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{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T781","span":{"begin":91,"end":97},"obj":"NCBITaxon:33208"},{"id":"T782","span":{"begin":126,"end":132},"obj":"NCBITaxon:39107"},{"id":"T783","span":{"begin":164,"end":168},"obj":"SO_EXT:0000704"},{"id":"T784","span":{"begin":183,"end":192},"obj":"UBERON:0000922"},{"id":"T785","span":{"begin":183,"end":202},"obj":"CL:0002322"},{"id":"T786","span":{"begin":198,"end":202},"obj":"CL_GO_EXT:cell"}],"text":" this disease. A major hurdle in developing new treatments has been the lack of a suitable animal model.\n\nMethods\nTo create a murine model of classic MSUD, we used gene targeting and embryonic stem cell techno"}

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