Authors' contributions
JHP conceived and designed the study, coordinated the experiments and drafted the manuscript. AS developed and performed the tail bleeding assay and participated in drafting the manuscript. EH carried out the vascular injury model and analyses and the tail bleeding assay, participated in the tail collagen analyses, and coordination of the mouse breeding. JS participated in the analysis of the vascular injury model results and collagen analyses. JHN and AHE provided the CSS breeding pairs, JHN participated in discussions of the results, and JBS and JHN developed the CSS. All the authors have read and approved the final manuscript.