Long-term survival of the mice from these two transgenic lines that survived beyond weaning is plotted in Fig. 4D. Although survival data for control animals was not collected, it is readily apparent that survival of the rescue mice was compromised. By 16 weeks, all mice of Line A were moribund and humanely sacrificed, or were found dead in their cage. Survival of Line 525A appeared to be somewhat better. At 20 weeks of age, ~12% of mice (2 of 16) were still alive. These two rare survivors died at 40 and 60 weeks of age.