Table 3 Genes differentially expressed (p < 0.05, two-fold change or greater) in the Pygo1/Pygo2 null E18.5 kidney normalized to wild-type samples. Gene symbol Gene name Pygo1/2 null average fold change C920006O11Rik Hypothetical protein 7.1 Tia1 Cytotoxic granule-assoc RNA binding 1 6.6 Akr1e1 Aldo-keto reductase family 1, E1 5.5 5830417I10Rik Hypothetical protein 3.8 XM_193262 Protein 40kD (LOC269251) mRNA. 3.8 Picalm Pl-binding clathrin assembly protein 3.1 Pck1 PEP carboxykinase 1, cytosolic 2.9 Klk5 Kallikrein 5 2.8 Klk6 Kallikrein 6 2.7 AK051496 4933409K07Rik protein 2.5 Timeless Timeless homolog 2.4 Klk27 Kallikrein 27 2.4 Gsta2 Glutathione S-transferase, alpha 1 2.4 Tia1 cytotoxic granule-assoc RNA binding 1 2.3 AK049070 Hypothetical protein 2.3 BC051083 Cisplatin resistance associated 2.3 1500015O10Rik Esophageal cancer related gene 4 2.3 Klk27 Kallikrein 27 2.2 Npy Neuropeptide Y 2.2 Ren2 Renin 2 2.2 Gsta2 Glutathione S-transferase, alpha 2 2.1 Col8a1 Procollagen, type VIII, alpha 1 2.1 Col8a1 Procollagen, type VIII, alpha 1 2.1 G6pc Glucose-6-phosphatase, catalytic 2.1 Rgs4 Regulator of G-protein signaling 4 2.0 XM_358675 Hypothetical protein 2.0 Ctse Cathepsin E preproprotein - 2.0 Masp2 Mannan-binding lectin serine protease 2 - 2.0 Slco1a4 Solute carrier organic anion transporter 1a4 - 2.1 Cyp2e1 Cytochrome P450 2E1 - 2.1 Sah SA hypertension-associated homolog - 2.1 Aldh1a7 Aldehyde dehydrogenase 1A7 - 2.2 1200006F02Rik Hypothetical protein - 2.3 2600001B17Rik Hypothetical protein - 2.3 D630004N19Rik Hypothetical protein - 2.3 Cxcl13 Chemokine (C-X-C motif) ligand 13 - 2.3 Hpgd Hydroxyprostaglandin dehydrogenase 15 - 2.4 Lum Lumican - 2.5 Pvalb Parvalbumin - 2.5 Cml4 N-acetyltransferase Camello 4 - 2.7 Slc5a2 Solute carrier 5 (sodium/glucose) 2 - 2.8 Pygo2 Pygopus 2 - 3.9 Pygo1 Pygopus 1 - 5.3 2610305D13Rik Hypothetical protein - 5.6 Csrp1 Cysteine and glycine-rich protein 1 - 7.1