Author contributions. EMCF, JTR, and ABS conceived and designed the experiments. JvdL, JC, MAK, LAH, SS, MRC, HCF, XL, DH, JSS, IR, and HC performed the experiments. JvdL, JC, MAK, SS, MRC, KGH, HCF, JSS, JTR, and ABS analyzed the data. HH, NWW, PG, JH, ES, RJMG, SMF, HC, and ABS contributed reagents/materials/analysis tools. RJMG, EMCF, and ABS wrote the paper.