We also used the gene expression data (described above in the microarray analysis section) to further test the suggested TRN as follows. We obtained approximate TF activities for both the training and suggested TRNs. Then, for each gene we calculated the linear correlation coefficient between the expression data and the sum of TF activity profiles (accounting separately up versus down regulation). Higher scores indicate better consistency between expression data and TRN. The average scores for the training and suggested TRNs were calculated to be 0.47 and 0.54, respectively, showing an improvement in the overall consistency of the TRN with gene expression profiles.