PMC:1914394 / 13961-14617 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T7436","span":{"begin":0,"end":4},"obj":"NN"},{"id":"T7437","span":{"begin":25,"end":32},"obj":"VBZ"},{"id":"T7438","span":{"begin":5,"end":7},"obj":"IN"},{"id":"T7439","span":{"begin":8,"end":10},"obj":"NN"},{"id":"T7440","span":{"begin":11,"end":13},"obj":"IN"},{"id":"T7441","span":{"begin":14,"end":17},"obj":"DT"},{"id":"T7442","span":{"begin":18,"end":24},"obj":"NN"},{"id":"T7443","span":{"begin":33,"end":35},"obj":"IN"},{"id":"T7444","span":{"begin":36,"end":48},"obj":"JJ"},{"id":"T7445","span":{"begin":53,"end":62},"obj":"NN"},{"id":"T7446","span":{"begin":49,"end":52},"obj":"NN"},{"id":"T7447","span":{"begin":62,"end":64},"obj":","},{"id":"T7448","span":{"begin":64,"end":75},"obj":"VBG"},{"id":"T7449","span":{"begin":76,"end":80},"obj":"JJS"},{"id":"T7450","span":{"begin":102,"end":107},"obj":"NNS"},{"id":"T7451","span":{"begin":81,"end":88},"obj":"JJ"},{"id":"T7452","span":{"begin":89,"end":92},"obj":"CC"},{"id":"T7453","span":{"begin":93,"end":101},"obj":"NN"},{"id":"T7454","span":{"begin":108,"end":110},"obj":"RB"},{"id":"T7455","span":{"begin":116,"end":118},"obj":"IN"},{"id":"T7456","span":{"begin":111,"end":115},"obj":"RB"},{"id":"T7457","span":{"begin":119,"end":123},"obj":"JJ"},{"id":"T7458","span":{"begin":124,"end":128},"obj":"NNS"},{"id":"T7459","span":{"begin":129,"end":130},"obj":"-LRB-"},{"id":"T7460","span":{"begin":137,"end":139},"obj":"NN"},{"id":"T7461","span":{"begin":130,"end":136},"obj":"NN"},{"id":"T7462","span":{"begin":139,"end":140},"obj":"SYM"},{"id":"T7463","span":{"begin":140,"end":142},"obj":"NN"},{"id":"T7464","span":{"begin":142,"end":143},"obj":"-RRB-"},{"id":"T7465","span":{"begin":144,"end":145},"obj":"-LRB-"},{"id":"T7466","span":{"begin":147,"end":148},"obj":"CD"},{"id":"T7467","span":{"begin":145,"end":146},"obj":"CD"},{"id":"T7468","span":{"begin":146,"end":147},"obj":","},{"id":"T7469","span":{"begin":148,"end":149},"obj":"-RRB-"},{"id":"T7470","span":{"begin":149,"end":150},"obj":"."},{"id":"T7471","span":{"begin":150,"end":406},"obj":"sentence"},{"id":"T7472","span":{"begin":151,"end":154},"obj":"DT"},{"id":"T7473","span":{"begin":155,"end":159},"obj":"NN"},{"id":"T7474","span":{"begin":174,"end":176},"obj":"VBZ"},{"id":"T7475","span":{"begin":160,"end":162},"obj":"IN"},{"id":"T7476","span":{"begin":163,"end":165},"obj":"NN"},{"id":"T7477","span":{"begin":166,"end":168},"obj":"NN"},{"id":"T7478","span":{"begin":169,"end":173},"obj":"NNS"},{"id":"T7479","span":{"begin":177,"end":184},"obj":"JJ"},{"id":"T7480","span":{"begin":185,"end":189},"obj":"IN"},{"id":"T7481","span":{"begin":190,"end":193},"obj":"DT"},{"id":"T7482","span":{"begin":202,"end":205},"obj":"NN"},{"id":"T7483","span":{"begin":194,"end":201},"obj":"JJ"},{"id":"T7484","span":{"begin":205,"end":207},"obj":","},{"id":"T7485","span":{"begin":207,"end":210},"obj":"CC"},{"id":"T7486","span":{"begin":211,"end":214},"obj":"DT"},{"id":"T7487","span":{"begin":215,"end":220},"obj":"NN"},{"id":"T7488","span":{"begin":283,"end":291},"obj":"VBN"},{"id":"T7489","span":{"begin":221,"end":223},"obj":"IN"},{"id":"T7490","span":{"begin":224,"end":229},"obj":"DT"},{"id":"T7491","span":{"begin":230,"end":235},"obj":"NNS"},{"id":"T7492","span":{"begin":236,"end":238},"obj":"RB"},{"id":"T7493","span":{"begin":244,"end":246},"obj":"IN"},{"id":"T7494","span":{"begin":239,"end":243},"obj":"RB"},{"id":"T7495","span":{"begin":247,"end":254},"obj":"JJ"},{"id":"T7496","span":{"begin":268,"end":275},"obj":"NNS"},{"id":"T7497","span":{"begin":255,"end":258},"obj":"CC"},{"id":"T7498","span":{"begin":259,"end":267},"obj":"NN"},{"id":"T7499","span":{"begin":276,"end":279},"obj":"MD"},{"id":"T7500","span":{"begin":280,"end":282},"obj":"VB"},{"id":"T7501","span":{"begin":292,"end":300},"obj":"RB"},{"id":"T7502","span":{"begin":301,"end":303},"obj":"IN"},{"id":"T7503","span":{"begin":304,"end":310},"obj":"RB"},{"id":"T7504","span":{"begin":311,"end":320},"obj":"VBG"},{"id":"T7505","span":{"begin":321,"end":324},"obj":"IN"},{"id":"T7506","span":{"begin":325,"end":334},"obj":"JJ"},{"id":"T7507","span":{"begin":358,"end":365},"obj":"NNS"},{"id":"T7508","span":{"begin":335,"end":338},"obj":"CC"},{"id":"T7509","span":{"begin":339,"end":343},"obj":"NN"},{"id":"T7510","span":{"begin":344,"end":348},"obj":"NN"},{"id":"T7511","span":{"begin":343,"end":344},"obj":"HYPH"},{"id":"T7512","span":{"begin":349,"end":357},"obj":"JJ"},{"id":"T7513","span":{"begin":348,"end":349},"obj":"HYPH"},{"id":"T7514","span":{"begin":366,"end":367},"obj":"-LRB-"},{"id":"T7515","span":{"begin":367,"end":368},"obj":"CD"},{"id":"T7516","span":{"begin":368,"end":369},"obj":"-RRB-"},{"id":"T7517","span":{"begin":370,"end":371},"obj":"-LRB-"},{"id":"T7518","span":{"begin":371,"end":373},"obj":"NNP"},{"id":"T7519","span":{"begin":374,"end":376},"obj":"NNP"},{"id":"T7520","span":{"begin":377,"end":380},"obj":"CC"},{"id":"T7521","span":{"begin":381,"end":383},"obj":"NNP"},{"id":"T7522","span":{"begin":384,"end":386},"obj":"NNP"},{"id":"T7523","span":{"begin":386,"end":388},"obj":","},{"id":"T7524","span":{"begin":388,"end":399},"obj":"JJ"},{"id":"T7525","span":{"begin":400,"end":404},"obj":"NNS"},{"id":"T7526","span":{"begin":404,"end":405},"obj":"-RRB-"},{"id":"T7527","span":{"begin":405,"end":406},"obj":"."},{"id":"T7528","span":{"begin":406,"end":532},"obj":"sentence"},{"id":"T7529","span":{"begin":407,"end":411},"obj":"NN"},{"id":"T7530","span":{"begin":447,"end":449},"obj":"VBZ"},{"id":"T7531","span":{"begin":412,"end":414},"obj":"IN"},{"id":"T7532","span":{"begin":415,"end":425},"obj":"JJ"},{"id":"T7533","span":{"begin":441,"end":446},"obj":"NNS"},{"id":"T7534","span":{"begin":426,"end":428},"obj":"NN"},{"id":"T7535","span":{"begin":429,"end":431},"obj":"NN"},{"id":"T7536","span":{"begin":432,"end":440},"obj":"NN"},{"id":"T7537","span":{"begin":450,"end":454},"obj":"RB"},{"id":"T7538","span":{"begin":455,"end":462},"obj":"JJ"},{"id":"T7539","span":{"begin":463,"end":467},"obj":"IN"},{"id":"T7540","span":{"begin":468,"end":476},"obj":"VBG"},{"id":"T7541","span":{"begin":477,"end":479},"obj":"IN"},{"id":"T7542","span":{"begin":480,"end":483},"obj":"DT"},{"id":"T7543","span":{"begin":490,"end":495},"obj":"NN"},{"id":"T7544","span":{"begin":484,"end":489},"obj":"JJ"},{"id":"T7545","span":{"begin":496,"end":497},"obj":"-LRB-"},{"id":"T7546","span":{"begin":497,"end":499},"obj":"NNP"},{"id":"T7547","span":{"begin":500,"end":502},"obj":"NNP"},{"id":"T7548","span":{"begin":503,"end":506},"obj":"CC"},{"id":"T7549","span":{"begin":507,"end":509},"obj":"NNP"},{"id":"T7550","span":{"begin":510,"end":512},"obj":"NNP"},{"id":"T7551","span":{"begin":512,"end":514},"obj":","},{"id":"T7552","span":{"begin":514,"end":525},"obj":"JJ"},{"id":"T7553","span":{"begin":526,"end":530},"obj":"NNS"},{"id":"T7554","span":{"begin":530,"end":531},"obj":"-RRB-"},{"id":"T7555","span":{"begin":531,"end":532},"obj":"."},{"id":"T7556","span":{"begin":532,"end":656},"obj":"sentence"},{"id":"T7557","span":{"begin":533,"end":541},"obj":"VBG"},{"id":"T7558","span":{"begin":570,"end":577},"obj":"VBD"},{"id":"T7559","span":{"begin":542,"end":546},"obj":"NN"},{"id":"T7560","span":{"begin":546,"end":548},"obj":","},{"id":"T7561","span":{"begin":548,"end":551},"obj":"CC"},{"id":"T7562","span":{"begin":552,"end":555},"obj":"RB"},{"id":"T7563","span":{"begin":556,"end":560},"obj":"NN"},{"id":"T7564","span":{"begin":561,"end":563},"obj":"CC"},{"id":"T7565","span":{"begin":564,"end":568},"obj":"NN"},{"id":"T7566","span":{"begin":568,"end":570},"obj":","},{"id":"T7567","span":{"begin":578,"end":582},"obj":"DT"},{"id":"T7568","span":{"begin":596,"end":601},"obj":"NN"},{"id":"T7569","span":{"begin":583,"end":590},"obj":"JJ"},{"id":"T7570","span":{"begin":591,"end":595},"obj":"NN"},{"id":"T7571","span":{"begin":602,"end":604},"obj":"IN"},{"id":"T7572","span":{"begin":605,"end":606},"obj":"DT"},{"id":"T7573","span":{"begin":622,"end":629},"obj":"NN"},{"id":"T7574","span":{"begin":607,"end":611},"obj":"NN"},{"id":"T7575","span":{"begin":612,"end":621},"obj":"JJ"},{"id":"T7576","span":{"begin":611,"end":612},"obj":"HYPH"},{"id":"T7577","span":{"begin":630,"end":631},"obj":"-LRB-"},{"id":"T7578","span":{"begin":639,"end":641},"obj":"NN"},{"id":"T7579","span":{"begin":631,"end":638},"obj":"NNS"},{"id":"T7580","span":{"begin":641,"end":643},"obj":","},{"id":"T7581","span":{"begin":643,"end":645},"obj":"NN"},{"id":"T7582","span":{"begin":645,"end":647},"obj":","},{"id":"T7583","span":{"begin":647,"end":650},"obj":"CC"},{"id":"T7584","span":{"begin":651,"end":654},"obj":"NN"},{"id":"T7585","span":{"begin":654,"end":655},"obj":"-RRB-"},{"id":"T7586","span":{"begin":655,"end":656},"obj":"."}],"relations":[{"id":"R1998","pred":"dobj","subj":"T7450","obj":"T7448"},{"id":"R2000","pred":"amod","subj":"T7451","obj":"T7450"},{"id":"R2002","pred":"cc","subj":"T7452","obj":"T7451"},{"id":"R2004","pred":"conj","subj":"T7453","obj":"T7451"},{"id":"R2005","pred":"advmod","subj":"T7454","obj":"T7455"},{"id":"R2006","pred":"cc","subj":"T7455","obj":"T7450"},{"id":"R2008","pred":"advmod","subj":"T7456","obj":"T7455"},{"id":"R2009","pred":"amod","subj":"T7457","obj":"T7458"},{"id":"R2011","pred":"conj","subj":"T7458","obj":"T7450"},{"id":"R2012","pred":"punct","subj":"T7459","obj":"T7460"},{"id":"R2013","pred":"parataxis","subj":"T7460","obj":"T7448"},{"id":"R2014","pred":"compound","subj":"T7461","obj":"T7460"},{"id":"R2016","pred":"punct","subj":"T7462","obj":"T7463"},{"id":"R2017","pred":"prep","subj":"T7463","obj":"T7460"},{"id":"R2019","pred":"punct","subj":"T7464","obj":"T7460"},{"id":"R2020","pred":"punct","subj":"T7465","obj":"T7466"},{"id":"R2021","pred":"parataxis","subj":"T7466","obj":"T7448"},{"id":"R2022","pred":"nummod","subj":"T7467","obj":"T7466"},{"id":"R2024","pred":"punct","subj":"T7468","obj":"T7466"},{"id":"R2025","pred":"punct","subj":"T7469","obj":"T7466"},{"id":"R2027","pred":"punct","subj":"T7470","obj":"T7437"},{"id":"R2029","pred":"det","subj":"T7472","obj":"T7473"},{"id":"R2030","pred":"nsubj","subj":"T7473","obj":"T7474"},{"id":"R2031","pred":"prep","subj":"T7475","obj":"T7473"},{"id":"R2032","pred":"compound","subj":"T7476","obj":"T7477"},{"id":"R2035","pred":"compound","subj":"T7477","obj":"T7478"},{"id":"R2037","pred":"pobj","subj":"T7478","obj":"T7475"},{"id":"R2038","pred":"acomp","subj":"T7479","obj":"T7474"},{"id":"R2039","pred":"prep","subj":"T7480","obj":"T7474"},{"id":"R2041","pred":"det","subj":"T7481","obj":"T7482"},{"id":"R2043","pred":"pobj","subj":"T7482","obj":"T7480"},{"id":"R2044","pred":"amod","subj":"T7483","obj":"T7482"},{"id":"R2045","pred":"punct","subj":"T7484","obj":"T7474"},{"id":"R2046","pred":"cc","subj":"T7485","obj":"T7474"},{"id":"R2048","pred":"det","subj":"T7486","obj":"T7487"},{"id":"R2049","pred":"nsubjpass","subj":"T7487","obj":"T7488"},{"id":"R2051","pred":"conj","subj":"T7488","obj":"T7474"},{"id":"R2052","pred":"prep","subj":"T7489","obj":"T7487"},{"id":"R2053","pred":"det","subj":"T7490","obj":"T7491"},{"id":"R2055","pred":"pobj","subj":"T7491","obj":"T7489"},{"id":"R2056","pred":"advmod","subj":"T7492","obj":"T7493"},{"id":"R2058","pred":"cc","subj":"T7493","obj":"T7491"},{"id":"R2059","pred":"advmod","subj":"T7494","obj":"T7493"},{"id":"R2060","pred":"amod","subj":"T7495","obj":"T7496"},{"id":"R2062","pred":"conj","subj":"T7496","obj":"T7491"},{"id":"R2063","pred":"cc","subj":"T7497","obj":"T7495"},{"id":"R2064","pred":"conj","subj":"T7498","obj":"T7495"},{"id":"R2066","pred":"aux","subj":"T7499","obj":"T7488"},{"id":"R2067","pred":"auxpass","subj":"T7500","obj":"T7488"},{"id":"R2068","pred":"advmod","subj":"T7501","obj":"T7488"},{"id":"R2070","pred":"prep","subj":"T7502","obj":"T7488"},{"id":"R2071","pred":"advmod","subj":"T7503","obj":"T7504"},{"id":"R2073","pred":"pcomp","subj":"T7504","obj":"T7502"},{"id":"R2074","pred":"prep","subj":"T7505","obj":"T7504"},{"id":"R2075","pred":"amod","subj":"T7506","obj":"T7507"},{"id":"R2077","pred":"pobj","subj":"T7507","obj":"T7505"},{"id":"R2078","pred":"cc","subj":"T7508","obj":"T7506"},{"id":"R2080","pred":"compound","subj":"T7509","obj":"T7510"},{"id":"R2081","pred":"npadvmod","subj":"T7510","obj":"T7512"},{"id":"R2082","pred":"punct","subj":"T7511","obj":"T7510"},{"id":"R2083","pred":"conj","subj":"T7512","obj":"T7506"},{"id":"R2084","pred":"punct","subj":"T7513","obj":"T7512"},{"id":"R2085","pred":"punct","subj":"T7514","obj":"T7515"},{"id":"R2087","pred":"parataxis","subj":"T7515","obj":"T7488"},{"id":"R2088","pred":"punct","subj":"T7516","obj":"T7515"},{"id":"R2089","pred":"punct","subj":"T7517","obj":"T7518"},{"id":"R2091","pred":"meta","subj":"T7518","obj":"T7488"},{"id":"R2092","pred":"nmod","subj":"T7519","obj":"T7518"},{"id":"R2094","pred":"cc","subj":"T7520","obj":"T7518"},{"id":"R2095","pred":"conj","subj":"T7521","obj":"T7518"},{"id":"R2096","pred":"nmod","subj":"T7522","obj":"T7521"},{"id":"R2098","pred":"punct","subj":"T7523","obj":"T7521"},{"id":"R2099","pred":"amod","subj":"T7524","obj":"T7525"},{"id":"R2100","pred":"conj","subj":"T7525","obj":"T7521"},{"id":"R2102","pred":"punct","subj":"T7526","obj":"T7525"},{"id":"R2103","pred":"punct","subj":"T7527","obj":"T7488"},{"id":"R2105","pred":"nsubj","subj":"T7529","obj":"T7530"},{"id":"R2107","pred":"prep","subj":"T7531","obj":"T7529"},{"id":"R2108","pred":"amod","subj":"T7532","obj":"T7533"},{"id":"R2109","pred":"pobj","subj":"T7533","obj":"T7531"},{"id":"R2111","pred":"compound","subj":"T7534","obj":"T7535"},{"id":"R2112","pred":"compound","subj":"T7535","obj":"T7533"},{"id":"R2113","pred":"compound","subj":"T7536","obj":"T7533"},{"id":"R2115","pred":"advmod","subj":"T7537","obj":"T7530"},{"id":"R2116","pred":"acomp","subj":"T7538","obj":"T7530"},{"id":"R2118","pred":"prep","subj":"T7539","obj":"T7530"},{"id":"R2119","pred":"pobj","subj":"T7540","obj":"T7539"},{"id":"R2120","pred":"prep","subj":"T7541","obj":"T7540"},{"id":"R2122","pred":"det","subj":"T7542","obj":"T7543"},{"id":"R2123","pred":"pobj","subj":"T7543","obj":"T7541"},{"id":"R2124","pred":"amod","subj":"T7544","obj":"T7543"},{"id":"R2126","pred":"punct","subj":"T7545","obj":"T7546"},{"id":"R2127","pred":"meta","subj":"T7546","obj":"T7530"},{"id":"R2128","pred":"nsubj","subj":"T7436","obj":"T7437"},{"id":"R2129","pred":"nmod","subj":"T7547","obj":"T7546"},{"id":"R2130","pred":"cc","subj":"T7548","obj":"T7546"},{"id":"R2131","pred":"conj","subj":"T7549","obj":"T7546"},{"id":"R2132","pred":"nmod","subj":"T7550","obj":"T7549"},{"id":"R2133","pred":"prep","subj":"T7438","obj":"T7436"},{"id":"R2134","pred":"punct","subj":"T7551","obj":"T7549"},{"id":"R2135","pred":"amod","subj":"T7552","obj":"T7553"},{"id":"R2136","pred":"conj","subj":"T7553","obj":"T7549"},{"id":"R2137","pred":"punct","subj":"T7554","obj":"T7553"},{"id":"R2138","pred":"punct","subj":"T7555","obj":"T7530"},{"id":"R2139","pred":"pobj","subj":"T7439","obj":"T7438"},{"id":"R2140","pred":"prep","subj":"T7440","obj":"T7436"},{"id":"R2141","pred":"det","subj":"T7441","obj":"T7442"},{"id":"R2142","pred":"csubj","subj":"T7557","obj":"T7558"},{"id":"R2143","pred":"pobj","subj":"T7442","obj":"T7440"},{"id":"R2144","pred":"dobj","subj":"T7559","obj":"T7557"},{"id":"R2145","pred":"punct","subj":"T7560","obj":"T7559"},{"id":"R2146","pred":"prep","subj":"T7443","obj":"T7437"},{"id":"R2147","pred":"cc","subj":"T7561","obj":"T7559"},{"id":"R2148","pred":"amod","subj":"T7444","obj":"T7445"},{"id":"R2149","pred":"pobj","subj":"T7445","obj":"T7443"},{"id":"R2150","pred":"compound","subj":"T7446","obj":"T7445"},{"id":"R2153","pred":"punct","subj":"T7447","obj":"T7437"},{"id":"R2155","pred":"advcl","subj":"T7448","obj":"T7437"},{"id":"R2160","pred":"amod","subj":"T7449","obj":"T7450"},{"id":"R2151","pred":"neg","subj":"T7562","obj":"T7561"},{"id":"R2152","pred":"conj","subj":"T7563","obj":"T7559"},{"id":"R2154","pred":"cc","subj":"T7564","obj":"T7563"},{"id":"R2156","pred":"conj","subj":"T7565","obj":"T7563"},{"id":"R2157","pred":"punct","subj":"T7566","obj":"T7558"},{"id":"R2158","pred":"det","subj":"T7567","obj":"T7568"},{"id":"R2159","pred":"dobj","subj":"T7568","obj":"T7558"},{"id":"R2161","pred":"amod","subj":"T7569","obj":"T7568"},{"id":"R2162","pred":"compound","subj":"T7570","obj":"T7568"},{"id":"R2164","pred":"prep","subj":"T7571","obj":"T7558"},{"id":"R2165","pred":"det","subj":"T7572","obj":"T7573"},{"id":"R2166","pred":"pobj","subj":"T7573","obj":"T7571"},{"id":"R2167","pred":"npadvmod","subj":"T7574","obj":"T7575"},{"id":"R2168","pred":"amod","subj":"T7575","obj":"T7573"},{"id":"R2170","pred":"punct","subj":"T7576","obj":"T7575"},{"id":"R2171","pred":"punct","subj":"T7577","obj":"T7578"},{"id":"R2173","pred":"parataxis","subj":"T7578","obj":"T7558"},{"id":"R2174","pred":"compound","subj":"T7579","obj":"T7578"},{"id":"R2175","pred":"punct","subj":"T7580","obj":"T7578"},{"id":"R2176","pred":"conj","subj":"T7581","obj":"T7578"},{"id":"R2178","pred":"punct","subj":"T7582","obj":"T7581"},{"id":"R2179","pred":"cc","subj":"T7583","obj":"T7581"},{"id":"R2180","pred":"conj","subj":"T7584","obj":"T7581"},{"id":"R2182","pred":"punct","subj":"T7585","obj":"T7578"},{"id":"R2183","pred":"punct","subj":"T7586","obj":"T7558"}],"text":"Loss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3]. The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data). Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data). Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6821","span":{"begin":8,"end":10},"obj":"PR_EXT:000013773"},{"id":"T6822","span":{"begin":18,"end":24},"obj":"UBERON:0000966"},{"id":"T6823","span":{"begin":53,"end":62},"obj":"GO:0006915"},{"id":"T6824","span":{"begin":64,"end":75},"obj":"GO_EXT:killing"},{"id":"T6825","span":{"begin":81,"end":88},"obj":"_FRAGMENT"},{"id":"T6826","span":{"begin":102,"end":107},"obj":"CL:0000103"},{"id":"T6827","span":{"begin":93,"end":101},"obj":"UBERON:0000045"},{"id":"T6828","span":{"begin":93,"end":107},"obj":"CL:0000740"},{"id":"T6829","span":{"begin":102,"end":107},"obj":"CL_GO_EXT:cell"},{"id":"T6830","span":{"begin":124,"end":128},"obj":"CL:0000604"},{"id":"T6831","span":{"begin":163,"end":165},"obj":"PR_EXT:000013773"},{"id":"T6832","span":{"begin":169,"end":173},"obj":"CL:0000604"},{"id":"T6833","span":{"begin":202,"end":205},"obj":"UBERON:0001789"},{"id":"T6834","span":{"begin":215,"end":223},"obj":"_FRAGMENT"},{"id":"T6835","span":{"begin":230,"end":235},"obj":"GO:0008219"},{"id":"T6836","span":{"begin":230,"end":235},"obj":"CL_GO_EXT:cell"},{"id":"T6837","span":{"begin":247,"end":254},"obj":"_FRAGMENT"},{"id":"T6838","span":{"begin":268,"end":275},"obj":"CL:0000103"},{"id":"T6839","span":{"begin":259,"end":267},"obj":"UBERON:0000045"},{"id":"T6840","span":{"begin":259,"end":275},"obj":"CL:0000740"},{"id":"T6841","span":{"begin":311,"end":320},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T6842","span":{"begin":325,"end":334},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T6843","span":{"begin":339,"end":343},"obj":"CL_GO_EXT:cell"},{"id":"T6844","span":{"begin":358,"end":365},"obj":"CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag"},{"id":"T6845","span":{"begin":426,"end":428},"obj":"PR_EXT:000013773"},{"id":"T6846","span":{"begin":432,"end":440},"obj":"UBERON:0000045"},{"id":"T6847","span":{"begin":432,"end":446},"obj":"CL:0000740"},{"id":"T6848","span":{"begin":441,"end":446},"obj":"CL_GO_EXT:cell"},{"id":"T6849","span":{"begin":484,"end":495},"obj":"UBERON_EXT:optic_nerve"},{"id":"T6850","span":{"begin":533,"end":541},"obj":"SO_EXT:sequence_deletion_process"},{"id":"T6851","span":{"begin":542,"end":546},"obj":"PR_EXT:000006852"},{"id":"T6852","span":{"begin":556,"end":560},"obj":"PR_EXT:000006853"},{"id":"T6853","span":{"begin":564,"end":568},"obj":"PR_EXT:000006854"},{"id":"T6854","span":{"begin":591,"end":595},"obj":"CL_GO_EXT:cell"},{"id":"T6855","span":{"begin":591,"end":601},"obj":"GO:0008219"}],"relations":[{"id":"R1516","pred":"_lexicallyChainedTo","subj":"T6826","obj":"T6825"},{"id":"R1517","pred":"_lexicallyChainedTo","subj":"T6835","obj":"T6834"},{"id":"R1518","pred":"_lexicallyChainedTo","subj":"T6838","obj":"T6837"}],"text":"Loss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3]. The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data). Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data). Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T6670","span":{"begin":124,"end":128},"obj":"CL:0000604"},{"id":"T6671","span":{"begin":163,"end":165},"obj":"PR:000013773"},{"id":"T6672","span":{"begin":169,"end":173},"obj":"CL:0000604"},{"id":"T6673","span":{"begin":202,"end":205},"obj":"UBERON:0001789"},{"id":"T6674","span":{"begin":215,"end":223},"obj":"_FRAGMENT"},{"id":"T6675","span":{"begin":230,"end":235},"obj":"GO:0008219"},{"id":"T6676","span":{"begin":247,"end":254},"obj":"_FRAGMENT"},{"id":"T6677","span":{"begin":268,"end":275},"obj":"CL:0000103"},{"id":"T6678","span":{"begin":259,"end":267},"obj":"UBERON:0000045"},{"id":"T6679","span":{"begin":259,"end":275},"obj":"CL:0000740"},{"id":"T6680","span":{"begin":426,"end":428},"obj":"PR:000013773"},{"id":"T6681","span":{"begin":432,"end":440},"obj":"UBERON:0000045"},{"id":"T6682","span":{"begin":432,"end":446},"obj":"CL:0000740"},{"id":"T6683","span":{"begin":484,"end":489},"obj":"UBERON:0000970"},{"id":"T6684","span":{"begin":542,"end":546},"obj":"PR:000006852"},{"id":"T6685","span":{"begin":556,"end":560},"obj":"PR:000006853"},{"id":"T6686","span":{"begin":564,"end":568},"obj":"PR:000006854"},{"id":"T6687","span":{"begin":591,"end":601},"obj":"GO:0008219"},{"id":"T6663","span":{"begin":8,"end":10},"obj":"PR:000013773"},{"id":"T6664","span":{"begin":18,"end":24},"obj":"UBERON:0000966"},{"id":"T6665","span":{"begin":53,"end":62},"obj":"GO:0006915"},{"id":"T6666","span":{"begin":81,"end":88},"obj":"_FRAGMENT"},{"id":"T6667","span":{"begin":102,"end":107},"obj":"CL:0000103"},{"id":"T6668","span":{"begin":93,"end":101},"obj":"UBERON:0000045"},{"id":"T6669","span":{"begin":93,"end":107},"obj":"CL:0000740"}],"relations":[{"id":"R1513","pred":"_lexicallyChainedTo","subj":"T6667","obj":"T6666"},{"id":"R1514","pred":"_lexicallyChainedTo","subj":"T6675","obj":"T6674"},{"id":"R1515","pred":"_lexicallyChainedTo","subj":"T6677","obj":"T6676"}],"text":"Loss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3]. The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data). Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data). Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B)."}

{"project":"2_test","denotations":[{"id":"17608565-15193257-84868975","span":{"begin":145,"end":146},"obj":"15193257"},{"id":"17608565-15231717-84868976","span":{"begin":147,"end":148},"obj":"15231717"},{"id":"17608565-15193257-84868977","span":{"begin":367,"end":368},"obj":"15193257"},{"id":"T2822","span":{"begin":145,"end":146},"obj":"15193257"},{"id":"T607","span":{"begin":147,"end":148},"obj":"15231717"},{"id":"T62078","span":{"begin":367,"end":368},"obj":"15193257"}],"text":"Loss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3]. The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data). Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data). Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B)."}