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A list of known Wnt targets was compiled from . Both Pygo1 and Pygo2 probe sets were included as references to illustrate significant down regulation. Remarkably, the known Wnt target genes showed very few differences in expression between wild-type and mutant kidneys (Figure 8). Only the expression of Ccnd1 encoding cyclin D1 [29], and Wisp1 [30] were significantly changed, with expression level changes of \u003c1.5-fold in Pygo1/Pygo2 null kidneys. These results indicate an absence of dramatic changes in expression of previously known Wnt signaling target genes in the Pygo1/Pygo2 mutant kidneys."}

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{"project":"craft-ca-core-dev","denotations":[{"id":"T11896","span":{"begin":718,"end":725},"obj":"UBERON:0002113"},{"id":"T11895","span":{"begin":705,"end":710},"obj":"PR:000013524"},{"id":"T11894","span":{"begin":699,"end":704},"obj":"PR:000013523"},{"id":"T11893","span":{"begin":686,"end":691},"obj":"SO:0000704"},{"id":"T11892","span":{"begin":665,"end":678},"obj":"GO:0016055"},{"id":"T11891","span":{"begin":634,"end":644},"obj":"GO:0010467"},{"id":"T11890","span":{"begin":568,"end":575},"obj":"UBERON:0002113"},{"id":"T11889","span":{"begin":557,"end":562},"obj":"PR:000013524"},{"id":"T11888","span":{"begin":551,"end":556},"obj":"PR:000013523"},{"id":"T11887","span":{"begin":510,"end":520},"obj":"GO:0010467"},{"id":"T11886","span":{"begin":466,"end":471},"obj":"PR:000017426"},{"id":"T11885","span":{"begin":446,"end":455},"obj":"PR:000005121"},{"id":"T11884","span":{"begin":431,"end":436},"obj":"PR:000005121"},{"id":"T11883","span":{"begin":417,"end":427},"obj":"GO:0010467"},{"id":"T11882","span":{"begin":388,"end":395},"obj":"UBERON:0002113"},{"id":"T11881","span":{"begin":348,"end":358},"obj":"GO:0010467"},{"id":"T11880","span":{"begin":311,"end":316},"obj":"SO:0000704"},{"id":"T11879","span":{"begin":190,"end":195},"obj":"PR:000013524"},{"id":"T11878","span":{"begin":180,"end":185},"obj":"PR:000013523"},{"id":"T11877","span":{"begin":118,"end":125},"obj":"UBERON:0002113"},{"id":"T11876","span":{"begin":102,"end":107},"obj":"PR:000013524"},{"id":"T11875","span":{"begin":93,"end":98},"obj":"PR:000013523"},{"id":"T11874","span":{"begin":43,"end":53},"obj":"GO:0010467"}],"text":"We were interested in the possible altered expression of previously known Wnt targets in the Pygo1-/-/Pygo2-/- mutant kidneys. A list of known Wnt targets was compiled from . Both Pygo1 and Pygo2 probe sets were included as references to illustrate significant down regulation. Remarkably, the known Wnt target genes showed very few differences in expression between wild-type and mutant kidneys (Figure 8). Only the expression of Ccnd1 encoding cyclin D1 [29], and Wisp1 [30] were significantly changed, with expression level changes of \u003c1.5-fold in Pygo1/Pygo2 null kidneys. These results indicate an absence of dramatic changes in expression of previously known Wnt signaling target genes in the Pygo1/Pygo2 mutant kidneys."}

{"project":"2_test","denotations":[{"id":"17425782-10318916-8469470","span":{"begin":457,"end":459},"obj":"10318916"},{"id":"17425782-10716946-8469471","span":{"begin":473,"end":475},"obj":"10716946"}],"text":"We were interested in the possible altered expression of previously known Wnt targets in the Pygo1-/-/Pygo2-/- mutant kidneys. A list of known Wnt targets was compiled from . Both Pygo1 and Pygo2 probe sets were included as references to illustrate significant down regulation. Remarkably, the known Wnt target genes showed very few differences in expression between wild-type and mutant kidneys (Figure 8). Only the expression of Ccnd1 encoding cyclin D1 [29], and Wisp1 [30] were significantly changed, with expression level changes of \u003c1.5-fold in Pygo1/Pygo2 null kidneys. These results indicate an absence of dramatic changes in expression of previously known Wnt signaling target genes in the Pygo1/Pygo2 mutant kidneys."}