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aberrant Sertoli cell organization in Dmrt7 mutant testes raised the possibility that the germ cell phenotype might indirectly result from defects in Sertoli cell function. To test this possibility, we deleted Dmrt7 just in the Sertoli cell lineage by crossing mice carrying the floxed Dmrt7 allele with Dhh-Cre transgenic mice [51]. The Desert hedgehog (Dhh) promoter is active starting at about E12.5 in pre-Sertoli cells but not in germ cells, allowing deletion of Dmrt7 in Sertoli cells well before any likely requirement for its function [52]. Testicular size in Sertoli-targeted (SC-Dmrt7KO) animals was slightly reduced from that of wild-type, but histological analysis revealed no obvious difference between wild-type and SC-Dmrt7KO testes (Figure 6D). Spermatogenesis appeared normal, mature sperm were present, and SC-Dmrt7KO mice were fertile. In addition, GATA1 staining showed that Sertoli cell nuclei were located adjacent to the basement membrane as in wild-type (Figure 6E). These results suggest the germ cell defects of Dmrt7 mutants are not caused by lack of Dmrt7 in Sertoli cells. Rather, the abnormal organization of Sertoli cells appears to result from lack of Dmrt7 in the germ line."}

{"project":"2_test","denotations":[{"id":"17447844-12954777-85805842","span":{"begin":333,"end":335},"obj":"12954777"},{"id":"17447844-8805249-85805843","span":{"begin":548,"end":550},"obj":"8805249"},{"id":"T32303","span":{"begin":333,"end":335},"obj":"12954777"},{"id":"T40950","span":{"begin":548,"end":550},"obj":"8805249"}],"text":"The aberrant Sertoli cell organization in Dmrt7 mutant testes raised the possibility that the germ cell phenotype might indirectly result from defects in Sertoli cell function. To test this possibility, we deleted Dmrt7 just in the Sertoli cell lineage by crossing mice carrying the floxed Dmrt7 allele with Dhh-Cre transgenic mice [51]. The Desert hedgehog (Dhh) promoter is active starting at about E12.5 in pre-Sertoli cells but not in germ cells, allowing deletion of Dmrt7 in Sertoli cells well before any likely requirement for its function [52]. Testicular size in Sertoli-targeted (SC-Dmrt7KO) animals was slightly reduced from that of wild-type, but histological analysis revealed no obvious difference between wild-type and SC-Dmrt7KO testes (Figure 6D). Spermatogenesis appeared normal, mature sperm were present, and SC-Dmrt7KO mice were fertile. In addition, GATA1 staining showed that Sertoli cell nuclei were located adjacent to the basement membrane as in wild-type (Figure 6E). These results suggest the germ cell defects of Dmrt7 mutants are not caused by lack of Dmrt7 in Sertoli cells. Rather, the abnormal organization of Sertoli cells appears to result from lack of Dmrt7 in the germ line."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T12918","span":{"begin":13,"end":25},"obj":"CL:0000216"},{"id":"T12919","span":{"begin":42,"end":47},"obj":"PR:000006549"},{"id":"T12920","span":{"begin":55,"end":61},"obj":"UBERON:0000473"},{"id":"T12921","span":{"begin":94,"end":103},"obj":"CL:0000586"},{"id":"T12922","span":{"begin":154,"end":166},"obj":"CL:0000216"},{"id":"T12923","span":{"begin":214,"end":219},"obj":"PR:000006549"},{"id":"T12924","span":{"begin":232,"end":244},"obj":"CL:0000216"},{"id":"T12925","span":{"begin":265,"end":269},"obj":"NCBITaxon:10088"},{"id":"T12926","span":{"begin":283,"end":289},"obj":"SO:0000359"},{"id":"T12927","span":{"begin":290,"end":295},"obj":"PR:000006549"},{"id":"T12928","span":{"begin":296,"end":302},"obj":"SO:0001023"},{"id":"T12929","span":{"begin":308,"end":311},"obj":"PR:000006459"},{"id":"T12930","span":{"begin":327,"end":331},"obj":"NCBITaxon:10088"},{"id":"T12931","span":{"begin":342,"end":357},"obj":"PR:000006459"},{"id":"T12932","span":{"begin":359,"end":362},"obj":"PR:000006459"},{"id":"T12933","span":{"begin":364,"end":372},"obj":"SO:0000167"},{"id":"T12934","span":{"begin":414,"end":427},"obj":"CL:0000216"},{"id":"T12935","span":{"begin":439,"end":449},"obj":"CL:0000586"},{"id":"T12936","span":{"begin":472,"end":477},"obj":"PR:000006549"},{"id":"T12937","span":{"begin":481,"end":494},"obj":"CL:0000216"},{"id":"T12938","span":{"begin":553,"end":563},"obj":"UBERON:0000473"},{"id":"T12939","span":{"begin":572,"end":579},"obj":"CL:0000216"},{"id":"T12940","span":{"begin":590,"end":592},"obj":"CL:0000216"},{"id":"T12941","span":{"begin":602,"end":609},"obj":"NCBITaxon:33208"},{"id":"T12942","span":{"begin":734,"end":736},"obj":"CL:0000216"},{"id":"T12943","span":{"begin":745,"end":751},"obj":"UBERON:0000473"},{"id":"T12944","span":{"begin":765,"end":780},"obj":"GO:0007283"},{"id":"T12945","span":{"begin":805,"end":810},"obj":"CL:0000019"},{"id":"T12946","span":{"begin":829,"end":831},"obj":"CL:0000216"},{"id":"T12947","span":{"begin":840,"end":844},"obj":"NCBITaxon:10088"},{"id":"T12948","span":{"begin":872,"end":877},"obj":"PR:000007857"},{"id":"T12949","span":{"begin":899,"end":911},"obj":"CL:0000216"},{"id":"T12950","span":{"begin":907,"end":918},"obj":"GO:0005634"},{"id":"T12951","span":{"begin":1021,"end":1030},"obj":"CL:0000586"},{"id":"T12952","span":{"begin":1042,"end":1047},"obj":"PR:000006549"},{"id":"T12953","span":{"begin":1082,"end":1087},"obj":"PR:000006549"},{"id":"T12954","span":{"begin":1091,"end":1104},"obj":"CL:0000216"},{"id":"T12955","span":{"begin":1143,"end":1156},"obj":"CL:0000216"},{"id":"T12956","span":{"begin":1188,"end":1193},"obj":"PR:000006549"}],"text":"The aberrant Sertoli cell organization in Dmrt7 mutant testes raised the possibility that the germ cell phenotype might indirectly result from defects in Sertoli cell function. To test this possibility, we deleted Dmrt7 just in the Sertoli cell lineage by crossing mice carrying the floxed Dmrt7 allele with Dhh-Cre transgenic mice [51]. The Desert hedgehog (Dhh) promoter is active starting at about E12.5 in pre-Sertoli cells but not in germ cells, allowing deletion of Dmrt7 in Sertoli cells well before any likely requirement for its function [52]. Testicular size in Sertoli-targeted (SC-Dmrt7KO) animals was slightly reduced from that of wild-type, but histological analysis revealed no obvious difference between wild-type and SC-Dmrt7KO testes (Figure 6D). Spermatogenesis appeared normal, mature sperm were present, and SC-Dmrt7KO mice were fertile. In addition, GATA1 staining showed that Sertoli cell nuclei were located adjacent to the basement membrane as in wild-type (Figure 6E). These results suggest the germ cell defects of Dmrt7 mutants are not caused by lack of Dmrt7 in Sertoli cells. Rather, the abnormal organization of Sertoli cells appears to result from lack of Dmrt7 in the germ line."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T13017","span":{"begin":13,"end":25},"obj":"CL:0000216"},{"id":"T13018","span":{"begin":21,"end":25},"obj":"CL_GO_EXT:cell"},{"id":"T13019","span":{"begin":42,"end":47},"obj":"PR_EXT:000006549"},{"id":"T13020","span":{"begin":48,"end":54},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T13021","span":{"begin":55,"end":61},"obj":"UBERON:0000473"},{"id":"T13022","span":{"begin":94,"end":103},"obj":"CL:0000586"},{"id":"T13023","span":{"begin":99,"end":103},"obj":"CL_GO_EXT:cell"},{"id":"T13024","span":{"begin":154,"end":166},"obj":"CL:0000216"},{"id":"T13025","span":{"begin":162,"end":166},"obj":"CL_GO_EXT:cell"},{"id":"T13026","span":{"begin":206,"end":213},"obj":"SO_EXT:sequence_deletion_process"},{"id":"T13027","span":{"begin":214,"end":219},"obj":"PR_EXT:000006549"},{"id":"T13028","span":{"begin":232,"end":244},"obj":"CL:0000216"},{"id":"T13029","span":{"begin":240,"end":244},"obj":"CL_GO_EXT:cell"},{"id":"T13030","span":{"begin":265,"end":269},"obj":"NCBITaxon:10088"},{"id":"T13031","span":{"begin":283,"end":289},"obj":"SO:0000359"},{"id":"T13032","span":{"begin":290,"end":295},"obj":"PR_EXT:000006549"},{"id":"T13033","span":{"begin":296,"end":302},"obj":"SO_EXT:0001023"},{"id":"T13034","span":{"begin":308,"end":311},"obj":"PR_EXT:000006459"},{"id":"T13035","span":{"begin":316,"end":326},"obj":"SO_EXT:transgenic_entity"},{"id":"T13036","span":{"begin":327,"end":331},"obj":"NCBITaxon:10088"},{"id":"T13037","span":{"begin":342,"end":357},"obj":"PR_EXT:000006459"},{"id":"T13038","span":{"begin":359,"end":362},"obj":"PR_EXT:000006459"},{"id":"T13039","span":{"begin":364,"end":372},"obj":"SO_EXT:0000167"},{"id":"T13040","span":{"begin":414,"end":427},"obj":"CL:0000216"},{"id":"T13041","span":{"begin":422,"end":427},"obj":"CL_GO_EXT:cell"},{"id":"T13042","span":{"begin":439,"end":449},"obj":"CL:0000586"},{"id":"T13043","span":{"begin":444,"end":449},"obj":"CL_GO_EXT:cell"},{"id":"T13044","span":{"begin":460,"end":468},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T13045","span":{"begin":472,"end":477},"obj":"PR_EXT:000006549"},{"id":"T13046","span":{"begin":481,"end":494},"obj":"CL:0000216"},{"id":"T13047","span":{"begin":489,"end":494},"obj":"CL_GO_EXT:cell"},{"id":"T13048","span":{"begin":553,"end":563},"obj":"UBERON:0000473"},{"id":"T13049","span":{"begin":572,"end":579},"obj":"CL:0000216"},{"id":"T13050","span":{"begin":590,"end":592},"obj":"CL:0000216"},{"id":"T13051","span":{"begin":602,"end":609},"obj":"NCBITaxon:33208"},{"id":"T13052","span":{"begin":644,"end":653},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T13053","span":{"begin":720,"end":729},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T13054","span":{"begin":734,"end":736},"obj":"CL:0000216"},{"id":"T13055","span":{"begin":745,"end":751},"obj":"UBERON:0000473"},{"id":"T13056","span":{"begin":765,"end":780},"obj":"GO:0007283"},{"id":"T13057","span":{"begin":805,"end":810},"obj":"CL:0000019"},{"id":"T13058","span":{"begin":829,"end":831},"obj":"CL:0000216"},{"id":"T13059","span":{"begin":840,"end":844},"obj":"NCBITaxon:10088"},{"id":"T13060","span":{"begin":872,"end":877},"obj":"PR_EXT:000007857"},{"id":"T13061","span":{"begin":899,"end":911},"obj":"CL:0000216"},{"id":"T13062","span":{"begin":907,"end":918},"obj":"GO:0005634"},{"id":"T13063","span":{"begin":948,"end":965},"obj":"GO_UBERON_EXT:basement_membrane"},{"id":"T13064","span":{"begin":972,"end":981},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T13065","span":{"begin":1021,"end":1030},"obj":"CL:0000586"},{"id":"T13066","span":{"begin":1026,"end":1030},"obj":"CL_GO_EXT:cell"},{"id":"T13067","span":{"begin":1042,"end":1047},"obj":"PR_EXT:000006549"},{"id":"T13068","span":{"begin":1048,"end":1055},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T13069","span":{"begin":1082,"end":1087},"obj":"PR_EXT:000006549"},{"id":"T13070","span":{"begin":1091,"end":1104},"obj":"CL:0000216"},{"id":"T13071","span":{"begin":1099,"end":1104},"obj":"CL_GO_EXT:cell"},{"id":"T13072","span":{"begin":1143,"end":1156},"obj":"CL:0000216"},{"id":"T13073","span":{"begin":1151,"end":1156},"obj":"CL_GO_EXT:cell"},{"id":"T13074","span":{"begin":1188,"end":1193},"obj":"PR_EXT:000006549"}],"text":"The aberrant Sertoli cell organization in Dmrt7 mutant testes raised the possibility that the germ cell phenotype might indirectly result from defects in Sertoli cell function. To test this possibility, we deleted Dmrt7 just in the Sertoli cell lineage by crossing mice carrying the floxed Dmrt7 allele with Dhh-Cre transgenic mice [51]. The Desert hedgehog (Dhh) promoter is active starting at about E12.5 in pre-Sertoli cells but not in germ cells, allowing deletion of Dmrt7 in Sertoli cells well before any likely requirement for its function [52]. Testicular size in Sertoli-targeted (SC-Dmrt7KO) animals was slightly reduced from that of wild-type, but histological analysis revealed no obvious difference between wild-type and SC-Dmrt7KO testes (Figure 6D). Spermatogenesis appeared normal, mature sperm were present, and SC-Dmrt7KO mice were fertile. In addition, GATA1 staining showed that Sertoli cell nuclei were located adjacent to the basement membrane as in wild-type (Figure 6E). These results suggest the germ cell defects of Dmrt7 mutants are not caused by lack of Dmrt7 in Sertoli cells. Rather, the abnormal organization of Sertoli cells appears to result from lack of Dmrt7 in the germ line."}