The results of the HSE and CN comparisons are shown in Table 3. The table shows how many of the 100 HSE/CN minimized conformations are below a certain RMSD threshold. The associated RMSDs and energy values of the 100 conformations are also shown. In Figures 8 to 12, histograms show the RMSD and energy distribution of the CN- or HSE-optimized structures. The histograms reveal that most of the lowest energy structures are similar to the native structure. This trend is much more prevalent for the HSE-optimized structures. Based on the histograms, we conclude that the CN-/HSE-energy functions have a large smooth minimum around the structure of the native state and few smaller local minima scattered around the conformational space.