2.1 Protein interaction data
The core data of S. Cerevisiae was obtained from the DIP database [22]. This dataset include 2526 proteins and 5949 filtered reliable physical interactions. Species such as S. Cerevisae provide important test beds for the study of the PPI networks since it is a well-studied organism for which most proteomics data is available for the organism, by virtue of the availability of a defined and relatively stable proteome, full genome clone libraries, established molecular biology experimental techniques and an assortment of well designed genomics databases [6,22].