As in the section "practical case", we consider two genomes: Escherichia coli K12 (ℓ = n = 4639675) and Mycoplasma genitalium (ℓ = n = 580076). For each Markov model order m from 1 to 6, we estimate π on the sequence (by maximum of likelihood), compute the REF list and then draw a sample of REF_ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaqiaaqaaiabbkfasjabbweafjabbAeagbGaayPadaaaaa@30BD@ from which we get estimates for the expectation of TP and RA rates.