Table 3 Kendall's tau (rank correlation) comparing the most significant exact p-values (the reference) to the Karlin's approximations. The column "all" gives the result for all sequences while the Ri give the results for a certain range of sequence lengths: smaller than 100 for R1, between 100 and 200 for R2, between 200 and 500 for R3, between 500 and 1 000 for R4, between 1 000 and 2 000 for R5 and greater than 2 000 for R6. number of p-values all R1 R2 R3 R4 R5 R6 10 0.30 0.64 0.24 -0.20 0.58 0.64 0.97 50 0.14 0.73 0.50 0.46 0.56 0.78 0.97 100 0.37 0.70 0.67 0.62 0.61 0.80 0.98