PMC:1540739 / 16527-17736 JSONTXT

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We next determined whether p53+/ΔPGFP ES cells could generate chimeric mice and transmit the modified allele through the germline. Two p53+/ΔPGFP ES cell clones were injected into blastocysts and highly chimeric (\u003e80%) mice were obtained. Heterozygote pups were recovered from the mating the chimeras with WT mice (Figure 3C). 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