Q k , j   = C k , j   + b j   t + ∑ J ∈ { A , T , G , C }   b J            ( 2 )    MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGrbqudaWgaaWcbaGaem4AaSMaeiilaWIaemOAaOgabeaakiabg2da9maalaaabaGaem4qam0aaSbaaSqaaiabdUgaRjabcYcaSiabdQgaQbqabaGccqGHRaWkcqWGIbGydaWgaaWcbaGaemOAaOgabeaaaOqaaiabdsha0jabgUcaRmaaqababaGaemOyai2aaSbaaSqaaiabdQeakbqabaaabaGaemOsaOKaeyicI4Saei4EaSNaemyqaeKaeiilaWIaemivaqLaeiilaWIaem4raCKaeiilaWIaem4qamKaeiyFa0habeqdcqGHris5aaaakiaaxMaacaWLjaWaaeWaaeaacqaIYaGmaiaawIcacaGLPaaaaaa@528F@