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PMC:2664230 / 13846-16966 JSONTXT

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bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T6229 13-20 Regulation denotes effects true
T6230 35-42 Positive_regulation denotes induced
T6231 43-48 Protein denotes TNF-α
T6232 49-59 Gene_expression denotes production
T6233 107-112 Protein denotes TNF-α
T6234 113-123 Gene_expression denotes production
T6235 134-145 Positive_regulation denotes stimulation
T6236 244-250 Regulation denotes effect
T6237 254-259 Protein denotes TNF-α
T6238 260-270 Gene_expression denotes production
T6483 548-557 Positive_regulation denotes increased
T6484 558-567 Positive_regulation denotes following
T6485 676-689 Negative_regulation denotes downregulated
T6486 694-701 Positive_regulation denotes induced
T6487 702-707 Protein denotes I-κBα
T6488 708-723 Phosphorylation denotes phosphorylation
T6489 781-784 Protein denotes p65
T6490 785-800 Phosphorylation denotes phosphorylation
T6491 805-814 Positive_regulation denotes increased
T6492 815-824 Positive_regulation denotes following
T6493 888-897 Negative_regulation denotes decreased
T6494 902-909 Positive_regulation denotes induced
T6495 916-919 Protein denotes p65
T6496 928-943 Phosphorylation denotes phosphorylation
T7586 2331-2337 Regulation denotes Effect true
T7587 2348-2353 Protein denotes TNF-α
T7588 2354-2364 Gene_expression denotes production
T7589 2365-2383 Regulation denotes in the presence of
T7590 2403-2407 Regulation denotes role
T7591 2422-2429 Positive_regulation denotes induced
T7592 2430-2444 Negative_regulation denotes downregulation
T7593 2448-2453 Protein denotes TNF-α
T7594 2454-2464 Gene_expression denotes production
T7595 2643-2651 Positive_regulation denotes resulted
T7596 2657-2666 Negative_regulation denotes reduction
T7597 2670-2675 Protein denotes TNF-α
T7598 2848-2854 Regulation denotes result true
T7599 2874-2884 Regulation denotes modulation
T7600 2888-2893 Protein denotes TNF-α
T7601 2894-2904 Gene_expression denotes production
T7602 3003-3017 Negative_regulation denotes downregulation
T7603 3021-3026 Protein denotes TNF-α
T7604 3027-3037 Gene_expression denotes production
T7605 3107-3118 Regulation denotes independent true
T6476 358-363 Positive_regulation denotes leads
T6477 386-397 Protein_catabolism denotes degradation
T6478 401-406 Protein denotes I-κBα
T6479 476-483 Regulation denotes effects true
T6480 494-499 Protein denotes I-κBα
T6481 513-518 Protein denotes I-κBα
T6482 519-534 Phosphorylation denotes phosphorylation
T7080 2268-2277 Positive_regulation denotes increased
T7081 2278-2282 Protein denotes CREB
T7082 2287-2294 Binding denotes binding
R5365 T6477 T6476 themeOf degradation,leads
R5367 T6480 T6479 themeOf I-κBα,effects
R5368 T6481 T6482 themeOf I-κBα,phosphorylation
R5369 T6482 T6483 themeOf phosphorylation,increased
R5370 T6483 T6484 themeOf increased,following
R5371 T6486 T6485 themeOf induced,downregulated
R5372 T6487 T6488 themeOf I-κBα,phosphorylation
R5373 T6488 T6486 themeOf phosphorylation,induced
R5374 T6489 T6490 themeOf p65,phosphorylation
R5375 T6490 T6491 themeOf phosphorylation,increased
R5376 T6491 T6492 themeOf increased,following
R5377 T6494 T6493 themeOf induced,decreased
R5378 T6495 T6496 themeOf p65,phosphorylation
R5379 T6496 T6494 themeOf phosphorylation,induced
R6258 T7586 T7589 themeOf Effect,in the presence of
R6259 T7587 T7588 themeOf TNF-α,production
R6260 T7588 T7586 themeOf production,Effect
R6261 T7591 T7590 themeOf induced,role
R6262 T7592 T7591 themeOf downregulation,induced
R6263 T7593 T7594 themeOf TNF-α,production
R6264 T7594 T7592 themeOf production,downregulation
R6265 T7596 T7595 themeOf reduction,resulted
R6266 T7597 T7596 themeOf TNF-α,reduction
R6267 T7599 T7598 themeOf modulation,result
R6268 T7600 T7601 themeOf TNF-α,production
R6269 T7601 T7599 themeOf production,modulation
R6270 T7602 T7605 themeOf downregulation,independent
R6271 T7603 T7604 themeOf TNF-α,production
R6272 T7604 T7602 themeOf production,downregulation
R5179 T6230 T6229 themeOf induced,effects
R5180 T6231 T6232 themeOf TNF-α,production
R5181 T6232 T6230 themeOf production,induced
R5182 T6233 T6234 themeOf TNF-α,production
R5183 T6234 T6235 themeOf production,stimulation
R5184 T6237 T6238 themeOf TNF-α,production
R5185 T6238 T6236 themeOf production,effect
R5366 T6478 T6477 themeOf I-κBα,degradation
R5874 T7081 T7082 themeOf CREB,binding
R5875 T7082 T7080 themeOf binding,increased

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T6293 9-12 DT denotes The
T6294 13-20 NN denotes effects
T6295 21-23 IN denotes of
T6296 24-27 NN denotes PTX
T6297 28-30 IN denotes on
T6298 31-42 JJ denotes LPS-induced
T6299 43-48 NN denotes TNF-α
T6300 49-59 NN denotes production
T6301 60-62 TO denotes To
T6302 63-72 VB denotes determine
T6303 73-76 DT denotes the
T6304 77-85 NN denotes duration
T6305 86-88 IN denotes of
T6306 89-92 NN denotes PDE
T6307 93-103 NN denotes inhibition
T6308 104-106 IN denotes on
T6309 107-112 NN denotes TNF-α
T6310 113-123 NN denotes production
T6311 124-129 IN denotes after
T6312 130-133 NN denotes LPS
T6313 134-145 NN denotes stimulation
T6314 145-146 -COMMA- denotes ,
T6315 147-151 NN denotes time
T6316 152-158 NN denotes course
T6317 159-166 NN denotes studies
T6318 167-171 VB denotes were
T6319 172-181 VB denotes conducted
T6320 183-185 IN denotes In
T6321 186-196 NN denotes accordance
T6322 197-201 IN denotes with
T6323 202-207 JJ denotes prior
T6324 208-212 NN denotes work
T6325 212-213 -COMMA- denotes ,
T6326 214-217 NN denotes PTX
T6327 218-221 VB denotes had
T6328 222-223 DT denotes a
T6329 224-229 JJ denotes rapid
T6330 230-233 CC denotes and
T6331 234-243 JJ denotes sustained
T6332 244-250 NN denotes effect
T6333 251-253 IN denotes on
T6334 254-259 NN denotes TNF-α
T6335 260-270 NN denotes production
T6336 271-273 FW denotes in
T6337 274-279 FW denotes vitro
T6338 280-281 -LRB- denotes (
T6339 281-287 NN denotes Figure
T6340 288-289 CD denotes 1
T6341 289-290 -RRB- denotes )
T6696 293-296 NN denotes PTX
T6697 297-306 VB denotes decreases
T6698 307-318 JJ denotes LPS-induced
T6699 319-324 NN denotes NF-κB
T6700 325-335 NN denotes activation
T6701 336-341 IN denotes Since
T6702 342-357 NN denotes phosphorylation
T6703 358-363 VB denotes leads
T6704 364-366 TO denotes to
T6705 367-381 NN denotes ubiquitination
T6706 382-385 CC denotes and
T6707 386-397 NN denotes degradation
T6708 398-400 IN denotes of
T6709 401-406 JJ denotes I-κBα
T6710 407-410 CC denotes and
T6711 411-421 JJ denotes subsequent
T6712 422-429 JJ denotes nuclear
T6713 430-443 NN denotes translocation
T6714 444-446 IN denotes of
T6715 447-452 NN denotes NF-κB
T6716 452-453 -COMMA- denotes ,
T6717 454-456 PRP denotes we
T6718 457-462 RB denotes first
T6719 463-471 VB denotes examined
T6720 472-475 DT denotes the
T6721 476-483 NN denotes effects
T6722 484-486 IN denotes of
T6723 487-490 NN denotes PTX
T6724 491-493 IN denotes on
T6725 494-499 NN denotes I-κBα
T6726 501-512 JJ denotes Cytoplasmic
T6727 513-518 JJ denotes I-κBα
T6728 519-534 NN denotes phosphorylation
T6729 535-538 VB denotes was
T6730 539-547 RB denotes markedly
T6731 548-557 VB denotes increased
T6732 558-567 VB denotes following
T6733 568-571 NN denotes LPS
T6734 572-583 NN denotes stimulation
T6735 584-588 WRB denotes when
T6736 589-597 VB denotes compared
T6737 598-600 TO denotes to
T6738 601-608 NN denotes control
T6739 609-610 -LRB- denotes (
T6740 610-613 CD denotes 100
T6741 614-615 SYM denotes ±
T6742 616-617 CD denotes 0
T6743 618-621 IN denotes vs.
T6744 622-624 CD denotes 20
T6745 625-626 CC denotes ±
T6746 627-629 CD denotes 18
T6747 629-630 -COLON- denotes ;
T6748 631-632 NN denotes P
T6749 633-634 SYM denotes <
T6750 635-639 CD denotes 0.05
T6751 639-640 -RRB- denotes )
T6752 642-645 DT denotes The
T6753 646-654 NN denotes addition
T6754 655-657 IN denotes of
T6755 658-661 NN denotes PTX
T6756 662-675 RB denotes significantly
T6757 676-689 VB denotes downregulated
T6758 690-701 JJ denotes LPS-induced
T6759 702-707 NN denotes I-κBα
T6760 708-723 NN denotes phosphorylation
T6761 724-725 -LRB- denotes (
T6762 725-726 NN denotes P
T6763 727-728 SYM denotes =
T6764 729-733 CD denotes 0.02
T6765 733-734 -COLON- denotes ;
T6766 735-741 NN denotes Figure
T6767 742-743 CD denotes 2
T6768 743-744 -RRB- denotes )
T6769 745-747 IN denotes In
T6770 748-749 DT denotes a
T6771 750-757 JJ denotes similar
T6772 758-765 NN denotes fashion
T6773 765-766 -COMMA- denotes ,
T6774 767-774 JJ denotes nuclear
T6775 775-780 NN denotes NF-κB
T6776 781-784 NN denotes p65
T6777 785-800 NN denotes phosphorylation
T6778 801-804 VB denotes was
T6779 805-814 VB denotes increased
T6780 815-824 VB denotes following
T6781 825-828 NN denotes LPS
T6782 829-840 NN denotes stimulation
T6783 841-842 -LRB- denotes (
T6784 842-845 CD denotes 100
T6785 846-847 SYM denotes ±
T6786 848-849 CD denotes 0
T6787 850-853 IN denotes vs.
T6788 854-856 CD denotes 38
T6789 857-858 CC denotes ±
T6790 859-861 CD denotes 20
T6791 861-862 -COLON- denotes ;
T6792 863-864 NN denotes P
T6793 865-866 SYM denotes <
T6794 867-871 CD denotes 0.01
T6795 871-872 -RRB- denotes )
T6796 874-877 NN denotes PTX
T6797 878-887 RB denotes similarly
T6798 888-897 VB denotes decreased
T6799 898-909 JJ denotes LPS-induced
T6800 910-915 NN denotes NF-κB
T6801 916-919 NN denotes p65
T6802 920-927 JJ denotes nuclear
T6803 928-943 NN denotes phosphorylation
T6804 943-944 -COMMA- denotes ,
T6805 945-946 DT denotes a
T6806 947-953 NN denotes marker
T6807 954-956 IN denotes of
T6808 957-962 NN denotes NF-κB
T6809 963-973 NN denotes activation
T6810 974-977 CC denotes and
T6811 978-985 JJ denotes nuclear
T6812 986-999 NN denotes translocation
T6813 1000-1001 -LRB- denotes (
T6814 1001-1004 CD denotes 100
T6815 1005-1006 SYM denotes ±
T6816 1007-1008 CD denotes 0
T6817 1009-1012 IN denotes vs.
T6818 1013-1015 CD denotes 40
T6819 1016-1017 CC denotes ±
T6820 1018-1019 CD denotes 6
T6821 1019-1020 -COLON- denotes ;
T6822 1021-1022 NN denotes P
T6823 1023-1028 CD denotes =0.03
T6824 1028-1029 -COLON- denotes ;
T6825 1030-1036 NN denotes Figure
T6826 1037-1039 NN denotes 3A
T6827 1039-1040 -RRB- denotes )
T6828 1042-1047 NN denotes EMSAs
T6829 1048-1052 VB denotes were
T6830 1053-1057 RB denotes then
T6831 1058-1067 VB denotes performed
T6832 1068-1070 TO denotes to
T6833 1071-1077 VB denotes verify
T6834 1078-1081 DT denotes the
T6835 1082-1093 JJ denotes PTX-induced
T6836 1094-1105 NN denotes alterations
T6837 1106-1108 IN denotes in
T6838 1109-1116 JJ denotes nuclear
T6839 1117-1132 NN denotes phosphorylation
T6840 1133-1141 VB denotes resulted
T6841 1142-1144 IN denotes in
T6842 1145-1152 JJ denotes similar
T6843 1153-1160 NN denotes effects
T6844 1161-1163 IN denotes on
T6845 1164-1167 DT denotes the
T6846 1168-1171 NN denotes DNA
T6847 1172-1179 NN denotes binding
T6848 1180-1188 NN denotes activity
T6849 1189-1191 IN denotes of
T6850 1192-1197 NN denotes NF-κB
T6851 1199-1202 DT denotes The
T6852 1203-1211 NN denotes addition
T6853 1212-1214 IN denotes of
T6854 1215-1218 NN denotes PTX
T6855 1219-1221 TO denotes to
T6856 1222-1236 JJ denotes LPS-stimulated
T6857 1237-1248 JJ denotes mononuclear
T6858 1249-1254 NN denotes cells
T6859 1255-1263 VB denotes resulted
T6860 1264-1266 IN denotes in
T6861 1267-1277 JJ denotes comparable
T6862 1278-1292 NN denotes downregulation
T6863 1293-1295 IN denotes of
T6864 1296-1299 NN denotes DNA
T6865 1300-1307 NN denotes binding
T6866 1308-1316 NN denotes activity
T6867 1316-1317 -COMMA- denotes ,
T6868 1318-1325 JJ denotes similar
T6869 1326-1328 TO denotes to
T6870 1329-1332 DT denotes the
T6871 1333-1341 VB denotes observed
T6872 1342-1356 NN denotes downregulation
T6873 1357-1359 IN denotes of
T6874 1360-1365 NN denotes NF-κB
T6875 1366-1381 NN denotes phosphorylation
T6876 1382-1383 -LRB- denotes (
T6877 1383-1389 NN denotes Figure
T6878 1390-1392 NN denotes 3B
T6879 1392-1393 -RRB- denotes )
T7258 1396-1399 NN denotes PTX
T7259 1400-1411 VB denotes upregulates
T7260 1412-1416 NN denotes CREB
T7261 1417-1432 NN denotes phosphorylation
T7262 1433-1436 CC denotes and
T7263 1437-1447 NN denotes activation
T7264 1448-1453 IN denotes after
T7265 1454-1457 NN denotes LPS
T7266 1458-1469 NN denotes stimulation
T7267 1470-1485 NN denotes Phosphorylation
T7268 1486-1488 IN denotes of
T7269 1489-1496 JJ denotes nuclear
T7270 1497-1501 NN denotes CREB
T7271 1502-1505 VB denotes was
T7272 1506-1510 VB denotes used
T7273 1511-1513 IN denotes as
T7274 1514-1515 DT denotes a
T7275 1516-1522 NN denotes marker
T7276 1523-1526 IN denotes for
T7277 1527-1531 NN denotes CREB
T7278 1532-1542 NN denotes activation
T7279 1544-1547 NN denotes LPS
T7280 1548-1559 NN denotes stimulation
T7281 1560-1566 VB denotes caused
T7282 1567-1568 DT denotes a
T7283 1569-1579 JJ denotes negligible
T7284 1580-1588 NN denotes increase
T7285 1589-1591 IN denotes in
T7286 1592-1596 NN denotes CREB
T7287 1597-1612 NN denotes phosphorylation
T7288 1613-1617 WRB denotes when
T7289 1618-1626 VB denotes compared
T7290 1627-1629 TO denotes to
T7291 1630-1637 NN denotes control
T7292 1638-1639 -LRB- denotes (
T7293 1639-1645 NN denotes Figure
T7294 1646-1648 NN denotes 4A
T7295 1648-1649 -RRB- denotes )
T7296 1651-1654 NN denotes PTX
T7297 1655-1660 RB denotes alone
T7298 1661-1667 VB denotes caused
T7299 1668-1669 DT denotes a
T7300 1670-1676 JJ denotes marked
T7301 1677-1685 NN denotes increase
T7302 1686-1688 IN denotes in
T7303 1689-1693 NN denotes CREB
T7304 1694-1709 NN denotes phosphorylation
T7305 1710-1711 -LRB- denotes (
T7306 1711-1712 NN denotes P
T7307 1713-1714 JJ denotes <
T7308 1715-1719 CD denotes 0.01
T7309 1720-1723 CC denotes vs.
T7310 1724-1728 NN denotes HBSS
T7311 1728-1729 -RRB- denotes )
T7312 1731-1735 WRB denotes When
T7313 1736-1739 NN denotes LPS
T7314 1740-1743 CC denotes and
T7315 1744-1747 NN denotes PTX
T7316 1748-1756 NN denotes exposure
T7317 1757-1765 VB denotes occurred
T7318 1766-1780 RB denotes simultaneously
T7319 1780-1781 -COMMA- denotes ,
T7320 1782-1786 NN denotes CREB
T7321 1787-1802 NN denotes phosphorylation
T7322 1803-1806 VB denotes was
T7323 1807-1820 RB denotes significantly
T7324 1821-1827 JJ denotes higher
T7325 1828-1832 IN denotes than
T7326 1833-1837 IN denotes with
T7327 1838-1841 NN denotes LPS
T7328 1842-1853 NN denotes stimulation
T7329 1854-1859 RB denotes alone
T7330 1860-1861 -LRB- denotes (
T7331 1861-1864 CD denotes 543
T7332 1865-1866 CC denotes ±
T7333 1867-1869 CD denotes 92
T7334 1870-1873 IN denotes vs.
T7335 1874-1877 CD denotes 100
T7336 1878-1879 SYM denotes ±
T7337 1880-1881 CD denotes 0
T7338 1881-1882 -COLON- denotes ;
T7339 1883-1884 NN denotes P
T7340 1885-1886 SYM denotes <
T7341 1887-1891 CD denotes 0.01
T7342 1891-1892 -RRB- denotes )
T7343 1894-1896 IN denotes In
T7344 1897-1905 NN denotes addition
T7345 1905-1906 -COMMA- denotes ,
T7346 1907-1910 DT denotes the
T7347 1911-1917 NN denotes amount
T7348 1918-1920 IN denotes of
T7349 1921-1925 NN denotes CREB
T7350 1926-1941 NN denotes phosphorylation
T7351 1942-1946 VB denotes seen
T7352 1947-1951 IN denotes with
T7353 1952-1963 JJ denotes concomitant
T7354 1964-1967 NN denotes LPS
T7355 1968-1971 CC denotes and
T7356 1972-1975 NN denotes PTX
T7357 1976-1985 NN denotes treatment
T7358 1986-1989 VB denotes was
T7359 1990-1994 JJ denotes less
T7360 1995-1999 IN denotes than
T7361 2000-2004 DT denotes that
T7362 2005-2009 VB denotes seen
T7363 2010-2014 IN denotes with
T7364 2015-2018 NN denotes PTX
T7365 2019-2024 RB denotes alone
T7366 2024-2025 -COMMA- denotes ,
T7367 2026-2034 IN denotes although
T7368 2035-2039 DT denotes this
T7369 2040-2050 NN denotes difference
T7370 2051-2054 VB denotes was
T7371 2055-2058 RB denotes not
T7372 2059-2072 RB denotes statistically
T7373 2073-2084 JJ denotes significant
T7374 2085-2086 -LRB- denotes (
T7375 2086-2087 NN denotes P
T7376 2088-2089 SYM denotes =
T7377 2090-2094 CD denotes 0.08
T7378 2094-2095 -RRB- denotes )
T7379 2097-2099 TO denotes To
T7380 2100-2109 VB denotes determine
T7381 2110-2112 IN denotes if
T7382 2113-2121 NN denotes CREB-DNA
T7383 2122-2129 NN denotes binding
T7384 2130-2133 VB denotes was
T7385 2134-2142 VB denotes affected
T7386 2143-2145 IN denotes by
T7387 2146-2149 NN denotes PTX
T7388 2150-2152 IN denotes in
T7389 2153-2154 DT denotes a
T7390 2155-2161 NN denotes manner
T7391 2162-2169 JJ denotes similar
T7392 2170-2172 TO denotes to
T7393 2173-2177 NN denotes CREB
T7394 2178-2193 NN denotes phosphorylation
T7395 2193-2194 -COMMA- denotes ,
T7396 2195-2197 DT denotes an
T7397 2198-2202 NN denotes EMSA
T7398 2203-2206 VB denotes was
T7399 2207-2216 VB denotes performed
T7400 2218-2226 NN denotes Exposure
T7401 2227-2229 IN denotes of
T7402 2230-2244 JJ denotes LPS-stimulated
T7403 2245-2250 NN denotes cells
T7404 2251-2253 TO denotes to
T7405 2254-2257 NN denotes PTX
T7406 2258-2267 RB denotes similarly
T7407 2268-2277 VB denotes increased
T7408 2278-2282 NN denotes CREB
T7409 2283-2294 NN denotes DNA-binding
T7410 2295-2303 VB denotes compared
T7411 2304-2306 TO denotes to
T7412 2307-2310 NN denotes LPS
T7413 2311-2316 RB denotes alone
T7414 2317-2318 -LRB- denotes (
T7415 2318-2324 NN denotes Figure
T7416 2325-2327 NN denotes 4B
T7417 2327-2328 -RRB- denotes )
T7755 2331-2337 NN denotes Effect
T7756 2338-2340 IN denotes of
T7757 2341-2344 NN denotes PTX
T7758 2345-2347 IN denotes on
T7759 2348-2353 NN denotes TNF-α
T7760 2354-2364 NN denotes production
T7761 2365-2367 IN denotes in
T7762 2368-2371 DT denotes the
T7763 2372-2380 NN denotes presence
T7764 2381-2383 IN denotes of
T7765 2384-2387 NN denotes PKA
T7766 2388-2398 NN denotes inhibition
T7767 2399-2402 DT denotes The
T7768 2403-2407 NN denotes role
T7769 2408-2410 IN denotes of
T7770 2411-2414 NN denotes PKA
T7771 2415-2417 IN denotes in
T7772 2418-2429 JJ denotes PTX-induced
T7773 2430-2444 NN denotes downregulation
T7774 2445-2447 IN denotes of
T7775 2448-2453 NN denotes TNF-α
T7776 2454-2464 NN denotes production
T7777 2465-2467 IN denotes in
T7778 2468-2482 JJ denotes LPS-stimulated
T7779 2483-2494 JJ denotes mononuclear
T7780 2495-2500 NN denotes cells
T7781 2501-2504 VB denotes was
T7782 2505-2513 VB denotes assessed
T7783 2514-2516 IN denotes by
T7784 2517-2525 VB denotes treating
T7785 2526-2537 JJ denotes mononuclear
T7786 2538-2543 NN denotes cells
T7787 2544-2548 IN denotes with
T7788 2549-2552 NN denotes H89
T7789 2552-2553 -COMMA- denotes ,
T7790 2554-2555 DT denotes a
T7791 2556-2559 NN denotes PKA
T7792 2560-2569 NN denotes inhibitor
T7793 2569-2570 -COMMA- denotes ,
T7794 2571-2576 JJ denotes prior
T7795 2577-2579 TO denotes to
T7796 2580-2583 NN denotes LPS
T7797 2584-2587 CC denotes and
T7798 2588-2591 NN denotes PTX
T7799 2592-2600 NN denotes exposure
T7800 2602-2605 DT denotes The
T7801 2606-2614 NN denotes addition
T7802 2615-2618 NN denotes PTX
T7803 2619-2621 TO denotes to
T7804 2622-2636 JJ denotes LPS-stimulated
T7805 2637-2642 NN denotes cells
T7806 2643-2651 VB denotes resulted
T7807 2652-2654 IN denotes in
T7808 2655-2656 DT denotes a
T7809 2657-2666 NN denotes reduction
T7810 2667-2669 IN denotes in
T7811 2670-2675 NN denotes TNF-α
T7812 2675-2676 -COMMA- denotes ,
T7813 2677-2684 JJ denotes similar
T7814 2685-2687 TO denotes to
T7815 2688-2692 DT denotes that
T7816 2693-2701 VB denotes observed
T7817 2702-2704 IN denotes in
T7818 2705-2708 PRP-DOLLAR- denotes our
T7819 2709-2717 JJ denotes previous
T7820 2718-2729 NN denotes experiments
T7821 2730-2731 -LRB- denotes (
T7822 2731-2734 CD denotes 529
T7823 2735-2740 NN denotes pg/mL
T7824 2741-2742 IN denotes ±
T7825 2743-2746 CD denotes 112
T7826 2747-2750 IN denotes vs.
T7827 2751-2753 CD denotes 37
T7828 2754-2759 NN denotes pg/mL
T7829 2760-2761 NN denotes ±
T7830 2762-2764 CD denotes 10
T7831 2764-2765 -COLON- denotes ;
T7832 2766-2767 NN denotes P
T7833 2768-2769 SYM denotes <
T7834 2770-2774 CD denotes 0.01
T7835 2774-2775 -RRB- denotes )
T7836 2777-2791 NN denotes Pre-incubation
T7837 2792-2794 IN denotes of
T7838 2795-2800 NN denotes cells
T7839 2801-2805 IN denotes with
T7840 2806-2809 NN denotes H89
T7841 2810-2815 JJ denotes prior
T7842 2816-2818 TO denotes to
T7843 2819-2822 NN denotes LPS
T7844 2823-2826 CC denotes and
T7845 2827-2830 NN denotes PTX
T7846 2831-2839 NN denotes exposure
T7847 2840-2843 VB denotes did
T7848 2844-2847 RB denotes not
T7849 2848-2854 VB denotes result
T7850 2855-2857 IN denotes in
T7851 2858-2861 DT denotes any
T7852 2862-2873 JJ denotes significant
T7853 2874-2884 NN denotes modulation
T7854 2885-2887 IN denotes of
T7855 2888-2893 NN denotes TNF-α
T7856 2894-2904 NN denotes production
T7857 2905-2909 WRB denotes when
T7858 2910-2918 VB denotes compared
T7859 2919-2921 TO denotes to
T7860 2922-2926 DT denotes that
T7861 2927-2939 VB denotes demonstrated
T7862 2940-2944 IN denotes with
T7863 2945-2948 NN denotes PTX
T7864 2949-2954 RB denotes alone
T7865 2955-2956 -LRB- denotes (
T7866 2956-2957 NN denotes P
T7867 2958-2959 SYM denotes =
T7868 2960-2963 CD denotes 0.2
T7869 2963-2964 -COLON- denotes ;
T7870 2965-2971 NN denotes Figure
T7871 2972-2973 CD denotes 5
T7872 2973-2974 -RRB- denotes )
T7873 2976-2981 DT denotes These
T7874 2982-2989 NN denotes results
T7875 2990-2997 VB denotes suggest
T7876 2998-3002 IN denotes that
T7877 3003-3017 NN denotes downregulation
T7878 3018-3020 IN denotes of
T7879 3021-3026 NN denotes TNF-α
T7880 3027-3037 NN denotes production
T7881 3038-3040 IN denotes by
T7882 3041-3044 NN denotes PTX
T7883 3045-3047 IN denotes in
T7884 3048-3062 JJ denotes LPS-stimulated
T7885 3063-3074 JJ denotes mononuclear
T7886 3075-3080 NN denotes cells
T7887 3081-3083 VB denotes is
T7888 3083-3084 -COMMA- denotes ,
T7889 3085-3087 IN denotes at
T7890 3088-3093 JJ denotes least
T7891 3094-3096 IN denotes in
T7892 3097-3101 NN denotes part
T7893 3101-3102 -COMMA- denotes ,
T7894 3103-3118 JJ denotes PKA-independent
R5237 T6294 T6293 arg1Of effects,The
R5238 T6294 T6295 arg1Of effects,of
R5239 T6294 T6297 arg1Of effects,on
R5240 T6296 T6295 arg2Of PTX,of
R5241 T6300 T6297 arg2Of production,on
R5242 T6300 T6298 arg1Of production,LPS-induced
R5243 T6300 T6299 arg1Of production,TNF-α
R5244 T6302 T6301 arg1Of determine,To
R5245 T6302 T6311 arg1Of determine,after
R5246 T6304 T6302 arg2Of duration,determine
R5247 T6304 T6303 arg1Of duration,the
R5248 T6304 T6305 arg1Of duration,of
R5249 T6304 T6308 arg1Of duration,on
R5250 T6307 T6305 arg2Of inhibition,of
R5251 T6307 T6306 arg1Of inhibition,PDE
R5252 T6310 T6308 arg2Of production,on
R5253 T6310 T6309 arg1Of production,TNF-α
R5254 T6313 T6311 arg2Of stimulation,after
R5255 T6313 T6312 arg1Of stimulation,LPS
R5256 T6317 T6315 arg1Of studies,time
R5257 T6317 T6316 arg1Of studies,course
R5258 T6317 T6318 arg1Of studies,were
R5259 T6317 T6319 arg2Of studies,conducted
R5260 T6319 T6301 modOf conducted,To
R5261 T6319 T6314 arg1Of conducted,","
R5262 T6319 T6318 arg2Of conducted,were
R5263 T6321 T6320 arg2Of accordance,In
R5264 T6321 T6322 arg1Of accordance,with
R5265 T6324 T6322 arg2Of work,with
R5266 T6324 T6323 arg1Of work,prior
R5267 T6326 T6327 arg1Of PTX,had
R5268 T6327 T6320 arg1Of had,In
R5269 T6327 T6325 arg1Of had,","
R5270 T6327 T6333 arg1Of had,on
R5271 T6329 T6330 arg1Of rapid,and
R5272 T6331 T6330 arg2Of sustained,and
R5273 T6332 T6327 arg2Of effect,had
R5274 T6332 T6328 arg1Of effect,a
R5275 T6332 T6329 arg1Of effect,rapid
R5276 T6332 T6331 arg1Of effect,sustained
R5277 T6335 T6333 arg2Of production,on
R5278 T6335 T6334 arg1Of production,TNF-α
R5279 T6335 T6337 arg1Of production,vitro
R5280 T6335 T6338 arg1Of production,(
R5281 T6337 T6336 arg1Of vitro,in
R5282 T6339 T6338 arg2Of Figure,(
R5283 T6339 T6340 arg1Of Figure,1
R5284 T6341 T6338 arg3Of ),(
R5571 T6696 T6697 arg1Of PTX,decreases
R5572 T6700 T6697 arg2Of activation,decreases
R5573 T6700 T6698 arg1Of activation,LPS-induced
R5574 T6700 T6699 arg1Of activation,NF-κB
R5575 T6702 T6703 arg1Of phosphorylation,leads
R5576 T6703 T6701 arg2Of leads,Since
R5577 T6703 T6704 arg1Of leads,to
R5578 T6705 T6706 arg1Of ubiquitination,and
R5579 T6706 T6704 arg2Of and,to
R5580 T6706 T6708 arg1Of and,of
R5581 T6707 T6706 arg2Of degradation,and
R5582 T6709 T6710 arg1Of I-κBα,and
R5583 T6711 T6710 arg2Of subsequent,and
R5584 T6713 T6708 arg2Of translocation,of
R5585 T6713 T6709 arg1Of translocation,I-κBα
R5586 T6713 T6711 arg1Of translocation,subsequent
R5587 T6713 T6712 arg1Of translocation,nuclear
R5588 T6713 T6714 arg1Of translocation,of
R5589 T6715 T6714 arg2Of NF-κB,of
R5590 T6717 T6719 arg1Of we,examined
R5591 T6719 T6701 arg1Of examined,Since
R5592 T6719 T6716 arg1Of examined,","
R5593 T6719 T6718 arg1Of examined,first
R5594 T6721 T6719 arg2Of effects,examined
R5595 T6721 T6720 arg1Of effects,the
R5596 T6721 T6722 arg1Of effects,of
R5597 T6721 T6724 arg1Of effects,on
R5598 T6723 T6722 arg2Of PTX,of
R5599 T6725 T6724 arg2Of I-κBα,on
R5600 T6728 T6726 arg1Of phosphorylation,Cytoplasmic
R5601 T6728 T6727 arg1Of phosphorylation,I-κBα
R5602 T6728 T6729 arg1Of phosphorylation,was
R5603 T6728 T6731 arg2Of phosphorylation,increased
R5604 T6728 T6736 arg1Of phosphorylation,compared
R5605 T6731 T6729 arg2Of increased,was
R5606 T6731 T6730 arg1Of increased,markedly
R5607 T6731 T6732 arg1Of increased,following
R5608 T6731 T6735 arg1Of increased,when
R5609 T6734 T6732 arg2Of stimulation,following
R5610 T6734 T6733 arg1Of stimulation,LPS
R5611 T6736 T6735 arg2Of compared,when
R5612 T6736 T6737 arg1Of compared,to
R5613 T6738 T6737 arg2Of control,to
R5614 T6738 T6739 arg1Of control,(
R5615 T6742 T6739 arg2Of 0,(
R5616 T6742 T6740 arg1Of 0,100
R5617 T6742 T6741 arg1Of 0,±
R5618 T6742 T6743 arg1Of 0,vs.
R5619 T6742 T6747 arg1Of 0,;
R5620 T6744 T6745 arg1Of 20,±
R5621 T6745 T6743 arg2Of ±,vs.
R5622 T6746 T6745 arg2Of 18,±
R5623 T6748 T6747 arg2Of P,;
R5624 T6748 T6749 arg1Of P,<
R5625 T6748 T6750 arg1Of P,0.05
R5626 T6751 T6739 arg3Of ),(
R5627 T6753 T6752 arg1Of addition,The
R5628 T6753 T6754 arg1Of addition,of
R5629 T6753 T6757 arg1Of addition,downregulated
R5630 T6755 T6754 arg2Of PTX,of
R5631 T6757 T6756 arg1Of downregulated,significantly
R5632 T6760 T6757 arg2Of phosphorylation,downregulated
R5633 T6760 T6758 arg1Of phosphorylation,LPS-induced
R5634 T6760 T6759 arg1Of phosphorylation,I-κBα
R5635 T6760 T6761 arg1Of phosphorylation,(
R5636 T6762 T6761 arg2Of P,(
R5637 T6762 T6763 arg1Of P,=
R5638 T6762 T6764 arg1Of P,0.02
R5639 T6762 T6765 arg1Of P,;
R5640 T6766 T6765 arg2Of Figure,;
R5641 T6766 T6767 arg1Of Figure,2
R5642 T6768 T6761 arg3Of ),(
R5643 T6772 T6769 arg2Of fashion,In
R5644 T6772 T6770 arg1Of fashion,a
R5645 T6772 T6771 arg1Of fashion,similar
R5646 T6777 T6774 arg1Of phosphorylation,nuclear
R5647 T6777 T6775 arg1Of phosphorylation,NF-κB
R5648 T6777 T6776 arg1Of phosphorylation,p65
R5649 T6777 T6778 arg1Of phosphorylation,was
R5650 T6777 T6779 arg2Of phosphorylation,increased
R5651 T6779 T6769 arg1Of increased,In
R5652 T6779 T6773 arg1Of increased,","
R5653 T6779 T6778 arg2Of increased,was
R5654 T6779 T6780 arg1Of increased,following
R5655 T6782 T6780 arg2Of stimulation,following
R5656 T6782 T6781 arg1Of stimulation,LPS
R5657 T6782 T6783 arg1Of stimulation,(
R5658 T6786 T6783 arg2Of 0,(
R5659 T6786 T6784 arg1Of 0,100
R5660 T6786 T6785 arg1Of 0,±
R5661 T6786 T6787 arg1Of 0,vs.
R5662 T6786 T6791 arg1Of 0,;
R5663 T6788 T6789 arg1Of 38,±
R5664 T6789 T6787 arg2Of ±,vs.
R5665 T6790 T6789 arg2Of 20,±
R5666 T6792 T6791 arg2Of P,;
R5667 T6792 T6793 arg1Of P,<
R5668 T6792 T6794 arg1Of P,0.01
R5669 T6795 T6783 arg3Of ),(
R5670 T6796 T6798 arg1Of PTX,decreased
R5671 T6798 T6797 arg1Of decreased,similarly
R5672 T6803 T6798 arg2Of phosphorylation,decreased
R5673 T6803 T6799 arg1Of phosphorylation,LPS-induced
R5674 T6803 T6800 arg1Of phosphorylation,NF-κB
R5675 T6803 T6801 arg1Of phosphorylation,p65
R5676 T6803 T6802 arg1Of phosphorylation,nuclear
R5677 T6803 T6804 arg1Of phosphorylation,","
R5678 T6806 T6804 arg2Of marker,","
R5679 T6806 T6805 arg1Of marker,a
R5680 T6806 T6807 arg1Of marker,of
R5681 T6809 T6808 arg1Of activation,NF-κB
R5682 T6809 T6810 arg1Of activation,and
R5683 T6810 T6807 arg2Of and,of
R5684 T6812 T6810 arg2Of translocation,and
R5685 T6812 T6811 arg1Of translocation,nuclear
R5686 T6812 T6813 arg1Of translocation,(
R5687 T6816 T6813 arg2Of 0,(
R5688 T6816 T6814 arg1Of 0,100
R5689 T6816 T6815 arg1Of 0,±
R5690 T6816 T6817 arg1Of 0,vs.
R5691 T6816 T6821 arg1Of 0,;
R5692 T6816 T6824 arg1Of 0,;
R5693 T6818 T6819 arg1Of 40,±
R5694 T6819 T6817 arg2Of ±,vs.
R5695 T6820 T6819 arg2Of 6,±
R5696 T6822 T6821 arg2Of P,;
R5697 T6822 T6823 arg1Of P,=0.03
R5698 T6826 T6824 arg2Of 3A,;
R5699 T6826 T6825 arg1Of 3A,Figure
R5700 T6827 T6813 arg3Of ),(
R5701 T6828 T6829 arg1Of EMSAs,were
R5702 T6828 T6831 arg2Of EMSAs,performed
R5703 T6831 T6829 arg2Of performed,were
R5704 T6831 T6830 arg1Of performed,then
R5705 T6833 T6831 arg3Of verify,performed
R5706 T6833 T6832 arg1Of verify,to
R5707 T6836 T6834 arg1Of alterations,the
R5708 T6836 T6835 arg1Of alterations,PTX-induced
R5709 T6836 T6837 arg1Of alterations,in
R5710 T6836 T6840 arg1Of alterations,resulted
R5711 T6839 T6837 arg2Of phosphorylation,in
R5712 T6839 T6838 arg1Of phosphorylation,nuclear
R5713 T6840 T6833 arg2Of resulted,verify
R5714 T6840 T6841 arg1Of resulted,in
R5715 T6840 T6844 arg1Of resulted,on
R5716 T6843 T6841 arg2Of effects,in
R5717 T6843 T6842 arg1Of effects,similar
R5718 T6848 T6844 arg2Of activity,on
R5719 T6848 T6845 arg1Of activity,the
R5720 T6848 T6846 arg1Of activity,DNA
R5721 T6848 T6847 arg1Of activity,binding
R5722 T6848 T6849 arg1Of activity,of
R5723 T6850 T6849 arg2Of NF-κB,of
R5724 T6852 T6851 arg1Of addition,The
R5725 T6852 T6853 arg1Of addition,of
R5726 T6852 T6855 arg1Of addition,to
R5727 T6852 T6859 arg1Of addition,resulted
R5728 T6854 T6853 arg2Of PTX,of
R5729 T6858 T6855 arg2Of cells,to
R5730 T6858 T6856 arg1Of cells,LPS-stimulated
R5731 T6858 T6857 arg1Of cells,mononuclear
R5732 T6859 T6860 arg1Of resulted,in
R5733 T6859 T6867 arg1Of resulted,","
R5734 T6862 T6860 arg2Of downregulation,in
R5735 T6862 T6861 arg1Of downregulation,comparable
R5736 T6862 T6863 arg1Of downregulation,of
R5737 T6866 T6863 arg2Of activity,of
R5738 T6866 T6864 arg1Of activity,DNA
R5739 T6866 T6865 arg1Of activity,binding
R5740 T6868 T6859 arg2Of similar,resulted
R5741 T6868 T6869 arg1Of similar,to
R5742 T6872 T6869 arg2Of downregulation,to
R5743 T6872 T6870 arg1Of downregulation,the
R5744 T6872 T6871 arg2Of downregulation,observed
R5745 T6872 T6873 arg1Of downregulation,of
R5746 T6875 T6873 arg2Of phosphorylation,of
R5747 T6875 T6874 arg1Of phosphorylation,NF-κB
R5748 T6875 T6876 arg1Of phosphorylation,(
R5749 T6878 T6876 arg2Of 3B,(
R5750 T6878 T6877 arg1Of 3B,Figure
R5751 T6879 T6876 arg3Of ),(
R6043 T7258 T7259 arg1Of PTX,upregulates
R6044 T7259 T7264 arg1Of upregulates,after
R6045 T7261 T7262 arg1Of phosphorylation,and
R6046 T7262 T7259 arg2Of and,upregulates
R6047 T7262 T7260 arg1Of and,CREB
R6048 T7263 T7262 arg2Of activation,and
R6049 T7266 T7264 arg2Of stimulation,after
R6050 T7266 T7265 arg1Of stimulation,LPS
R6051 T7267 T7268 arg1Of Phosphorylation,of
R6052 T7267 T7271 arg1Of Phosphorylation,was
R6053 T7267 T7272 arg2Of Phosphorylation,used
R6054 T7270 T7268 arg2Of CREB,of
R6055 T7270 T7269 arg1Of CREB,nuclear
R6056 T7272 T7271 arg2Of used,was
R6057 T7272 T7273 arg1Of used,as
R6058 T7275 T7273 arg2Of marker,as
R6059 T7275 T7274 arg1Of marker,a
R6060 T7275 T7276 arg1Of marker,for
R6061 T7278 T7276 arg2Of activation,for
R6062 T7278 T7277 arg1Of activation,CREB
R6063 T7280 T7279 arg1Of stimulation,LPS
R6064 T7280 T7281 arg1Of stimulation,caused
R6065 T7280 T7289 arg1Of stimulation,compared
R6066 T7281 T7288 arg1Of caused,when
R6067 T7284 T7281 arg2Of increase,caused
R6068 T7284 T7282 arg1Of increase,a
R6069 T7284 T7283 arg1Of increase,negligible
R6070 T7284 T7285 arg1Of increase,in
R6071 T7287 T7285 arg2Of phosphorylation,in
R6072 T7287 T7286 arg1Of phosphorylation,CREB
R6073 T7289 T7288 arg2Of compared,when
R6074 T7289 T7290 arg1Of compared,to
R6075 T7291 T7290 arg2Of control,to
R6076 T7291 T7292 arg1Of control,(
R6077 T7294 T7292 arg2Of 4A,(
R6078 T7294 T7293 arg1Of 4A,Figure
R6079 T7295 T7292 arg3Of ),(
R6080 T7296 T7297 arg1Of PTX,alone
R6081 T7296 T7298 arg1Of PTX,caused
R6082 T7301 T7298 arg2Of increase,caused
R6083 T7301 T7299 arg1Of increase,a
R6084 T7301 T7300 arg1Of increase,marked
R6085 T7301 T7302 arg1Of increase,in
R6086 T7304 T7302 arg2Of phosphorylation,in
R6087 T7304 T7303 arg1Of phosphorylation,CREB
R6088 T7304 T7305 arg1Of phosphorylation,(
R6089 T7306 T7305 arg2Of P,(
R6090 T7306 T7307 arg1Of P,<
R6091 T7306 T7309 arg1Of P,vs.
R6092 T7307 T7308 arg1Of <,0.01
R6093 T7310 T7309 arg2Of HBSS,vs.
R6094 T7311 T7305 arg3Of ),(
R6095 T7313 T7314 arg1Of LPS,and
R6096 T7314 T7317 arg1Of and,occurred
R6097 T7316 T7314 arg2Of exposure,and
R6098 T7316 T7315 arg1Of exposure,PTX
R6099 T7317 T7312 arg2Of occurred,When
R6100 T7317 T7318 arg1Of occurred,simultaneously
R6101 T7321 T7320 arg1Of phosphorylation,CREB
R6102 T7321 T7322 arg1Of phosphorylation,was
R6103 T7321 T7324 arg1Of phosphorylation,higher
R6104 T7322 T7312 arg1Of was,When
R6105 T7322 T7319 arg1Of was,","
R6106 T7322 T7330 arg1Of was,(
R6107 T7324 T7322 arg2Of higher,was
R6108 T7324 T7323 arg1Of higher,significantly
R6109 T7324 T7325 arg1Of higher,than
R6110 T7326 T7325 arg2Of with,than
R6111 T7328 T7326 arg2Of stimulation,with
R6112 T7328 T7327 arg1Of stimulation,LPS
R6113 T7328 T7329 arg1Of stimulation,alone
R6114 T7331 T7332 arg1Of 543,±
R6115 T7332 T7330 arg2Of ±,(
R6116 T7332 T7334 arg1Of ±,vs.
R6117 T7332 T7338 arg1Of ±,;
R6118 T7333 T7332 arg2Of 92,±
R6119 T7337 T7334 arg2Of 0,vs.
R6120 T7337 T7335 arg1Of 0,100
R6121 T7337 T7336 arg1Of 0,±
R6122 T7339 T7338 arg2Of P,;
R6123 T7339 T7340 arg1Of P,<
R6124 T7339 T7341 arg1Of P,0.01
R6125 T7342 T7330 arg3Of ),(
R6126 T7344 T7343 arg2Of addition,In
R6127 T7347 T7346 arg1Of amount,the
R6128 T7347 T7348 arg1Of amount,of
R6129 T7347 T7358 arg1Of amount,was
R6130 T7347 T7359 arg1Of amount,less
R6131 T7350 T7348 arg2Of phosphorylation,of
R6132 T7350 T7349 arg1Of phosphorylation,CREB
R6133 T7350 T7351 arg2Of phosphorylation,seen
R6134 T7351 T7352 arg1Of seen,with
R6135 T7354 T7353 arg1Of LPS,concomitant
R6136 T7354 T7355 arg1Of LPS,and
R6137 T7355 T7352 arg2Of and,with
R6138 T7357 T7355 arg2Of treatment,and
R6139 T7357 T7356 arg1Of treatment,PTX
R6140 T7358 T7343 arg1Of was,In
R6141 T7358 T7345 arg1Of was,","
R6142 T7358 T7366 arg1Of was,","
R6143 T7358 T7367 arg1Of was,although
R6144 T7359 T7358 arg2Of less,was
R6145 T7359 T7360 arg1Of less,than
R6146 T7361 T7360 arg2Of that,than
R6147 T7361 T7362 arg2Of that,seen
R6148 T7362 T7363 arg1Of seen,with
R6149 T7364 T7363 arg2Of PTX,with
R6150 T7364 T7365 arg1Of PTX,alone
R6151 T7369 T7368 arg1Of difference,this
R6152 T7369 T7370 arg1Of difference,was
R6153 T7369 T7373 arg1Of difference,significant
R6154 T7370 T7367 arg2Of was,although
R6155 T7370 T7371 arg1Of was,not
R6156 T7370 T7372 arg1Of was,statistically
R6157 T7373 T7370 arg2Of significant,was
R6158 T7373 T7374 arg1Of significant,(
R6159 T7375 T7374 arg2Of P,(
R6160 T7375 T7376 arg1Of P,=
R6161 T7375 T7377 arg1Of P,0.08
R6162 T7378 T7374 arg3Of ),(
R6163 T7380 T7379 arg1Of determine,To
R6164 T7383 T7382 arg1Of binding,CREB-DNA
R6165 T7383 T7384 arg1Of binding,was
R6166 T7383 T7385 arg2Of binding,affected
R6167 T7385 T7380 arg2Of affected,determine
R6168 T7385 T7381 arg1Of affected,if
R6169 T7385 T7384 arg2Of affected,was
R6170 T7385 T7388 arg1Of affected,in
R6171 T7387 T7385 arg1Of PTX,affected
R6172 T7387 T7386 arg2Of PTX,by
R6173 T7390 T7388 arg2Of manner,in
R6174 T7390 T7389 arg1Of manner,a
R6175 T7390 T7391 arg1Of manner,similar
R6176 T7391 T7392 arg1Of similar,to
R6177 T7394 T7392 arg2Of phosphorylation,to
R6178 T7394 T7393 arg1Of phosphorylation,CREB
R6179 T7397 T7396 arg1Of EMSA,an
R6180 T7397 T7398 arg1Of EMSA,was
R6181 T7397 T7399 arg2Of EMSA,performed
R6182 T7399 T7379 modOf performed,To
R6183 T7399 T7395 arg1Of performed,","
R6184 T7399 T7398 arg2Of performed,was
R6185 T7400 T7401 arg1Of Exposure,of
R6186 T7400 T7404 arg1Of Exposure,to
R6187 T7400 T7407 arg1Of Exposure,increased
R6188 T7403 T7401 arg2Of cells,of
R6189 T7403 T7402 arg1Of cells,LPS-stimulated
R6190 T7405 T7404 arg2Of PTX,to
R6191 T7407 T7406 arg1Of increased,similarly
R6192 T7407 T7410 arg1Of increased,compared
R6193 T7409 T7407 arg2Of DNA-binding,increased
R6194 T7409 T7408 arg1Of DNA-binding,CREB
R6195 T7411 T7410 arg2Of to,compared
R6196 T7412 T7411 arg2Of LPS,to
R6197 T7412 T7413 arg1Of LPS,alone
R6198 T7412 T7414 arg1Of LPS,(
R6199 T7416 T7414 arg2Of 4B,(
R6200 T7416 T7415 arg1Of 4B,Figure
R6201 T7417 T7414 arg3Of ),(
R6417 T7755 T7756 arg1Of Effect,of
R6418 T7755 T7758 arg1Of Effect,on
R6419 T7757 T7756 arg2Of PTX,of
R6420 T7760 T7758 arg2Of production,on
R6421 T7760 T7759 arg1Of production,TNF-α
R6422 T7760 T7761 arg1Of production,in
R6423 T7763 T7761 arg2Of presence,in
R6424 T7763 T7762 arg1Of presence,the
R6425 T7763 T7764 arg1Of presence,of
R6426 T7766 T7764 arg2Of inhibition,of
R6427 T7766 T7765 arg1Of inhibition,PKA
R6428 T7768 T7767 arg1Of role,The
R6429 T7768 T7769 arg1Of role,of
R6430 T7768 T7771 arg1Of role,in
R6431 T7768 T7777 arg1Of role,in
R6432 T7768 T7781 arg1Of role,was
R6433 T7768 T7782 arg2Of role,assessed
R6434 T7770 T7769 arg2Of PKA,of
R6435 T7773 T7771 arg2Of downregulation,in
R6436 T7773 T7772 arg1Of downregulation,PTX-induced
R6437 T7773 T7774 arg1Of downregulation,of
R6438 T7776 T7774 arg2Of production,of
R6439 T7776 T7775 arg1Of production,TNF-α
R6440 T7780 T7777 arg2Of cells,in
R6441 T7780 T7778 arg1Of cells,LPS-stimulated
R6442 T7780 T7779 arg1Of cells,mononuclear
R6443 T7782 T7781 arg2Of assessed,was
R6444 T7782 T7783 arg1Of assessed,by
R6445 T7784 T7783 arg2Of treating,by
R6446 T7786 T7784 arg2Of cells,treating
R6447 T7786 T7785 arg1Of cells,mononuclear
R6448 T7786 T7787 arg1Of cells,with
R6449 T7786 T7793 arg1Of cells,","
R6450 T7786 T7794 arg1Of cells,prior
R6451 T7788 T7787 arg2Of H89,with
R6452 T7788 T7789 arg1Of H89,","
R6453 T7792 T7789 arg2Of inhibitor,","
R6454 T7792 T7790 arg1Of inhibitor,a
R6455 T7792 T7791 arg1Of inhibitor,PKA
R6456 T7794 T7795 arg1Of prior,to
R6457 T7796 T7797 arg1Of LPS,and
R6458 T7797 T7795 arg2Of and,to
R6459 T7799 T7797 arg2Of exposure,and
R6460 T7799 T7798 arg1Of exposure,PTX
R6461 T7802 T7800 arg1Of PTX,The
R6462 T7802 T7801 arg1Of PTX,addition
R6463 T7802 T7803 arg1Of PTX,to
R6464 T7802 T7806 arg1Of PTX,resulted
R6465 T7805 T7803 arg2Of cells,to
R6466 T7805 T7804 arg1Of cells,LPS-stimulated
R6467 T7806 T7807 arg1Of resulted,in
R6468 T7809 T7807 arg2Of reduction,in
R6469 T7809 T7808 arg1Of reduction,a
R6470 T7809 T7810 arg1Of reduction,in
R6471 T7809 T7812 arg1Of reduction,","
R6472 T7809 T7813 arg1Of reduction,similar
R6473 T7809 T7821 arg1Of reduction,(
R6474 T7811 T7810 arg2Of TNF-α,in
R6475 T7813 T7814 arg1Of similar,to
R6476 T7815 T7814 arg2Of that,to
R6477 T7815 T7816 arg2Of that,observed
R6478 T7816 T7817 arg1Of observed,in
R6479 T7820 T7817 arg2Of experiments,in
R6480 T7820 T7818 arg1Of experiments,our
R6481 T7820 T7819 arg1Of experiments,previous
R6482 T7823 T7822 arg1Of pg/mL,529
R6483 T7824 T7823 arg1Of ±,pg/mL
R6484 T7827 T7826 arg1Of 37,vs.
R6485 T7829 T7821 arg2Of ±,(
R6486 T7829 T7824 arg1Of ±,±
R6487 T7829 T7825 arg1Of ±,112
R6488 T7829 T7827 arg1Of ±,37
R6489 T7829 T7828 arg1Of ±,pg/mL
R6490 T7829 T7830 arg1Of ±,10
R6491 T7829 T7831 arg1Of ±,;
R6492 T7832 T7831 arg2Of P,;
R6493 T7832 T7833 arg1Of P,<
R6494 T7832 T7834 arg1Of P,0.01
R6495 T7835 T7821 arg3Of ),(
R6496 T7836 T7837 arg1Of Pre-incubation,of
R6497 T7836 T7839 arg1Of Pre-incubation,with
R6498 T7836 T7847 arg1Of Pre-incubation,did
R6499 T7836 T7849 arg1Of Pre-incubation,result
R6500 T7838 T7837 arg2Of cells,of
R6501 T7840 T7839 arg2Of H89,with
R6502 T7840 T7841 arg1Of H89,prior
R6503 T7841 T7842 arg1Of prior,to
R6504 T7843 T7844 arg1Of LPS,and
R6505 T7845 T7844 arg2Of PTX,and
R6506 T7846 T7842 arg2Of exposure,to
R6507 T7846 T7843 arg1Of exposure,LPS
R6508 T7846 T7845 arg1Of exposure,PTX
R6509 T7849 T7847 arg2Of result,did
R6510 T7849 T7848 arg1Of result,not
R6511 T7849 T7850 arg1Of result,in
R6512 T7853 T7850 arg2Of modulation,in
R6513 T7853 T7851 arg1Of modulation,any
R6514 T7853 T7852 arg1Of modulation,significant
R6515 T7853 T7854 arg1Of modulation,of
R6516 T7853 T7858 arg1Of modulation,compared
R6517 T7853 T7861 arg2Of modulation,demonstrated
R6518 T7856 T7854 arg2Of production,of
R6519 T7856 T7855 arg1Of production,TNF-α
R6520 T7858 T7857 arg2Of compared,when
R6521 T7858 T7859 arg1Of compared,to
R6522 T7860 T7859 arg2Of that,to
R6523 T7861 T7857 arg1Of demonstrated,when
R6524 T7861 T7862 arg1Of demonstrated,with
R6525 T7863 T7862 arg2Of PTX,with
R6526 T7863 T7864 arg1Of PTX,alone
R6527 T7864 T7865 arg1Of alone,(
R6528 T7866 T7865 arg2Of P,(
R6529 T7866 T7867 arg1Of P,=
R6530 T7866 T7868 arg1Of P,0.2
R6531 T7866 T7869 arg1Of P,;
R6532 T7870 T7869 arg2Of Figure,;
R6533 T7870 T7871 arg1Of Figure,5
R6534 T7872 T7865 arg3Of ),(
R6535 T7874 T7873 arg1Of results,These
R6536 T7874 T7875 arg1Of results,suggest
R6537 T7877 T7878 arg1Of downregulation,of
R6538 T7877 T7883 arg1Of downregulation,in
R6539 T7877 T7887 arg1Of downregulation,is
R6540 T7880 T7878 arg2Of production,of
R6541 T7880 T7879 arg1Of production,TNF-α
R6542 T7880 T7881 arg1Of production,by
R6543 T7882 T7881 arg2Of PTX,by
R6544 T7886 T7883 arg2Of cells,in
R6545 T7886 T7884 arg1Of cells,LPS-stimulated
R6546 T7886 T7885 arg1Of cells,mononuclear
R6547 T7887 T7875 arg2Of is,suggest
R6548 T7887 T7876 arg1Of is,that
R6549 T7887 T7888 arg1Of is,","
R6550 T7887 T7891 arg1Of is,in
R6551 T7887 T7893 arg1Of is,","
R6552 T7890 T7889 arg1Of least,at
R6553 T7891 T7890 arg1Of in,least
R6554 T7892 T7891 arg2Of part,in
R6555 T7894 T7887 arg2Of PKA-independent,is

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T6242 9-12 DT denotes The
T6243 13-20 NNS denotes effects
T6244 21-23 IN denotes of
T6245 24-27 NNP denotes PTX
T6246 28-30 IN denotes on
T6247 31-42 JJ denotes LPS-induced
T6248 43-48 JJ denotes TNF-α
T6249 49-59 NN denotes production
T6250 60-62 TO denotes To
T6251 63-72 VB denotes determine
T6252 73-76 DT denotes the
T6253 77-85 NN denotes duration
T6254 86-88 IN denotes of
T6255 89-92 NNP denotes PDE
T6256 93-103 NN denotes inhibition
T6257 104-106 IN denotes on
T6258 107-112 JJ denotes TNF-α
T6259 113-123 NN denotes production
T6260 124-129 IN denotes after
T6261 130-133 NNP denotes LPS
T6262 134-145 NN denotes stimulation
T6263 145-146 , denotes ,
T6264 147-151 NN denotes time
T6265 152-158 NN denotes course
T6266 159-166 NNS denotes studies
T6267 167-171 VBD denotes were
T6268 172-181 VBN denotes conducted
T6269 181-182 . denotes .
T6270 183-185 IN denotes In
T6271 186-196 NN denotes accordance
T6272 197-201 IN denotes with
T6273 202-207 JJ denotes prior
T6274 208-212 NN denotes work
T6275 212-213 , denotes ,
T6276 214-217 NNP denotes PTX
T6277 218-221 VBD denotes had
T6278 222-223 DT denotes a
T6279 224-229 JJ denotes rapid
T6280 230-233 CC denotes and
T6281 234-243 VBD denotes sustained
T6282 244-250 NN denotes effect
T6283 251-253 IN denotes on
T6284 254-259 JJ denotes TNF-α
T6285 260-270 NN denotes production
T6286 271-273 IN denotes in
T6287 274-279 NN denotes vitro
T6288 280-281 -LRB- denotes (
T6289 281-287 NN denotes Figure
T6290 288-289 CD denotes 1
T6291 289-290 -RRB- denotes )
T6292 290-291 . denotes .
T6505 293-296 NNP denotes PTX
T6506 297-306 VBZ denotes decreases
T6507 307-318 JJ denotes LPS-induced
T6508 319-324 NN denotes NF-κB
T6509 325-335 NN denotes activation
T6510 336-341 IN denotes Since
T6511 342-357 NN denotes phosphorylation
T6512 358-363 VBZ denotes leads
T6513 364-366 TO denotes to
T6514 367-381 NN denotes ubiquitination
T6515 382-385 CC denotes and
T6516 386-397 NN denotes degradation
T6517 398-400 IN denotes of
T6518 401-406 NNP denotes I-κBα
T6519 407-410 CC denotes and
T6520 411-421 JJ denotes subsequent
T6521 422-429 JJ denotes nuclear
T6522 430-443 NN denotes translocation
T6523 444-446 IN denotes of
T6524 447-452 NNP denotes NF-κB
T6525 452-453 , denotes ,
T6526 454-456 PRP denotes we
T6527 457-462 RB denotes first
T6528 463-471 VBD denotes examined
T6529 472-475 DT denotes the
T6530 476-483 NNS denotes effects
T6531 484-486 IN denotes of
T6532 487-490 NNP denotes PTX
T6533 491-493 IN denotes on
T6534 494-499 NNP denotes I-κBα
T6535 499-500 . denotes .
T6536 501-512 NNP denotes Cytoplasmic
T6537 513-518 NNP denotes I-κBα
T6538 519-534 NN denotes phosphorylation
T6539 535-538 VBD denotes was
T6540 539-547 RB denotes markedly
T6541 548-557 VBN denotes increased
T6542 558-567 VBG denotes following
T6543 568-571 NNP denotes LPS
T6544 572-583 NN denotes stimulation
T6545 584-588 WRB denotes when
T6546 589-597 VBN denotes compared
T6547 598-600 TO denotes to
T6548 601-608 VB denotes control
T6549 609-610 -LRB- denotes (
T6550 610-613 CD denotes 100
T6551 614-615 CD denotes ±
T6552 616-617 CD denotes 0
T6553 618-621 IN denotes vs.
T6554 622-624 CD denotes 20
T6555 625-626 CD denotes ±
T6556 627-629 CD denotes 18
T6557 629-630 : denotes ;
T6558 631-632 NNP denotes P
T6559 633-634 NNP denotes <
T6560 635-639 CD denotes 0.05
T6561 639-640 -RRB- denotes )
T6562 640-641 . denotes .
T6563 642-645 DT denotes The
T6564 646-654 NN denotes addition
T6565 655-657 IN denotes of
T6566 658-661 NNP denotes PTX
T6567 662-675 RB denotes significantly
T6568 676-689 VBD denotes downregulated
T6569 690-701 JJ denotes LPS-induced
T6570 702-707 JJ denotes I-κBα
T6571 708-723 NN denotes phosphorylation
T6572 724-725 -LRB- denotes (
T6573 725-726 NNP denotes P
T6574 727-728 SYM denotes =
T6575 729-733 CD denotes 0.02
T6576 733-734 : denotes ;
T6577 735-741 NN denotes Figure
T6578 742-743 CD denotes 2
T6579 743-744 -RRB- denotes )
T6580 745-747 IN denotes In
T6581 748-749 DT denotes a
T6582 750-757 JJ denotes similar
T6583 758-765 NN denotes fashion
T6584 765-766 , denotes ,
T6585 767-774 JJ denotes nuclear
T6586 775-780 NNP denotes NF-κB
T6587 781-784 CD denotes p65
T6588 785-800 NN denotes phosphorylation
T6589 801-804 VBD denotes was
T6590 805-814 VBN denotes increased
T6591 815-824 VBG denotes following
T6592 825-828 NNP denotes LPS
T6593 829-840 NN denotes stimulation
T6594 841-842 -LRB- denotes (
T6595 842-845 CD denotes 100
T6596 846-847 CD denotes ±
T6597 848-849 CD denotes 0
T6598 850-853 IN denotes vs.
T6599 854-856 CD denotes 38
T6600 857-858 CD denotes ±
T6601 859-861 CD denotes 20
T6602 861-862 : denotes ;
T6603 863-864 NNP denotes P
T6604 865-866 NNP denotes <
T6605 867-871 CD denotes 0.01
T6606 871-872 -RRB- denotes )
T6607 872-873 . denotes .
T6608 874-877 NNP denotes PTX
T6609 878-887 RB denotes similarly
T6610 888-897 VBD denotes decreased
T6611 898-909 JJ denotes LPS-induced
T6612 910-915 NNP denotes NF-κB
T6613 916-919 CD denotes p65
T6614 920-927 JJ denotes nuclear
T6615 928-943 NN denotes phosphorylation
T6616 943-944 , denotes ,
T6617 945-946 DT denotes a
T6618 947-953 NN denotes marker
T6619 954-956 IN denotes of
T6620 957-962 JJ denotes NF-κB
T6621 963-973 NN denotes activation
T6622 974-977 CC denotes and
T6623 978-985 JJ denotes nuclear
T6624 986-999 NN denotes translocation
T6625 1000-1001 -LRB- denotes (
T6626 1001-1004 CD denotes 100
T6627 1005-1006 CD denotes ±
T6628 1007-1008 CD denotes 0
T6629 1009-1012 IN denotes vs.
T6630 1013-1015 CD denotes 40
T6631 1016-1017 NN denotes ±
T6632 1018-1019 CD denotes 6
T6633 1019-1020 : denotes ;
T6634 1021-1022 NNP denotes P
T6635 1023-1024 SYM denotes =
T6636 1024-1028 CD denotes 0.03
T6637 1028-1029 : denotes ;
T6638 1030-1036 NNP denotes Figure
T6639 1037-1039 NNP denotes 3A
T6640 1039-1040 -RRB- denotes )
T6641 1040-1041 . denotes .
T6642 1042-1047 NNS denotes EMSAs
T6643 1048-1052 VBD denotes were
T6644 1053-1057 RB denotes then
T6645 1058-1067 VBN denotes performed
T6646 1068-1070 TO denotes to
T6647 1071-1077 VB denotes verify
T6648 1078-1081 DT denotes the
T6649 1082-1093 JJ denotes PTX-induced
T6650 1094-1105 NNS denotes alterations
T6651 1106-1108 IN denotes in
T6652 1109-1116 JJ denotes nuclear
T6653 1117-1132 NN denotes phosphorylation
T6654 1133-1141 VBD denotes resulted
T6655 1142-1144 IN denotes in
T6656 1145-1152 JJ denotes similar
T6657 1153-1160 NNS denotes effects
T6658 1161-1163 IN denotes on
T6659 1164-1167 DT denotes the
T6660 1168-1171 NNP denotes DNA
T6661 1172-1179 JJ denotes binding
T6662 1180-1188 NN denotes activity
T6663 1189-1191 IN denotes of
T6664 1192-1197 NN denotes NF-κB
T6665 1197-1198 . denotes .
T6666 1199-1202 DT denotes The
T6667 1203-1211 NN denotes addition
T6668 1212-1214 IN denotes of
T6669 1215-1218 NNP denotes PTX
T6670 1219-1221 TO denotes to
T6671 1222-1236 JJ denotes LPS-stimulated
T6672 1237-1248 NN denotes mononuclear
T6673 1249-1254 NNS denotes cells
T6674 1255-1263 VBD denotes resulted
T6675 1264-1266 IN denotes in
T6676 1267-1277 JJ denotes comparable
T6677 1278-1292 NN denotes downregulation
T6678 1293-1295 IN denotes of
T6679 1296-1299 NNP denotes DNA
T6680 1300-1307 JJ denotes binding
T6681 1308-1316 NN denotes activity
T6682 1316-1317 , denotes ,
T6683 1318-1325 JJ denotes similar
T6684 1326-1328 TO denotes to
T6685 1329-1332 DT denotes the
T6686 1333-1341 JJ denotes observed
T6687 1342-1356 NN denotes downregulation
T6688 1357-1359 IN denotes of
T6689 1360-1365 JJ denotes NF-κB
T6690 1366-1381 NN denotes phosphorylation
T6691 1382-1383 -LRB- denotes (
T6692 1383-1389 NN denotes Figure
T6693 1390-1392 NN denotes 3B
T6694 1392-1393 -RRB- denotes )
T6695 1393-1394 . denotes .
T7091 1396-1399 NNP denotes PTX
T7092 1400-1411 VBZ denotes upregulates
T7093 1412-1416 NNP denotes CREB
T7094 1417-1432 NN denotes phosphorylation
T7095 1433-1436 CC denotes and
T7096 1437-1447 NN denotes activation
T7097 1448-1453 IN denotes after
T7098 1454-1457 NNP denotes LPS
T7099 1458-1469 NN denotes stimulation
T7100 1470-1485 NNP denotes Phosphorylation
T7101 1486-1488 IN denotes of
T7102 1489-1496 JJ denotes nuclear
T7103 1497-1501 NNP denotes CREB
T7104 1502-1505 VBD denotes was
T7105 1506-1510 VBN denotes used
T7106 1511-1513 IN denotes as
T7107 1514-1515 DT denotes a
T7108 1516-1522 NN denotes marker
T7109 1523-1526 IN denotes for
T7110 1527-1531 NNP denotes CREB
T7111 1532-1542 NN denotes activation
T7112 1542-1543 . denotes .
T7113 1544-1547 NNP denotes LPS
T7114 1548-1559 NN denotes stimulation
T7115 1560-1566 VBD denotes caused
T7116 1567-1568 DT denotes a
T7117 1569-1579 JJ denotes negligible
T7118 1580-1588 NN denotes increase
T7119 1589-1591 IN denotes in
T7120 1592-1596 NNP denotes CREB
T7121 1597-1612 NN denotes phosphorylation
T7122 1613-1617 WRB denotes when
T7123 1618-1626 VBN denotes compared
T7124 1627-1629 TO denotes to
T7125 1630-1637 VB denotes control
T7126 1638-1639 -LRB- denotes (
T7127 1639-1645 NN denotes Figure
T7128 1646-1648 NN denotes 4A
T7129 1648-1649 -RRB- denotes )
T7130 1649-1650 . denotes .
T7131 1651-1654 NNP denotes PTX
T7132 1655-1660 RB denotes alone
T7133 1661-1667 VBD denotes caused
T7134 1668-1669 DT denotes a
T7135 1670-1676 JJ denotes marked
T7136 1677-1685 NN denotes increase
T7137 1686-1688 IN denotes in
T7138 1689-1693 NNP denotes CREB
T7139 1694-1709 NN denotes phosphorylation
T7140 1710-1711 -LRB- denotes (
T7141 1711-1712 NNP denotes P
T7142 1713-1714 CD denotes <
T7143 1715-1719 CD denotes 0.01
T7144 1720-1723 IN denotes vs.
T7145 1724-1728 NNP denotes HBSS
T7146 1728-1729 -RRB- denotes )
T7147 1729-1730 . denotes .
T7148 1731-1735 WRB denotes When
T7149 1736-1739 NNP denotes LPS
T7150 1740-1743 CC denotes and
T7151 1744-1747 NNP denotes PTX
T7152 1748-1756 NN denotes exposure
T7153 1757-1765 VBD denotes occurred
T7154 1766-1780 RB denotes simultaneously
T7155 1780-1781 , denotes ,
T7156 1782-1786 NNP denotes CREB
T7157 1787-1802 NN denotes phosphorylation
T7158 1803-1806 VBD denotes was
T7159 1807-1820 RB denotes significantly
T7160 1821-1827 JJR denotes higher
T7161 1828-1832 IN denotes than
T7162 1833-1837 IN denotes with
T7163 1838-1841 NNP denotes LPS
T7164 1842-1853 NN denotes stimulation
T7165 1854-1859 RB denotes alone
T7166 1860-1861 -LRB- denotes (
T7167 1861-1864 CD denotes 543
T7168 1865-1866 CD denotes ±
T7169 1867-1869 CD denotes 92
T7170 1870-1873 IN denotes vs.
T7171 1874-1877 CD denotes 100
T7172 1878-1879 CD denotes ±
T7173 1880-1881 CD denotes 0
T7174 1881-1882 : denotes ;
T7175 1883-1884 NNP denotes P
T7176 1885-1886 NNP denotes <
T7177 1887-1891 CD denotes 0.01
T7178 1891-1892 -RRB- denotes )
T7179 1892-1893 . denotes .
T7180 1894-1896 IN denotes In
T7181 1897-1905 NN denotes addition
T7182 1905-1906 , denotes ,
T7183 1907-1910 DT denotes the
T7184 1911-1917 NN denotes amount
T7185 1918-1920 IN denotes of
T7186 1921-1925 NNP denotes CREB
T7187 1926-1941 NN denotes phosphorylation
T7188 1942-1946 VBN denotes seen
T7189 1947-1951 IN denotes with
T7190 1952-1963 JJ denotes concomitant
T7191 1964-1967 NNP denotes LPS
T7192 1968-1971 CC denotes and
T7193 1972-1975 NNP denotes PTX
T7194 1976-1985 NN denotes treatment
T7195 1986-1989 VBD denotes was
T7196 1990-1994 JJR denotes less
T7197 1995-1999 IN denotes than
T7198 2000-2004 DT denotes that
T7199 2005-2009 VBN denotes seen
T7200 2010-2014 IN denotes with
T7201 2015-2018 NNP denotes PTX
T7202 2019-2024 RB denotes alone
T7203 2024-2025 , denotes ,
T7204 2026-2034 IN denotes although
T7205 2035-2039 DT denotes this
T7206 2040-2050 NN denotes difference
T7207 2051-2054 VBD denotes was
T7208 2055-2058 RB denotes not
T7209 2059-2072 RB denotes statistically
T7210 2073-2084 JJ denotes significant
T7211 2085-2086 -LRB- denotes (
T7212 2086-2087 NNP denotes P
T7213 2088-2089 SYM denotes =
T7214 2090-2094 CD denotes 0.08
T7215 2094-2095 -RRB- denotes )
T7216 2095-2096 . denotes .
T7217 2097-2099 TO denotes To
T7218 2100-2109 VB denotes determine
T7219 2110-2112 IN denotes if
T7220 2113-2121 NNP denotes CREB-DNA
T7221 2122-2129 JJ denotes binding
T7222 2130-2133 VBD denotes was
T7223 2134-2142 VBN denotes affected
T7224 2143-2145 IN denotes by
T7225 2146-2149 NNP denotes PTX
T7226 2150-2152 IN denotes in
T7227 2153-2154 DT denotes a
T7228 2155-2161 NN denotes manner
T7229 2162-2169 JJ denotes similar
T7230 2170-2172 TO denotes to
T7231 2173-2177 NNP denotes CREB
T7232 2178-2193 NN denotes phosphorylation
T7233 2193-2194 , denotes ,
T7234 2195-2197 DT denotes an
T7235 2198-2202 NNP denotes EMSA
T7236 2203-2206 VBD denotes was
T7237 2207-2216 VBN denotes performed
T7238 2216-2217 . denotes .
T7239 2218-2226 NN denotes Exposure
T7240 2227-2229 IN denotes of
T7241 2230-2244 JJ denotes LPS-stimulated
T7242 2245-2250 NNS denotes cells
T7243 2251-2253 TO denotes to
T7244 2254-2257 NNP denotes PTX
T7245 2258-2267 RB denotes similarly
T7246 2268-2277 VBD denotes increased
T7247 2278-2282 NNP denotes CREB
T7248 2283-2294 JJ denotes DNA-binding
T7249 2295-2303 VBN denotes compared
T7250 2304-2306 TO denotes to
T7251 2307-2310 NNP denotes LPS
T7252 2311-2316 RB denotes alone
T7253 2317-2318 -LRB- denotes (
T7254 2318-2324 NN denotes Figure
T7255 2325-2327 NN denotes 4B
T7256 2327-2328 -RRB- denotes )
T7257 2328-2329 . denotes .
T7611 2331-2337 NN denotes Effect
T7612 2338-2340 IN denotes of
T7613 2341-2344 NNP denotes PTX
T7614 2345-2347 IN denotes on
T7615 2348-2353 JJ denotes TNF-α
T7616 2354-2364 NN denotes production
T7617 2365-2367 IN denotes in
T7618 2368-2371 DT denotes the
T7619 2372-2380 NN denotes presence
T7620 2381-2383 IN denotes of
T7621 2384-2387 NNP denotes PKA
T7622 2388-2398 NN denotes inhibition
T7623 2399-2402 DT denotes The
T7624 2403-2407 NN denotes role
T7625 2408-2410 IN denotes of
T7626 2411-2414 NNP denotes PKA
T7627 2415-2417 IN denotes in
T7628 2418-2429 JJ denotes PTX-induced
T7629 2430-2444 NN denotes downregulation
T7630 2445-2447 IN denotes of
T7631 2448-2453 JJ denotes TNF-α
T7632 2454-2464 NN denotes production
T7633 2465-2467 IN denotes in
T7634 2468-2482 JJ denotes LPS-stimulated
T7635 2483-2494 NN denotes mononuclear
T7636 2495-2500 NNS denotes cells
T7637 2501-2504 VBD denotes was
T7638 2505-2513 VBN denotes assessed
T7639 2514-2516 IN denotes by
T7640 2517-2525 VBG denotes treating
T7641 2526-2537 NN denotes mononuclear
T7642 2538-2543 NNS denotes cells
T7643 2544-2548 IN denotes with
T7644 2549-2552 NNP denotes H89
T7645 2552-2553 , denotes ,
T7646 2554-2555 DT denotes a
T7647 2556-2559 NNP denotes PKA
T7648 2560-2569 NN denotes inhibitor
T7649 2569-2570 , denotes ,
T7650 2571-2576 RB denotes prior
T7651 2577-2579 TO denotes to
T7652 2580-2583 NNP denotes LPS
T7653 2584-2587 CC denotes and
T7654 2588-2591 NNP denotes PTX
T7655 2592-2600 NN denotes exposure
T7656 2600-2601 . denotes .
T7657 2602-2605 DT denotes The
T7658 2606-2614 NN denotes addition
T7659 2615-2618 NNP denotes PTX
T7660 2619-2621 TO denotes to
T7661 2622-2636 JJ denotes LPS-stimulated
T7662 2637-2642 NNS denotes cells
T7663 2643-2651 VBD denotes resulted
T7664 2652-2654 IN denotes in
T7665 2655-2656 DT denotes a
T7666 2657-2666 NN denotes reduction
T7667 2667-2669 IN denotes in
T7668 2670-2675 NNP denotes TNF-α
T7669 2675-2676 , denotes ,
T7670 2677-2684 JJ denotes similar
T7671 2685-2687 TO denotes to
T7672 2688-2692 DT denotes that
T7673 2693-2701 VBN denotes observed
T7674 2702-2704 IN denotes in
T7675 2705-2708 PRP$ denotes our
T7676 2709-2717 JJ denotes previous
T7677 2718-2729 NNS denotes experiments
T7678 2730-2731 -LRB- denotes (
T7679 2731-2734 CD denotes 529
T7680 2735-2740 JJ denotes pg/mL
T7681 2741-2742 NN denotes ±
T7682 2743-2746 CD denotes 112
T7683 2747-2750 FW denotes vs.
T7684 2751-2753 CD denotes 37
T7685 2754-2759 NNP denotes pg/mL
T7686 2760-2761 CD denotes ±
T7687 2762-2764 CD denotes 10
T7688 2764-2765 : denotes ;
T7689 2766-2767 NNP denotes P
T7690 2768-2769 NNP denotes <
T7691 2770-2774 CD denotes 0.01
T7692 2774-2775 -RRB- denotes )
T7693 2775-2776 . denotes .
T7694 2777-2791 NN denotes Pre-incubation
T7695 2792-2794 IN denotes of
T7696 2795-2800 NNS denotes cells
T7697 2801-2805 IN denotes with
T7698 2806-2809 NNP denotes H89
T7699 2810-2815 RB denotes prior
T7700 2816-2818 TO denotes to
T7701 2819-2822 NNP denotes LPS
T7702 2823-2826 CC denotes and
T7703 2827-2830 NNP denotes PTX
T7704 2831-2839 NN denotes exposure
T7705 2840-2843 VBD denotes did
T7706 2844-2847 RB denotes not
T7707 2848-2854 VB denotes result
T7708 2855-2857 IN denotes in
T7709 2858-2861 DT denotes any
T7710 2862-2873 JJ denotes significant
T7711 2874-2884 NN denotes modulation
T7712 2885-2887 IN denotes of
T7713 2888-2893 JJ denotes TNF-α
T7714 2894-2904 NN denotes production
T7715 2905-2909 WRB denotes when
T7716 2910-2918 VBN denotes compared
T7717 2919-2921 TO denotes to
T7718 2922-2926 DT denotes that
T7719 2927-2939 VBD denotes demonstrated
T7720 2940-2944 IN denotes with
T7721 2945-2948 NNP denotes PTX
T7722 2949-2954 RB denotes alone
T7723 2955-2956 -LRB- denotes (
T7724 2956-2957 NNP denotes P
T7725 2958-2959 SYM denotes =
T7726 2960-2963 CD denotes 0.2
T7727 2963-2964 : denotes ;
T7728 2965-2971 NN denotes Figure
T7729 2972-2973 CD denotes 5
T7730 2973-2974 -RRB- denotes )
T7731 2974-2975 . denotes .
T7732 2976-2981 DT denotes These
T7733 2982-2989 NNS denotes results
T7734 2990-2997 VBP denotes suggest
T7735 2998-3002 IN denotes that
T7736 3003-3017 NN denotes downregulation
T7737 3018-3020 IN denotes of
T7738 3021-3026 JJ denotes TNF-α
T7739 3027-3037 NN denotes production
T7740 3038-3040 IN denotes by
T7741 3041-3044 NNP denotes PTX
T7742 3045-3047 IN denotes in
T7743 3048-3062 JJ denotes LPS-stimulated
T7744 3063-3074 NN denotes mononuclear
T7745 3075-3080 NNS denotes cells
T7746 3081-3083 VBZ denotes is
T7747 3083-3084 , denotes ,
T7748 3085-3087 IN denotes at
T7749 3088-3093 JJS denotes least
T7750 3094-3096 IN denotes in
T7751 3097-3101 NN denotes part
T7752 3101-3102 , denotes ,
T7753 3103-3118 JJ denotes PKA-independent
T7754 3118-3119 . denotes .
R5186 T6242 T6243 det The,effects
R5187 T6243 T6251 nsubj effects,determine
R5188 T6244 T6243 prep of,effects
R5189 T6245 T6244 pobj PTX,of
R5190 T6246 T6243 prep on,effects
R5191 T6247 T6249 amod LPS-induced,production
R5192 T6248 T6249 amod TNF-α,production
R5193 T6249 T6246 pobj production,on
R5194 T6250 T6251 aux To,determine
R5195 T6251 T6251 ROOT determine,determine
R5196 T6252 T6253 det the,duration
R5197 T6253 T6251 dobj duration,determine
R5198 T6254 T6253 prep of,duration
R5199 T6255 T6256 compound PDE,inhibition
R5200 T6256 T6254 pobj inhibition,of
R5201 T6257 T6256 prep on,inhibition
R5202 T6258 T6259 amod TNF-α,production
R5203 T6259 T6257 pobj production,on
R5204 T6260 T6251 prep after,determine
R5205 T6261 T6262 compound LPS,stimulation
R5206 T6262 T6260 pobj stimulation,after
R5207 T6263 T6268 punct ",",conducted
R5208 T6264 T6268 npadvmod time,conducted
R5209 T6265 T6266 compound course,studies
R5210 T6266 T6268 nsubjpass studies,conducted
R5211 T6267 T6268 auxpass were,conducted
R5212 T6268 T6251 advcl conducted,determine
R5213 T6269 T6251 punct .,determine
R5214 T6270 T6277 prep In,had
R5215 T6271 T6270 pobj accordance,In
R5216 T6272 T6271 prep with,accordance
R5217 T6273 T6274 amod prior,work
R5218 T6274 T6272 pobj work,with
R5219 T6275 T6277 punct ",",had
R5220 T6276 T6277 nsubj PTX,had
R5221 T6277 T6277 ROOT had,had
R5222 T6278 T6282 det a,effect
R5223 T6279 T6282 amod rapid,effect
R5224 T6280 T6279 cc and,rapid
R5225 T6281 T6279 conj sustained,rapid
R5226 T6282 T6277 dobj effect,had
R5227 T6283 T6282 prep on,effect
R5228 T6284 T6285 amod TNF-α,production
R5229 T6285 T6283 pobj production,on
R5230 T6286 T6285 prep in,production
R5231 T6287 T6289 amod vitro,Figure
R5232 T6288 T6289 punct (,Figure
R5233 T6289 T6286 pobj Figure,in
R5234 T6290 T6289 nummod 1,Figure
R5235 T6291 T6289 punct ),Figure
R5236 T6292 T6277 punct .,had
R5380 T6505 T6506 nsubj PTX,decreases
R5381 T6506 T6506 ROOT decreases,decreases
R5382 T6507 T6509 amod LPS-induced,activation
R5383 T6508 T6509 compound NF-κB,activation
R5384 T6509 T6506 dobj activation,decreases
R5385 T6510 T6512 mark Since,leads
R5386 T6511 T6512 nsubj phosphorylation,leads
R5387 T6512 T6528 advcl leads,examined
R5388 T6513 T6512 prep to,leads
R5389 T6514 T6513 pobj ubiquitination,to
R5390 T6515 T6514 cc and,ubiquitination
R5391 T6516 T6514 conj degradation,ubiquitination
R5392 T6517 T6516 prep of,degradation
R5393 T6518 T6517 pobj I-κBα,of
R5394 T6519 T6518 cc and,I-κBα
R5395 T6520 T6522 amod subsequent,translocation
R5396 T6521 T6522 amod nuclear,translocation
R5397 T6522 T6518 conj translocation,I-κBα
R5398 T6523 T6522 prep of,translocation
R5399 T6524 T6523 pobj NF-κB,of
R5400 T6525 T6528 punct ",",examined
R5401 T6526 T6528 nsubj we,examined
R5402 T6527 T6528 advmod first,examined
R5403 T6528 T6506 advcl examined,decreases
R5404 T6529 T6530 det the,effects
R5405 T6530 T6528 dobj effects,examined
R5406 T6531 T6530 prep of,effects
R5407 T6532 T6531 pobj PTX,of
R5408 T6533 T6530 prep on,effects
R5409 T6534 T6533 pobj I-κBα,on
R5410 T6535 T6506 punct .,decreases
R5411 T6536 T6538 compound Cytoplasmic,phosphorylation
R5412 T6537 T6538 compound I-κBα,phosphorylation
R5413 T6538 T6541 nsubjpass phosphorylation,increased
R5414 T6539 T6541 auxpass was,increased
R5415 T6540 T6541 advmod markedly,increased
R5416 T6541 T6541 ROOT increased,increased
R5417 T6542 T6541 prep following,increased
R5418 T6543 T6544 compound LPS,stimulation
R5419 T6544 T6542 pobj stimulation,following
R5420 T6545 T6546 advmod when,compared
R5421 T6546 T6541 advcl compared,increased
R5422 T6547 T6548 aux to,control
R5423 T6548 T6546 xcomp control,compared
R5424 T6549 T6552 punct (,0
R5425 T6550 T6552 nummod 100,0
R5426 T6551 T6552 nummod ±,0
R5427 T6552 T6548 dobj 0,control
R5428 T6553 T6552 prep vs.,0
R5429 T6554 T6556 nummod 20,18
R5430 T6555 T6556 nummod ±,18
R5431 T6556 T6553 pobj 18,vs.
R5432 T6557 T6560 punct ;,0.05
R5433 T6558 T6559 compound P,<
R5434 T6559 T6560 compound <,0.05
R5435 T6560 T6541 npadvmod 0.05,increased
R5436 T6561 T6560 punct ),0.05
R5437 T6562 T6541 punct .,increased
R5438 T6563 T6564 det The,addition
R5439 T6564 T6568 nsubj addition,downregulated
R5440 T6565 T6564 prep of,addition
R5441 T6566 T6565 pobj PTX,of
R5442 T6567 T6568 advmod significantly,downregulated
R5443 T6568 T6568 ROOT downregulated,downregulated
R5444 T6569 T6571 amod LPS-induced,phosphorylation
R5445 T6570 T6571 amod I-κBα,phosphorylation
R5446 T6571 T6568 dobj phosphorylation,downregulated
R5447 T6572 T6573 punct (,P
R5448 T6573 T6571 appos P,phosphorylation
R5449 T6574 T6573 punct =,P
R5450 T6575 T6573 nummod 0.02,P
R5451 T6576 T6573 punct ;,P
R5452 T6577 T6577 ROOT Figure,Figure
R5453 T6578 T6577 nummod 2,Figure
R5454 T6579 T6577 punct ),Figure
R5455 T6580 T6590 prep In,increased
R5456 T6581 T6583 det a,fashion
R5457 T6582 T6583 amod similar,fashion
R5458 T6583 T6580 pobj fashion,In
R5459 T6584 T6590 punct ",",increased
R5460 T6585 T6588 amod nuclear,phosphorylation
R5461 T6586 T6588 nmod NF-κB,phosphorylation
R5462 T6587 T6588 nummod p65,phosphorylation
R5463 T6588 T6590 nsubjpass phosphorylation,increased
R5464 T6589 T6590 auxpass was,increased
R5465 T6590 T6590 ROOT increased,increased
R5466 T6591 T6590 prep following,increased
R5467 T6592 T6593 compound LPS,stimulation
R5468 T6593 T6591 pobj stimulation,following
R5469 T6594 T6597 punct (,0
R5470 T6595 T6597 nummod 100,0
R5471 T6596 T6597 nummod ±,0
R5472 T6597 T6590 npadvmod 0,increased
R5473 T6598 T6597 prep vs.,0
R5474 T6599 T6601 nummod 38,20
R5475 T6600 T6601 nummod ±,20
R5476 T6601 T6598 pobj 20,vs.
R5477 T6602 T6605 punct ;,0.01
R5478 T6603 T6604 compound P,<
R5479 T6604 T6605 compound <,0.01
R5480 T6605 T6590 npadvmod 0.01,increased
R5481 T6606 T6605 punct ),0.01
R5482 T6607 T6590 punct .,increased
R5483 T6608 T6610 nsubj PTX,decreased
R5484 T6609 T6610 advmod similarly,decreased
R5485 T6610 T6610 ROOT decreased,decreased
R5486 T6611 T6615 amod LPS-induced,phosphorylation
R5487 T6612 T6615 nmod NF-κB,phosphorylation
R5488 T6613 T6612 nummod p65,NF-κB
R5489 T6614 T6615 amod nuclear,phosphorylation
R5490 T6615 T6610 dobj phosphorylation,decreased
R5491 T6616 T6615 punct ",",phosphorylation
R5492 T6617 T6618 det a,marker
R5493 T6618 T6615 appos marker,phosphorylation
R5494 T6619 T6618 prep of,marker
R5495 T6620 T6621 amod NF-κB,activation
R5496 T6621 T6619 pobj activation,of
R5497 T6622 T6621 cc and,activation
R5498 T6623 T6624 amod nuclear,translocation
R5499 T6624 T6621 conj translocation,activation
R5500 T6625 T6628 punct (,0
R5501 T6626 T6628 nummod 100,0
R5502 T6627 T6628 nummod ±,0
R5503 T6628 T6615 appos 0,phosphorylation
R5504 T6629 T6630 quantmod vs.,40
R5505 T6630 T6631 nummod 40,±
R5506 T6631 T6628 pobj ±,0
R5507 T6632 T6631 nummod 6,±
R5508 T6633 T6631 punct ;,±
R5509 T6634 T6636 compound P,0.03
R5510 T6635 T6636 punct =,0.03
R5511 T6636 T6631 conj 0.03,±
R5512 T6637 T6636 punct ;,0.03
R5513 T6638 T6639 compound Figure,3A
R5514 T6639 T6636 appos 3A,0.03
R5515 T6640 T6636 punct ),0.03
R5516 T6641 T6631 punct .,±
R5517 T6642 T6645 nsubjpass EMSAs,performed
R5518 T6643 T6645 auxpass were,performed
R5519 T6644 T6645 advmod then,performed
R5520 T6645 T6645 ROOT performed,performed
R5521 T6646 T6647 aux to,verify
R5522 T6647 T6645 advcl verify,performed
R5523 T6648 T6650 det the,alterations
R5524 T6649 T6650 amod PTX-induced,alterations
R5525 T6650 T6647 dobj alterations,verify
R5526 T6651 T6650 prep in,alterations
R5527 T6652 T6653 amod nuclear,phosphorylation
R5528 T6653 T6651 pobj phosphorylation,in
R5529 T6654 T6645 conj resulted,performed
R5530 T6655 T6654 prep in,resulted
R5531 T6656 T6657 amod similar,effects
R5532 T6657 T6655 pobj effects,in
R5533 T6658 T6657 prep on,effects
R5534 T6659 T6662 det the,activity
R5535 T6660 T6662 compound DNA,activity
R5536 T6661 T6662 amod binding,activity
R5537 T6662 T6658 pobj activity,on
R5538 T6663 T6662 prep of,activity
R5539 T6664 T6663 pobj NF-κB,of
R5540 T6665 T6645 punct .,performed
R5541 T6666 T6667 det The,addition
R5542 T6667 T6674 nsubj addition,resulted
R5543 T6668 T6667 prep of,addition
R5544 T6669 T6668 pobj PTX,of
R5545 T6670 T6667 prep to,addition
R5546 T6671 T6673 amod LPS-stimulated,cells
R5547 T6672 T6673 compound mononuclear,cells
R5548 T6673 T6670 pobj cells,to
R5549 T6674 T6674 ROOT resulted,resulted
R5550 T6675 T6674 prep in,resulted
R5551 T6676 T6677 amod comparable,downregulation
R5552 T6677 T6675 pobj downregulation,in
R5553 T6678 T6677 prep of,downregulation
R5554 T6679 T6678 pobj DNA,of
R5555 T6680 T6681 amod binding,activity
R5556 T6681 T6677 conj activity,downregulation
R5557 T6682 T6681 punct ",",activity
R5558 T6683 T6681 amod similar,activity
R5559 T6684 T6683 prep to,similar
R5560 T6685 T6687 det the,downregulation
R5561 T6686 T6687 amod observed,downregulation
R5562 T6687 T6684 pobj downregulation,to
R5563 T6688 T6687 prep of,downregulation
R5564 T6689 T6690 amod NF-κB,phosphorylation
R5565 T6690 T6688 pobj phosphorylation,of
R5566 T6691 T6693 punct (,3B
R5567 T6692 T6693 compound Figure,3B
R5568 T6693 T6690 appos 3B,phosphorylation
R5569 T6694 T6690 punct ),phosphorylation
R5570 T6695 T6674 punct .,resulted
R5876 T7091 T7092 nsubj PTX,upregulates
R5877 T7092 T7092 ROOT upregulates,upregulates
R5878 T7093 T7094 compound CREB,phosphorylation
R5879 T7094 T7092 dobj phosphorylation,upregulates
R5880 T7095 T7094 cc and,phosphorylation
R5881 T7096 T7094 conj activation,phosphorylation
R5882 T7097 T7105 mark after,used
R5883 T7098 T7100 compound LPS,Phosphorylation
R5884 T7099 T7100 compound stimulation,Phosphorylation
R5885 T7100 T7105 nsubjpass Phosphorylation,used
R5886 T7101 T7100 prep of,Phosphorylation
R5887 T7102 T7103 amod nuclear,CREB
R5888 T7103 T7101 pobj CREB,of
R5889 T7104 T7105 auxpass was,used
R5890 T7105 T7092 advcl used,upregulates
R5891 T7106 T7105 prep as,used
R5892 T7107 T7108 det a,marker
R5893 T7108 T7106 pobj marker,as
R5894 T7109 T7108 prep for,marker
R5895 T7110 T7111 compound CREB,activation
R5896 T7111 T7109 pobj activation,for
R5897 T7112 T7092 punct .,upregulates
R5898 T7113 T7114 compound LPS,stimulation
R5899 T7114 T7115 nsubj stimulation,caused
R5900 T7115 T7115 ROOT caused,caused
R5901 T7116 T7118 det a,increase
R5902 T7117 T7118 amod negligible,increase
R5903 T7118 T7115 dobj increase,caused
R5904 T7119 T7118 prep in,increase
R5905 T7120 T7121 compound CREB,phosphorylation
R5906 T7121 T7119 pobj phosphorylation,in
R5907 T7122 T7123 advmod when,compared
R5908 T7123 T7115 advcl compared,caused
R5909 T7124 T7125 aux to,control
R5910 T7125 T7123 xcomp control,compared
R5911 T7126 T7128 punct (,4A
R5912 T7127 T7128 compound Figure,4A
R5913 T7128 T7125 dobj 4A,control
R5914 T7129 T7128 punct ),4A
R5915 T7130 T7115 punct .,caused
R5916 T7131 T7133 nsubj PTX,caused
R5917 T7132 T7131 advmod alone,PTX
R5918 T7133 T7133 ROOT caused,caused
R5919 T7134 T7136 det a,increase
R5920 T7135 T7136 amod marked,increase
R5921 T7136 T7133 dobj increase,caused
R5922 T7137 T7136 prep in,increase
R5923 T7138 T7139 compound CREB,phosphorylation
R5924 T7139 T7137 pobj phosphorylation,in
R5925 T7140 T7141 punct (,P
R5926 T7141 T7136 appos P,increase
R5927 T7142 T7143 compound <,0.01
R5928 T7143 T7141 nummod 0.01,P
R5929 T7144 T7141 prep vs.,P
R5930 T7145 T7144 pobj HBSS,vs.
R5931 T7146 T7141 punct ),P
R5932 T7147 T7133 punct .,caused
R5933 T7148 T7153 advmod When,occurred
R5934 T7149 T7153 nsubj LPS,occurred
R5935 T7150 T7149 cc and,LPS
R5936 T7151 T7149 conj PTX,LPS
R5937 T7152 T7149 conj exposure,LPS
R5938 T7153 T7158 advcl occurred,was
R5939 T7154 T7153 advmod simultaneously,occurred
R5940 T7155 T7158 punct ",",was
R5941 T7156 T7157 compound CREB,phosphorylation
R5942 T7157 T7158 nsubj phosphorylation,was
R5943 T7158 T7158 ROOT was,was
R5944 T7159 T7160 advmod significantly,higher
R5945 T7160 T7158 acomp higher,was
R5946 T7161 T7160 prep than,higher
R5947 T7162 T7161 prep with,than
R5948 T7163 T7164 compound LPS,stimulation
R5949 T7164 T7162 pobj stimulation,with
R5950 T7165 T7164 advmod alone,stimulation
R5951 T7166 T7164 punct (,stimulation
R5952 T7167 T7169 nummod 543,92
R5953 T7168 T7169 nummod ±,92
R5954 T7169 T7164 appos 92,stimulation
R5955 T7170 T7169 prep vs.,92
R5956 T7171 T7173 nummod 100,0
R5957 T7172 T7173 nummod ±,0
R5958 T7173 T7170 pobj 0,vs.
R5959 T7174 T7176 punct ;,<
R5960 T7175 T7176 compound P,<
R5961 T7176 T7158 attr <,was
R5962 T7177 T7176 nummod 0.01,<
R5963 T7178 T7176 punct ),<
R5964 T7179 T7158 punct .,was
R5965 T7180 T7195 prep In,was
R5966 T7181 T7180 pobj addition,In
R5967 T7182 T7195 punct ",",was
R5968 T7183 T7184 det the,amount
R5969 T7184 T7195 nsubj amount,was
R5970 T7185 T7184 prep of,amount
R5971 T7186 T7187 compound CREB,phosphorylation
R5972 T7187 T7185 pobj phosphorylation,of
R5973 T7188 T7184 acl seen,amount
R5974 T7189 T7188 prep with,seen
R5975 T7190 T7191 amod concomitant,LPS
R5976 T7191 T7189 pobj LPS,with
R5977 T7192 T7191 cc and,LPS
R5978 T7193 T7194 compound PTX,treatment
R5979 T7194 T7184 conj treatment,amount
R5980 T7195 T7195 ROOT was,was
R5981 T7196 T7195 acomp less,was
R5982 T7197 T7196 prep than,less
R5983 T7198 T7197 pobj that,than
R5984 T7199 T7198 acl seen,that
R5985 T7200 T7199 prep with,seen
R5986 T7201 T7200 pobj PTX,with
R5987 T7202 T7201 advmod alone,PTX
R5988 T7203 T7195 punct ",",was
R5989 T7204 T7207 mark although,was
R5990 T7205 T7206 det this,difference
R5991 T7206 T7207 nsubj difference,was
R5992 T7207 T7195 advcl was,was
R5993 T7208 T7207 neg not,was
R5994 T7209 T7210 advmod statistically,significant
R5995 T7210 T7207 acomp significant,was
R5996 T7211 T7214 punct (,0.08
R5997 T7212 T7214 dep P,0.08
R5998 T7213 T7214 punct =,0.08
R5999 T7214 T7210 parataxis 0.08,significant
R6000 T7215 T7214 punct ),0.08
R6001 T7216 T7195 punct .,was
R6002 T7217 T7218 aux To,determine
R6003 T7218 T7237 advcl determine,performed
R6004 T7219 T7223 mark if,affected
R6005 T7220 T7221 compound CREB-DNA,binding
R6006 T7221 T7223 nsubjpass binding,affected
R6007 T7222 T7223 auxpass was,affected
R6008 T7223 T7237 advcl affected,performed
R6009 T7224 T7223 agent by,affected
R6010 T7225 T7224 pobj PTX,by
R6011 T7226 T7223 prep in,affected
R6012 T7227 T7228 det a,manner
R6013 T7228 T7226 pobj manner,in
R6014 T7229 T7228 amod similar,manner
R6015 T7230 T7229 prep to,similar
R6016 T7231 T7232 compound CREB,phosphorylation
R6017 T7232 T7230 pobj phosphorylation,to
R6018 T7233 T7237 punct ",",performed
R6019 T7234 T7235 det an,EMSA
R6020 T7235 T7237 nsubjpass EMSA,performed
R6021 T7236 T7237 auxpass was,performed
R6022 T7237 T7237 ROOT performed,performed
R6023 T7238 T7237 punct .,performed
R6024 T7239 T7246 nsubj Exposure,increased
R6025 T7240 T7239 prep of,Exposure
R6026 T7241 T7242 amod LPS-stimulated,cells
R6027 T7242 T7240 pobj cells,of
R6028 T7243 T7239 prep to,Exposure
R6029 T7244 T7243 pobj PTX,to
R6030 T7245 T7246 advmod similarly,increased
R6031 T7246 T7246 ROOT increased,increased
R6032 T7247 T7248 compound CREB,DNA-binding
R6033 T7248 T7246 dobj DNA-binding,increased
R6034 T7249 T7246 prep compared,increased
R6035 T7250 T7249 prep to,compared
R6036 T7251 T7250 pobj LPS,to
R6037 T7252 T7251 advmod alone,LPS
R6038 T7253 T7255 punct (,4B
R6039 T7254 T7255 compound Figure,4B
R6040 T7255 T7251 appos 4B,LPS
R6041 T7256 T7246 punct ),increased
R6042 T7257 T7246 punct .,increased
R6273 T7611 T7611 ROOT Effect,Effect
R6274 T7612 T7611 prep of,Effect
R6275 T7613 T7612 pobj PTX,of
R6276 T7614 T7611 prep on,Effect
R6277 T7615 T7616 amod TNF-α,production
R6278 T7616 T7614 pobj production,on
R6279 T7617 T7616 prep in,production
R6280 T7618 T7619 det the,presence
R6281 T7619 T7617 pobj presence,in
R6282 T7620 T7619 prep of,presence
R6283 T7621 T7622 compound PKA,inhibition
R6284 T7622 T7620 pobj inhibition,of
R6285 T7623 T7624 det The,role
R6286 T7624 T7638 nsubjpass role,assessed
R6287 T7625 T7624 prep of,role
R6288 T7626 T7625 pobj PKA,of
R6289 T7627 T7624 prep in,role
R6290 T7628 T7629 amod PTX-induced,downregulation
R6291 T7629 T7627 pobj downregulation,in
R6292 T7630 T7629 prep of,downregulation
R6293 T7631 T7632 amod TNF-α,production
R6294 T7632 T7630 pobj production,of
R6295 T7633 T7632 prep in,production
R6296 T7634 T7636 amod LPS-stimulated,cells
R6297 T7635 T7636 compound mononuclear,cells
R6298 T7636 T7633 pobj cells,in
R6299 T7637 T7638 auxpass was,assessed
R6300 T7638 T7638 ROOT assessed,assessed
R6301 T7639 T7638 prep by,assessed
R6302 T7640 T7639 pcomp treating,by
R6303 T7641 T7642 compound mononuclear,cells
R6304 T7642 T7640 dobj cells,treating
R6305 T7643 T7640 prep with,treating
R6306 T7644 T7643 pobj H89,with
R6307 T7645 T7644 punct ",",H89
R6308 T7646 T7648 det a,inhibitor
R6309 T7647 T7648 compound PKA,inhibitor
R6310 T7648 T7644 appos inhibitor,H89
R6311 T7649 T7644 punct ",",H89
R6312 T7650 T7640 advmod prior,treating
R6313 T7651 T7650 prep to,prior
R6314 T7652 T7651 pobj LPS,to
R6315 T7653 T7652 cc and,LPS
R6316 T7654 T7655 compound PTX,exposure
R6317 T7655 T7652 conj exposure,LPS
R6318 T7656 T7638 punct .,assessed
R6319 T7657 T7658 det The,addition
R6320 T7658 T7659 nsubj addition,PTX
R6321 T7659 T7663 nsubj PTX,resulted
R6322 T7660 T7659 prep to,PTX
R6323 T7661 T7662 amod LPS-stimulated,cells
R6324 T7662 T7660 pobj cells,to
R6325 T7663 T7663 ROOT resulted,resulted
R6326 T7664 T7663 prep in,resulted
R6327 T7665 T7666 det a,reduction
R6328 T7666 T7664 pobj reduction,in
R6329 T7667 T7666 prep in,reduction
R6330 T7668 T7667 pobj TNF-α,in
R6331 T7669 T7668 punct ",",TNF-α
R6332 T7670 T7666 amod similar,reduction
R6333 T7671 T7673 aux to,observed
R6334 T7672 T7673 nsubj that,observed
R6335 T7673 T7666 relcl observed,reduction
R6336 T7674 T7673 prep in,observed
R6337 T7675 T7677 poss our,experiments
R6338 T7676 T7677 amod previous,experiments
R6339 T7677 T7674 pobj experiments,in
R6340 T7678 T7677 punct (,experiments
R6341 T7679 T7684 quantmod 529,37
R6342 T7680 T7683 nmod pg/mL,vs.
R6343 T7681 T7683 nmod ±,vs.
R6344 T7682 T7681 nummod 112,±
R6345 T7683 T7684 nmod vs.,37
R6346 T7684 T7687 nummod 37,10
R6347 T7685 T7686 compound pg/mL,±
R6348 T7686 T7687 nummod ±,10
R6349 T7687 T7677 appos 10,experiments
R6350 T7688 T7677 punct ;,experiments
R6351 T7689 T7690 compound P,<
R6352 T7690 T7677 appos <,experiments
R6353 T7691 T7690 nummod 0.01,<
R6354 T7692 T7677 punct ),experiments
R6355 T7693 T7663 punct .,resulted
R6356 T7694 T7707 nsubj Pre-incubation,result
R6357 T7695 T7694 prep of,Pre-incubation
R6358 T7696 T7695 pobj cells,of
R6359 T7697 T7696 prep with,cells
R6360 T7698 T7697 pobj H89,with
R6361 T7699 T7707 advmod prior,result
R6362 T7700 T7699 prep to,prior
R6363 T7701 T7700 pobj LPS,to
R6364 T7702 T7701 cc and,LPS
R6365 T7703 T7704 compound PTX,exposure
R6366 T7704 T7701 conj exposure,LPS
R6367 T7705 T7707 aux did,result
R6368 T7706 T7707 neg not,result
R6369 T7707 T7707 ROOT result,result
R6370 T7708 T7707 prep in,result
R6371 T7709 T7711 det any,modulation
R6372 T7710 T7711 amod significant,modulation
R6373 T7711 T7708 pobj modulation,in
R6374 T7712 T7711 prep of,modulation
R6375 T7713 T7714 compound TNF-α,production
R6376 T7714 T7712 pobj production,of
R6377 T7715 T7716 advmod when,compared
R6378 T7716 T7707 advcl compared,result
R6379 T7717 T7716 prep to,compared
R6380 T7718 T7717 pobj that,to
R6381 T7719 T7718 acl demonstrated,that
R6382 T7720 T7719 prep with,demonstrated
R6383 T7721 T7720 pobj PTX,with
R6384 T7722 T7721 advmod alone,PTX
R6385 T7723 T7721 punct (,PTX
R6386 T7724 T7721 appos P,PTX
R6387 T7725 T7726 punct =,0.2
R6388 T7726 T7724 nummod 0.2,P
R6389 T7727 T7728 punct ;,Figure
R6390 T7728 T7724 appos Figure,P
R6391 T7729 T7728 nummod 5,Figure
R6392 T7730 T7728 punct ),Figure
R6393 T7731 T7707 punct .,result
R6394 T7732 T7733 det These,results
R6395 T7733 T7734 nsubj results,suggest
R6396 T7734 T7734 ROOT suggest,suggest
R6397 T7735 T7746 mark that,is
R6398 T7736 T7746 nsubj downregulation,is
R6399 T7737 T7736 prep of,downregulation
R6400 T7738 T7739 compound TNF-α,production
R6401 T7739 T7737 pobj production,of
R6402 T7740 T7739 prep by,production
R6403 T7741 T7740 pobj PTX,by
R6404 T7742 T7736 prep in,downregulation
R6405 T7743 T7745 amod LPS-stimulated,cells
R6406 T7744 T7745 compound mononuclear,cells
R6407 T7745 T7742 pobj cells,in
R6408 T7746 T7734 ccomp is,suggest
R6409 T7747 T7746 punct ",",is
R6410 T7748 T7749 advmod at,least
R6411 T7749 T7750 advmod least,in
R6412 T7750 T7746 prep in,is
R6413 T7751 T7750 pobj part,in
R6414 T7752 T7753 punct ",",PKA-independent
R6415 T7753 T7746 acomp PKA-independent,is
R6416 T7754 T7734 punct .,suggest

GO-BP

Id Subject Object Predicate Lexical cue
T6351 43-59 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T6352 107-123 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T6353 254-270 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T6354 43-59 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α production
T6355 107-123 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α production
T6356 254-270 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α production
T6357 89-92 http://purl.obolibrary.org/obo/GO_0004114 denotes PDE
T6358 93-112 http://purl.obolibrary.org/obo/GO_1904468 denotes inhibition on TNF-α
T6892 342-357 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6893 519-534 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6894 708-723 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6895 785-800 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6896 928-943 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6897 1117-1132 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6898 1366-1381 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6899 386-397 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6900 1278-1307 http://purl.obolibrary.org/obo/GO_0043392 denotes downregulation of DNA binding
T6901 1278-1307 http://purl.obolibrary.org/obo/GO_1904743 denotes downregulation of DNA binding
T6902 1360-1381 http://purl.obolibrary.org/obo/GO_0007252 denotes NF-κB phosphorylation
T7486 1417-1432 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7487 1597-1612 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7488 1694-1709 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7489 1787-1802 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7490 1926-1941 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7491 2178-2193 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7492 1417-1447 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation and activation
T7493 1458-1485 http://purl.obolibrary.org/obo/GO_0042327 denotes stimulation Phosphorylation
T7494 1527-1542 http://purl.obolibrary.org/obo/GO_0032793 denotes CREB activation
T7910 2348-2364 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T7911 2448-2464 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T7912 2888-2904 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T7913 3021-3037 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T7914 2348-2364 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α production
T7915 2448-2464 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α production
T7916 2888-2904 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α production
T7917 3021-3037 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α production
T7918 2384-2387 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T7919 2411-2414 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T7920 2556-2559 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T7921 3103-3106 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T7922 2430-2453 http://purl.obolibrary.org/obo/GO_1904468 denotes downregulation of TNF-α
T7923 3003-3026 http://purl.obolibrary.org/obo/GO_1904468 denotes downregulation of TNF-α

GO-MF

Id Subject Object Predicate Lexical cue
T6369 89-92 http://purl.obolibrary.org/obo/GO_0004114 denotes PDE
T6924 1168-1179 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T6925 1296-1307 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T6926 1172-1179 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T6927 1300-1307 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7498 2118-2129 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T7499 2283-2294 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T7500 2122-2129 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7501 2287-2294 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T7944 2384-2387 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T7945 2411-2414 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T7946 2556-2559 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T7947 3103-3106 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA

GO-CC

Id Subject Object Predicate Lexical cue
T6928 1249-1254 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7502 2245-2250 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7948 2384-2387 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T7949 2411-2414 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T7950 2556-2559 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T7951 3103-3106 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T7952 2495-2500 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7953 2538-2543 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7954 2637-2642 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7955 2795-2800 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7956 3075-3080 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T6239 9-59 Sentence denotes The effects of PTX on LPS-induced TNF-α production
T6240 60-182 Sentence denotes To determine the duration of PDE inhibition on TNF-α production after LPS stimulation, time course studies were conducted.
T6241 183-291 Sentence denotes In accordance with prior work, PTX had a rapid and sustained effect on TNF-α production in vitro (Figure 1).
T6497 293-335 Sentence denotes PTX decreases LPS-induced NF-κB activation
T6498 336-500 Sentence denotes Since phosphorylation leads to ubiquitination and degradation of I-κBα and subsequent nuclear translocation of NF-κB, we first examined the effects of PTX on I-κBα.
T6499 501-641 Sentence denotes Cytoplasmic I-κBα phosphorylation was markedly increased following LPS stimulation when compared to control (100 ± 0 vs. 20 ± 18; P < 0.05).
T6500 642-744 Sentence denotes The addition of PTX significantly downregulated LPS-induced I-κBα phosphorylation (P = 0.02; Figure 2)
T6501 745-873 Sentence denotes In a similar fashion, nuclear NF-κB p65 phosphorylation was increased following LPS stimulation (100 ± 0 vs. 38 ± 20; P < 0.01).
T6502 874-1041 Sentence denotes PTX similarly decreased LPS-induced NF-κB p65 nuclear phosphorylation, a marker of NF-κB activation and nuclear translocation (100 ± 0 vs. 40 ± 6; P =0.03; Figure 3A).
T6503 1042-1198 Sentence denotes EMSAs were then performed to verify the PTX-induced alterations in nuclear phosphorylation resulted in similar effects on the DNA binding activity of NF-κB.
T6504 1199-1394 Sentence denotes The addition of PTX to LPS-stimulated mononuclear cells resulted in comparable downregulation of DNA binding activity, similar to the observed downregulation of NF-κB phosphorylation (Figure 3B).
T7083 1396-1469 Sentence denotes PTX upregulates CREB phosphorylation and activation after LPS stimulation
T7084 1470-1543 Sentence denotes Phosphorylation of nuclear CREB was used as a marker for CREB activation.
T7085 1544-1650 Sentence denotes LPS stimulation caused a negligible increase in CREB phosphorylation when compared to control (Figure 4A).
T7086 1651-1730 Sentence denotes PTX alone caused a marked increase in CREB phosphorylation (P < 0.01 vs. HBSS).
T7087 1731-1893 Sentence denotes When LPS and PTX exposure occurred simultaneously, CREB phosphorylation was significantly higher than with LPS stimulation alone (543 ± 92 vs. 100 ± 0; P < 0.01).
T7088 1894-2096 Sentence denotes In addition, the amount of CREB phosphorylation seen with concomitant LPS and PTX treatment was less than that seen with PTX alone, although this difference was not statistically significant (P = 0.08).
T7089 2097-2217 Sentence denotes To determine if CREB-DNA binding was affected by PTX in a manner similar to CREB phosphorylation, an EMSA was performed.
T7090 2218-2329 Sentence denotes Exposure of LPS-stimulated cells to PTX similarly increased CREB DNA-binding compared to LPS alone (Figure 4B).
T7606 2331-2398 Sentence denotes Effect of PTX on TNF-α production in the presence of PKA inhibition
T7607 2399-2601 Sentence denotes The role of PKA in PTX-induced downregulation of TNF-α production in LPS-stimulated mononuclear cells was assessed by treating mononuclear cells with H89, a PKA inhibitor, prior to LPS and PTX exposure.
T7608 2602-2776 Sentence denotes The addition PTX to LPS-stimulated cells resulted in a reduction in TNF-α, similar to that observed in our previous experiments (529 pg/mL ± 112 vs. 37 pg/mL ± 10; P < 0.01).
T7609 2777-2975 Sentence denotes Pre-incubation of cells with H89 prior to LPS and PTX exposure did not result in any significant modulation of TNF-α production when compared to that demonstrated with PTX alone (P = 0.2; Figure 5).
T7610 2976-3119 Sentence denotes These results suggest that downregulation of TNF-α production by PTX in LPS-stimulated mononuclear cells is, at least in part, PKA-independent.
T105 0-7 Sentence denotes RESULTS
T106 9-59 Sentence denotes The effects of PTX on LPS-induced TNF-α production
T107 60-182 Sentence denotes To determine the duration of PDE inhibition on TNF-α production after LPS stimulation, time course studies were conducted.
T108 183-291 Sentence denotes In accordance with prior work, PTX had a rapid and sustained effect on TNF-α production in vitro (Figure 1).
T109 293-335 Sentence denotes PTX decreases LPS-induced NF-κB activation
T110 336-500 Sentence denotes Since phosphorylation leads to ubiquitination and degradation of I-κBα and subsequent nuclear translocation of NF-κB, we first examined the effects of PTX on I-κBα.
T111 501-641 Sentence denotes Cytoplasmic I-κBα phosphorylation was markedly increased following LPS stimulation when compared to control (100 ± 0 vs. 20 ± 18; P < 0.05).
T112 642-744 Sentence denotes The addition of PTX significantly downregulated LPS-induced I-κBα phosphorylation (P = 0.02; Figure 2)
T113 745-873 Sentence denotes In a similar fashion, nuclear NF-κB p65 phosphorylation was increased following LPS stimulation (100 ± 0 vs. 38 ± 20; P < 0.01).
T114 874-1041 Sentence denotes PTX similarly decreased LPS-induced NF-κB p65 nuclear phosphorylation, a marker of NF-κB activation and nuclear translocation (100 ± 0 vs. 40 ± 6; P =0.03; Figure 3A).
T115 1042-1198 Sentence denotes EMSAs were then performed to verify the PTX-induced alterations in nuclear phosphorylation resulted in similar effects on the DNA binding activity of NF-κB.
T116 1199-1394 Sentence denotes The addition of PTX to LPS-stimulated mononuclear cells resulted in comparable downregulation of DNA binding activity, similar to the observed downregulation of NF-κB phosphorylation (Figure 3B).
T117 1396-1469 Sentence denotes PTX upregulates CREB phosphorylation and activation after LPS stimulation
T118 1470-1543 Sentence denotes Phosphorylation of nuclear CREB was used as a marker for CREB activation.
T119 1544-1650 Sentence denotes LPS stimulation caused a negligible increase in CREB phosphorylation when compared to control (Figure 4A).
T120 1651-1730 Sentence denotes PTX alone caused a marked increase in CREB phosphorylation (P < 0.01 vs. HBSS).
T121 1731-1893 Sentence denotes When LPS and PTX exposure occurred simultaneously, CREB phosphorylation was significantly higher than with LPS stimulation alone (543 ± 92 vs. 100 ± 0; P < 0.01).
T122 1894-2096 Sentence denotes In addition, the amount of CREB phosphorylation seen with concomitant LPS and PTX treatment was less than that seen with PTX alone, although this difference was not statistically significant (P = 0.08).
T123 2097-2217 Sentence denotes To determine if CREB-DNA binding was affected by PTX in a manner similar to CREB phosphorylation, an EMSA was performed.
T124 2218-2329 Sentence denotes Exposure of LPS-stimulated cells to PTX similarly increased CREB DNA-binding compared to LPS alone (Figure 4B).
T125 2331-2398 Sentence denotes Effect of PTX on TNF-α production in the presence of PKA inhibition
T126 2399-2601 Sentence denotes The role of PKA in PTX-induced downregulation of TNF-α production in LPS-stimulated mononuclear cells was assessed by treating mononuclear cells with H89, a PKA inhibitor, prior to LPS and PTX exposure.
T127 2602-2776 Sentence denotes The addition PTX to LPS-stimulated cells resulted in a reduction in TNF-α, similar to that observed in our previous experiments (529 pg/mL ± 112 vs. 37 pg/mL ± 10; P < 0.01).
T128 2777-2975 Sentence denotes Pre-incubation of cells with H89 prior to LPS and PTX exposure did not result in any significant modulation of TNF-α production when compared to that demonstrated with PTX alone (P = 0.2; Figure 5).
T129 2976-3119 Sentence denotes These results suggest that downregulation of TNF-α production by PTX in LPS-stimulated mononuclear cells is, at least in part, PKA-independent.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T6411 13-20 Regulation denotes effects true
T6412 35-42 Positive_regulation denotes induced
T6413 43-48 Protein denotes TNF-α
T6414 49-59 Gene_expression denotes production
T6415 107-112 Protein denotes TNF-α
T6416 113-123 Gene_expression denotes production
T6417 134-145 Positive_regulation denotes stimulation
T6418 244-250 Regulation denotes effect
T6419 254-259 Protein denotes TNF-α
T6420 260-270 Gene_expression denotes production
T6929 358-363 Positive_regulation denotes leads
T6930 386-397 Protein_catabolism denotes degradation
T6931 401-406 Protein denotes I-κBα
T6932 476-483 Regulation denotes effects true
T6933 494-499 Protein denotes I-κBα
T6934 513-518 Protein denotes I-κBα
T6935 519-534 Phosphorylation denotes phosphorylation
T6936 548-557 Positive_regulation denotes increased
T6937 558-567 Positive_regulation denotes following
T6938 676-689 Negative_regulation denotes downregulated
T6939 694-701 Positive_regulation denotes induced
T6940 702-707 Protein denotes I-κBα
T6941 708-723 Phosphorylation denotes phosphorylation
T6942 781-784 Protein denotes p65
T6943 785-800 Phosphorylation denotes phosphorylation
T6944 805-814 Positive_regulation denotes increased
T6945 815-824 Positive_regulation denotes following
T6946 888-897 Negative_regulation denotes decreased
T6947 902-909 Positive_regulation denotes induced
T6948 916-919 Protein denotes p65
T6949 928-943 Phosphorylation denotes phosphorylation
T7544 2268-2277 Positive_regulation denotes increased
T7545 2278-2282 Protein denotes CREB
T7546 2287-2294 Binding denotes binding
T7957 2331-2337 Regulation denotes Effect true
T7958 2348-2353 Protein denotes TNF-α
T7959 2354-2364 Gene_expression denotes production
T7960 2365-2383 Regulation denotes in the presence of
T7961 2403-2407 Regulation denotes role
T7962 2422-2429 Positive_regulation denotes induced
T7963 2430-2444 Negative_regulation denotes downregulation
T7964 2448-2453 Protein denotes TNF-α
T7965 2454-2464 Gene_expression denotes production
T7966 2643-2651 Positive_regulation denotes resulted
T7967 2657-2666 Negative_regulation denotes reduction
T7968 2670-2675 Protein denotes TNF-α
T7969 2848-2854 Regulation denotes result true
T7970 2874-2884 Regulation denotes modulation
T7971 2888-2893 Protein denotes TNF-α
T7972 2894-2904 Gene_expression denotes production
T7973 3003-3017 Negative_regulation denotes downregulation
T7974 3021-3026 Protein denotes TNF-α
T7975 3027-3037 Gene_expression denotes production
T7976 3107-3118 Regulation denotes independent true
R5320 T6412 T6411 themeOf induced,effects
R5321 T6413 T6414 themeOf TNF-α,production
R5322 T6414 T6412 themeOf production,induced
R5323 T6415 T6416 themeOf TNF-α,production
R5324 T6416 T6417 themeOf production,stimulation
R5325 T6419 T6420 themeOf TNF-α,production
R5326 T6420 T6418 themeOf production,effect
R5767 T6930 T6929 themeOf degradation,leads
R5768 T6931 T6930 themeOf I-κBα,degradation
R5769 T6933 T6932 themeOf I-κBα,effects
R5770 T6934 T6935 themeOf I-κBα,phosphorylation
R5771 T6935 T6936 themeOf phosphorylation,increased
R5772 T6936 T6937 themeOf increased,following
R5773 T6939 T6938 themeOf induced,downregulated
R5774 T6940 T6941 themeOf I-κBα,phosphorylation
R5775 T6941 T6939 themeOf phosphorylation,induced
R5776 T6942 T6943 themeOf p65,phosphorylation
R5777 T6943 T6944 themeOf phosphorylation,increased
R5778 T6944 T6945 themeOf increased,following
R5779 T6947 T6946 themeOf induced,decreased
R5780 T6948 T6949 themeOf p65,phosphorylation
R5781 T6949 T6947 themeOf phosphorylation,induced
R6228 T7545 T7546 themeOf CREB,binding
R6229 T7546 T7544 themeOf binding,increased
R6571 T7957 T7960 themeOf Effect,in the presence of
R6572 T7958 T7959 themeOf TNF-α,production
R6573 T7959 T7957 themeOf production,Effect
R6574 T7962 T7961 themeOf induced,role
R6575 T7963 T7962 themeOf downregulation,induced
R6576 T7964 T7965 themeOf TNF-α,production
R6577 T7965 T7963 themeOf production,downregulation
R6578 T7967 T7966 themeOf reduction,resulted
R6579 T7968 T7967 themeOf TNF-α,reduction
R6580 T7970 T7969 themeOf modulation,result
R6581 T7971 T7972 themeOf TNF-α,production
R6582 T7972 T7970 themeOf production,modulation
R6583 T7973 T7976 themeOf downregulation,independent
R6584 T7974 T7975 themeOf TNF-α,production
R6585 T7975 T7973 themeOf production,downregulation

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T6370 24-27 Protein denotes PTX
T6371 43-48 Protein denotes TNF-α
T6372 49-59 Gene_expression denotes production
T6373 13-20 Regulation denotes effects
T6374 31-42 Positive_regulation denotes LPS-induced
T6375 89-92 Protein denotes PDE
T6376 107-112 Protein denotes TNF-α
T6377 93-103 Negative_regulation denotes inhibition
T6378 113-123 Gene_expression denotes production
T6379 214-217 Protein denotes PTX
T6380 254-259 Protein denotes TNF-α
T6381 260-270 Gene_expression denotes production
T6382 244-250 Regulation denotes effect
T6950 319-324 Protein denotes NF-κB
T6951 401-406 Protein denotes I-κBα
T6952 447-452 Protein denotes NF-κB
T6953 494-499 Protein denotes I-κBα
T6954 386-397 Protein_catabolism denotes degradation
T6955 422-429 Entity denotes nuclear
T6956 430-443 Localization denotes translocation
T6957 430-443 Localization denotes translocation
T6958 476-483 Regulation denotes effects
T6959 501-514 Protein denotes Cytoplasmic I
T6960 515-518 Protein denotes κBα
T6961 519-534 Phosphorylation denotes phosphorylation
T6962 519-534 Phosphorylation denotes phosphorylation
T6963 548-557 Positive_regulation denotes increased
T6964 548-557 Positive_regulation denotes increased
T6965 658-661 Protein denotes PTX
T6966 702-707 Protein denotes I-κBα
T6967 708-723 Phosphorylation denotes phosphorylation
T6968 676-689 Negative_regulation denotes downregulated
T6969 690-701 Positive_regulation denotes LPS-induced
T6970 676-689 Negative_regulation denotes downregulated
T6971 781-784 Protein denotes p65
T6972 767-774 Entity denotes nuclear
T6973 785-800 Phosphorylation denotes phosphorylation
T6974 805-814 Positive_regulation denotes increased
T6975 910-915 Protein denotes NF-κB
T6976 916-919 Protein denotes p65
T6977 957-962 Protein denotes NF-κB
T6978 920-927 Entity denotes nuclear
T6979 928-943 Phosphorylation denotes phosphorylation
T6980 928-943 Phosphorylation denotes phosphorylation
T6981 963-973 Positive_regulation denotes activation
T6982 986-999 Localization denotes translocation
T6983 986-999 Localization denotes translocation
T6984 898-909 Positive_regulation denotes LPS-induced
T6985 898-909 Positive_regulation denotes LPS-induced
T6986 888-897 Negative_regulation denotes decreased
T6987 888-897 Negative_regulation denotes decreased
T6988 1082-1085 Protein denotes PTX
T6989 1192-1197 Protein denotes NF-κB
T6990 1172-1179 Binding denotes binding
T6991 1215-1218 Protein denotes PTX
T6992 1360-1365 Protein denotes NF-κB
T6993 1366-1381 Phosphorylation denotes phosphorylation
T6994 1342-1356 Negative_regulation denotes downregulation
T7503 1412-1416 Protein denotes CREB
T7504 1417-1432 Phosphorylation denotes phosphorylation
T7505 1437-1447 Positive_regulation denotes activation
T7506 1400-1411 Positive_regulation denotes upregulates
T7507 1527-1531 Protein denotes CREB
T7508 1532-1542 Positive_regulation denotes activation
T7509 1592-1596 Protein denotes CREB
T7510 1597-1612 Phosphorylation denotes phosphorylation
T7511 1580-1588 Positive_regulation denotes increase
T7512 1651-1654 Protein denotes PTX
T7513 1689-1693 Protein denotes CREB
T7514 1694-1709 Phosphorylation denotes phosphorylation
T7515 1677-1685 Positive_regulation denotes increase
T7516 1744-1747 Protein denotes PTX
T7517 1782-1786 Protein denotes CREB
T7518 1787-1802 Phosphorylation denotes phosphorylation
T7519 1821-1827 Positive_regulation denotes higher
T7520 1921-1925 Protein denotes CREB
T7521 2015-2018 Protein denotes PTX
T7522 1926-1941 Phosphorylation denotes phosphorylation
T7523 2113-2121 Protein denotes CREB-DNA
T7524 2146-2149 Protein denotes PTX
T7525 2173-2177 Protein denotes CREB
T7526 2122-2129 Binding denotes binding
T7527 2134-2142 Regulation denotes affected
T7528 2178-2193 Phosphorylation denotes phosphorylation
T7529 2254-2257 Protein denotes PTX
T7530 2278-2282 Protein denotes CREB
T7531 2268-2277 Positive_regulation denotes increased
T7977 2341-2344 Protein denotes PTX
T7978 2348-2353 Protein denotes TNF-α
T7979 2384-2387 Protein denotes PKA
T7980 2354-2364 Gene_expression denotes production
T7981 2388-2398 Negative_regulation denotes inhibition
T7982 2331-2337 Regulation denotes Effect
T7983 2411-2414 Protein denotes PKA
T7984 2418-2421 Protein denotes PTX
T7985 2448-2453 Protein denotes TNF-α
T7986 2556-2559 Protein denotes PKA
T7987 2588-2591 Protein denotes PTX
T7988 2454-2464 Gene_expression denotes production
T7989 2560-2569 Negative_regulation denotes inhibitor
T7990 2670-2675 Protein denotes TNF-α
T7991 2657-2666 Negative_regulation denotes reduction
T7992 2827-2830 Protein denotes PTX
T7993 2888-2893 Protein denotes TNF-α
T7994 2945-2948 Protein denotes PTX
T7995 2894-2904 Gene_expression denotes production
T7996 2874-2884 Regulation denotes modulation
T7997 3021-3026 Protein denotes TNF-α
T7998 3041-3044 Protein denotes PTX
T7999 3103-3106 Protein denotes PKA
T8000 3027-3037 Gene_expression denotes production
T8001 3003-3017 Negative_regulation denotes downregulation
T8002 3107-3118 Negative_regulation denotes independent
R5292 T6370 T6373 causeOf PTX,effects
R5293 T6371 T6372 themeOf TNF-α,production
R5294 T6372 T6373 themeOf production,effects
R5295 T6372 T6374 themeOf production,LPS-induced
R5296 T6375 T6377 themeOf PDE,inhibition
R5297 T6376 T6378 themeOf TNF-α,production
R5298 T6379 T6382 causeOf PTX,effect
R5299 T6380 T6381 themeOf TNF-α,production
R5300 T6381 T6382 themeOf production,effect
R5782 T6951 T6954 themeOf I-κBα,degradation
R5783 T6951 T6956 themeOf I-κBα,translocation
R5784 T6952 T6957 themeOf NF-κB,translocation
R5785 T6953 T6958 themeOf I-κBα,effects
R5786 T6955 T6956 locationOf nuclear,translocation
R5787 T6955 T6957 locationOf nuclear,translocation
R5788 T6959 T6961 themeOf Cytoplasmic I,phosphorylation
R5789 T6960 T6962 themeOf κBα,phosphorylation
R5790 T6961 T6963 themeOf phosphorylation,increased
R5791 T6962 T6964 themeOf phosphorylation,increased
R5792 T6965 T6968 causeOf PTX,downregulated
R5793 T6965 T6970 causeOf PTX,downregulated
R5794 T6966 T6967 themeOf I-κBα,phosphorylation
R5795 T6967 T6968 themeOf phosphorylation,downregulated
R5796 T6967 T6969 themeOf phosphorylation,LPS-induced
R5797 T6969 T6970 themeOf LPS-induced,downregulated
R5798 T6971 T6973 themeOf p65,phosphorylation
R5799 T6972 T6973 Site nuclear,phosphorylation
R5800 T6973 T6974 themeOf phosphorylation,increased
R5801 T6975 T6979 themeOf NF-κB,phosphorylation
R5802 T6975 T6982 themeOf NF-κB,translocation
R5803 T6976 T6980 themeOf p65,phosphorylation
R5804 T6976 T6983 themeOf p65,translocation
R5805 T6977 T6981 themeOf NF-κB,activation
R5806 T6978 T6979 Site nuclear,phosphorylation
R5807 T6978 T6980 Site nuclear,phosphorylation
R5808 T6979 T6984 themeOf phosphorylation,LPS-induced
R5809 T6980 T6985 themeOf phosphorylation,LPS-induced
R5810 T6984 T6986 themeOf LPS-induced,decreased
R5811 T6985 T6987 themeOf LPS-induced,decreased
R5812 T6989 T6990 themeOf NF-κB,binding
R5813 T6992 T6993 themeOf NF-κB,phosphorylation
R5814 T6993 T6994 themeOf phosphorylation,downregulation
R6204 T7503 T7504 themeOf CREB,phosphorylation
R6205 T7504 T7505 themeOf phosphorylation,activation
R6206 T7505 T7506 themeOf activation,upregulates
R6207 T7507 T7508 themeOf CREB,activation
R6208 T7509 T7510 themeOf CREB,phosphorylation
R6209 T7510 T7511 themeOf phosphorylation,increase
R6210 T7512 T7515 causeOf PTX,increase
R6211 T7513 T7514 themeOf CREB,phosphorylation
R6212 T7514 T7515 themeOf phosphorylation,increase
R6213 T7517 T7518 themeOf CREB,phosphorylation
R6214 T7518 T7519 themeOf phosphorylation,higher
R6215 T7520 T7522 themeOf CREB,phosphorylation
R6216 T7523 T7526 themeOf CREB-DNA,binding
R6217 T7524 T7527 causeOf PTX,affected
R6218 T7525 T7528 themeOf CREB,phosphorylation
R6219 T7526 T7527 themeOf binding,affected
R6220 T7530 T7531 themeOf CREB,increased
R6586 T7977 T7982 causeOf PTX,Effect
R6587 T7978 T7980 themeOf TNF-α,production
R6588 T7979 T7981 themeOf PKA,inhibition
R6589 T7980 T7982 themeOf production,Effect
R6590 T7985 T7988 themeOf TNF-α,production
R6591 T7986 T7989 themeOf PKA,inhibitor
R6592 T7990 T7991 themeOf TNF-α,reduction
R6593 T7993 T7995 themeOf TNF-α,production
R6594 T7995 T7996 themeOf production,modulation
R6595 T7997 T8000 themeOf TNF-α,production
R6596 T7998 T8001 causeOf PTX,downregulation
R6597 T7999 T8002 causeOf PKA,independent
R6598 T8000 T8001 themeOf production,downregulation
R6599 T8001 T8002 themeOf downregulation,independent

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T6342 43-46 P01375 denotes TNF
T6343 43-48 P01375 denotes TNF-α
T6344 107-110 P01375 denotes TNF
T6345 107-112 P01375 denotes TNF-α
T6346 254-257 P01375 denotes TNF
T6347 254-259 P01375 denotes TNF-α
T6880 781-784 Q04206 denotes p65
T6881 781-784 P21579 denotes p65
T6882 916-919 Q04206 denotes p65
T6883 916-919 P21579 denotes p65
T7418 1412-1416 Q8TEY5 denotes CREB
T7419 1412-1416 Q02930 denotes CREB
T7420 1412-1416 P18848 denotes CREB
T7421 1412-1416 P16220 denotes CREB
T7422 1412-1416 P15336 denotes CREB
T7423 1412-1416 O43889 denotes CREB
T7424 1497-1501 Q8TEY5 denotes CREB
T7425 1497-1501 Q02930 denotes CREB
T7426 1497-1501 P18848 denotes CREB
T7427 1497-1501 P16220 denotes CREB
T7428 1497-1501 P15336 denotes CREB
T7429 1497-1501 O43889 denotes CREB
T7430 1527-1531 Q8TEY5 denotes CREB
T7431 1527-1531 Q02930 denotes CREB
T7432 1527-1531 P18848 denotes CREB
T7433 1527-1531 P16220 denotes CREB
T7434 1527-1531 P15336 denotes CREB
T7435 1527-1531 O43889 denotes CREB
T7436 1592-1596 Q8TEY5 denotes CREB
T7437 1592-1596 Q02930 denotes CREB
T7438 1592-1596 P18848 denotes CREB
T7439 1592-1596 P16220 denotes CREB
T7440 1592-1596 P15336 denotes CREB
T7441 1592-1596 O43889 denotes CREB
T7442 1689-1693 Q8TEY5 denotes CREB
T7443 1689-1693 Q02930 denotes CREB
T7444 1689-1693 P18848 denotes CREB
T7445 1689-1693 P16220 denotes CREB
T7446 1689-1693 P15336 denotes CREB
T7447 1689-1693 O43889 denotes CREB
T7448 1782-1786 Q8TEY5 denotes CREB
T7449 1782-1786 Q02930 denotes CREB
T7450 1782-1786 P18848 denotes CREB
T7451 1782-1786 P16220 denotes CREB
T7452 1782-1786 P15336 denotes CREB
T7453 1782-1786 O43889 denotes CREB
T7454 1921-1925 Q8TEY5 denotes CREB
T7455 1921-1925 Q02930 denotes CREB
T7456 1921-1925 P18848 denotes CREB
T7457 1921-1925 P16220 denotes CREB
T7458 1921-1925 P15336 denotes CREB
T7459 1921-1925 O43889 denotes CREB
T7460 2113-2117 Q8TEY5 denotes CREB
T7461 2113-2117 Q02930 denotes CREB
T7462 2113-2117 P18848 denotes CREB
T7463 2113-2117 P16220 denotes CREB
T7464 2113-2117 P15336 denotes CREB
T7465 2113-2117 O43889 denotes CREB
T7466 2173-2177 Q8TEY5 denotes CREB
T7467 2173-2177 Q02930 denotes CREB
T7468 2173-2177 P18848 denotes CREB
T7469 2173-2177 P16220 denotes CREB
T7470 2173-2177 P15336 denotes CREB
T7471 2173-2177 O43889 denotes CREB
T7472 2278-2282 Q8TEY5 denotes CREB
T7473 2278-2282 Q02930 denotes CREB
T7474 2278-2282 P18848 denotes CREB
T7475 2278-2282 P16220 denotes CREB
T7476 2278-2282 P15336 denotes CREB
T7477 2278-2282 O43889 denotes CREB
T7895 2348-2351 P01375 denotes TNF
T7896 2348-2353 P01375 denotes TNF-α
T7897 2448-2451 P01375 denotes TNF
T7898 2448-2453 P01375 denotes TNF-α
T7899 2670-2673 P01375 denotes TNF
T7900 2670-2675 P01375 denotes TNF-α
T7901 2888-2891 P01375 denotes TNF
T7902 2888-2893 P01375 denotes TNF-α
T7903 3021-3024 P01375 denotes TNF
T7904 3021-3026 P01375 denotes TNF-α

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T6219 13-20 Regulation denotes effects true
T6220 35-42 Positive_regulation denotes induced
T6221 43-48 Protein denotes TNF-α
T6222 49-59 Gene_expression denotes production
T6223 93-103 Negative_regulation denotes inhibition
T6224 107-112 Protein denotes TNF-α
T6225 113-123 Gene_expression denotes production
T6226 244-250 Regulation denotes effect
T6227 254-259 Protein denotes TNF-α
T6228 260-270 Gene_expression denotes production
T6452 386-397 Protein_catabolism denotes degradation
T6453 401-406 Protein denotes I-κBα
T6454 422-429 Entity denotes nuclear true
T6455 430-443 Localization denotes translocation
T6456 476-483 Regulation denotes effects
T6457 494-499 Protein denotes I-κBα
T6458 513-518 Protein denotes I-κBα
T6459 519-534 Phosphorylation denotes phosphorylation
T6460 548-557 Positive_regulation denotes increased
T6461 558-567 Positive_regulation denotes following
T6462 676-689 Negative_regulation denotes downregulated
T6463 694-701 Positive_regulation denotes induced
T6464 702-707 Protein denotes I-κBα
T6465 708-723 Phosphorylation denotes phosphorylation
T6466 781-784 Protein denotes p65
T6467 785-800 Phosphorylation denotes phosphorylation
T6468 805-814 Positive_regulation denotes increased
T6469 815-824 Positive_regulation denotes following
T6470 888-897 Negative_regulation denotes decreased
T6471 902-909 Positive_regulation denotes induced
T6472 916-919 Protein denotes p65
T6473 920-927 Entity denotes nuclear
T6474 928-943 Phosphorylation denotes phosphorylation
T6475 1109-1116 Entity denotes nuclear
T7077 2268-2277 Positive_regulation denotes increased
T7078 2278-2282 Protein denotes CREB
T7079 2287-2294 Binding denotes binding
T7570 2331-2337 Regulation denotes Effect true
T7571 2348-2353 Protein denotes TNF-α
T7572 2354-2364 Gene_expression denotes production
T7573 2422-2429 Positive_regulation denotes induced
T7574 2430-2444 Negative_regulation denotes downregulation
T7575 2448-2453 Protein denotes TNF-α
T7576 2454-2464 Gene_expression denotes production
T7577 2643-2651 Positive_regulation denotes resulted
T7578 2657-2666 Negative_regulation denotes reduction
T7579 2670-2675 Protein denotes TNF-α true
T7580 2874-2884 Regulation denotes modulation
T7581 2888-2893 Protein denotes TNF-α
T7582 2894-2904 Gene_expression denotes production
T7583 3003-3017 Negative_regulation denotes downregulation
T7584 3021-3026 Protein denotes TNF-α true
T7585 3027-3037 Gene_expression denotes production
R5173 T6221 T6222 themeOf TNF-α,production
R5174 T6222 T6220 themeOf production,induced
R5175 T6224 T6225 themeOf TNF-α,production
R5176 T6225 T6223 themeOf production,inhibition
R5177 T6227 T6228 themeOf TNF-α,production
R5178 T6228 T6226 themeOf production,effect
R5349 T6453 T6452 themeOf I-κBα,degradation
R5350 T6454 T6455 locationOf nuclear,translocation
R5351 T6457 T6456 themeOf I-κBα,effects
R5352 T6458 T6459 themeOf I-κBα,phosphorylation
R5353 T6459 T6460 themeOf phosphorylation,increased
R5354 T6460 T6461 themeOf increased,following
R5355 T6463 T6462 themeOf induced,downregulated
R5356 T6464 T6465 themeOf I-κBα,phosphorylation
R5357 T6465 T6463 themeOf phosphorylation,induced
R5358 T6466 T6467 themeOf p65,phosphorylation
R5359 T6467 T6468 themeOf phosphorylation,increased
R5360 T6468 T6469 themeOf increased,following
R5361 T6471 T6470 themeOf induced,decreased
R5362 T6472 T6474 themeOf p65,phosphorylation
R5363 T6473 T6474 locationOf nuclear,phosphorylation
R5364 T6474 T6471 themeOf phosphorylation,induced
R5872 T7078 T7079 themeOf CREB,binding
R5873 T7079 T7077 themeOf binding,increased
R6247 T7571 T7572 themeOf TNF-α,production
R6248 T7572 T7570 themeOf production,Effect
R6249 T7574 T7573 themeOf downregulation,induced
R6250 T7575 T7576 themeOf TNF-α,production
R6251 T7576 T7574 themeOf production,downregulation
R6252 T7578 T7577 themeOf reduction,resulted
R6253 T7579 T7578 themeOf TNF-α,reduction
R6254 T7581 T7582 themeOf TNF-α,production
R6255 T7582 T7580 themeOf production,modulation
R6256 T7584 T7585 themeOf TNF-α,production
R6257 T7585 T7583 themeOf production,downregulation