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PMC:1448208 / 32692-34524 JSONTXT

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Id Subject Object Predicate Lexical cue
T20227 1805-1816 JJ denotes biochemical
T20226 1817-1827 NNS denotes phenotypes
T20225 1797-1804 JJ denotes several
T20224 1794-1796 IN denotes to
T20223 1786-1793 NN denotes respect
T20222 1781-1785 IN denotes with
T20221 1767-1772 JJ denotes human
T20220 1773-1780 NN denotes disease
T20219 1763-1766 DT denotes the
T20218 1760-1762 IN denotes of
T20217 1745-1753 JJ denotes faithful
T20216 1754-1759 NN denotes model
T20215 1743-1744 DT denotes a
T20214 1740-1742 VB denotes be
T20213 1737-1739 TO denotes to
T20212 1729-1736 VBZ denotes appears
T20211 1725-1728 CC denotes and
T20210 1720-1724 NN denotes MSUD
T20209 1712-1719 JJ denotes classic
T20208 1709-1711 IN denotes of
T20207 1703-1708 NN denotes model
T20206 1701-1702 DT denotes a
T20205 1679-1689 RB denotes accurately
T20204 1664-1672 NN denotes mutation
T20203 1659-1663 JJ denotes null
T20202 1673-1678 NN denotes mouse
T20201 1655-1658 DT denotes the
T20200 1653-1655 , denotes ,
T20199 1650-1653 RB denotes far
T20198 1645-1649 RB denotes thus
T20197 1635-1644 VBN denotes completed
T20196 1610-1626 NN denotes characterization
T20195 1627-1634 NNS denotes studies
T20194 1606-1609 DT denotes the
T20193 1690-1700 VBZ denotes represents
T20192 1601-1605 IN denotes From
T20191 1600-1832 sentence denotes From the characterization studies completed thus far, the null mutation mouse accurately represents a model of classic MSUD and appears to be a faithful model of the human disease with respect to several biochemical phenotypes [1].
T20190 1599-1600 . denotes .
T20189 1581-1590 JJ denotes enzymatic
T20188 1591-1599 NN denotes activity
T20187 1575-1580 NN denotes BCKDH
T20186 1572-1574 IN denotes of
T20185 1567-1571 NN denotes half
T20184 1553-1566 RB denotes approximately
T20183 1546-1552 VBG denotes having
T20182 1538-1545 IN denotes despite
T20181 1533-1537 NN denotes BCAA
T20180 1530-1532 IN denotes of
T20179 1523-1529 NNS denotes levels
T20178 1516-1522 JJ denotes normal
T20177 1512-1515 VBD denotes had
T20176 1508-1511 CC denotes and
T20175 1501-1507 JJ denotes normal
T20174 1496-1500 VBD denotes were
T20173 1486-1495 NNS denotes knockouts
T20172 1473-1485 JJ denotes Heterozygous
T20171 1472-1600 sentence denotes Heterozygous knockouts were normal and had normal levels of BCAA despite having approximately half of BCKDH enzymatic activity.
T20170 1471-1472 . denotes .
T20169 1470-1471 -RRB- denotes ]
T20168 1469-1470 CD denotes 1
T20167 1468-1469 -LRB- denotes [
T20166 1454-1458 NN denotes MSUD
T20165 1459-1467 NNS denotes patients
T20164 1446-1453 JJ denotes classic
T20163 1443-1445 IN denotes in
T20162 1439-1442 CC denotes and
T20161 1437-1438 -RRB- denotes ]
T20160 1435-1437 CD denotes 17
T20159 1434-1435 -LRB- denotes [
T20158 1424-1428 NN denotes MSUD
T20157 1429-1433 NN denotes calf
T20156 1420-1423 DT denotes the
T20155 1417-1419 IN denotes in
T20154 1408-1416 VBN denotes observed
T20153 1405-1407 IN denotes as
T20152 1392-1404 NN denotes malnutrition
T20151 1388-1391 CC denotes and
T20150 1386-1388 , denotes ,
T20149 1375-1386 NN denotes dehydration
T20148 1373-1375 , denotes ,
T20147 1368-1373 NN denotes edema
T20146 1362-1367 NN denotes brain
T20145 1360-1362 , denotes ,
T20144 1348-1360 NN denotes ketoacidosis
T20143 1346-1348 , denotes ,
T20142 1340-1346 NNS denotes levels
T20141 1329-1339 JJ denotes neurotoxic
T20140 1326-1328 IN denotes to
T20139 1321-1325 NN denotes BCAA
T20138 1318-1320 IN denotes of
T20137 1305-1317 NN denotes accumulation
T20136 1301-1304 DT denotes the
T20135 1298-1300 IN denotes to
T20134 1294-1297 IN denotes due
T20133 1287-1293 RB denotes likely
T20132 1284-1286 VBZ denotes is
T20131 1265-1273 JJ denotes neonatal
T20130 1274-1283 NN denotes lethality
T20129 1260-1264 DT denotes This
T20128 1259-1472 sentence denotes This neonatal lethality is likely due to the accumulation of BCAA to neurotoxic levels, ketoacidosis, brain edema, dehydration, and malnutrition as observed in the MSUD calf [17] and in classic MSUD patients [1].
T20127 1258-1259 . denotes .
T20126 1253-1258 NN denotes birth
T20125 1250-1252 IN denotes of
T20124 1244-1249 NNS denotes hours
T20123 1241-1243 CD denotes 72
T20122 1234-1240 IN denotes within
T20121 1213-1223 JJ denotes homozygous
T20120 1224-1228 NNS denotes pups
T20119 1209-1212 DT denotes the
T20118 1206-1208 IN denotes of
T20117 1202-1205 DT denotes all
T20116 1195-1201 RB denotes nearly
T20115 1193-1195 , denotes ,
T20114 1229-1233 VBD denotes died
T20113 1186-1193 RB denotes Finally
T20112 1185-1259 sentence denotes Finally, nearly all of the homozygous pups died within 72 hours of birth.
T20111 1184-1185 . denotes .
T20110 1183-1184 -RRB- denotes ]
T20109 1180-1181 , denotes ,
T20108 1179-1180 CD denotes 1
T20107 1181-1183 CD denotes 37
T20106 1178-1179 -LRB- denotes [
T20105 1169-1177 NNS denotes patients
T20104 1166-1168 IN denotes in
T20103 1149-1165 NNS denotes encephalopathies
T20102 1144-1148 NN denotes MSUD
T20101 1140-1143 IN denotes for
T20100 1132-1139 NN denotes culprit
T20099 1128-1131 DT denotes the
T20098 1113-1116 VBP denotes are
T20097 1117-1127 VBN denotes considered
T20096 1107-1112 WDT denotes which
T20095 1105-1107 , denotes ,
T20094 1094-1099 NN denotes amino
T20093 1082-1093 JJ denotes neuroactive
T20092 1074-1081 JJ denotes similar
T20091 1100-1105 NNS denotes acids
T20090 1068-1073 JJ denotes other
T20089 1064-1067 CC denotes and
T20088 1062-1064 , denotes ,
T20087 1055-1062 NN denotes alanine
T20086 1053-1055 , denotes ,
T20085 1044-1053 NN denotes glutamine
T20084 1042-1044 , denotes ,
T20083 1033-1042 NN denotes glutamate
T20082 1030-1032 IN denotes of
T20081 1023-1029 NNS denotes levels
T20080 1015-1022 VBN denotes reduced
T20079 1010-1014 IN denotes from
T20078 999-1002 MD denotes may
T20077 1003-1009 VB denotes result
T20076 979-989 JJ denotes neurologic
T20075 990-998 NNS denotes symptoms
T20074 973-978 DT denotes These
T20073 972-1185 sentence denotes These neurologic symptoms may result from reduced levels of glutamate, glutamine, alanine, and other similar neuroactive amino acids, which are considered the culprit for MSUD encephalopathies in patients [1,37].
T20072 971-972 . denotes .
T20071 970-971 -RRB- denotes ]
T20070 969-970 CD denotes 1
T20069 968-969 -LRB- denotes [
T20068 955-967 NNS denotes difficulties
T20067 943-954 JJ denotes respiratory
T20066 939-942 CC denotes and
T20065 937-939 , denotes ,
T20064 929-937 NN denotes activity
T20063 923-928 NN denotes motor
T20062 920-922 IN denotes of
T20061 915-919 NN denotes loss
T20060 913-915 , denotes ,
T20059 905-913 NN denotes lethargy
T20058 903-905 , denotes ,
T20057 897-903 NN denotes stupor
T20056 895-897 , denotes ,
T20055 887-895 NNS denotes seizures
T20054 884-886 IN denotes as
T20053 879-883 JJ denotes such
T20052 867-878 NN denotes dysfunction
T20051 856-866 JJ denotes neurologic
T20050 853-855 IN denotes of
T20049 847-852 NNS denotes signs
T20048 839-846 VBP denotes include
T20047 833-838 DT denotes These
T20046 832-972 sentence denotes These include signs of neurologic dysfunction such as seizures, stupor, lethargy, loss of motor activity, and respiratory difficulties [1].
T20045 831-832 . denotes .
T20044 818-822 NN denotes MSUD
T20043 810-817 JJ denotes classic
T20042 823-831 NNS denotes patients
T20041 802-809 JJ denotes newborn
T20040 799-801 IN denotes in
T20039 794-798 VBN denotes seen
T20038 785-793 NNS denotes symptoms
T20037 764-769 NN denotes mouse
T20036 770-774 NNS denotes pups
T20035 753-763 JJ denotes homozygous
T20034 750-752 IN denotes of
T20033 775-784 VBZ denotes resembles
T20032 730-740 JJ denotes phenotypic
T20031 741-749 NN denotes behavior
T20030 726-729 DT denotes The
T20029 725-832 sentence denotes The phenotypic behavior of homozygous mouse pups resembles symptoms seen in newborn classic MSUD patients.
T20028 724-725 . denotes .
T20027 720-724 NNS denotes pups
T20026 709-719 JJ denotes homozygous
T20025 706-708 IN denotes of
T20024 694-705 NNS denotes fibroblasts
T20023 690-693 CC denotes and
T20022 684-689 NN denotes liver
T20021 681-683 IN denotes in
T20020 674-680 JJ denotes absent
T20019 670-673 VBD denotes was
T20018 659-661 NN denotes E2
T20017 662-669 NN denotes protein
T20016 644-658 JJ denotes Immunoreactive
T20015 643-725 sentence denotes Immunoreactive E2 protein was absent in liver and fibroblasts of homozygous pups.
T20014 642-643 . denotes .
T20013 638-642 NN denotes BCAA
T20012 624-637 JJ denotes unmetabolized
T19940 247-252 NN denotes birth
T19939 244-246 IN denotes at
T19938 237-243 JJ denotes normal
T19937 228-236 VBD denotes appeared
T19936 224-227 CC denotes and
T19935 205-213 VBN denotes expected
T19934 214-223 NN denotes frequency
T19933 201-204 DT denotes the
T19932 198-200 IN denotes at
T19931 188-192 VBD denotes were
T19930 193-197 VBN denotes born
T19929 183-187 NNS denotes mice
T19928 174-182 NN denotes Knockout
T19927 173-253 sentence denotes Knockout mice were born at the expected frequency and appeared normal at birth.
T19926 172-173 . denotes .
T19925 168-172 NN denotes MSUD
T19924 160-167 JJ denotes classic
T19923 155-159 IN denotes with
T19922 148-154 NNS denotes humans
T19921 145-147 IN denotes to
T19920 137-144 JJ denotes similar
T19919 126-136 RB denotes strikingly
T19918 106-114 NN denotes knockout
T19917 115-122 NNS denotes animals
T19916 100-105 DT denotes these
T19915 97-99 IN denotes of
T19914 123-125 VBZ denotes is
T19913 87-96 NN denotes phenotype
T19912 83-86 DT denotes The
T19911 82-173 sentence denotes The phenotype of these knockout animals is strikingly similar to humans with classic MSUD.
T19910 81-82 . denotes .
T19909 76-81 NN denotes BCKDH
T19908 73-75 IN denotes of
T19907 62-64 NN denotes E2
T19906 65-72 NN denotes subunit
T19905 58-61 DT denotes the
T19904 55-57 IN denotes of
T19903 46-54 NN denotes knockout
T19902 41-45 NN denotes gene
T19901 38-40 IN denotes by
T19900 26-29 VBD denotes was
T19899 21-25 NN denotes MSUD
T19898 13-20 JJ denotes classic
T19897 10-12 IN denotes of
T19896 30-37 VBN denotes created
T19895 4-9 NN denotes model
T19894 0-3 PRP$ denotes Our
T20231 1831-1832 . denotes .
T20230 1830-1831 -RRB- denotes ]
T20229 1829-1830 CD denotes 1
T20228 1828-1829 -LRB- denotes [
T20011 621-623 IN denotes of
T20010 608-620 NN denotes accumulation
T20009 604-607 DT denotes the
T20008 600-603 IN denotes for
T20007 589-599 VBG denotes accounting
T20006 587-589 , denotes ,
T20005 575-587 JJ denotes undetectable
T20004 560-565 NN denotes mouse
T20003 566-570 NNS denotes pups
T20002 551-559 NN denotes knockout
T20001 540-550 JJ denotes homozygous
T20000 537-539 IN denotes of
T19999 530-536 NNS denotes livers
T19998 527-529 IN denotes in
T19997 521-526 NN denotes BCKDH
T19996 518-520 IN denotes of
T19995 571-574 VBD denotes was
T19994 509-517 NN denotes activity
T19993 505-508 DT denotes The
T19992 504-643 sentence denotes The activity of BCKDH in livers of homozygous knockout mouse pups was undetectable, accounting for the accumulation of unmetabolized BCAA.
T19991 503-504 . denotes .
T19990 502-503 -RRB- denotes )
T19989 501-502 CD denotes 1
T19988 495-500 NN denotes Table
T19987 494-495 -LRB- denotes (
T19986 479-483 VBD denotes were
T19985 477-479 , denotes ,
T19984 473-477 NN denotes BCAA
T19983 470-472 IN denotes of
T19982 459-469 NN denotes metabolism
T19981 452-458 JJ denotes normal
T19980 447-451 IN denotes with
T19979 437-439 VBZ denotes is
T19978 440-446 VBN denotes linked
T19977 427-436 NN denotes synthesis
T19976 421-426 WP$ denotes whose
T19975 419-421 , denotes ,
T19974 410-419 NN denotes glutamine
T19973 406-409 CC denotes and
T19972 404-406 , denotes ,
T19971 395-404 NN denotes glutamate
T19970 393-395 , denotes ,
T19969 386-393 NN denotes alanine
T19968 374-379 NN denotes amino
T19967 380-385 NNS denotes acids
T19966 370-373 DT denotes the
T19965 367-369 IN denotes of
T19964 360-366 NNS denotes levels
T19963 358-360 , denotes ,
T19962 484-493 VBN denotes decreased
T19961 345-358 RB denotes Concomitantly
T19960 344-504 sentence denotes Concomitantly, levels of the amino acids alanine, glutamate, and glutamine, whose synthesis is linked with normal metabolism of BCAA, were decreased (Table 1).
T19959 343-344 . denotes .
T19958 335-343 JJ denotes elevated
T19957 326-334 RB denotes markedly
T19956 316-320 NN denotes BCAA
T19955 313-315 IN denotes of
T19954 306-312 NNS denotes levels
T19953 300-305 NN denotes blood
T19952 298-300 , denotes ,
T19951 290-298 NN denotes suckling
T19950 280-289 VBG denotes following
T19949 276-279 CC denotes and
T19948 270-275 NN denotes birth
T19947 267-269 IN denotes of
T19946 263-266 NN denotes day
T19945 261-262 DT denotes a
T19944 321-325 VBD denotes were
T19943 254-260 IN denotes Within
T19942 253-344 sentence denotes Within a day of birth and following suckling, blood levels of BCAA were markedly elevated.
T19941 252-253 . denotes .
R5030 T19894 T19895 poss Our,model
R5031 T19895 T19896 nsubjpass model,created
R5032 T19897 T19895 prep of,model
R5033 T19898 T19899 amod classic,MSUD
R5034 T19899 T19897 pobj MSUD,of
R5035 T19900 T19896 auxpass was,created
R5036 T19901 T19896 prep by,created
R5037 T19902 T19903 compound gene,knockout
R5038 T19903 T19901 pobj knockout,by
R5039 T19904 T19903 prep of,knockout
R5040 T19905 T19906 det the,subunit
R5041 T19906 T19904 pobj subunit,of
R5042 T19907 T19906 compound E2,subunit
R5043 T19908 T19906 prep of,subunit
R5044 T19909 T19908 pobj BCKDH,of
R5045 T19910 T19896 punct .,created
R5046 T19912 T19913 det The,phenotype
R5047 T19913 T19914 nsubj phenotype,is
R5048 T19915 T19913 prep of,phenotype
R5049 T19916 T19917 det these,animals
R5050 T19917 T19915 pobj animals,of
R5051 T19918 T19917 compound knockout,animals
R5052 T19919 T19920 advmod strikingly,similar
R5053 T19920 T19914 acomp similar,is
R5054 T19921 T19920 prep to,similar
R5055 T19922 T19921 pobj humans,to
R5056 T19923 T19922 prep with,humans
R5057 T19924 T19925 amod classic,MSUD
R5058 T19925 T19923 pobj MSUD,with
R5059 T19926 T19914 punct .,is
R5060 T19928 T19929 compound Knockout,mice
R5061 T19929 T19930 nsubjpass mice,born
R5062 T19931 T19930 auxpass were,born
R5063 T19932 T19930 prep at,born
R5064 T19933 T19934 det the,frequency
R5065 T19934 T19932 pobj frequency,at
R5066 T19935 T19934 amod expected,frequency
R5067 T19936 T19930 cc and,born
R5068 T19937 T19930 conj appeared,born
R5069 T19938 T19937 oprd normal,appeared
R5070 T19939 T19937 prep at,appeared
R5071 T19940 T19939 pobj birth,at
R5072 T19941 T19930 punct .,born
R5073 T19943 T19944 prep Within,were
R5074 T19945 T19946 det a,day
R5075 T19946 T19943 pobj day,Within
R5076 T19947 T19946 prep of,day
R5077 T19948 T19947 pobj birth,of
R5078 T19949 T19943 cc and,Within
R5079 T19950 T19943 conj following,Within
R5080 T19951 T19950 pobj suckling,following
R5081 T19952 T19944 punct ", ",were
R5082 T19953 T19954 compound blood,levels
R5083 T19954 T19944 nsubj levels,were
R5084 T19955 T19954 prep of,levels
R5085 T19956 T19955 pobj BCAA,of
R5086 T19957 T19958 advmod markedly,elevated
R5087 T19958 T19944 acomp elevated,were
R5088 T19959 T19944 punct .,were
R5089 T19961 T19962 advmod Concomitantly,decreased
R5090 T19963 T19962 punct ", ",decreased
R5091 T19964 T19962 nsubjpass levels,decreased
R5092 T19965 T19964 prep of,levels
R5093 T19966 T19967 det the,acids
R5094 T19967 T19965 pobj acids,of
R5095 T19968 T19967 compound amino,acids
R5096 T19969 T19967 appos alanine,acids
R5097 T19970 T19969 punct ", ",alanine
R5098 T19971 T19969 conj glutamate,alanine
R5099 T19972 T19971 punct ", ",glutamate
R5100 T19973 T19971 cc and,glutamate
R5101 T19974 T19971 conj glutamine,glutamate
R5102 T19975 T19967 punct ", ",acids
R5103 T19976 T19977 poss whose,synthesis
R5104 T19977 T19978 dep synthesis,linked
R5105 T19978 T19967 relcl linked,acids
R5106 T19979 T19978 auxpass is,linked
R5107 T19980 T19978 prep with,linked
R5108 T19981 T19982 amod normal,metabolism
R5109 T19982 T19980 pobj metabolism,with
R5110 T19983 T19982 prep of,metabolism
R5111 T19984 T19983 pobj BCAA,of
R5112 T19985 T19962 punct ", ",decreased
R5113 T19986 T19962 auxpass were,decreased
R5114 T19987 T19988 punct (,Table
R5115 T19988 T19962 parataxis Table,decreased
R5116 T19989 T19988 nummod 1,Table
R5117 T19990 T19988 punct ),Table
R5118 T19991 T19962 punct .,decreased
R5119 T19993 T19994 det The,activity
R5120 T19994 T19995 nsubj activity,was
R5121 T19996 T19994 prep of,activity
R5122 T19997 T19996 pobj BCKDH,of
R5123 T19998 T19994 prep in,activity
R5124 T19999 T19998 pobj livers,in
R5125 T20000 T19999 prep of,livers
R5126 T20001 T20002 amod homozygous,knockout
R5127 T20002 T20003 compound knockout,pups
R5128 T20003 T20000 pobj pups,of
R5129 T20004 T20003 compound mouse,pups
R5130 T20005 T19995 acomp undetectable,was
R5131 T20006 T19995 punct ", ",was
R5132 T20007 T19995 advcl accounting,was
R5133 T20008 T20007 prep for,accounting
R5134 T20009 T20010 det the,accumulation
R5135 T20010 T20008 pobj accumulation,for
R5136 T20011 T20010 prep of,accumulation
R5137 T20012 T20013 amod unmetabolized,BCAA
R5138 T20013 T20011 pobj BCAA,of
R5139 T20014 T19995 punct .,was
R5140 T20016 T20017 amod Immunoreactive,protein
R5141 T20017 T20019 nsubj protein,was
R5142 T20018 T20017 compound E2,protein
R5143 T20020 T20019 acomp absent,was
R5144 T20021 T20019 prep in,was
R5145 T20022 T20021 pobj liver,in
R5146 T20023 T20022 cc and,liver
R5147 T20024 T20022 conj fibroblasts,liver
R5148 T20025 T20022 prep of,liver
R5149 T20026 T20027 amod homozygous,pups
R5150 T20027 T20025 pobj pups,of
R5151 T20028 T20019 punct .,was
R5152 T20030 T20031 det The,behavior
R5153 T20031 T20033 nsubj behavior,resembles
R5154 T20032 T20031 amod phenotypic,behavior
R5155 T20034 T20031 prep of,behavior
R5156 T20035 T20036 amod homozygous,pups
R5157 T20036 T20034 pobj pups,of
R5158 T20037 T20036 compound mouse,pups
R5159 T20038 T20033 dobj symptoms,resembles
R5160 T20039 T20038 acl seen,symptoms
R5161 T20040 T20039 prep in,seen
R5162 T20041 T20042 amod newborn,patients
R5163 T20042 T20040 pobj patients,in
R5164 T20043 T20042 amod classic,patients
R5165 T20044 T20042 compound MSUD,patients
R5166 T20045 T20033 punct .,resembles
R5167 T20047 T20048 nsubj These,include
R5168 T20049 T20048 dobj signs,include
R5169 T20050 T20049 prep of,signs
R5170 T20051 T20052 amod neurologic,dysfunction
R5171 T20052 T20050 pobj dysfunction,of
R5172 T20053 T20054 amod such,as
R5173 T20054 T20049 prep as,signs
R5174 T20055 T20054 pobj seizures,as
R5175 T20056 T20055 punct ", ",seizures
R5176 T20057 T20055 conj stupor,seizures
R5177 T20058 T20057 punct ", ",stupor
R5178 T20059 T20057 conj lethargy,stupor
R5179 T20060 T20059 punct ", ",lethargy
R5180 T20061 T20059 conj loss,lethargy
R5181 T20062 T20061 prep of,loss
R5182 T20063 T20064 compound motor,activity
R5183 T20064 T20062 pobj activity,of
R5184 T20065 T20061 punct ", ",loss
R5185 T20066 T20061 cc and,loss
R5186 T20067 T20068 amod respiratory,difficulties
R5187 T20068 T20061 conj difficulties,loss
R5188 T20069 T20070 punct [,1
R5189 T20070 T20048 parataxis 1,include
R5190 T20071 T20070 punct ],1
R5191 T20072 T20048 punct .,include
R5192 T20074 T20075 det These,symptoms
R5193 T20075 T20077 nsubj symptoms,result
R5194 T20076 T20075 amod neurologic,symptoms
R5195 T20078 T20077 aux may,result
R5196 T20079 T20077 prep from,result
R5197 T20080 T20081 amod reduced,levels
R5198 T20081 T20079 pobj levels,from
R5199 T20082 T20081 prep of,levels
R5200 T20083 T20082 pobj glutamate,of
R5201 T20084 T20083 punct ", ",glutamate
R5202 T20085 T20083 conj glutamine,glutamate
R5203 T20086 T20085 punct ", ",glutamine
R5204 T20087 T20085 conj alanine,glutamine
R5205 T20088 T20087 punct ", ",alanine
R5206 T20089 T20087 cc and,alanine
R5207 T20090 T20091 amod other,acids
R5208 T20091 T20087 conj acids,alanine
R5209 T20092 T20091 amod similar,acids
R5210 T20093 T20091 amod neuroactive,acids
R5211 T20094 T20091 compound amino,acids
R5212 T20095 T20083 punct ", ",glutamate
R5213 T20096 T20097 dep which,considered
R5214 T20097 T20083 relcl considered,glutamate
R5215 T20098 T20097 auxpass are,considered
R5216 T20099 T20100 det the,culprit
R5217 T20100 T20097 oprd culprit,considered
R5218 T20101 T20100 prep for,culprit
R5219 T20102 T20103 compound MSUD,encephalopathies
R5220 T20103 T20101 pobj encephalopathies,for
R5221 T20104 T20100 prep in,culprit
R5222 T20105 T20104 pobj patients,in
R5223 T20106 T20107 punct [,37
R5224 T20107 T20077 parataxis 37,result
R5225 T20108 T20107 nummod 1,37
R5226 T20109 T20107 punct ",",37
R5227 T20110 T20107 punct ],37
R5228 T20111 T20077 punct .,result
R5229 T20113 T20114 advmod Finally,died
R5230 T20115 T20114 punct ", ",died
R5231 T20116 T20117 advmod nearly,all
R5232 T20117 T20114 nsubj all,died
R5233 T20118 T20117 prep of,all
R5234 T20119 T20120 det the,pups
R5235 T20120 T20118 pobj pups,of
R5236 T20121 T20120 amod homozygous,pups
R5237 T20122 T20114 prep within,died
R5238 T20123 T20124 nummod 72,hours
R5239 T20124 T20122 pobj hours,within
R5240 T20125 T20124 prep of,hours
R5241 T20126 T20125 pobj birth,of
R5242 T20127 T20114 punct .,died
R5243 T20129 T20130 det This,lethality
R5244 T20130 T20132 nsubj lethality,is
R5245 T20131 T20130 amod neonatal,lethality
R5246 T20133 T20134 advmod likely,due
R5247 T20134 T20132 prep due,is
R5248 T20135 T20134 pcomp to,due
R5249 T20136 T20137 det the,accumulation
R5250 T20137 T20134 pobj accumulation,due
R5251 T20138 T20137 prep of,accumulation
R5252 T20139 T20138 pobj BCAA,of
R5253 T20140 T20137 prep to,accumulation
R5254 T20141 T20142 amod neurotoxic,levels
R5255 T20142 T20140 pobj levels,to
R5256 T20143 T20142 punct ", ",levels
R5257 T20144 T20142 conj ketoacidosis,levels
R5258 T20145 T20144 punct ", ",ketoacidosis
R5259 T20146 T20147 compound brain,edema
R5260 T20147 T20144 conj edema,ketoacidosis
R5261 T20148 T20147 punct ", ",edema
R5262 T20149 T20147 conj dehydration,edema
R5263 T20150 T20149 punct ", ",dehydration
R5264 T20151 T20149 cc and,dehydration
R5265 T20152 T20149 conj malnutrition,dehydration
R5266 T20153 T20154 mark as,observed
R5267 T20154 T20132 advcl observed,is
R5268 T20155 T20154 prep in,observed
R5269 T20156 T20157 det the,calf
R5270 T20157 T20155 pobj calf,in
R5271 T20158 T20157 compound MSUD,calf
R5272 T20159 T20160 punct [,17
R5273 T20160 T20157 parataxis 17,calf
R5274 T20161 T20160 punct ],17
R5275 T20162 T20155 cc and,in
R5276 T20163 T20155 conj in,in
R5277 T20164 T20165 amod classic,patients
R5278 T20165 T20163 pobj patients,in
R5279 T20166 T20165 compound MSUD,patients
R5280 T20167 T20168 punct [,1
R5281 T20168 T20165 parataxis 1,patients
R5282 T20169 T20168 punct ],1
R5283 T20170 T20132 punct .,is
R5284 T20172 T20173 amod Heterozygous,knockouts
R5285 T20173 T20174 nsubj knockouts,were
R5286 T20175 T20174 acomp normal,were
R5287 T20176 T20174 cc and,were
R5288 T20177 T20174 conj had,were
R5289 T20178 T20179 amod normal,levels
R5290 T20179 T20177 dobj levels,had
R5291 T20180 T20179 prep of,levels
R5292 T20181 T20180 pobj BCAA,of
R5293 T20182 T20177 prep despite,had
R5294 T20183 T20182 pcomp having,despite
R5295 T20184 T20185 advmod approximately,half
R5296 T20185 T20183 dobj half,having
R5297 T20186 T20185 prep of,half
R5298 T20187 T20188 nmod BCKDH,activity
R5299 T20188 T20186 pobj activity,of
R5300 T20189 T20188 amod enzymatic,activity
R5301 T20190 T20174 punct .,were
R5302 T20192 T20193 prep From,represents
R5303 T20194 T20195 det the,studies
R5304 T20195 T20192 pobj studies,From
R5305 T20196 T20195 compound characterization,studies
R5306 T20197 T20195 acl completed,studies
R5307 T20198 T20199 advmod thus,far
R5308 T20199 T20197 advmod far,completed
R5309 T20200 T20193 punct ", ",represents
R5310 T20201 T20202 det the,mouse
R5311 T20202 T20193 nsubj mouse,represents
R5312 T20203 T20204 amod null,mutation
R5313 T20204 T20202 compound mutation,mouse
R5314 T20205 T20193 advmod accurately,represents
R5315 T20206 T20207 det a,model
R5316 T20207 T20193 dobj model,represents
R5317 T20208 T20207 prep of,model
R5318 T20209 T20210 amod classic,MSUD
R5319 T20210 T20208 pobj MSUD,of
R5320 T20211 T20193 cc and,represents
R5321 T20212 T20193 conj appears,represents
R5322 T20213 T20214 aux to,be
R5323 T20214 T20212 xcomp be,appears
R5324 T20215 T20216 det a,model
R5325 T20216 T20214 attr model,be
R5326 T20217 T20216 amod faithful,model
R5327 T20218 T20216 prep of,model
R5328 T20219 T20220 det the,disease
R5329 T20220 T20218 pobj disease,of
R5330 T20221 T20220 amod human,disease
R5331 T20222 T20214 prep with,be
R5332 T20223 T20222 pobj respect,with
R5333 T20224 T20223 prep to,respect
R5334 T20225 T20226 amod several,phenotypes
R5335 T20226 T20224 pobj phenotypes,to
R5336 T20227 T20226 amod biochemical,phenotypes
R5337 T20228 T20229 punct [,1
R5338 T20229 T20212 parataxis 1,appears
R5339 T20230 T20229 punct ],1
R5340 T20231 T20193 punct .,represents

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T19707 1805-1816 CHEBI_EXT:biochemical denotes biochemical
T19706 1767-1772 NCBITaxon:9606 denotes human
T19705 1673-1678 NCBITaxon:10088 denotes mouse
T19704 1664-1672 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T19703 1659-1663 SO_EXT:sequence_nullness denotes null
T19702 1581-1590 CHEBI_GO_SO_EXT:enzyme denotes enzymatic
T19701 1533-1537 CHEBI:22918 denotes BCAA
T19700 1429-1433 NCBITaxon_UBERON_EXT:calf denotes calf
T19699 1362-1367 UBERON:0000955 denotes brain
T19698 1321-1325 CHEBI:22918 denotes BCAA
T19697 1274-1283 GO_EXT:fatality_or_lethality denotes lethality
T19696 1265-1273 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T19695 1253-1258 GO:0007567 denotes birth
T19694 1229-1233 GO:0016265 denotes died
T19693 1224-1228 NCBITaxon_UBERON_EXT:pup denotes pups
T19692 1094-1105 CHEBI_SO_EXT:amino_acid denotes amino acids
T19691 1055-1062 CHEBI_SO_EXT:alanine denotes alanine
T19690 1044-1053 CHEBI_SO_EXT:glutamine denotes glutamine
T19689 1033-1042 CHEBI_EXT:glutamate denotes glutamate
T19688 979-989 UBERON:0001016 denotes neurologic
T19687 943-954 UBERON:0001004 denotes respiratory
T19686 923-928 GO_EXT:biological_movement_or_translocation_process denotes motor
T19685 856-866 UBERON:0001016 denotes neurologic
T19684 802-809 PATO_UBERON_EXT:neonate_or_newborn denotes newborn
T19683 770-774 NCBITaxon_UBERON_EXT:pup denotes pups
T19682 764-769 NCBITaxon:10088 denotes mouse
T19681 741-749 GO_PATO_EXT:biological_behavior denotes behavior
T19680 720-724 NCBITaxon_UBERON_EXT:pup denotes pups
T19679 694-705 CL:0000057 denotes fibroblasts
T19678 684-689 UBERON:0002107 denotes liver
T19677 662-669 CHEBI_PR_EXT:protein denotes protein
T19676 659-661 PR_EXT:000006300 denotes E2
T19675 638-642 CHEBI:22918 denotes BCAA
T19674 626-637 GO:0008152 denotes metabolized
T19673 566-570 NCBITaxon_UBERON_EXT:pup denotes pups
T19672 560-565 NCBITaxon:10088 denotes mouse
T19671 530-536 UBERON:0002107 denotes livers
T19670 473-477 CHEBI:22918 denotes BCAA
T19669 459-477 GO:0009081 denotes metabolism of BCAA
T19668 410-419 CHEBI_SO_EXT:glutamine denotes glutamine
T19667 395-404 CHEBI_EXT:glutamate denotes glutamate
T19666 386-393 CHEBI_SO_EXT:alanine denotes alanine
T19665 374-385 CHEBI_SO_EXT:amino_acid denotes amino acids
T19664 316-320 CHEBI:22918 denotes BCAA
T19663 300-305 UBERON:0000178 denotes blood
T19662 290-298 GO:0001967 denotes suckling
T19661 270-275 GO:0007567 denotes birth
T19660 247-252 GO:0007567 denotes birth
T19659 193-197 GO:0007567 denotes born
T19658 183-187 NCBITaxon:10088 denotes mice
T19657 148-154 NCBITaxon:9606 denotes humans
T19656 115-122 NCBITaxon:33208 denotes animals
T19655 62-81 PR_EXT:000006300 denotes E2 subunit of BCKDH
T19654 41-45 SO_EXT:0000704 denotes gene

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T19543 659-661 PR:000006300 denotes E2
T19542 638-642 CHEBI:22918 denotes BCAA
T19541 626-637 GO:0008152 denotes metabolized
T19540 560-565 NCBITaxon:10088 denotes mouse
T19539 530-536 UBERON:0002107 denotes livers
T19538 473-477 CHEBI:22918 denotes BCAA
T19537 459-477 GO:0009081 denotes metabolism of BCAA
T19536 316-320 CHEBI:22918 denotes BCAA
T19535 300-305 UBERON:0000178 denotes blood
T19534 290-298 GO:0001967 denotes suckling
T19533 270-275 GO:0007567 denotes birth
T19532 247-252 GO:0007567 denotes birth
T19531 193-197 GO:0007567 denotes born
T19530 183-187 NCBITaxon:10088 denotes mice
T19529 148-154 NCBITaxon:9606 denotes humans
T19528 115-122 NCBITaxon:33208 denotes animals
T19527 62-81 PR:000006300 denotes E2 subunit of BCKDH
T19526 41-45 SO:0000704 denotes gene
T19556 1767-1772 NCBITaxon:9606 denotes human
T19555 1673-1678 NCBITaxon:10088 denotes mouse
T19554 1533-1537 CHEBI:22918 denotes BCAA
T19553 1362-1367 UBERON:0000955 denotes brain
T19552 1321-1325 CHEBI:22918 denotes BCAA
T19551 1253-1258 GO:0007567 denotes birth
T19550 1229-1233 GO:0016265 denotes died
T19549 979-989 UBERON:0001016 denotes neurologic
T19548 943-954 UBERON:0001004 denotes respiratory
T19547 856-866 UBERON:0001016 denotes neurologic
T19546 764-769 NCBITaxon:10088 denotes mouse
T19545 694-705 CL:0000057 denotes fibroblasts
T19544 684-689 UBERON:0002107 denotes liver