High-throughput sequencing of expression data provides compelling evidence that the long held hypothesis "one gene produces one protein" is far less common than previously thought. Surveys from the human genome estimate that as many as 70% of human genes produce more than one transcribed form [1]. Examples are found in a variety of metazoan organisms confirming that a significant number of genes produce multiple distinct transcripts [2,3]. Alternative splicing is an important biological mechanism for producing multiple distinct transcripts from a single gene locus. Exon intron junctions are pieced together to produce differing mRNAs. In some cases alternative exon splicing leads to different functional proteins thereby increasing protein diversity. In other cases an alternatively spliced exon leads to non-functional mRNA, effectively regulating gene expression [3].