The multivariate analysis from all pharmacokinetic parameters combined with the slow dynamic analysis (combined analysis) resulted in an AUC of 0.93 (95% CI = 0.85–0.96) and 0.90 (95% CI = 0.83–0.95) for reader 1 and 2, respectively. The results from the combined analysis were significantly higher when compared with the fast dynamic analysis for both readers (P = 0.01 and P = 0.02). This was also found for the slow dynamic analysis (P = 0.02 for both readers). The ROC curves are presented in Fig. 3.
Fig. 3 ROC curve for reader 1 (a) and reader 2 (b) displaying the fast dynamic, slow dynamic and combined analysis. No significant differences were found between the fast and slow dynamic analysis in both readers. A significant difference was found between the slow dynamic analysis and the combined analysis for both readers (P = 0.02 for both readers). The comparison between the fast dynamic analysis and the combined analysis also resulted in a significant difference for both readers (P = 0.01 and P = 0.02). No significant differences were found between the two readers