Table 1 Phenotypes of Pygo2 wild-type, heterozyogous, and null E18.5 embryos on a Pygo1 null background. Pygo2 +/+ Pygo2 +/- Pygo2 -/- Sample size 6 14 10 Observed phenotypes  Average weight (g) 1.36 1.33 0.97 *  Cleft palate 0 0 6  Exencephaly 0 0 2  Lens defect 0 0 10  Reabsorption/in utero death 0 0 2 * Denotes a significant change (p < 0.01) of the average weight of the Pygo2 null group compared with both the Pygo wild-type and heterozygous groups.