-814 Q8TEY5 denotes CREB
T777 810-814 Q02930 denotes CREB
T778 810-814 P18848 denotes CREB
T779 810-814 P15336 denotes CREB
T780 856-860 O43889 denotes CREB
T781 856-860 Q02930 denotes CREB
T782 856-860 P15336 denotes CREB
T783 856-860 P16220 denotes CREB
T784 856-860 Q8TEY5 denotes CREB
T785 856-860 P18848 denotes CREB
T786 915-918 P01375 denotes TNF
T787 915-920 P01375 denotes TNF-α
T788 1185-1188 Q04206 denotes p65
T789 1185-1188 P21579 denotes p65
T790 1328-1332 O43889 denotes CREB
T791 1328-1332 Q8TEY5 denotes CREB
T792 1328-1332 Q02930 denotes CREB
T793 1328-1332 P18848 denotes CREB
T794 1328-1332 P16220 denotes CREB
T795 1328-1332 P15336 denotes CREB
T796 1406-1409 P01375 denotes TNF
T797 1406-1411 P01375 denotes TNF-α
T798 1656-1660 P16220 denotes CREB
T799 1656-1660 P18848 denotes CREB
T800 1656-1660 Q02930 denotes CREB
T801 1656-1660 P15336 denotes CREB
T802 1656-1660 Q8TEY5 denotes CREB
T803 1656-1660 O43889 denotes CREB

test2

Id Subject Object Predicate Lexical cue Negation
T32 149-176 Protein denotes tumor necrosis factor-alpha
T33 178-183 Protein denotes TNF-α
T34 185-195 Gene_expression denotes production
T35 278-288 Gene_expression denotes production
T36 292-297 Protein denotes TNF-α
T37 298-307 Positive_regulation denotes following
T38 438-444 Regulation denotes alters
T39 445-450 Protein denotes TNF-α
T40 451-461 Gene_expression denotes production
T41 694-708 Phosphorylation denotes phosphorylated
T42 721-726 Protein denotes I-κBα
T43 746-749 Protein denotes p65
T44 915-920 Protein denotes TNF-α
T45 1135-1141 Negative_regulation denotes reduce true
T46 1154-1159 Protein denotes I-κBα
T47 1160-1175 Phosphorylation denotes phosphorylation
T48 1185-1188 Protein denotes p65
T49 1189-1204 Phosphorylation denotes phosphorylation
T50 1218-1225 Binding denotes binding
T51 1271-1279 Positive_regulation denotes enhanced
T52 1379-1387 Gene_expression denotes secreted
T53 1406-1411 Protein denotes TNF-α
R20 T32 T34 themeOf tumor necrosis factor-alpha,production
R21 T35 T37 themeOf production,following
R22 T36 T35 themeOf TNF-α,production
R23 T39 T40 themeOf TNF-α,production
R24 T40 T38 themeOf production,alters
R25 T42 T41 themeOf I-κBα,phosphorylated
R26 T46 T47 themeOf I-κBα,phosphorylation
R27 T47 T45 themeOf phosphorylation,reduce
R28 T48 T49 themeOf p65,phosphorylation
R29 T48 T50 themeOf p65,binding
R30 T49 T45 themeOf phosphorylation,reduce
R31 T50 T45 themeOf binding,reduce
R32 T53 T52 themeOf TNF-α,secreted