Thus, an intergenic region with a strong site will make its presence known via a strong (i.e., low) value for the p1/w1 term, and an intergenic region that does not have a strong site, but that does have an ith best site that is surprisingly strong (given its rank as ith best), will be detected through a strong value for the pi/wi term. This enables us to detect both transcription factors that tend to bind strongly but in isolation and transcription factors that tend to bind multiply but weakly.