Q 0 , j   = C 0 , j    ∑ J ∈ { A , T , G , C }   C 0 , J             ( 1 )    MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGrbqudaWgaaWcbaGaeGimaaJaeiilaWIaemOAaOgabeaakiabg2da9maalaaabaGaem4qam0aaSbaaSqaaiabicdaWiabcYcaSiabdQgaQbqabaaakeaadaaeqaqaaiabdoeadnaaBaaaleaacqaIWaamcqGGSaalcqWGkbGsaeqaaaqaaiabdQeakjabgIGiolabcUha7jabdgeabjabcYcaSiabdsfaujabcYcaSiabdEeahjabcYcaSiabdoeadjabc2ha9bqab0GaeyyeIuoaaaGccaWLjaGaaCzcamaabmaabaGaeGymaedacaGLOaGaayzkaaaaaa@4D26@