Our approach is to calculate phylogenic similarity for gene-gene pairs follows the methodology proposed by [20] (referred to as 'likelihood of neighboring profiles' in their work). In this analysis all bacteria sequence information is downloaded from [24] and all preliminary gene/TF interactions are from [14]. Once we have phylogenic similarity scores for all gene pairs, we calculate the gene/TF scores based on the methodology described in the From Gene-Gene Scores to Gene/TF Scores Section.