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PMC:1941754 / 13772-15513 JSON TXT

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3 Histology of Mutant Gonads\nAll are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below.\n(A) Wild-type 25-d-old ovary.\n(B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.\n(C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles.\n(D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.”\n(E) Wild-type testis.\n(F) Trip13Gt/Gt testis with uniform pachytene arrest.\n(G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).\n(H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I).\n(I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes.\n(J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K).\n(K) Mei1 −/− Trip13Gt/Gt testis.\n(L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M).\n(M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.\n(N) Dmc1 −/− Trip13Gt/Gt testis.\n(O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P).\n(P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.\n(Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R).\n(R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.\n(S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T).\n(T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary."}

craft-ca-core-dev

{"project":"craft-ca-core-dev","denotations":[{"id":"T10876","span":{"begin":30,"end":36},"obj":"UBERON:0000991"},{"id":"T10877","span":{"begin":45,"end":56},"obj":"CHEBI:51686"},{"id":"T10878","span":{"begin":90,"end":96},"obj":"UBERON:0000473"},{"id":"T10879","span":{"begin":172,"end":177},"obj":"UBERON:0000992"},{"id":"T10880","span":{"begin":183,"end":189},"obj":"PR:000016672"},{"id":"T10881","span":{"begin":205,"end":210},"obj":"UBERON:0000992"},{"id":"T10882","span":{"begin":250,"end":257},"obj":"CL:0000023"},{"id":"T10883","span":{"begin":263,"end":269},"obj":"PR:000016672"},{"id":"T10884","span":{"begin":290,"end":295},"obj":"UBERON:0000992"},{"id":"T10885","span":{"begin":313,"end":320},"obj":"CL:0000023"},{"id":"T10886","span":{"begin":353,"end":359},"obj":"PR:000016672"},{"id":"T10887","span":{"begin":373,"end":378},"obj":"UBERON:0000992"},{"id":"T10888","span":{"begin":404,"end":411},"obj":"CL:0000023"},{"id":"T10889","span":{"begin":479,"end":485},"obj":"UBERON:0000473"},{"id":"T10890","span":{"begin":491,"end":497},"obj":"PR:000016672"},{"id":"T10891","span":{"begin":503,"end":509},"obj":"UBERON:0000473"},{"id":"T10892","span":{"begin":523,"end":532},"obj":"GO:0000239"},{"id":"T10893","span":{"begin":545,"end":551},"obj":"PR:000016672"},{"id":"T10894","span":{"begin":566,"end":572},"obj":"UBERON:0000473"},{"id":"T10895","span":{"begin":587,"end":594},"obj":"GO:0007126"},{"id":"T10896","span":{"begin":595,"end":605},"obj":"CL:0000018"},{"id":"T10897","span":{"begin":620,"end":625},"obj":"PR:000015553"},{"id":"T10898","span":{"begin":629,"end":635},"obj":"UBERON:0000473"},{"id":"T10899","span":{"begin":639,"end":645},"obj":"UBERON:0000025"},{"id":"T10900","span":{"begin":651,"end":664},"obj":"CL:0000017"},{"id":"T10901","span":{"begin":668,"end":677},"obj":"GO:0000237"},{"id":"T10902","span":{"begin":678,"end":686},"obj":"GO:0000238"},{"id":"T10903","span":{"begin":717,"end":724},"obj":"UBERON:0000025"},{"id":"T10904","span":{"begin":740,"end":753},"obj":"CL:0000017"},{"id":"T10905","span":{"begin":844,"end":849},"obj":"PR:000015553"},{"id":"T10906","span":{"begin":854,"end":860},"obj":"PR:000016672"},{"id":"T10907","span":{"begin":866,"end":872},"obj":"UBERON:0000473"},{"id":"T10908","span":{"begin":927,"end":933},"obj":"UBERON:0000025"},{"id":"T10909","span":{"begin":939,"end":948},"obj":"GO:0000237"},{"id":"T10910","span":{"begin":949,"end":957},"obj":"GO:0000238"},{"id":"T10911","span":{"begin":958,"end":971},"obj":"CL:0000017"},{"id":"T10912","span":{"begin":977,"end":981},"obj":"PR:000031227"},{"id":"T10913","span":{"begin":986,"end":992},"obj":"PR:000016672"},{"id":"T10914","span":{"begin":997,"end":1003},"obj":"UBERON:0000473"},{"id":"T10915","span":{"begin":1066,"end":1070},"obj":"PR:000031227"},{"id":"T10916","span":{"begin":1075,"end":1081},"obj":"PR:000016672"},{"id":"T10917","span":{"begin":1087,"end":1093},"obj":"UBERON:0000473"},{"id":"T10918","span":{"begin":1099,"end":1103},"obj":"PR:000013858"},{"id":"T10919","span":{"begin":1108,"end":1112},"obj":"PR:000013858"},{"id":"T10920","span":{"begin":1117,"end":1123},"obj":"PR:000016672"},{"id":"T10940","span":{"begin":1549,"end":1553},"obj":"PR:000031227"},{"id":"T10941","span":{"begin":1558,"end":1564},"obj":"PR:000016672"},{"id":"T10942","span":{"begin":1579,"end":1584},"obj":"UBERON:0000992"},{"id":"T10943","span":{"begin":1590,"end":1594},"obj":"PR:000013858"},{"id":"T10944","span":{"begin":1599,"end":1603},"obj":"PR:000013858"},{"id":"T10945","span":{"begin":1608,"end":1614},"obj":"PR:000016672"},{"id":"T10946","span":{"begin":1628,"end":1633},"obj":"UBERON:0000992"},{"id":"T10947","span":{"begin":1696,"end":1700},"obj":"PR:000013858"},{"id":"T10948","span":{"begin":1705,"end":1709},"obj":"PR:000013858"},{"id":"T10949","span":{"begin":1714,"end":1720},"obj":"PR:000016672"},{"id":"T10950","span":{"begin":1735,"end":1740},"obj":"UBERON:0000992"},{"id":"T10921","span":{"begin":1128,"end":1134},"obj":"UBERON:0000473"},{"id":"T10922","span":{"begin":1140,"end":1144},"obj":"PR:000013858"},{"id":"T10923","span":{"begin":1149,"end":1155},"obj":"SO:0001023"},{"id":"T10924","span":{"begin":1237,"end":1241},"obj":"PR:000013858"},{"id":"T10925","span":{"begin":1246,"end":1250},"obj":"PR:000013858"},{"id":"T10926","span":{"begin":1255,"end":1261},"obj":"PR:000016672"},{"id":"T10927","span":{"begin":1267,"end":1273},"obj":"UBERON:0000473"},{"id":"T10928","span":{"begin":1279,"end":1283},"obj":"PR:000006536"},{"id":"T10929","span":{"begin":1288,"end":1294},"obj":"PR:000016672"},{"id":"T10930","span":{"begin":1300,"end":1306},"obj":"UBERON:0000473"},{"id":"T10931","span":{"begin":1312,"end":1317},"obj":"PR:000015553"},{"id":"T10932","span":{"begin":1322,"end":1328},"obj":"PR:000016672"},{"id":"T10933","span":{"begin":1342,"end":1347},"obj":"UBERON:0000992"},{"id":"T10934","span":{"begin":1410,"end":1415},"obj":"PR:000015553"},{"id":"T10935","span":{"begin":1420,"end":1426},"obj":"PR:000016672"},{"id":"T10936","span":{"begin":1441,"end":1446},"obj":"UBERON:0000992"},{"id":"T10937","span":{"begin":1452,"end":1456},"obj":"PR:000031227"},{"id":"T10938","span":{"begin":1461,"end":1467},"obj":"PR:000016672"},{"id":"T10939","span":{"begin":1481,"end":1486},"obj":"UBERON:0000992"}],"text":"Figure 3 Histology of Mutant Gonads\nAll are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below.\n(A) Wild-type 25-d-old ovary.\n(B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.\n(C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles.\n(D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.”\n(E) Wild-type testis.\n(F) Trip13Gt/Gt testis with uniform pachytene arrest.\n(G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).\n(H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I).\n(I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes.\n(J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K).\n(K) Mei1 −/− Trip13Gt/Gt testis.\n(L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M).\n(M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.\n(N) Dmc1 −/− Trip13Gt/Gt testis.\n(O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P).\n(P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.\n(Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R).\n(R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.\n(S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T).\n(T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary."}

2_test

{"project":"2_test","denotations":[{"id":"17696610-15515002-85497896","span":{"begin":1171,"end":1173},"obj":"15515002"},{"id":"T34992","span":{"begin":1171,"end":1173},"obj":"15515002"}],"text":"Figure 3 Histology of Mutant Gonads\nAll are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below.\n(A) Wild-type 25-d-old ovary.\n(B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.\n(C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles.\n(D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.”\n(E) Wild-type testis.\n(F) Trip13Gt/Gt testis with uniform pachytene arrest.\n(G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).\n(H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I).\n(I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes.\n(J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K).\n(K) Mei1 −/− Trip13Gt/Gt testis.\n(L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M).\n(M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.\n(N) Dmc1 −/− Trip13Gt/Gt testis.\n(O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P).\n(P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.\n(Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R).\n(R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.\n(S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T).\n(T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary."}

craft-ca-core-ex-dev

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T10951","span":{"begin":23,"end":29},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T10952","span":{"begin":30,"end":36},"obj":"UBERON:0000991"},{"id":"T10953","span":{"begin":45,"end":56},"obj":"CHEBI:51686"},{"id":"T10954","span":{"begin":57,"end":62},"obj":"CHEBI_EXT:eosin"},{"id":"T10955","span":{"begin":90,"end":96},"obj":"UBERON:0000473"},{"id":"T10956","span":{"begin":115,"end":120},"obj":"PATO_UBERON_EXT:male_or_bearer_of_maleness"},{"id":"T10957","span":{"begin":153,"end":162},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T10958","span":{"begin":172,"end":177},"obj":"UBERON:0000992"},{"id":"T10959","span":{"begin":183,"end":189},"obj":"PR_EXT:000016672"},{"id":"T10960","span":{"begin":205,"end":210},"obj":"UBERON:0000992"},{"id":"T10961","span":{"begin":250,"end":257},"obj":"CL:0000023"},{"id":"T10962","span":{"begin":263,"end":269},"obj":"PR_EXT:000016672"},{"id":"T10963","span":{"begin":272,"end":273},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T10964","span":{"begin":290,"end":295},"obj":"UBERON:0000992"},{"id":"T10965","span":{"begin":313,"end":320},"obj":"CL:0000023"},{"id":"T10966","span":{"begin":338,"end":347},"obj":"UBERON_EXT:follicle"},{"id":"T10967","span":{"begin":353,"end":359},"obj":"PR_EXT:000016672"},{"id":"T10968","span":{"begin":373,"end":378},"obj":"UBERON:0000992"},{"id":"T10969","span":{"begin":404,"end":411},"obj":"CL:0000023"},{"id":"T10970","span":{"begin":469,"end":478},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T10971","span":{"begin":479,"end":485},"obj":"UBERON:0000473"},{"id":"T10972","span":{"begin":491,"end":497},"obj":"PR_EXT:000016672"},{"id":"T10973","span":{"begin":503,"end":509},"obj":"UBERON:0000473"},{"id":"T10974","span":{"begin":523,"end":532},"obj":"GO:0000239"},{"id":"T10975","span":{"begin":545,"end":551},"obj":"PR_EXT:000016672"},{"id":"T10976","span":{"begin":566,"end":572},"obj":"UBERON:0000473"},{"id":"T10977","span":{"begin":587,"end":594},"obj":"GO:0007126"},{"id":"T10978","span":{"begin":595,"end":605},"obj":"CL:0000018"},{"id":"T10979","span":{"begin":620,"end":625},"obj":"PR_EXT:000015553"},{"id":"T10980","span":{"begin":625,"end":626},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T10981","span":{"begin":627,"end":628},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T10982","span":{"begin":629,"end":635},"obj":"UBERON:0000473"},{"id":"T10983","span":{"begin":639,"end":645},"obj":"UBERON:0000025"},{"id":"T10984","span":{"begin":651,"end":664},"obj":"CL:0000017"},{"id":"T10985","span":{"begin":668,"end":677},"obj":"GO:0000237"},{"id":"T10986","span":{"begin":678,"end":686},"obj":"GO:0000238"},{"id":"T10987","span":{"begin":717,"end":724},"obj":"UBERON:0000025"},{"id":"T10988","span":{"begin":730,"end":739},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T10989","span":{"begin":740,"end":753},"obj":"CL:0000017"},{"id":"T10990","span":{"begin":844,"end":849},"obj":"PR_EXT:000015553"},{"id":"T10991","span":{"begin":850,"end":851},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T10992","span":{"begin":852,"end":853},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T10993","span":{"begin":854,"end":860},"obj":"PR_EXT:000016672"},{"id":"T10994","span":{"begin":866,"end":872},"obj":"UBERON:0000473"},{"id":"T10995","span":{"begin":927,"end":933},"obj":"UBERON:0000025"},{"id":"T10996","span":{"begin":939,"end":948},"obj":"GO:0000237"},{"id":"T10997","span":{"begin":949,"end":957},"obj":"GO:0000238"},{"id":"T10998","span":{"begin":958,"end":971},"obj":"CL:0000017"},{"id":"T10999","span":{"begin":977,"end":981},"obj":"PR_EXT:000031227"},{"id":"T11000","span":{"begin":982,"end":983},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11001","span":{"begin":984,"end":985},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11002","span":{"begin":986,"end":992},"obj":"PR_EXT:000016672"},{"id":"T11003","span":{"begin":995,"end":996},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11004","span":{"begin":997,"end":1003},"obj":"UBERON:0000473"},{"id":"T11005","span":{"begin":1066,"end":1070},"obj":"PR_EXT:000031227"},{"id":"T11006","span":{"begin":1071,"end":1072},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11007","span":{"begin":1073,"end":1074},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11008","span":{"begin":1075,"end":1081},"obj":"PR_EXT:000016672"},{"id":"T11009","span":{"begin":1087,"end":1093},"obj":"UBERON:0000473"},{"id":"T11010","span":{"begin":1099,"end":1103},"obj":"PR_EXT:000013858"},{"id":"T11011","span":{"begin":1108,"end":1112},"obj":"PR_EXT:000013858"},{"id":"T11012","span":{"begin":1117,"end":1123},"obj":"PR_EXT:000016672"},{"id":"T11013","span":{"begin":1126,"end":1127},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11014","span":{"begin":1128,"end":1134},"obj":"UBERON:0000473"},{"id":"T11015","span":{"begin":1140,"end":1144},"obj":"PR_EXT:000013858"},{"id":"T11016","span":{"begin":1149,"end":1155},"obj":"SO_EXT:0001023"},{"id":"T11017","span":{"begin":1237,"end":1241},"obj":"PR_EXT:000013858"},{"id":"T11018","span":{"begin":1246,"end":1250},"obj":"PR_EXT:000013858"},{"id":"T11019","span":{"begin":1255,"end":1261},"obj":"PR_EXT:000016672"},{"id":"T11020","span":{"begin":1267,"end":1273},"obj":"UBERON:0000473"},{"id":"T11021","span":{"begin":1279,"end":1283},"obj":"PR_EXT:000006536"},{"id":"T11022","span":{"begin":1284,"end":1285},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11023","span":{"begin":1286,"end":1287},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11024","span":{"begin":1288,"end":1294},"obj":"PR_EXT:000016672"},{"id":"T11025","span":{"begin":1300,"end":1306},"obj":"UBERON:0000473"},{"id":"T11026","span":{"begin":1312,"end":1317},"obj":"PR_EXT:000015553"},{"id":"T11027","span":{"begin":1318,"end":1319},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11028","span":{"begin":1320,"end":1321},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11029","span":{"begin":1322,"end":1328},"obj":"PR_EXT:000016672"},{"id":"T11030","span":{"begin":1331,"end":1332},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11031","span":{"begin":1342,"end":1347},"obj":"UBERON:0000992"},{"id":"T11032","span":{"begin":1410,"end":1415},"obj":"PR_EXT:000015553"},{"id":"T11033","span":{"begin":1416,"end":1417},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11034","span":{"begin":1418,"end":1419},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11035","span":{"begin":1420,"end":1426},"obj":"PR_EXT:000016672"},{"id":"T11036","span":{"begin":1441,"end":1446},"obj":"UBERON:0000992"},{"id":"T11037","span":{"begin":1452,"end":1456},"obj":"PR_EXT:000031227"},{"id":"T11038","span":{"begin":1457,"end":1458},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11056","span":{"begin":1735,"end":1740},"obj":"UBERON:0000992"},{"id":"T11039","span":{"begin":1459,"end":1460},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11040","span":{"begin":1461,"end":1467},"obj":"PR_EXT:000016672"},{"id":"T11041","span":{"begin":1470,"end":1471},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11042","span":{"begin":1481,"end":1486},"obj":"UBERON:0000992"},{"id":"T11043","span":{"begin":1549,"end":1553},"obj":"PR_EXT:000031227"},{"id":"T11044","span":{"begin":1554,"end":1555},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11045","span":{"begin":1556,"end":1557},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11046","span":{"begin":1558,"end":1564},"obj":"PR_EXT:000016672"},{"id":"T11047","span":{"begin":1579,"end":1584},"obj":"UBERON:0000992"},{"id":"T11048","span":{"begin":1590,"end":1594},"obj":"PR_EXT:000013858"},{"id":"T11049","span":{"begin":1599,"end":1603},"obj":"PR_EXT:000013858"},{"id":"T11050","span":{"begin":1608,"end":1614},"obj":"PR_EXT:000016672"},{"id":"T11051","span":{"begin":1617,"end":1618},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11052","span":{"begin":1628,"end":1633},"obj":"UBERON:0000992"},{"id":"T11053","span":{"begin":1696,"end":1700},"obj":"PR_EXT:000013858"},{"id":"T11054","span":{"begin":1705,"end":1709},"obj":"PR_EXT:000013858"},{"id":"T11055","span":{"begin":1714,"end":1720},"obj":"PR_EXT:000016672"}],"text":"Figure 3 Histology of Mutant Gonads\nAll are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below.\n(A) Wild-type 25-d-old ovary.\n(B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.\n(C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles.\n(D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.”\n(E) Wild-type testis.\n(F) Trip13Gt/Gt testis with uniform pachytene arrest.\n(G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).\n(H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I).\n(I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes.\n(J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K).\n(K) Mei1 −/− Trip13Gt/Gt testis.\n(L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M).\n(M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.\n(N) Dmc1 −/− Trip13Gt/Gt testis.\n(O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P).\n(P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.\n(Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R).\n(R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.\n(S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T).\n(T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary."}