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PMC:1448208 / 23053-23837 JSONTXT

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Id Subject Object Predicate Lexical cue
T15888 743-750 JJ denotes minimal
T15887 732-742 VBG denotes containing
T15886 728-731 NN denotes TRE
T15885 726-727 DT denotes a
T15884 721-725 IN denotes from
T15883 713-715 NN denotes E2
T15882 707-712 JJ denotes human
T15881 716-720 NN denotes cDNA
T15880 705-706 DT denotes a
T15879 697-704 VB denotes express
T15878 694-696 TO denotes to
T15877 681-684 VBD denotes was
T15876 685-693 VBN denotes designed
T15875 667-668 HYPH denotes -
T15874 668-670 NN denotes E2
T15873 664-667 NN denotes TRE
T15872 671-680 NN denotes transgene
T15871 660-663 DT denotes The
T15870 659-784 sentence denotes The TRE-E2 transgene was designed to express a human E2 cDNA from a TRE containing minimal promoter upon stimulation by tTA.
T15869 658-659 . denotes .
T15868 657-658 -RRB- denotes )
T15867 654-657 NN denotes TRE
T15866 653-654 -LRB- denotes (
T15865 636-644 NN denotes response
T15864 621-635 NN denotes transactivator
T15863 645-652 NN denotes element
T15862 619-620 DT denotes a
T15861 612-618 VBP denotes harbor
T15860 607-611 WDT denotes that
T15859 597-606 NNS denotes promoters
T15858 594-596 IN denotes of
T15857 583-593 NN denotes expression
T15856 572-582 VBZ denotes stimulates
T15855 567-571 WDT denotes that
T15854 546-559 NN denotes transcription
T15853 560-566 NN denotes factor
T15852 544-545 DT denotes a
T15851 542-544 , denotes ,
T15850 541-542 -RRB- denotes )
T15849 538-541 NN denotes tTA
T15848 537-538 -LRB- denotes (
T15847 510-511 HYPH denotes -
T15846 511-521 VBN denotes controlled
T15845 498-510 NN denotes tetracycline
T15844 522-536 NN denotes transactivator
T15843 494-497 DT denotes the
T15842 491-493 IN denotes of
T15841 480-490 NN denotes expression
T15840 471-479 JJ denotes specific
T15839 465-470 NN denotes liver
T15838 462-464 IN denotes of
T15837 455-461 NNS denotes levels
T15836 450-454 JJ denotes high
T15835 440-441 -RRB- denotes ]
T15834 438-440 CD denotes 34
T15833 437-438 -LRB- denotes [
T15832 442-449 VBZ denotes directs
T15831 422-423 HYPH denotes -
T15830 423-426 NN denotes tTA
T15829 419-422 NN denotes LAP
T15828 427-436 NN denotes transgene
T15827 415-418 DT denotes The
T15826 414-659 sentence denotes The LAP-tTA transgene [34] directs high levels of liver specific expression of the tetracycline-controlled transactivator (tTA), a transcription factor that stimulates expression of promoters that harbor a transactivator response element (TRE).
T15825 413-414 . denotes .
T15824 412-413 -RRB- denotes )
T15823 405-409 NN denotes Fig.
T15822 410-412 NN denotes 3A
T15821 404-405 -LRB- denotes (
T15820 390-391 HYPH denotes -
T15819 391-393 NN denotes E2
T15818 387-390 NN denotes TRE
T15817 394-403 NN denotes transgene
T15816 385-386 DT denotes a
T15815 381-384 CC denotes and
T15814 366-367 HYPH denotes -
T15813 367-370 NN denotes tTA
T15812 363-366 NN denotes LAP
T15811 371-380 NN denotes transgene
T15810 361-362 DT denotes a
T15809 358-360 IN denotes of
T15808 348-357 VBD denotes consisted
T15807 327-340 JJ denotes bi-transgenic
T15806 341-347 NN denotes system
T15805 322-326 DT denotes This
T15804 321-414 sentence denotes This bi-transgenic system consisted of a LAP-tTA transgene and a TRE-E2 transgene (Fig. 3A).
T15803 320-321 . denotes .
T15802 301-309 NN denotes knockout
T15801 298-300 NN denotes E2
T15800 310-320 NN denotes background
T15799 294-297 DT denotes the
T15798 291-293 IN denotes on
T15797 285-290 NN denotes liver
T15796 282-284 IN denotes in
T15795 279-281 NN denotes E2
T15794 273-278 JJ denotes human
T15793 265-272 VB denotes express
T15792 262-264 TO denotes to
T15791 244-254 JJ denotes transgenic
T15790 239-243 NN denotes part
T15789 235-238 CD denotes two
T15788 255-261 NN denotes system
T15787 233-234 DT denotes a
T15786 230-232 IN denotes of
T15785 217-220 VBD denotes was
T15784 221-229 VBN denotes composed
T15783 208-216 NN denotes strategy
T15782 204-207 PRP$ denotes Our
T15781 203-321 sentence denotes Our strategy was composed of a two part transgenic system to express human E2 in liver on the E2 knockout background.
T15780 202-203 . denotes .
T15779 191-196 NN denotes mouse
T15778 186-190 NN denotes MSUD
T15777 178-185 JJ denotes classic
T15776 197-202 NN denotes model
T15775 174-177 DT denotes the
T15774 171-173 IN denotes in
T15773 164-170 VBZ denotes occurs
T15772 159-163 WDT denotes that
T15771 149-158 NN denotes lethality
T15770 140-148 JJ denotes neonatal
T15769 136-139 CC denotes and
T15768 131-135 NN denotes BCAA
T15767 128-130 IN denotes of
T15766 111-117 JJ denotes severe
T15765 118-127 NN denotes elevation
T15764 107-110 DT denotes the
T15763 100-106 VB denotes rescue
T15762 97-99 TO denotes to
T15761 77-87 JJ denotes transgenic
T15760 88-96 NN denotes strategy
T15759 75-76 DT denotes a
T15758 67-69 PRP denotes we
T15757 65-67 , denotes ,
T15756 61-65 NN denotes MSUD
T15755 58-60 IN denotes of
T15754 45-52 NN denotes variant
T15753 32-44 JJ denotes intermediate
T15752 53-57 NN denotes form
T15751 28-31 DT denotes the
T15750 25-27 IN denotes of
T15749 12-18 JJ denotes murine
T15748 19-24 NN denotes model
T15747 10-11 DT denotes a
T15746 70-74 VBD denotes used
T15745 3-9 VB denotes create
T15744 0-2 TO denotes To
T15894 783-784 . denotes .
T15893 780-783 NN denotes tTA
T15892 777-779 IN denotes by
T15891 765-776 NN denotes stimulation
T15890 760-764 IN denotes upon
T15889 751-759 NN denotes promoter
R3851 T15744 T15745 aux To,create
R3852 T15745 T15746 advcl create,used
R3853 T15747 T15748 det a,model
R3854 T15748 T15745 dobj model,create
R3855 T15749 T15748 amod murine,model
R3856 T15750 T15748 prep of,model
R3857 T15751 T15752 det the,form
R3858 T15752 T15750 pobj form,of
R3859 T15753 T15752 amod intermediate,form
R3860 T15754 T15752 compound variant,form
R3861 T15755 T15752 prep of,form
R3862 T15756 T15755 pobj MSUD,of
R3863 T15757 T15746 punct ", ",used
R3864 T15758 T15746 nsubj we,used
R3865 T15759 T15760 det a,strategy
R3866 T15760 T15746 dobj strategy,used
R3867 T15761 T15760 amod transgenic,strategy
R3868 T15762 T15763 aux to,rescue
R3869 T15763 T15746 advcl rescue,used
R3870 T15764 T15765 det the,elevation
R3871 T15765 T15763 dobj elevation,rescue
R3872 T15766 T15765 amod severe,elevation
R3873 T15767 T15765 prep of,elevation
R3874 T15768 T15767 pobj BCAA,of
R3875 T15769 T15765 cc and,elevation
R3876 T15770 T15771 amod neonatal,lethality
R3877 T15771 T15765 conj lethality,elevation
R3878 T15772 T15773 dep that,occurs
R3879 T15773 T15771 relcl occurs,lethality
R3880 T15774 T15773 prep in,occurs
R3881 T15775 T15776 det the,model
R3882 T15776 T15774 pobj model,in
R3883 T15777 T15776 amod classic,model
R3884 T15778 T15776 compound MSUD,model
R3885 T15779 T15776 compound mouse,model
R3886 T15780 T15746 punct .,used
R3887 T15782 T15783 poss Our,strategy
R3888 T15783 T15784 nsubjpass strategy,composed
R3889 T15785 T15784 auxpass was,composed
R3890 T15786 T15784 prep of,composed
R3891 T15787 T15788 det a,system
R3892 T15788 T15786 pobj system,of
R3893 T15789 T15790 nummod two,part
R3894 T15790 T15788 nmod part,system
R3895 T15791 T15788 amod transgenic,system
R3896 T15792 T15793 aux to,express
R3897 T15793 T15788 advcl express,system
R3898 T15794 T15795 amod human,E2
R3899 T15795 T15793 dobj E2,express
R3900 T15796 T15793 prep in,express
R3901 T15797 T15796 pobj liver,in
R3902 T15798 T15793 prep on,express
R3903 T15799 T15800 det the,background
R3904 T15800 T15798 pobj background,on
R3905 T15801 T15802 compound E2,knockout
R3906 T15802 T15800 compound knockout,background
R3907 T15803 T15784 punct .,composed
R3908 T15805 T15806 det This,system
R3909 T15806 T15808 nsubj system,consisted
R3910 T15807 T15806 amod bi-transgenic,system
R3911 T15809 T15808 prep of,consisted
R3912 T15810 T15811 det a,transgene
R3913 T15811 T15809 pobj transgene,of
R3914 T15812 T15813 compound LAP,tTA
R3915 T15813 T15811 compound tTA,transgene
R3916 T15814 T15813 punct -,tTA
R3917 T15815 T15811 cc and,transgene
R3918 T15816 T15817 det a,transgene
R3919 T15817 T15811 conj transgene,transgene
R3920 T15818 T15819 compound TRE,E2
R3921 T15819 T15817 compound E2,transgene
R3922 T15820 T15819 punct -,E2
R3923 T15821 T15822 punct (,3A
R3924 T15822 T15808 parataxis 3A,consisted
R3925 T15823 T15822 compound Fig.,3A
R3926 T15824 T15822 punct ),3A
R3927 T15825 T15808 punct .,consisted
R3944 T15844 T15842 pobj transactivator,of
R3945 T15845 T15846 npadvmod tetracycline,controlled
R3946 T15846 T15844 amod controlled,transactivator
R3947 T15847 T15846 punct -,controlled
R3948 T15848 T15844 punct (,transactivator
R3949 T15849 T15844 appos tTA,transactivator
R3950 T15850 T15844 punct ),transactivator
R3951 T15851 T15844 punct ", ",transactivator
R3952 T15852 T15853 det a,factor
R3953 T15853 T15844 appos factor,transactivator
R3954 T15854 T15853 compound transcription,factor
R3955 T15855 T15856 dep that,stimulates
R3956 T15856 T15853 relcl stimulates,factor
R3957 T15857 T15856 dobj expression,stimulates
R3958 T15858 T15857 prep of,expression
R3959 T15859 T15858 pobj promoters,of
R3960 T15860 T15861 dep that,harbor
R3961 T15861 T15859 relcl harbor,promoters
R3962 T15862 T15863 det a,element
R3963 T15863 T15861 dobj element,harbor
R3964 T15864 T15863 compound transactivator,element
R3965 T15865 T15863 compound response,element
R3966 T15866 T15863 punct (,element
R3967 T15867 T15863 appos TRE,element
R3968 T15868 T15832 punct ),directs
R3969 T15869 T15832 punct .,directs
R3970 T15871 T15872 det The,transgene
R3971 T15872 T15876 nsubjpass transgene,designed
R3972 T15873 T15874 compound TRE,E2
R3973 T15874 T15872 compound E2,transgene
R3974 T15875 T15874 punct -,E2
R3975 T15877 T15876 auxpass was,designed
R3976 T15878 T15879 aux to,express
R3977 T15879 T15876 advcl express,designed
R3978 T15880 T15881 det a,cDNA
R3979 T15881 T15879 dobj cDNA,express
R3980 T15882 T15881 amod human,cDNA
R3981 T15883 T15881 compound E2,cDNA
R3982 T15884 T15879 prep from,express
R3983 T15885 T15886 det a,TRE
R3984 T15886 T15884 pobj TRE,from
R3985 T15887 T15886 acl containing,TRE
R3986 T15888 T15889 amod minimal,promoter
R3987 T15889 T15887 dobj promoter,containing
R3988 T15890 T15879 prep upon,express
R3989 T15891 T15890 pobj stimulation,upon
R3990 T15892 T15891 prep by,stimulation
R3991 T15893 T15892 pobj tTA,by
R3992 T15894 T15876 punct .,designed
R3928 T15827 T15828 det The,transgene
R3929 T15828 T15832 nsubj transgene,directs
R3930 T15829 T15830 compound LAP,tTA
R3931 T15830 T15828 compound tTA,transgene
R3932 T15831 T15830 punct -,tTA
R3933 T15833 T15834 punct [,34
R3934 T15834 T15828 parataxis 34,transgene
R3935 T15835 T15834 punct ],34
R3936 T15836 T15837 amod high,levels
R3937 T15837 T15832 dobj levels,directs
R3938 T15838 T15837 prep of,levels
R3939 T15839 T15840 npadvmod liver,specific
R3940 T15840 T15841 amod specific,expression
R3941 T15841 T15838 pobj expression,of
R3942 T15842 T15841 prep of,expression
R3943 T15843 T15844 det the,transactivator

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T15538 751-759 SO_EXT:0000167 denotes promoter
T15537 716-720 SO_EXT:cDNA denotes cDNA
T15536 713-715 PR_EXT:000006300 denotes E2
T15535 707-712 NCBITaxon:9606 denotes human
T15534 697-704 GO:0010467 denotes express
T15533 671-680 SO_EXT:0000902 denotes transgene
T15532 668-670 PR_EXT:000006300 denotes E2
T15531 636-644 GO_EXT:reaction_or_response denotes response
T15530 597-606 SO_EXT:0000167 denotes promoters
T15529 583-593 GO:0010467 denotes expression
T15528 546-566 GO_EXT:transcription_factor denotes transcription factor
T15527 546-559 GO_EXT:transcription denotes transcription
T15526 511-521 GO:0065007 denotes controlled
T15525 498-510 CHEBI:27902 denotes tetracycline
T15524 480-490 GO:0010467 denotes expression
T15523 465-470 UBERON:0002107 denotes liver
T15522 442-449 GO_EXT:biological_direction_or_guidance denotes directs
T15521 427-436 SO_EXT:0000902 denotes transgene
T15520 419-422 PR_EXT:000005308 denotes LAP
T15519 394-403 SO_EXT:0000902 denotes transgene
T15518 391-393 PR_EXT:000006300 denotes E2
T15517 371-380 SO_EXT:0000902 denotes transgene
T15516 363-366 PR_EXT:000005308 denotes LAP
T15515 330-340 SO_EXT:transgenic_entity denotes transgenic
T15514 298-300 PR_EXT:000006300 denotes E2
T15513 285-290 UBERON:0002107 denotes liver
T15512 279-281 PR_EXT:000006300 denotes E2
T15511 273-278 NCBITaxon:9606 denotes human
T15510 265-272 GO:0010467 denotes express
T15509 244-254 SO_EXT:transgenic_entity denotes transgenic
T15508 191-196 NCBITaxon:10088 denotes mouse
T15507 149-158 GO_EXT:fatality_or_lethality denotes lethality
T15506 140-148 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T15505 131-135 CHEBI:22918 denotes BCAA
T15504 100-106 SO_EXT:sequence_rescue_process denotes rescue
T15503 77-87 SO_EXT:transgenic_entity denotes transgenic
T15502 12-18 NCBITaxon:39107 denotes murine

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T15380 751-759 SO:0000167 denotes promoter
T15379 713-715 PR:000006300 denotes E2
T15378 707-712 NCBITaxon:9606 denotes human
T15377 697-704 GO:0010467 denotes express
T15376 671-680 SO:0000902 denotes transgene
T15375 668-670 PR:000006300 denotes E2
T15374 597-606 SO:0000167 denotes promoters
T15373 583-593 GO:0010467 denotes expression
T15372 511-521 GO:0065007 denotes controlled
T15371 498-510 CHEBI:27902 denotes tetracycline
T15370 480-490 GO:0010467 denotes expression
T15369 465-470 UBERON:0002107 denotes liver
T15368 427-436 SO:0000902 denotes transgene
T15367 419-422 PR:000005308 denotes LAP
T15366 394-403 SO:0000902 denotes transgene
T15365 391-393 PR:000006300 denotes E2
T15364 371-380 SO:0000902 denotes transgene
T15363 363-366 PR:000005308 denotes LAP
T15362 298-300 PR:000006300 denotes E2
T15361 285-290 UBERON:0002107 denotes liver
T15360 279-281 PR:000006300 denotes E2
T15359 273-278 NCBITaxon:9606 denotes human
T15358 265-272 GO:0010467 denotes express
T15357 191-196 NCBITaxon:10088 denotes mouse
T15356 131-135 CHEBI:22918 denotes BCAA
T15355 12-18 NCBITaxon:39107 denotes murine