Table 2  Summary of the small-effect QTL identified in this study
Loci  Chromosome  Peak marker  Position (Mb)  P value  Susceptibility allele  Overlapping QTL in mouse models of RA  Snyternic region linked to RA (linked marker)
1a,b,c  5  D5Mit348  23,9  0.00691  DBA/1  Cia13
2b  5  D5Mit425  119,1  0.04397  DBA/1   Cia14  22q11 (D22S264), 12p13-q24 (D12S95)
3a,b,c  6  D6Mit14  145,7  0.00315  FVB/N   12p13-pter (D12S99)
4a,b,c  7  D7Mit248  59,3  0.03250  DBA/1
5a,c  10  D10Mit261  85,1  0.00647  DBA/1   Cia8  21q22-qter (D21S268), 10q22-23 (D10S2327)
6b,c  11  D11Mit214  115,2  0.00521  DBA/1   Pgia7  17q21-q25 (D17S1301)
7c  16  D16Mit138  45,4  0.01499  FVB/N   3q29-qter (D3S1311)
8c  17  D17Mit197  18,3  0.02994  FVB/N
aIdentified in all F2 290 progeny. bIdentified in 76 C5+/+ F2 progeny. cIdentified in 133 C5+/- F2 progeny. QTL, quantitative trait loci; RA, rheumatoid arthritis.