Figure 5  The truncal OFT fails to rotate in Alk5/Wnt1-Cre mutants. Left (A, C) and right (B, D) lateral images of ink-injected control (A-B) and mutant (C-D) embryos at E11.5 demonstrate the abnormally straight OFT in mutants lacking the typical conotruncal transition (black arrow in A vs. black arrowhead in C) seen in control. Red arrowhead (C) points to the abnormally shaped aortic sac. Red "s", aortic sac; t, truncus; c, conus.