∑ j ∈ { A , T , G , C }   Q k , j     = 1   ∀ k = 0 , 1 , 2 , ... l           ( 3 )    MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaafaqabeqacaaabaWaaabuaeaacqWGrbqudaWgaaWcbaGaem4AaSMaeiilaWIaemOAaOgabeaaaeaacqWGQbGAcqGHiiIZcqGG7bWEcqWGbbqqcqGGSaalcqWGubavcqGGSaalcqWGhbWrcqGGSaalcqWGdbWqcqGG9bqFaeqaniabggHiLdGccqGH9aqpcqaIXaqmaeaacqGHaiIicqWGRbWAcqGH9aqpcqaIWaamcqGGSaalcqaIXaqmcqGGSaalcqaIYaGmcqGGSaalcqGGUaGlcqGGUaGlcqGGUaGlcqWGSbaBaaGaaCzcaiaaxMaadaqadaqaaiabiodaZaGaayjkaiaawMcaaaaa@531A@