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PMC:1914394 / 46023-46995 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T24616 0-13 JJ denotes Comprehensive
T24617 21-29 NN denotes analysis
T24618 14-20 NN denotes marker
T24619 30-38 VBD denotes revealed
T24620 39-43 IN denotes that
T24621 114-122 VB denotes suppress
T24622 43-45 , denotes ,
T24623 45-47 IN denotes in
T24624 48-56 JJ denotes striking
T24625 57-65 NN denotes contrast
T24626 66-68 IN denotes to
T24627 69-74 JJ denotes other
T24628 83-90 NNS denotes neurons
T24629 75-82 JJ denotes retinal
T24630 90-92 , denotes ,
T24631 92-96 NN denotes E2f1
T24632 97-105 NN denotes deletion
T24633 106-109 VBD denotes did
T24634 110-113 RB denotes not
T24635 123-130 NNS denotes defects
T24636 131-133 IN denotes in
T24637 134-136 NN denotes Rb
T24638 137-139 NN denotes KO
T24639 152-156 NNS denotes SACs
T24640 140-151 JJ denotes cholinergic
T24641 156-157 . denotes .
T24642 157-269 sentence denotes Instead, we observed E2f1-independent defects in the synthesis and transport of a large cohort of SAC proteins.
T24643 158-165 RB denotes Instead
T24644 170-178 VBD denotes observed
T24645 165-167 , denotes ,
T24646 167-169 PRP denotes we
T24647 179-183 NN denotes E2f1
T24648 184-195 JJ denotes independent
T24649 183-184 HYPH denotes -
T24650 196-203 NNS denotes defects
T24651 204-206 IN denotes in
T24652 207-210 DT denotes the
T24653 211-220 NN denotes synthesis
T24654 221-224 CC denotes and
T24655 225-234 NN denotes transport
T24656 235-237 IN denotes of
T24657 238-239 DT denotes a
T24658 246-252 NN denotes cohort
T24659 240-245 JJ denotes large
T24660 253-255 IN denotes of
T24661 256-259 NN denotes SAC
T24662 260-268 NN denotes proteins
T24663 268-269 . denotes .
T24664 269-482 sentence denotes These data expand insight into the development of these important interneurons, but more critically, provide to our knowledge the first unambiguous evidence that Rb regulates neurogenesis beyond terminal mitosis.
T24665 270-275 DT denotes These
T24666 276-280 NNS denotes data
T24667 281-287 VBP denotes expand
T24668 288-295 NN denotes insight
T24669 296-300 IN denotes into
T24670 301-304 DT denotes the
T24671 305-316 NN denotes development
T24672 317-319 IN denotes of
T24673 320-325 DT denotes these
T24674 336-348 NNS denotes interneurons
T24675 326-335 JJ denotes important
T24676 348-350 , denotes ,
T24677 350-353 CC denotes but
T24678 354-358 RBR denotes more
T24679 359-369 RB denotes critically
T24680 371-378 VB denotes provide
T24681 369-371 , denotes ,
T24682 379-381 IN denotes to
T24683 382-385 PRP$ denotes our
T24684 386-395 NN denotes knowledge
T24685 396-399 DT denotes the
T24686 418-426 NN denotes evidence
T24687 400-405 JJ denotes first
T24688 406-417 JJ denotes unambiguous
T24689 427-431 IN denotes that
T24690 435-444 VBZ denotes regulates
T24691 432-434 NN denotes Rb
T24692 445-457 NN denotes neurogenesis
T24693 458-464 IN denotes beyond
T24694 465-473 JJ denotes terminal
T24695 474-481 NN denotes mitosis
T24696 481-482 . denotes .
T24697 482-702 sentence denotes Rb binds more than 100 factors [43], and in several non-neuronal cells, such as skeletal muscle, adipocytes, and bone, it binds and potentiates tissue-specific transcription factors that promote differentiation [31–33].
T24698 483-485 NN denotes Rb
T24699 486-491 VBZ denotes binds
T24700 492-496 JJR denotes more
T24701 502-505 CD denotes 100
T24702 497-501 IN denotes than
T24703 506-513 NNS denotes factors
T24704 514-515 -LRB- denotes [
T24705 515-517 CD denotes 43
T24706 517-518 -RRB- denotes ]
T24707 518-520 , denotes ,
T24708 520-523 CC denotes and
T24709 524-526 IN denotes in
T24710 605-610 VBZ denotes binds
T24711 527-534 JJ denotes several
T24712 548-553 NNS denotes cells
T24713 535-547 JJ denotes non-neuronal
T24714 553-555 , denotes ,
T24715 555-559 JJ denotes such
T24716 560-562 IN denotes as
T24738 697-698 SYM denotes –
T24739 698-700 CD denotes 33
T24740 700-701 -RRB- denotes ]
T24741 701-702 . denotes .
T24742 702-875 sentence denotes The idea that Rb promotes muscle differentiation by potentiating Myod1 activity was contested [61], and other mechanisms proposed [62,63], but not involving E2f repression.
T24743 703-706 DT denotes The
T24744 707-711 NN denotes idea
T24745 787-796 VBN denotes contested
T24746 712-716 IN denotes that
T24747 720-728 VBZ denotes promotes
T24748 717-719 NN denotes Rb
T24749 729-735 NN denotes muscle
T24750 736-751 NN denotes differentiation
T24751 752-754 IN denotes by
T24752 755-767 VBG denotes potentiating
T24753 768-773 NN denotes Myod1
T24754 774-782 NN denotes activity
T24755 783-786 VBD denotes was
T24756 797-798 -LRB- denotes [
T24757 798-800 CD denotes 61
T24758 800-801 -RRB- denotes ]
T24759 801-803 , denotes ,
T24760 803-806 CC denotes and
T24761 807-812 JJ denotes other
T24762 813-823 NNS denotes mechanisms
T24763 824-832 VBN denotes proposed
T24764 833-834 -LRB- denotes [
T24765 837-839 CD denotes 63
T24766 834-836 CD denotes 62
T24767 836-837 , denotes ,
T24768 839-840 -RRB- denotes ]
T24769 840-842 , denotes ,
T24770 842-845 CC denotes but
T24771 850-859 VBG denotes involving
T24772 846-849 RB denotes not
T24773 860-863 NN denotes E2f
T24774 864-874 NN denotes repression
T24775 874-875 . denotes .
T24776 875-972 sentence denotes Strikingly, however, we discovered that Rb promotes SAC differentiation through E2f3 (Figure 8).
T24777 876-886 RB denotes Strikingly
T24778 900-910 VBD denotes discovered
T24779 886-888 , denotes ,
T24780 888-895 RB denotes however
T24781 895-897 , denotes ,
T24782 897-899 PRP denotes we
T24783 911-915 IN denotes that
T24784 919-927 VBZ denotes promotes
T24785 916-918 NN denotes Rb
T24786 928-931 NN denotes SAC
T24787 932-947 NN denotes differentiation
T24788 948-955 IN denotes through
T24789 956-960 NN denotes E2f3
T24790 961-962 -LRB- denotes (
T24791 962-968 NN denotes Figure
T24792 969-970 CD denotes 8
T24793 970-971 -RRB- denotes )
T24794 971-972 . denotes .
T24729 634-642 JJ denotes specific
T24730 633-634 HYPH denotes -
T24731 657-664 NNS denotes factors
T24732 643-656 NN denotes transcription
T24733 665-669 WDT denotes that
T24734 670-677 VBP denotes promote
T24735 678-693 NN denotes differentiation
T24736 694-695 -LRB- denotes [
T24737 695-697 CD denotes 31
T24717 563-571 JJ denotes skeletal
T24718 572-578 NN denotes muscle
T24719 578-580 , denotes ,
T24720 580-590 NNS denotes adipocytes
T24721 590-592 , denotes ,
T24722 592-595 CC denotes and
T24723 596-600 NN denotes bone
T24724 600-602 , denotes ,
T24725 602-604 PRP denotes it
T24726 611-614 CC denotes and
T24727 615-626 VBZ denotes potentiates
T24728 627-633 NN denotes tissue
R7134 T24616 T24617 amod Comprehensive,analysis
R7135 T24617 T24619 nsubj analysis,revealed
R7136 T24618 T24617 compound marker,analysis
R7137 T24620 T24621 mark that,suppress
R7138 T24621 T24619 ccomp suppress,revealed
R7139 T24622 T24621 punct ", ",suppress
R7140 T24623 T24621 prep in,suppress
R7141 T24624 T24625 amod striking,contrast
R7142 T24625 T24623 pobj contrast,in
R7143 T24626 T24625 prep to,contrast
R7144 T24627 T24628 amod other,neurons
R7145 T24628 T24626 pobj neurons,to
R7146 T24629 T24628 amod retinal,neurons
R7147 T24630 T24621 punct ", ",suppress
R7148 T24631 T24632 compound E2f1,deletion
R7149 T24632 T24621 nsubj deletion,suppress
R7150 T24633 T24621 aux did,suppress
R7151 T24634 T24621 neg not,suppress
R7152 T24635 T24621 dobj defects,suppress
R7153 T24636 T24621 prep in,suppress
R7154 T24637 T24638 nmod Rb,KO
R7155 T24638 T24639 nmod KO,SACs
R7156 T24639 T24636 pobj SACs,in
R7157 T24640 T24639 amod cholinergic,SACs
R7158 T24641 T24619 punct .,revealed
R7159 T24643 T24644 advmod Instead,observed
R7160 T24645 T24644 punct ", ",observed
R7161 T24646 T24644 nsubj we,observed
R7162 T24647 T24648 npadvmod E2f1,independent
R7163 T24648 T24650 amod independent,defects
R7164 T24649 T24648 punct -,independent
R7165 T24650 T24644 dobj defects,observed
R7166 T24651 T24650 prep in,defects
R7167 T24652 T24653 det the,synthesis
R7168 T24653 T24651 pobj synthesis,in
R7169 T24654 T24653 cc and,synthesis
R7170 T24655 T24653 conj transport,synthesis
R7171 T24656 T24653 prep of,synthesis
R7172 T24657 T24658 det a,cohort
R7173 T24658 T24656 pobj cohort,of
R7174 T24659 T24658 amod large,cohort
R7175 T24660 T24658 prep of,cohort
R7176 T24661 T24662 compound SAC,proteins
R7177 T24662 T24660 pobj proteins,of
R7178 T24663 T24644 punct .,observed
R7179 T24665 T24666 det These,data
R7180 T24666 T24667 nsubj data,expand
R7181 T24668 T24667 dobj insight,expand
R7182 T24669 T24668 prep into,insight
R7183 T24670 T24671 det the,development
R7184 T24671 T24669 pobj development,into
R7185 T24672 T24671 prep of,development
R7186 T24673 T24674 det these,interneurons
R7187 T24674 T24672 pobj interneurons,of
R7188 T24675 T24674 amod important,interneurons
R7189 T24676 T24667 punct ", ",expand
R7190 T24677 T24667 cc but,expand
R7191 T24678 T24679 advmod more,critically
R7192 T24679 T24680 advmod critically,provide
R7193 T24680 T24667 conj provide,expand
R7194 T24681 T24680 punct ", ",provide
R7195 T24682 T24680 prep to,provide
R7196 T24683 T24684 poss our,knowledge
R7197 T24684 T24682 pobj knowledge,to
R7198 T24685 T24686 det the,evidence
R7199 T24686 T24680 dobj evidence,provide
R7200 T24687 T24686 amod first,evidence
R7201 T24688 T24686 amod unambiguous,evidence
R7202 T24689 T24690 mark that,regulates
R7203 T24690 T24686 acl regulates,evidence
R7204 T24691 T24690 nsubj Rb,regulates
R7205 T24692 T24690 dobj neurogenesis,regulates
R7206 T24693 T24690 prep beyond,regulates
R7207 T24694 T24695 amod terminal,mitosis
R7208 T24695 T24693 pobj mitosis,beyond
R7209 T24696 T24667 punct .,expand
R7210 T24698 T24699 nsubj Rb,binds
R7211 T24700 T24701 amod more,100
R7212 T24701 T24703 nummod 100,factors
R7213 T24702 T24701 quantmod than,100
R7214 T24703 T24699 dobj factors,binds
R7215 T24704 T24705 punct [,43
R7216 T24705 T24699 parataxis 43,binds
R7217 T24706 T24705 punct ],43
R7218 T24707 T24699 punct ", ",binds
R7219 T24708 T24699 cc and,binds
R7220 T24709 T24710 prep in,binds
R7221 T24710 T24699 conj binds,binds
R7222 T24711 T24712 amod several,cells
R7223 T24712 T24709 pobj cells,in
R7224 T24713 T24712 amod non-neuronal,cells
R7225 T24714 T24712 punct ", ",cells
R7226 T24715 T24716 amod such,as
R7227 T24716 T24712 prep as,cells
R7228 T24717 T24718 amod skeletal,muscle
R7229 T24718 T24716 pobj muscle,as
R7230 T24719 T24718 punct ", ",muscle
R7231 T24720 T24718 conj adipocytes,muscle
R7232 T24721 T24720 punct ", ",adipocytes
R7233 T24722 T24720 cc and,adipocytes
R7234 T24723 T24720 conj bone,adipocytes
R7235 T24724 T24710 punct ", ",binds
R7236 T24725 T24710 nsubj it,binds
R7237 T24726 T24710 cc and,binds
R7238 T24727 T24710 conj potentiates,binds
R7239 T24728 T24729 npadvmod tissue,specific
R7240 T24729 T24731 amod specific,factors
R7241 T24730 T24729 punct -,specific
R7242 T24731 T24727 dobj factors,potentiates
R7243 T24732 T24731 compound transcription,factors
R7244 T24733 T24734 dep that,promote
R7245 T24734 T24731 relcl promote,factors
R7246 T24735 T24734 dobj differentiation,promote
R7247 T24736 T24737 punct [,31
R7248 T24737 T24727 parataxis 31,potentiates
R7249 T24738 T24739 punct –,33
R7250 T24739 T24737 prep 33,31
R7251 T24740 T24737 punct ],31
R7252 T24741 T24710 punct .,binds
R7253 T24743 T24744 det The,idea
R7254 T24744 T24745 nsubjpass idea,contested
R7255 T24746 T24747 mark that,promotes
R7256 T24747 T24744 acl promotes,idea
R7257 T24748 T24747 nsubj Rb,promotes
R7258 T24749 T24750 compound muscle,differentiation
R7259 T24750 T24747 dobj differentiation,promotes
R7260 T24751 T24747 prep by,promotes
R7261 T24752 T24751 pcomp potentiating,by
R7262 T24753 T24754 compound Myod1,activity
R7263 T24754 T24752 dobj activity,potentiating
R7264 T24755 T24745 auxpass was,contested
R7265 T24756 T24757 punct [,61
R7266 T24757 T24745 parataxis 61,contested
R7267 T24758 T24757 punct ],61
R7268 T24759 T24745 punct ", ",contested
R7269 T24760 T24745 cc and,contested
R7270 T24761 T24762 amod other,mechanisms
R7271 T24762 T24763 nsubj mechanisms,proposed
R7272 T24763 T24745 conj proposed,contested
R7273 T24764 T24765 punct [,63
R7274 T24765 T24763 parataxis 63,proposed
R7275 T24766 T24765 nummod 62,63
R7276 T24767 T24765 punct ",",63
R7277 T24768 T24765 punct ],63
R7278 T24769 T24763 punct ", ",proposed
R7279 T24770 T24771 cc but,involving
R7280 T24771 T24763 dep involving,proposed
R7281 T24772 T24771 neg not,involving
R7282 T24773 T24774 compound E2f,repression
R7283 T24774 T24771 dobj repression,involving
R7284 T24775 T24763 punct .,proposed
R7285 T24777 T24778 advmod Strikingly,discovered
R7286 T24779 T24778 punct ", ",discovered
R7287 T24780 T24778 advmod however,discovered
R7288 T24781 T24778 punct ", ",discovered
R7289 T24782 T24778 nsubj we,discovered
R7290 T24783 T24784 mark that,promotes
R7291 T24784 T24778 ccomp promotes,discovered
R7292 T24785 T24784 nsubj Rb,promotes
R7293 T24786 T24787 compound SAC,differentiation
R7294 T24787 T24784 dobj differentiation,promotes
R7295 T24788 T24784 prep through,promotes
R7296 T24789 T24788 pobj E2f3,through
R7297 T24790 T24791 punct (,Figure
R7298 T24791 T24784 parataxis Figure,promotes
R7299 T24792 T24791 nummod 8,Figure
R7300 T24793 T24791 punct ),Figure
R7301 T24794 T24778 punct .,discovered

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T24511 179-183 PR_EXT:000006852 denotes E2f1
T24512 260-268 CHEBI_PR_EXT:protein denotes proteins
T24513 336-348 CL:0000099 denotes interneurons
T24514 432-434 PR_EXT:000013773 denotes Rb
T24515 435-444 GO:0065007 denotes regulates
T24516 445-457 GO:0022008 denotes neurogenesis
T24517 474-481 GO:0007067 denotes mitosis
T24518 483-485 PR_EXT:000013773 denotes Rb
T24519 486-491 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T24520 539-547 CL:0000540 denotes neuronal
T24521 548-553 CL_GO_EXT:cell denotes cells
T24522 563-578 UBERON_EXT:skeletal_muscle_organ_or_tissue denotes skeletal muscle
T24523 580-590 CL:0000136 denotes adipocytes
T24524 596-600 UBERON_EXT:bone_element_or_tissue denotes bone
T24525 605-610 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T24526 627-633 UBERON:0000479 denotes tissue
T24527 643-656 GO_EXT:transcription denotes transcription
T24528 643-664 GO_EXT:transcription_factor denotes transcription factors
T24529 678-693 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24530 717-719 PR_EXT:000013773 denotes Rb
T24531 729-735 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T24532 736-751 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24533 768-773 PR_EXT:000010875 denotes Myod1
T24534 860-863 PR_EXT:E2F denotes E2f
T24535 916-918 PR_EXT:000013773 denotes Rb
T24536 932-947 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24537 956-960 PR_EXT:000006854 denotes E2f3
T24504 14-20 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T24505 75-82 UBERON:0000966 denotes retinal
T24506 83-90 CL:0000540 denotes neurons
T24507 92-96 PR_EXT:000006852 denotes E2f1
T24508 97-105 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T24509 134-136 PR_EXT:000013773 denotes Rb
T24510 140-151 CHEBI:15355 denotes cholinergic

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T24444 539-547 CL:0000540 denotes neuronal
T24445 563-571 UBERON:0004288 denotes skeletal
T24446 580-590 CL:0000136 denotes adipocytes
T24447 627-633 UBERON:0000479 denotes tissue
T24448 717-719 PR:000013773 denotes Rb
T24449 768-773 PR:000010875 denotes Myod1
T24450 916-918 PR:000013773 denotes Rb
T24451 956-960 PR:000006854 denotes E2f3
T24432 75-82 UBERON:0000966 denotes retinal
T24433 83-90 CL:0000540 denotes neurons
T24434 92-96 PR:000006852 denotes E2f1
T24435 134-136 PR:000013773 denotes Rb
T24436 140-151 CHEBI:15355 denotes cholinergic
T24437 179-183 PR:000006852 denotes E2f1
T24438 336-348 CL:0000099 denotes interneurons
T24439 432-434 PR:000013773 denotes Rb
T24440 435-444 GO:0065007 denotes regulates
T24441 445-457 GO:0022008 denotes neurogenesis
T24442 474-481 GO:0007067 denotes mitosis
T24443 483-485 PR:000013773 denotes Rb

2_test

Id Subject Object Predicate Lexical cue
17608565-11447760-84869019 515-517 11447760 denotes 43
17608565-8381715-84869020 695-697 8381715 denotes 31
17608565-11545733-84869020 695-697 11545733 denotes 31
17608565-8946919-84869020 695-697 8946919 denotes 31
17608565-10601020-84869021 798-800 10601020 denotes 61
17608565-11684023-84869022 834-836 11684023 denotes 62
17608565-11034201-84869023 837-839 11034201 denotes 63
T97762 515-517 11447760 denotes 43
T62413 695-697 8381715 denotes 31
T83034 695-697 11545733 denotes 31
T20471 695-697 8946919 denotes 31
T83077 798-800 10601020 denotes 61
T32657 834-836 11684023 denotes 62
T9102 837-839 11034201 denotes 63