Table 2 Number of e-value smaller than a threshold are given for exact computations (exact) and asymptotic Karlin's approximations (Karlin). The last row gives the accuracy of asymptotic predictions (accuracy = Karlin/exact). e-value 10-1 10-2 10-3 10-4 10-5 10-6 exact 9473 7772 6271 4563 3232 2348 Karlin 3417 2047 1056 439 195 96 accuracy 34% 26% 17% 10% 6% 4%