Table 1 Comparison of theoretical and empirical pattern statistic mean and standard deviation on Escherichia coli K12. m S σ S ^ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacuWGtbWugaqcaaaa@2DEB@ σ ^ MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacuWFdpWCgaqcaaaa@2E86@ 1 35.57 0.28 35.57 0.27 2 31.61 0.49 31.60 0.50 3 46.75 1.04 46.77 1.03 4 45.33 1.74 45.32 1.81 5 62.27 3.45 62.36 3.34 We consider the pattern W = acgtacgt with Nobs = 150. The sequence length is ℓ = 4639675, we use an order m Markov model and a sample of size M = 1 000.