les, teeth, and oral and corneal epithelia. In addition, squamous metaplasia was observed in various epithelial-derived tissues, including the thymus. The aberrant growth of hair follicles and other appendages as well as the thymic abnormalities in K14-cre; ApcCKO/CKO mice suggest the Apc gene is crucial in embryonic cells to specify epithelial cell fates in organs that require epithelial–mesenchymal interactions for their development.

Synopsis
Patients with familial adenomatous polyposis (FAP) and its variant, Gardner's syndrome, will develop hundreds of colorectal polyps. It is a heritable disease that is linked to a genetic mutation in the tumor suppressor gene APC (adenomatous polyposis coli). These individu