nhibit TGF-β1–Induced FOXP3 Expression and the Formation of Regulatory T Cells GATA3 Inhibits FOXP3 and Inducible Tregs 

Abstract
Transcription factors act in concert to induce lineage commitment towards Th1, Th2, or T regulatory (Treg) cells, and their counter-regulatory mechanisms were shown to be critical for polarization between Th1 and Th2 phenotypes. FOXP3 is an essential transcription factor for natural, thymus-deriv