Table 4  Comparison of default vs. RIBOSUM substitution matrix by Wilcoxon tests
Program  k2  k3  k5  k7  k10  k15
ALIGN-M  /  +  +  +  /  /
CLUSTALW  -  -  -  -  -  -
POA  +  +  +  /  /  /
If the use of the RIBOSUM 85–60 matrix resulted in a statistically significant performance increase in comparison to use of the default matrix this is indicated with a "+"; "-" indicates that the default matrix scores significantly better. If no statistical significance was found this is indicated with a "/".