> top > docs > PMC:1440874 > spans > 6788-11597 > annotations

PMC:1440874 / 6788-11597 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

Id Subject Object Predicate Lexical cue
T1574 0-10 NN denotes Generation
T1575 11-13 IN denotes of
T1576 14-16 NN denotes ES
T1577 17-22 NNS denotes Cells
T1578 23-30 VBG denotes Lacking
T1579 31-35 JJ denotes Full
T1580 36-42 NN denotes Length
T1581 35-36 HYPH denotes -
T1582 43-47 NN denotes Atrx
T1583 47-226 sentence denotes Like the human gene, the mouse Atrx gene is also X-linked, such that a direct disruption of the single Atrx allele in male ES cells would immediately give rise to the null state.
T1584 48-52 IN denotes Like
T1585 89-91 VBZ denotes is
T1586 53-56 DT denotes the
T1587 63-67 NN denotes gene
T1588 57-62 JJ denotes human
T1589 67-69 , denotes ,
T1590 69-72 DT denotes the
T1591 84-88 NN denotes gene
T1592 73-78 NN denotes mouse
T1593 79-83 NN denotes Atrx
T1594 92-96 RB denotes also
T1595 97-98 NN denotes X
T1596 99-105 VBN denotes linked
T1597 98-99 HYPH denotes -
T1598 105-107 , denotes ,
T1599 107-111 JJ denotes such
T1600 198-202 VB denotes give
T1601 112-116 IN denotes that
T1602 117-118 DT denotes a
T1603 126-136 NN denotes disruption
T1604 119-125 JJ denotes direct
T1605 137-139 IN denotes of
T1606 140-143 DT denotes the
T1607 156-162 NN denotes allele
T1608 144-150 JJ denotes single
T1609 151-155 NN denotes Atrx
T1610 163-165 IN denotes in
T1611 166-170 JJ denotes male
T1612 174-179 NNS denotes cells
T1613 171-173 NN denotes ES
T1614 180-185 MD denotes would
T1615 186-197 RB denotes immediately
T1616 203-207 NN denotes rise
T1617 208-210 IN denotes to
T1618 211-214 DT denotes the
T1619 220-225 NN denotes state
T1620 215-219 JJ denotes null
T1621 225-226 . denotes .
T1622 226-393 sentence denotes No targeted clones were recovered after attempted homologous recombination in male E14TG2a ES cells using two different vectors that removed exon 18 of the Atrx gene.
T1623 227-229 DT denotes No
T1624 239-245 NNS denotes clones
T1625 230-238 VBN denotes targeted
T1626 251-260 VBN denotes recovered
T1627 246-250 VBD denotes were
T1628 261-266 IN denotes after
T1629 267-276 VBN denotes attempted
T1630 288-301 NN denotes recombination
T1631 277-287 JJ denotes homologous
T1632 302-304 IN denotes in
T1633 305-309 JJ denotes male
T1634 321-326 NNS denotes cells
T1635 310-317 NN denotes E14TG2a
T1636 318-320 NN denotes ES
T1637 327-332 VBG denotes using
T1638 333-336 CD denotes two
T1639 347-354 NNS denotes vectors
T1640 337-346 JJ denotes different
T1641 355-359 WDT denotes that
T1642 360-367 VBD denotes removed
T1643 368-372 NN denotes exon
T1644 373-375 CD denotes 18
T1645 376-378 IN denotes of
T1646 379-382 DT denotes the
T1647 388-392 NN denotes gene
T1648 383-387 NN denotes Atrx
T1649 392-393 . denotes .
T1650 393-636 sentence denotes Exon 18 encodes the first of the seven motifs composing the conserved SNF2-like domain of Atrx (Figure 1); mutation of the corresponding motif of the yeast SNF2 protein has been shown to severely impair SWI/SNF-dependent gene expression [12].
T1651 394-398 NN denotes Exon
T1652 402-409 VBZ denotes encodes
T1653 399-401 CD denotes 18
T1654 572-577 VBN denotes shown
T1655 410-413 DT denotes the
T1656 414-419 JJ denotes first
T1657 420-422 IN denotes of
T1658 423-426 DT denotes the
T1659 433-439 NNS denotes motifs
T1660 427-432 CD denotes seven
T1661 440-449 VBG denotes composing
T1662 450-453 DT denotes the
T1663 474-480 NN denotes domain
T1664 454-463 VBN denotes conserved
T1665 464-468 NN denotes SNF2
T1666 469-473 JJ denotes like
T1667 468-469 HYPH denotes -
T1668 481-483 IN denotes of
T1669 484-488 NN denotes Atrx
T1670 489-490 -LRB- denotes (
T1671 490-496 NN denotes Figure
T1672 497-498 CD denotes 1
T1673 498-499 -RRB- denotes )
T1674 499-500 : denotes ;
T1675 501-509 NN denotes mutation
T1676 510-512 IN denotes of
T1677 513-516 DT denotes the
T1678 531-536 NN denotes motif
T1679 517-530 VBG denotes corresponding
T1680 537-539 IN denotes of
T1681 540-543 DT denotes the
T1682 555-562 NN denotes protein
T1683 544-549 NN denotes yeast
T1684 550-554 NN denotes SNF2
T1685 563-566 VBZ denotes has
T1686 567-571 VBN denotes been
T1687 578-580 TO denotes to
T1688 590-596 VB denotes impair
T1689 581-589 RB denotes severely
T1690 597-600 NN denotes SWI
T1691 601-604 NN denotes SNF
T1692 600-601 HYPH denotes /
T1693 605-614 JJ denotes dependent
T1694 604-605 HYPH denotes -
T1695 620-630 NN denotes expression
T1696 615-619 NN denotes gene
T1697 631-632 -LRB- denotes [
T1698 632-634 CD denotes 12
T1699 634-635 -RRB- denotes ]
T1700 635-636 . denotes .
T1701 636-838 sentence denotes The failure to recover targeted clones with these vectors suggested that Atrx may be important for normal ES cell growth and expansion and that direct targeting of the single locus may not be possible.
T1702 637-640 DT denotes The
T1703 641-648 NN denotes failure
T1704 695-704 VBD denotes suggested
T1705 649-651 TO denotes to
T1706 652-659 VB denotes recover
T1707 660-668 VBN denotes targeted
T1708 669-675 NNS denotes clones
T1709 676-680 IN denotes with
T1710 681-686 DT denotes these
T1711 687-694 NNS denotes vectors
T1712 705-709 IN denotes that
T1713 719-721 VB denotes be
T1714 710-714 NN denotes Atrx
T1715 715-718 MD denotes may
T1716 722-731 JJ denotes important
T1717 732-735 IN denotes for
T1718 736-742 JJ denotes normal
T1719 746-750 NN denotes cell
T1720 743-745 NN denotes ES
T1721 751-757 NN denotes growth
T1722 758-761 CC denotes and
T1723 762-771 NN denotes expansion
T1724 772-775 CC denotes and
T1725 776-780 IN denotes that
T1726 826-828 VB denotes be
T1727 781-787 JJ denotes direct
T1728 788-797 NN denotes targeting
T1729 798-800 IN denotes of
T1730 801-804 DT denotes the
T1731 812-817 NN denotes locus
T1732 805-811 JJ denotes single
T1733 818-821 MD denotes may
T1734 822-825 RB denotes not
T1735 829-837 JJ denotes possible
T1736 837-838 . denotes .
T1737 838-1069 sentence denotes We therefore adopted a conditional strategy for targeting exon 18 (Figure 2) and recovered two clones in which exon 18 has been flanked by loxP recognition sites for the Cre recombinase (Atrx flox allele in Figure 2A) (Figure 2B).
T1738 839-841 PRP denotes We
T1739 852-859 VBD denotes adopted
T1740 842-851 RB denotes therefore
T1741 860-861 DT denotes a
T1742 874-882 NN denotes strategy
T1743 862-873 JJ denotes conditional
T1744 883-886 IN denotes for
T1745 887-896 VBG denotes targeting
T1746 897-901 NN denotes exon
T1747 902-904 CD denotes 18
T1748 905-906 -LRB- denotes (
T1749 906-912 NN denotes Figure
T1750 913-914 CD denotes 2
T1751 914-915 -RRB- denotes )
T1752 916-919 CC denotes and
T1753 920-929 VBD denotes recovered
T1754 930-933 CD denotes two
T1755 934-940 NNS denotes clones
T1756 941-943 IN denotes in
T1757 967-974 VBN denotes flanked
T1758 944-949 WDT denotes which
T1759 950-954 NN denotes exon
T1760 955-957 CD denotes 18
T1761 958-961 VBZ denotes has
T1762 962-966 VBN denotes been
T1763 975-977 IN denotes by
T1764 978-982 NN denotes loxP
T1765 995-1000 NNS denotes sites
T1766 983-994 NN denotes recognition
T1767 1001-1004 IN denotes for
T1768 1005-1008 DT denotes the
T1769 1013-1024 NN denotes recombinase
T1770 1009-1012 NN denotes Cre
T1771 1025-1026 -LRB- denotes (
T1772 1036-1042 NN denotes allele
T1773 1026-1035 NN denotes Atrx flox
T1774 1043-1045 IN denotes in
T1775 1046-1052 NN denotes Figure
T1776 1053-1055 NN denotes 2A
T1777 1055-1056 -RRB- denotes )
T1778 1057-1058 -LRB- denotes (
T1779 1065-1067 NN denotes 2B
T1780 1058-1064 NN denotes Figure
T1781 1067-1068 -RRB- denotes )
T1782 1068-1069 . denotes .
T1783 1069-1154 sentence denotes This allele also contains a loxP-flanked MC1-neor cassette in intron 17 (Figure 2A).
T1784 1070-1074 DT denotes This
T1785 1075-1081 NN denotes allele
T1786 1087-1095 VBZ denotes contains
T1787 1082-1086 RB denotes also
T1788 1096-1097 DT denotes a
T1789 1120-1128 NN denotes cassette
T1790 1098-1102 NN denotes loxP
T1791 1103-1110 VBN denotes flanked
T1792 1102-1103 HYPH denotes -
T1793 1111-1114 NN denotes MC1
T1794 1115-1119 NN denotes neor
T1795 1114-1115 HYPH denotes -
T1796 1129-1131 IN denotes in
T1797 1132-1138 NN denotes intron
T1798 1139-1141 CD denotes 17
T1799 1142-1143 -LRB- denotes (
T1800 1150-1152 NN denotes 2A
T1801 1143-1149 NN denotes Figure
T1802 1152-1153 -RRB- denotes )
T1803 1153-1154 . denotes .
T1804 1154-1328 sentence denotes Northern and Western blot analyses (Figure 2D and 2E) confirmed that the Atrx flox clones continued to express both full-length Atrx protein and the truncated Atrxt isoform.
T1805 1155-1163 NNP denotes Northern
T1806 1176-1180 NN denotes blot
T1807 1164-1167 CC denotes and
T1808 1168-1175 NNP denotes Western
T1809 1181-1189 NNS denotes analyses
T1810 1209-1218 VBD denotes confirmed
T1811 1190-1191 -LRB- denotes (
T1812 1198-1200 NN denotes 2D
T1813 1191-1197 NN denotes Figure
T1814 1201-1204 CC denotes and
T1815 1205-1207 NN denotes 2E
T1816 1207-1208 -RRB- denotes )
T1817 1219-1223 IN denotes that
T1818 1245-1254 VBD denotes continued
T1819 1224-1227 DT denotes the
T1820 1238-1244 NNS denotes clones
T1821 1228-1237 NN denotes Atrx flox
T1822 1255-1257 TO denotes to
T1823 1258-1265 VB denotes express
T1824 1266-1270 CC denotes both
T1825 1288-1295 NN denotes protein
T1826 1271-1275 JJ denotes full
T1827 1276-1282 NN denotes length
T1828 1275-1276 HYPH denotes -
T1829 1283-1287 NN denotes Atrx
T1830 1296-1299 CC denotes and
T1831 1300-1303 DT denotes the
T1832 1320-1327 NN denotes isoform
T1833 1304-1313 VBN denotes truncated
T1834 1314-1319 NN denotes Atrxt
T1835 1327-1328 . denotes .
T1836 1328-4060 sentence denotes Figure 2 Cre-Mediated Ablation of Full-Length Atrx Protein in ES Cells (A) Strategy for targeted deletion of exon 18 of the Atrx gene. The top line shows the wild-type allele (Atrx WT) at the region surrounding exon 18. Below is shown the targeting vector and the targeted allele (Atrx flox) resulting from homologous recombination. The loxP target sites of the Cre recombinase are shown as black triangles, and the three possible recombination events that can be mediated by the Cre recombinase are indicated (labelled A, B, and C in the Atrx flox allele). At bottom is shown the Cre-recombined allele (Atrx Δ18Δneo) (resulting from recombination event C) in which both exon 18 and the MC1neopA selection cassette have been deleted. EcoRI (labelled E) and SacI (labelled S) sites present on the targeted 129 strain X chromosome are indicated. Black bars indicate the positions of the probes used in Southern blots. (B) Southern blot analysis of EcoRI-digested DNA from either wild-type ES cells (E14) or targeted ES cell clones bearing the Atrx flox allele (1/F12 and 1/G11) hybridised with either the 20/27 (left blot) or Hae0.9 (right blot) probes. The EcoRI fragment of the Atrx WT allele (18.5 kb) has been replaced with the expected fragments of 11.2 kb (20/27 probe) or 8.5 kb (Hae0.9 probe) (C) Southern blot analysis of SacI-digested DNA from either wild-type ES cells (E14) or targeted ES cell clones bearing the Atrx flox allele (1/F12 and 1/G11) or Cre-recombinant clones derived from these (1/F12B1F12 and 1/G11D5). The membrane was hybridised with the intron 17 probe indicated in (A). The expected bands of 6.2 (Atrx WT), 5.0 (Atrx flox), and 2.8 (Atrx Δ18Δneo) kb were observed. (D) Northern blot analysis of RNA from ES cells shown in (C). The membrane was hybridised first to a probe from exon 10 of the Atrx gene (top blot) and subsequently to a β-actin cDNA probe as loading control (bottom blot). The transcripts responsible for full-length Atrx (~10 kb) and the truncated Atrxt isoforms (~7 kb) are indicated. (E) Western blot analysis of whole-cell extracts from the clones shown in (C) using an anti-ATRX monoclonal antibody (23C, raised against peptide A2 of the human ATRX protein shown in Figure 1). The full-length and truncated Atrx isoforms are indicated. To generate the full deletion in ES cells, the Atrx flox clones (1/F12 and 1/G11) were transiently transfected with a Cre-recombinase expression plasmid (pCAGGS-Cre-IRESpuro), and subclones were recovered bearing an allele (Atrx Δ18Δneo in Figure 2A) in which both exon 18 and the neor cassette had been deleted by the Cre recombinase (resulting from the recombination event labelled “C” in the Atrx flox allele shown in Figure 2A) (Figure 2C).
T1837 3616-3618 TO denotes To
T1838 3619-3627 VB denotes generate
T1839 3715-3726 VBN denotes transfected
T1840 3628-3631 DT denotes the
T1841 3637-3645 NN denotes deletion
T1842 3632-3636 JJ denotes full
T1843 3646-3648 IN denotes in
T1844 3649-3651 NN denotes ES
T1845 3652-3657 NNS denotes cells
T1846 3657-3659 , denotes ,
T1847 3659-3662 DT denotes the
T1848 3673-3679 NNS denotes clones
T1849 3663-3672 NN denotes Atrx flox
T1850 3680-3681 -LRB- denotes (
T1851 3683-3686 NN denotes F12
T1852 3681-3682 CD denotes 1
T1853 3682-3683 HYPH denotes /
T1854 3687-3690 CC denotes and
T1855 3691-3692 CD denotes 1
T1856 3693-3696 NN denotes G11
T1857 3692-3693 HYPH denotes /
T1858 3696-3697 -RRB- denotes )
T1859 3698-3702 VBD denotes were
T1860 3703-3714 RB denotes transiently
T1861 3727-3731 IN denotes with
T1862 3732-3733 DT denotes a
T1863 3761-3768 NN denotes plasmid
T1864 3734-3737 NN denotes Cre
T1865 3738-3749 NN denotes recombinase
T1866 3737-3738 HYPH denotes -
T1867 3750-3760 NN denotes expression
T1868 3769-3770 -LRB- denotes (
T1869 3770-3776 NN denotes pCAGGS
T1870 3781-3789 NN denotes IRESpuro
T1871 3776-3777 HYPH denotes -
T1872 3777-3780 NN denotes Cre
T1873 3780-3781 HYPH denotes -
T1874 3789-3790 -RRB- denotes )
T1875 3790-3792 , denotes ,
T1876 3792-3795 CC denotes and
T1877 3796-3805 NNS denotes subclones
T1878 3821-3828 VBG denotes bearing
T1879 3806-3810 VBD denotes were
T1880 3811-3820 VBN denotes recovered
T1881 3829-3831 DT denotes an
T1882 3832-3838 NN denotes allele
T1883 3839-3840 -LRB- denotes (
T1884 3840-3852 NN denotes Atrx Δ18Δneo
T1885 3853-3855 IN denotes in
T1886 3856-3862 NN denotes Figure
T1887 3863-3865 NN denotes 2A
T1888 3865-3866 -RRB- denotes )
T1889 3867-3869 IN denotes in
T1890 3920-3927 VBN denotes deleted
T1891 3870-3875 WDT denotes which
T1892 3876-3880 CC denotes both
T1893 3881-3885 NN denotes exon
T1894 3886-3888 CD denotes 18
T1895 3889-3892 CC denotes and
T1896 3893-3896 DT denotes the
T1897 3902-3910 NN denotes cassette
T1898 3897-3901 NN denotes neor
T1899 3911-3914 VBD denotes had
T1900 3915-3919 VBN denotes been
T1901 3928-3930 IN denotes by
T1902 3931-3934 DT denotes the
T1903 3939-3950 NN denotes recombinase
T1904 3935-3938 NN denotes Cre
T1905 3951-3952 -LRB- denotes (
T1906 3952-3961 VBG denotes resulting
T1907 3962-3966 IN denotes from
T1908 3967-3970 DT denotes the
T1909 3985-3990 NN denotes event
T1910 3971-3984 NN denotes recombination
T1911 3991-3999 VBN denotes labelled
T1912 4000-4001 `` denotes “
T1913 4001-4002 NN denotes C
T1914 4002-4003 '' denotes ”
T1915 4004-4006 IN denotes in
T1916 4007-4010 DT denotes the
T1917 4021-4027 NN denotes allele
T1918 4011-4020 NN denotes Atrx flox
T1919 4028-4033 VBN denotes shown
T1920 4034-4036 IN denotes in
T1921 4037-4043 NN denotes Figure
T1922 4044-4046 NN denotes 2A
T1923 4046-4047 -RRB- denotes )
T1924 4048-4049 -LRB- denotes (
T1925 4056-4058 NN denotes 2C
T1926 4049-4055 NN denotes Figure
T1927 4058-4059 -RRB- denotes )
T1928 4059-4060 . denotes .
T1929 4060-4341 sentence denotes Northern and Western blot analyses (Figure 2D and 2E) revealed that the full-length Atrx transcript and protein is completely abolished in the Atrx Δ18Δneo recombinant clones, suggesting that deletion of this region has a highly destabilising effect on the full-length transcript.
T1930 4061-4069 NNP denotes Northern
T1931 4082-4086 NN denotes blot
T1932 4070-4073 CC denotes and
T1933 4074-4081 NNP denotes Western
T1934 4087-4095 NNS denotes analyses
T1935 4115-4123 VBD denotes revealed
T1936 4096-4097 -LRB- denotes (
T1937 4104-4106 NN denotes 2D
T1938 4097-4103 NN denotes Figure
T1939 4107-4110 CC denotes and
T1940 4111-4113 NN denotes 2E
T1941 4113-4114 -RRB- denotes )
T1942 4124-4128 IN denotes that
T1943 4187-4196 VBN denotes abolished
T1944 4129-4132 DT denotes the
T1945 4150-4160 NN denotes transcript
T1946 4133-4137 JJ denotes full
T1947 4138-4144 NN denotes length
T1948 4137-4138 HYPH denotes -
T1949 4145-4149 NN denotes Atrx
T1950 4161-4164 CC denotes and
T1951 4165-4172 NN denotes protein
T1952 4173-4175 VBZ denotes is
T1953 4176-4186 RB denotes completely
T1954 4197-4199 IN denotes in
T1955 4200-4203 DT denotes the
T1956 4229-4235 NNS denotes clones
T1957 4204-4216 NN denotes Atrx Δ18Δneo
T1958 4217-4228 JJ denotes recombinant
T1959 4235-4237 , denotes ,
T1960 4237-4247 VBG denotes suggesting
T1961 4248-4252 IN denotes that
T1962 4277-4280 VBZ denotes has
T1963 4253-4261 NN denotes deletion
T1964 4262-4264 IN denotes of
T1965 4265-4269 DT denotes this
T1966 4270-4276 NN denotes region
T1967 4281-4282 DT denotes a
T1968 4304-4310 NN denotes effect
T1969 4283-4289 RB denotes highly
T1970 4290-4303 JJ denotes destabilising
T1971 4311-4313 IN denotes on
T1972 4314-4317 DT denotes the
T1973 4330-4340 NN denotes transcript
T1974 4318-4322 JJ denotes full
T1975 4323-4329 NN denotes length
T1976 4322-4323 HYPH denotes -
T1977 4340-4341 . denotes .
T1978 4341-4497 sentence denotes As expected, the truncated Atrxt isoform, the transcript of which is terminated within intron 11 [4], is unaffected by the deletion of exon 18 (Figure 2E).
T1979 4342-4344 IN denotes As
T1980 4345-4353 VBN denotes expected
T1981 4444-4446 VBZ denotes is
T1982 4353-4355 , denotes ,
T1983 4355-4358 DT denotes the
T1984 4375-4382 NN denotes isoform
T1985 4359-4368 VBN denotes truncated
T1986 4369-4374 NN denotes Atrxt
T1987 4382-4384 , denotes ,
T1988 4384-4387 DT denotes the
T1989 4388-4398 NN denotes transcript
T1990 4411-4421 VBN denotes terminated
T1991 4399-4401 IN denotes of
T1992 4402-4407 WDT denotes which
T1993 4408-4410 VBZ denotes is
T1994 4422-4428 IN denotes within
T1995 4429-4435 NN denotes intron
T1996 4436-4438 CD denotes 11
T1997 4439-4440 -LRB- denotes [
T1998 4440-4441 CD denotes 4
T1999 4441-4442 -RRB- denotes ]
T2000 4442-4444 , denotes ,
T2001 4447-4457 JJ denotes unaffected
T2002 4458-4460 IN denotes by
T2003 4461-4464 DT denotes the
T2004 4465-4473 NN denotes deletion
T2005 4474-4476 IN denotes of
T2006 4477-4481 NN denotes exon
T2007 4482-4484 CD denotes 18
T2008 4485-4486 -LRB- denotes (
T2009 4493-4495 NN denotes 2E
T2010 4486-4492 NN denotes Figure
T2011 4495-4496 -RRB- denotes )
T2012 4496-4497 . denotes .
T2013 4497-4701 sentence denotes While the function of Atrxt is not yet clear, this isoform, which contains the PHD-like domain but not the SWI/SNF motifs (Figure 1), is unlikely to be functionally equivalent to the full-length protein.
T2014 4498-4503 IN denotes While
T2015 4526-4528 VBZ denotes is
T2016 4504-4507 DT denotes the
T2017 4508-4516 NN denotes function
T2018 4517-4519 IN denotes of
T2019 4520-4525 NN denotes Atrxt
T2020 4632-4634 VBZ denotes is
T2021 4529-4532 RB denotes not
T2022 4533-4536 RB denotes yet
T2023 4537-4542 JJ denotes clear
T2024 4542-4544 , denotes ,
T2025 4544-4548 DT denotes this
T2026 4549-4556 NN denotes isoform
T2027 4556-4558 , denotes ,
T2028 4558-4563 WDT denotes which
T2029 4564-4572 VBZ denotes contains
T2030 4573-4576 DT denotes the
T2031 4586-4592 NN denotes domain
T2032 4577-4580 NN denotes PHD
T2033 4581-4585 JJ denotes like
T2034 4580-4581 HYPH denotes -
T2035 4593-4596 CC denotes but
T2036 4597-4600 RB denotes not
T2037 4601-4604 DT denotes the
T2038 4613-4619 NNS denotes motifs
T2039 4605-4608 NN denotes SWI
T2040 4609-4612 NN denotes SNF
T2041 4608-4609 HYPH denotes /
T2042 4620-4621 -LRB- denotes (
T2043 4621-4627 NN denotes Figure
T2044 4628-4629 CD denotes 1
T2045 4629-4630 -RRB- denotes )
T2046 4630-4632 , denotes ,
T2047 4635-4643 JJ denotes unlikely
T2048 4644-4646 TO denotes to
T2049 4647-4649 VB denotes be
T2050 4650-4662 RB denotes functionally
T2051 4663-4673 JJ denotes equivalent
T2052 4674-4676 IN denotes to
T2053 4677-4680 DT denotes the
T2054 4693-4700 NN denotes protein
T2055 4681-4685 JJ denotes full
T2056 4686-4692 NN denotes length
T2057 4685-4686 HYPH denotes -
T2058 4700-4701 . denotes .
T2059 4701-4809 sentence denotes Thus, a conditional knockout strategy allowed the isolation of ES cells that are null for full-length Atrx.
T2060 4702-4706 RB denotes Thus
T2061 4740-4747 VBD denotes allowed
T2062 4706-4708 , denotes ,
T2063 4708-4709 DT denotes a
T2064 4731-4739 NN denotes strategy
T2065 4710-4721 JJ denotes conditional
T2066 4722-4730 NN denotes knockout
T2067 4748-4751 DT denotes the
T2068 4752-4761 NN denotes isolation
T2069 4762-4764 IN denotes of
T2070 4765-4767 NN denotes ES
T2071 4768-4773 NNS denotes cells
T2072 4774-4778 WDT denotes that
T2073 4779-4782 VBP denotes are
T2074 4783-4787 JJ denotes null
T2075 4788-4791 IN denotes for
T2076 4792-4796 JJ denotes full
T2077 4797-4803 NN denotes length
T2078 4796-4797 HYPH denotes -
T2079 4804-4808 NN denotes Atrx
T2080 4808-4809 . denotes .
R830 T1575 T1574 prep of,Generation
R831 T1576 T1577 compound ES,Cells
R832 T1577 T1575 pobj Cells,of
R833 T1578 T1577 acl Lacking,Cells
R834 T1579 T1580 amod Full,Length
R835 T1580 T1582 compound Length,Atrx
R836 T1581 T1580 punct -,Length
R837 T1582 T1578 dobj Atrx,Lacking
R838 T1584 T1585 prep Like,is
R839 T1586 T1587 det the,gene
R840 T1587 T1584 pobj gene,Like
R841 T1588 T1587 amod human,gene
R842 T1589 T1585 punct ", ",is
R843 T1590 T1591 det the,gene
R844 T1591 T1585 nsubj gene,is
R845 T1592 T1591 compound mouse,gene
R846 T1593 T1591 compound Atrx,gene
R847 T1594 T1585 advmod also,is
R848 T1595 T1596 npadvmod X,linked
R849 T1596 T1585 acomp linked,is
R850 T1597 T1596 punct -,linked
R851 T1598 T1585 punct ", ",is
R852 T1599 T1600 amod such,give
R853 T1600 T1585 advcl give,is
R854 T1601 T1600 mark that,give
R855 T1602 T1603 det a,disruption
R856 T1603 T1600 nsubj disruption,give
R857 T1604 T1603 amod direct,disruption
R858 T1605 T1603 prep of,disruption
R859 T1606 T1607 det the,allele
R860 T1607 T1605 pobj allele,of
R861 T1608 T1607 amod single,allele
R862 T1609 T1607 compound Atrx,allele
R863 T1610 T1603 prep in,disruption
R864 T1611 T1612 amod male,cells
R865 T1612 T1610 pobj cells,in
R866 T1613 T1612 compound ES,cells
R867 T1614 T1600 aux would,give
R868 T1615 T1600 advmod immediately,give
R869 T1616 T1600 dobj rise,give
R870 T1617 T1600 prep to,give
R871 T1618 T1619 det the,state
R872 T1619 T1617 pobj state,to
R873 T1620 T1619 amod null,state
R874 T1621 T1585 punct .,is
R875 T1623 T1624 det No,clones
R876 T1624 T1626 nsubjpass clones,recovered
R877 T1625 T1624 amod targeted,clones
R878 T1627 T1626 auxpass were,recovered
R879 T1628 T1626 prep after,recovered
R880 T1629 T1630 amod attempted,recombination
R881 T1630 T1628 pobj recombination,after
R882 T1631 T1630 amod homologous,recombination
R883 T1632 T1630 prep in,recombination
R884 T1633 T1634 amod male,cells
R885 T1634 T1632 pobj cells,in
R886 T1635 T1636 compound E14TG2a,ES
R887 T1636 T1634 compound ES,cells
R888 T1637 T1626 advcl using,recovered
R889 T1638 T1639 nummod two,vectors
R890 T1639 T1637 dobj vectors,using
R891 T1640 T1639 amod different,vectors
R892 T1641 T1642 dep that,removed
R893 T1642 T1639 relcl removed,vectors
R894 T1643 T1642 dobj exon,removed
R895 T1644 T1643 nummod 18,exon
R896 T1645 T1643 prep of,exon
R897 T1646 T1647 det the,gene
R898 T1647 T1645 pobj gene,of
R899 T1648 T1647 compound Atrx,gene
R900 T1649 T1626 punct .,recovered
R901 T1651 T1652 nsubj Exon,encodes
R902 T1652 T1654 ccomp encodes,shown
R903 T1653 T1651 nummod 18,Exon
R904 T1655 T1656 det the,first
R905 T1656 T1652 dobj first,encodes
R906 T1657 T1656 prep of,first
R907 T1658 T1659 det the,motifs
R908 T1659 T1657 pobj motifs,of
R909 T1660 T1659 nummod seven,motifs
R910 T1661 T1656 acl composing,first
R911 T1662 T1663 det the,domain
R912 T1663 T1661 dobj domain,composing
R913 T1664 T1663 amod conserved,domain
R914 T1665 T1666 npadvmod SNF2,like
R915 T1666 T1663 amod like,domain
R916 T1667 T1666 punct -,like
R917 T1668 T1663 prep of,domain
R918 T1669 T1668 pobj Atrx,of
R919 T1670 T1671 punct (,Figure
R920 T1671 T1652 parataxis Figure,encodes
R921 T1672 T1671 nummod 1,Figure
R922 T1673 T1671 punct ),Figure
R923 T1674 T1654 punct ;,shown
R924 T1675 T1654 nsubjpass mutation,shown
R925 T1676 T1675 prep of,mutation
R926 T1677 T1678 det the,motif
R927 T1678 T1676 pobj motif,of
R928 T1679 T1678 amod corresponding,motif
R929 T1680 T1678 prep of,motif
R930 T1681 T1682 det the,protein
R931 T1682 T1680 pobj protein,of
R932 T1683 T1682 compound yeast,protein
R933 T1684 T1682 compound SNF2,protein
R934 T1685 T1654 aux has,shown
R935 T1686 T1654 auxpass been,shown
R936 T1687 T1688 aux to,impair
R937 T1688 T1654 xcomp impair,shown
R938 T1689 T1688 advmod severely,impair
R939 T1690 T1691 compound SWI,SNF
R940 T1691 T1693 npadvmod SNF,dependent
R941 T1692 T1691 punct /,SNF
R942 T1693 T1695 amod dependent,expression
R943 T1694 T1693 punct -,dependent
R944 T1695 T1688 dobj expression,impair
R945 T1696 T1695 compound gene,expression
R946 T1697 T1698 punct [,12
R947 T1698 T1654 parataxis 12,shown
R948 T1699 T1698 punct ],12
R949 T1700 T1654 punct .,shown
R950 T1702 T1703 det The,failure
R951 T1703 T1704 nsubj failure,suggested
R952 T1705 T1706 aux to,recover
R953 T1706 T1703 acl recover,failure
R954 T1707 T1708 amod targeted,clones
R955 T1708 T1706 dobj clones,recover
R956 T1709 T1706 prep with,recover
R957 T1710 T1711 det these,vectors
R958 T1711 T1709 pobj vectors,with
R959 T1712 T1713 mark that,be
R960 T1713 T1704 advcl be,suggested
R961 T1714 T1713 nsubj Atrx,be
R962 T1715 T1713 aux may,be
R963 T1716 T1713 acomp important,be
R964 T1717 T1716 prep for,important
R965 T1718 T1719 amod normal,cell
R966 T1719 T1717 pobj cell,for
R967 T1720 T1719 compound ES,cell
R968 T1721 T1719 appos growth,cell
R969 T1722 T1721 cc and,growth
R970 T1723 T1721 conj expansion,growth
R971 T1724 T1713 cc and,be
R972 T1725 T1726 mark that,be
R973 T1726 T1713 conj be,be
R974 T1727 T1728 amod direct,targeting
R975 T1728 T1726 nsubj targeting,be
R976 T1729 T1728 prep of,targeting
R977 T1730 T1731 det the,locus
R978 T1731 T1729 pobj locus,of
R979 T1732 T1731 amod single,locus
R980 T1733 T1726 aux may,be
R981 T1734 T1726 neg not,be
R982 T1735 T1726 acomp possible,be
R983 T1736 T1704 punct .,suggested
R984 T1738 T1739 nsubj We,adopted
R985 T1740 T1739 advmod therefore,adopted
R986 T1741 T1742 det a,strategy
R987 T1742 T1739 dobj strategy,adopted
R988 T1743 T1742 amod conditional,strategy
R989 T1744 T1742 prep for,strategy
R990 T1745 T1744 pcomp targeting,for
R991 T1746 T1745 dobj exon,targeting
R992 T1747 T1746 nummod 18,exon
R993 T1748 T1749 punct (,Figure
R994 T1749 T1739 parataxis Figure,adopted
R995 T1750 T1749 nummod 2,Figure
R996 T1751 T1749 punct ),Figure
R997 T1752 T1739 cc and,adopted
R998 T1753 T1739 conj recovered,adopted
R999 T1754 T1755 nummod two,clones
R1000 T1755 T1753 dobj clones,recovered
R1001 T1756 T1757 prep in,flanked
R1002 T1757 T1755 relcl flanked,clones
R1003 T1758 T1756 pobj which,in
R1004 T1759 T1757 nsubjpass exon,flanked
R1005 T1760 T1759 nummod 18,exon
R1006 T1761 T1757 aux has,flanked
R1007 T1762 T1757 auxpass been,flanked
R1008 T1763 T1757 agent by,flanked
R1009 T1764 T1765 compound loxP,sites
R1010 T1765 T1763 pobj sites,by
R1011 T1766 T1765 compound recognition,sites
R1012 T1767 T1765 prep for,sites
R1013 T1768 T1769 det the,recombinase
R1014 T1769 T1767 pobj recombinase,for
R1015 T1770 T1769 compound Cre,recombinase
R1016 T1771 T1772 punct (,allele
R1017 T1772 T1769 parataxis allele,recombinase
R1018 T1773 T1772 compound Atrx flox,allele
R1019 T1774 T1772 prep in,allele
R1020 T1775 T1776 compound Figure,2A
R1021 T1776 T1774 pobj 2A,in
R1022 T1777 T1772 punct ),allele
R1023 T1778 T1779 punct (,2B
R1024 T1779 T1753 parataxis 2B,recovered
R1025 T1780 T1779 compound Figure,2B
R1026 T1781 T1779 punct ),2B
R1027 T1782 T1739 punct .,adopted
R1028 T1784 T1785 det This,allele
R1029 T1785 T1786 nsubj allele,contains
R1030 T1787 T1786 advmod also,contains
R1031 T1788 T1789 det a,cassette
R1032 T1789 T1786 dobj cassette,contains
R1033 T1790 T1791 npadvmod loxP,flanked
R1034 T1791 T1789 amod flanked,cassette
R1035 T1792 T1791 punct -,flanked
R1036 T1793 T1794 compound MC1,neor
R1037 T1794 T1789 compound neor,cassette
R1038 T1795 T1794 punct -,neor
R1039 T1796 T1786 prep in,contains
R1040 T1797 T1796 pobj intron,in
R1041 T1798 T1797 nummod 17,intron
R1042 T1799 T1800 punct (,2A
R1043 T1800 T1786 parataxis 2A,contains
R1044 T1801 T1800 compound Figure,2A
R1045 T1802 T1800 punct ),2A
R1046 T1803 T1786 punct .,contains
R1047 T1805 T1806 nmod Northern,blot
R1048 T1806 T1809 compound blot,analyses
R1049 T1807 T1805 cc and,Northern
R1050 T1808 T1805 conj Western,Northern
R1051 T1809 T1810 nsubj analyses,confirmed
R1052 T1811 T1812 punct (,2D
R1053 T1812 T1809 parataxis 2D,analyses
R1054 T1813 T1812 compound Figure,2D
R1055 T1814 T1812 cc and,2D
R1056 T1815 T1812 conj 2E,2D
R1057 T1816 T1812 punct ),2D
R1058 T1817 T1818 mark that,continued
R1059 T1818 T1810 ccomp continued,confirmed
R1060 T1819 T1820 det the,clones
R1061 T1820 T1818 nsubj clones,continued
R1062 T1821 T1820 compound Atrx flox,clones
R1063 T1822 T1823 aux to,express
R1064 T1823 T1818 xcomp express,continued
R1065 T1824 T1825 preconj both,protein
R1066 T1825 T1823 dobj protein,express
R1067 T1826 T1827 amod full,length
R1068 T1827 T1825 compound length,protein
R1069 T1828 T1827 punct -,length
R1070 T1829 T1825 compound Atrx,protein
R1071 T1830 T1825 cc and,protein
R1072 T1831 T1832 det the,isoform
R1073 T1832 T1825 conj isoform,protein
R1074 T1833 T1832 amod truncated,isoform
R1075 T1834 T1832 compound Atrxt,isoform
R1076 T1835 T1810 punct .,confirmed
R1077 T1837 T1838 aux To,generate
R1078 T1838 T1839 advcl generate,transfected
R1079 T1840 T1841 det the,deletion
R1080 T1841 T1838 dobj deletion,generate
R1081 T1842 T1841 amod full,deletion
R1082 T1843 T1838 prep in,generate
R1083 T1844 T1845 compound ES,cells
R1084 T1845 T1843 pobj cells,in
R1085 T1846 T1839 punct ", ",transfected
R1086 T1847 T1848 det the,clones
R1087 T1848 T1839 nsubjpass clones,transfected
R1088 T1849 T1848 compound Atrx flox,clones
R1089 T1850 T1851 punct (,F12
R1090 T1851 T1848 parataxis F12,clones
R1091 T1852 T1851 nummod 1,F12
R1092 T1853 T1851 punct /,F12
R1093 T1854 T1851 cc and,F12
R1094 T1855 T1856 nummod 1,G11
R1095 T1856 T1851 conj G11,F12
R1096 T1857 T1856 punct /,G11
R1097 T1858 T1851 punct ),F12
R1098 T1859 T1839 auxpass were,transfected
R1099 T1860 T1839 advmod transiently,transfected
R1100 T1861 T1839 prep with,transfected
R1101 T1862 T1863 det a,plasmid
R1102 T1863 T1861 pobj plasmid,with
R1103 T1864 T1865 compound Cre,recombinase
R1104 T1865 T1863 compound recombinase,plasmid
R1105 T1866 T1865 punct -,recombinase
R1106 T1867 T1863 compound expression,plasmid
R1107 T1868 T1863 punct (,plasmid
R1108 T1869 T1870 compound pCAGGS,IRESpuro
R1109 T1870 T1863 appos IRESpuro,plasmid
R1110 T1871 T1870 punct -,IRESpuro
R1111 T1872 T1870 compound Cre,IRESpuro
R1112 T1873 T1870 punct -,IRESpuro
R1113 T1874 T1839 punct ),transfected
R1114 T1875 T1839 punct ", ",transfected
R1115 T1876 T1839 cc and,transfected
R1116 T1877 T1878 nsubjpass subclones,bearing
R1117 T1878 T1839 conj bearing,transfected
R1118 T1879 T1878 auxpass were,bearing
R1119 T1880 T1878 aux recovered,bearing
R1120 T1881 T1882 det an,allele
R1121 T1882 T1878 dobj allele,bearing
R1122 T1883 T1884 punct (,Atrx Δ18Δneo
R1123 T1884 T1882 parataxis Atrx Δ18Δneo,allele
R1124 T1885 T1884 prep in,Atrx Δ18Δneo
R1125 T1886 T1887 compound Figure,2A
R1126 T1887 T1885 pobj 2A,in
R1127 T1888 T1884 punct ),Atrx Δ18Δneo
R1128 T1889 T1890 prep in,deleted
R1129 T1890 T1882 relcl deleted,allele
R1130 T1891 T1889 pobj which,in
R1131 T1892 T1893 preconj both,exon
R1132 T1893 T1890 nsubjpass exon,deleted
R1133 T1894 T1893 nummod 18,exon
R1134 T1895 T1893 cc and,exon
R1135 T1896 T1897 det the,cassette
R1136 T1897 T1893 conj cassette,exon
R1137 T1898 T1897 compound neor,cassette
R1138 T1899 T1890 aux had,deleted
R1139 T1900 T1890 auxpass been,deleted
R1140 T1901 T1890 agent by,deleted
R1141 T1902 T1903 det the,recombinase
R1142 T1903 T1901 pobj recombinase,by
R1143 T1904 T1903 compound Cre,recombinase
R1144 T1905 T1906 punct (,resulting
R1145 T1906 T1890 parataxis resulting,deleted
R1146 T1907 T1906 prep from,resulting
R1147 T1908 T1909 det the,event
R1148 T1909 T1907 pobj event,from
R1149 T1910 T1909 compound recombination,event
R1150 T1911 T1909 acl labelled,event
R1151 T1912 T1913 punct “,C
R1152 T1913 T1911 oprd C,labelled
R1153 T1914 T1911 punct ”,labelled
R1154 T1915 T1911 prep in,labelled
R1155 T1916 T1917 det the,allele
R1156 T1917 T1915 pobj allele,in
R1157 T1918 T1917 compound Atrx flox,allele
R1158 T1919 T1917 acl shown,allele
R1159 T1920 T1919 prep in,shown
R1160 T1921 T1922 compound Figure,2A
R1161 T1922 T1920 pobj 2A,in
R1162 T1923 T1906 punct ),resulting
R1163 T1924 T1925 punct (,2C
R1164 T1925 T1890 parataxis 2C,deleted
R1165 T1926 T1925 compound Figure,2C
R1166 T1927 T1925 punct ),2C
R1167 T1928 T1878 punct .,bearing
R1168 T1930 T1931 nmod Northern,blot
R1169 T1931 T1934 compound blot,analyses
R1170 T1932 T1930 cc and,Northern
R1171 T1933 T1930 conj Western,Northern
R1172 T1934 T1935 nsubj analyses,revealed
R1173 T1936 T1937 punct (,2D
R1174 T1937 T1934 parataxis 2D,analyses
R1175 T1938 T1937 compound Figure,2D
R1176 T1939 T1937 cc and,2D
R1177 T1940 T1937 conj 2E,2D
R1178 T1941 T1937 punct ),2D
R1179 T1942 T1943 mark that,abolished
R1180 T1943 T1935 ccomp abolished,revealed
R1181 T1944 T1945 det the,transcript
R1182 T1945 T1943 nsubjpass transcript,abolished
R1183 T1946 T1947 amod full,length
R1184 T1947 T1945 compound length,transcript
R1185 T1948 T1947 punct -,length
R1186 T1949 T1945 compound Atrx,transcript
R1187 T1950 T1945 cc and,transcript
R1188 T1951 T1945 conj protein,transcript
R1189 T1952 T1943 auxpass is,abolished
R1190 T1953 T1943 advmod completely,abolished
R1191 T1954 T1943 prep in,abolished
R1192 T1955 T1956 det the,clones
R1193 T1956 T1954 pobj clones,in
R1194 T1957 T1958 npadvmod Atrx Δ18Δneo,recombinant
R1195 T1958 T1956 amod recombinant,clones
R1196 T1959 T1943 punct ", ",abolished
R1197 T1960 T1943 advcl suggesting,abolished
R1198 T1961 T1962 mark that,has
R1199 T1962 T1960 ccomp has,suggesting
R1200 T1963 T1962 nsubj deletion,has
R1201 T1964 T1963 prep of,deletion
R1202 T1965 T1966 det this,region
R1203 T1966 T1964 pobj region,of
R1204 T1967 T1968 det a,effect
R1205 T1968 T1962 dobj effect,has
R1206 T1969 T1970 advmod highly,destabilising
R1207 T1970 T1968 amod destabilising,effect
R1208 T1971 T1962 prep on,has
R1209 T1972 T1973 det the,transcript
R1210 T1973 T1971 pobj transcript,on
R1211 T1974 T1975 amod full,length
R1212 T1975 T1973 compound length,transcript
R1213 T1976 T1975 punct -,length
R1214 T1977 T1935 punct .,revealed
R1215 T1979 T1980 mark As,expected
R1216 T1980 T1981 advcl expected,is
R1217 T1982 T1981 punct ", ",is
R1218 T1983 T1984 det the,isoform
R1219 T1984 T1981 nsubj isoform,is
R1220 T1985 T1984 amod truncated,isoform
R1221 T1986 T1984 compound Atrxt,isoform
R1222 T1987 T1984 punct ", ",isoform
R1223 T1988 T1989 det the,transcript
R1224 T1989 T1990 dep transcript,terminated
R1225 T1990 T1984 relcl terminated,isoform
R1226 T1991 T1989 prep of,transcript
R1227 T1992 T1991 pobj which,of
R1228 T1993 T1990 auxpass is,terminated
R1229 T1994 T1990 prep within,terminated
R1230 T1995 T1994 pobj intron,within
R1231 T1996 T1995 nummod 11,intron
R1232 T1997 T1998 punct [,4
R1233 T1998 T1990 parataxis 4,terminated
R1234 T1999 T1998 punct ],4
R1235 T2000 T1981 punct ", ",is
R1236 T2001 T1981 acomp unaffected,is
R1237 T2002 T2001 prep by,unaffected
R1238 T2003 T2004 det the,deletion
R1239 T2004 T2002 pobj deletion,by
R1240 T2005 T2004 prep of,deletion
R1241 T2006 T2005 pobj exon,of
R1242 T2007 T2006 nummod 18,exon
R1243 T2008 T2009 punct (,2E
R1244 T2009 T1981 parataxis 2E,is
R1245 T2010 T2009 compound Figure,2E
R1246 T2011 T2009 punct ),2E
R1247 T2012 T1981 punct .,is
R1248 T2014 T2015 mark While,is
R1249 T2015 T2020 advcl is,is
R1250 T2016 T2017 det the,function
R1251 T2017 T2015 nsubj function,is
R1252 T2018 T2017 prep of,function
R1253 T2019 T2018 pobj Atrxt,of
R1254 T2021 T2015 neg not,is
R1255 T2022 T2015 advmod yet,is
R1256 T2023 T2015 acomp clear,is
R1257 T2024 T2020 punct ", ",is
R1258 T2025 T2026 det this,isoform
R1259 T2026 T2020 nsubj isoform,is
R1260 T2027 T2026 punct ", ",isoform
R1261 T2028 T2029 dep which,contains
R1262 T2029 T2026 relcl contains,isoform
R1263 T2030 T2031 det the,domain
R1264 T2031 T2029 dobj domain,contains
R1265 T2032 T2033 npadvmod PHD,like
R1266 T2033 T2031 amod like,domain
R1267 T2034 T2033 punct -,like
R1268 T2035 T2031 cc but,domain
R1269 T2036 T2035 neg not,but
R1270 T2037 T2038 det the,motifs
R1271 T2038 T2031 conj motifs,domain
R1272 T2039 T2040 compound SWI,SNF
R1273 T2040 T2038 compound SNF,motifs
R1274 T2041 T2040 punct /,SNF
R1275 T2042 T2043 punct (,Figure
R1276 T2043 T2029 parataxis Figure,contains
R1277 T2044 T2043 nummod 1,Figure
R1278 T2045 T2043 punct ),Figure
R1279 T2046 T2020 punct ", ",is
R1280 T2047 T2020 acomp unlikely,is
R1281 T2048 T2049 aux to,be
R1282 T2049 T2047 xcomp be,unlikely
R1283 T2050 T2051 advmod functionally,equivalent
R1284 T2051 T2049 acomp equivalent,be
R1285 T2052 T2051 prep to,equivalent
R1286 T2053 T2054 det the,protein
R1287 T2054 T2052 pobj protein,to
R1288 T2055 T2056 amod full,length
R1289 T2056 T2054 compound length,protein
R1290 T2057 T2056 punct -,length
R1291 T2058 T2020 punct .,is
R1292 T2060 T2061 advmod Thus,allowed
R1293 T2062 T2061 punct ", ",allowed
R1294 T2063 T2064 det a,strategy
R1295 T2064 T2061 nsubj strategy,allowed
R1296 T2065 T2066 amod conditional,knockout
R1297 T2066 T2064 compound knockout,strategy
R1298 T2067 T2068 det the,isolation
R1299 T2068 T2061 dobj isolation,allowed
R1300 T2069 T2068 prep of,isolation
R1301 T2070 T2071 compound ES,cells
R1302 T2071 T2069 pobj cells,of
R1303 T2072 T2073 dep that,are
R1304 T2073 T2068 relcl are,isolation
R1305 T2074 T2073 acomp null,are
R1306 T2075 T2074 prep for,null
R1307 T2076 T2077 amod full,length
R1308 T2077 T2079 compound length,Atrx
R1309 T2078 T2077 punct -,length
R1310 T2079 T2075 pobj Atrx,for
R1311 T2080 T2061 punct .,allowed

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1460 0-13 _FRAGMENT denotes Generation of
T1461 17-22 GO:0048468 denotes Cells
T1462 14-22 CL:0002322 denotes ES Cells
T1463 17-22 CL_GO_EXT:cell denotes Cells
T1464 43-47 PR_EXT:000004503 denotes Atrx
T1465 57-62 NCBITaxon:9606 denotes human
T1466 63-67 SO_EXT:0000704 denotes gene
T1467 73-78 NCBITaxon:10088 denotes mouse
T1468 79-83 PR_EXT:000004503 denotes Atrx
T1469 84-88 SO_EXT:0000704 denotes gene
T1470 97-98 GO:0000805 denotes X
T1471 151-155 PR_EXT:000004503 denotes Atrx
T1472 156-162 SO_EXT:0001023 denotes allele
T1473 166-170 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T1474 171-179 CL:0002322 denotes ES cells
T1475 174-179 CL_GO_EXT:cell denotes cells
T1476 215-219 SO_EXT:sequence_nullness denotes null
T1477 239-245 SO_EXT:sequence_cloned_entity denotes clones
T1478 288-301 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1479 305-309 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T1480 318-326 CL:0002322 denotes ES cells
T1481 321-326 CL_GO_EXT:cell denotes cells
T1482 347-354 SO_EXT:0000440 denotes vectors
T1483 368-372 SO_EXT:0000147 denotes exon
T1484 383-387 PR_EXT:000004503 denotes Atrx
T1485 388-392 SO_EXT:0000704 denotes gene
T1486 394-398 SO_EXT:0000147 denotes Exon
T1487 402-409 SO_EXT:sequence_coding_function denotes encodes
T1488 433-439 SO_EXT:sequence_or_structure_motif denotes motifs
T1489 454-463 SO_EXT:biological_conservation_process_or_quality denotes conserved
T1490 464-468 PR_EXT:P22082 denotes SNF2
T1491 474-480 SO_EXT:0000417 denotes domain
T1492 484-488 PR_EXT:000004503 denotes Atrx
T1493 501-509 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1494 531-536 SO_EXT:sequence_or_structure_motif denotes motif
T1495 544-549 NCBITaxon_EXT:yeast denotes yeast
T1496 550-554 PR_EXT:P22082 denotes SNF2
T1497 555-562 CHEBI_PR_EXT:protein denotes protein
T1498 597-604 GO:0016514 denotes SWI/SNF
T1499 615-619 SO_EXT:0000704 denotes gene
T1500 615-630 GO:0010467 denotes gene expression
T1501 669-675 SO_EXT:sequence_cloned_entity denotes clones
T1502 687-694 SO_EXT:0000440 denotes vectors
T1503 710-714 PR_EXT:000004503 denotes Atrx
T1504 743-750 CL:0002322 denotes ES cell
T1505 746-750 CL_GO_EXT:cell denotes cell
T1506 751-757 GO_EXT:biological_growth_entity_or_process denotes growth
T1507 897-901 SO_EXT:0000147 denotes exon
T1508 934-940 SO_EXT:sequence_cloned_entity denotes clones
T1509 950-954 SO_EXT:0000147 denotes exon
T1510 967-974 SO:0000357 denotes flanked
T1511 978-1000 SO_EXT:0000346 denotes loxP recognition sites
T1512 1013-1024 GO_EXT:recombinase denotes recombinase
T1513 1026-1030 PR_EXT:000004503 denotes Atrx
T1514 1031-1035 SO:0000359 denotes flox
T1515 1036-1042 SO_EXT:0001023 denotes allele
T1516 1075-1081 SO_EXT:0001023 denotes allele
T1517 1098-1110 SO:0000359 denotes loxP-flanked
T1518 1115-1119 GO_EXT:0008910 denotes neor
T1519 1120-1128 SO_EXT:0005853 denotes cassette
T1520 1132-1138 SO_EXT:0000188 denotes intron
T1521 1228-1232 PR_EXT:000004503 denotes Atrx
T1522 1233-1237 SO:0000359 denotes flox
T1523 1238-1244 SO_EXT:sequence_cloned_entity denotes clones
T1524 1258-1265 GO:0010467 denotes express
T1525 1283-1287 PR_EXT:000004503 denotes Atrx
T1526 1288-1295 CHEBI_PR_EXT:protein denotes protein
T1527 1304-1313 SO_EXT:sequence_truncation_process denotes truncated
T1528 1320-1327 SO_EXT:0001060 denotes isoform
T1529 3637-3645 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T1530 3649-3657 CL:0002322 denotes ES cells
T1531 3652-3657 CL_GO_EXT:cell denotes cells
T1532 3663-3667 PR_EXT:000004503 denotes Atrx
T1533 3668-3672 SO:0000359 denotes flox
T1534 3673-3679 SO_EXT:sequence_cloned_entity denotes clones
T1535 3715-3726 GO:0009294 denotes transfected
T1536 3738-3749 GO_EXT:recombinase denotes recombinase
T1537 3750-3760 GO:0010467 denotes expression
T1538 3761-3768 SO_EXT:0000155 denotes plasmid
T1539 3781-3785 SO_EXT:0000243 denotes IRES
T1540 3832-3838 SO_EXT:0001023 denotes allele
T1541 3840-3844 PR_EXT:000004503 denotes Atrx
T1542 3881-3885 SO_EXT:0000147 denotes exon
T1543 3897-3901 GO_EXT:0008910 denotes neor
T1544 3902-3910 SO_EXT:0005853 denotes cassette
T1545 3920-3927 SO_EXT:sequence_deletion_process denotes deleted
T1546 3939-3950 GO_EXT:recombinase denotes recombinase
T1547 3971-3984 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T1548 4011-4015 PR_EXT:000004503 denotes Atrx
T1549 4016-4020 SO:0000359 denotes flox
T1550 4021-4027 SO_EXT:0001023 denotes allele
T1551 4145-4149 PR_EXT:000004503 denotes Atrx
T1552 4150-4160 SO_EXT:0000673 denotes transcript
T1553 4165-4172 CHEBI_PR_EXT:protein denotes protein
T1554 4204-4208 PR_EXT:000004503 denotes Atrx
T1555 4217-4228 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T1556 4229-4235 SO_EXT:sequence_cloned_entity denotes clones
T1557 4253-4261 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T1558 4330-4340 SO_EXT:0000673 denotes transcript
T1559 4359-4368 SO_EXT:sequence_truncation_process denotes truncated
T1560 4375-4382 SO_EXT:0001060 denotes isoform
T1561 4388-4398 SO_EXT:0000673 denotes transcript
T1562 4429-4435 SO_EXT:0000188 denotes intron
T1563 4465-4473 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T1564 4477-4481 SO_EXT:0000147 denotes exon
T1565 4549-4556 SO_EXT:0001060 denotes isoform
T1566 4586-4592 SO_EXT:0000417 denotes domain
T1567 4605-4612 GO:0016514 denotes SWI/SNF
T1568 4613-4619 SO_EXT:sequence_or_structure_motif denotes motifs
T1569 4693-4700 CHEBI_PR_EXT:protein denotes protein
T1570 4765-4773 CL:0002322 denotes ES cells
T1571 4768-4773 CL_GO_EXT:cell denotes cells
T1572 4783-4787 SO_EXT:sequence_nullness denotes null
T1573 4804-4808 PR_EXT:000004503 denotes Atrx
R829 T1461 T1460 _lexicallyChainedTo Cells,Generation of

2_test

Id Subject Object Predicate Lexical cue
16628246-8871545-85799746 632-634 8871545 denotes 12
16628246-14729260-85799747 4440-4441 14729260 denotes 4
T3548 632-634 8871545 denotes 12
T20654 4440-4441 14729260 denotes 4

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1388 0-13 _FRAGMENT denotes Generation of
T1389 17-22 GO:0048468 denotes Cells
T1390 14-22 CL:0002322 denotes ES Cells
T1391 43-47 PR:000004503 denotes Atrx
T1392 57-62 NCBITaxon:9606 denotes human
T1393 63-67 SO:0000704 denotes gene
T1394 73-78 NCBITaxon:10088 denotes mouse
T1395 79-83 PR:000004503 denotes Atrx
T1396 84-88 SO:0000704 denotes gene
T1397 97-98 GO:0000805 denotes X
T1398 151-155 PR:000004503 denotes Atrx
T1399 156-162 SO:0001023 denotes allele
T1400 171-179 CL:0002322 denotes ES cells
T1401 318-326 CL:0002322 denotes ES cells
T1402 347-354 SO:0000440 denotes vectors
T1403 368-372 SO:0000147 denotes exon
T1404 383-387 PR:000004503 denotes Atrx
T1405 388-392 SO:0000704 denotes gene
T1406 394-398 SO:0000147 denotes Exon
T1407 464-468 PR:P22082 denotes SNF2
T1408 474-480 SO:0000417 denotes domain
T1409 484-488 PR:000004503 denotes Atrx
T1410 550-554 PR:P22082 denotes SNF2
T1411 597-604 GO:0016514 denotes SWI/SNF
T1412 615-619 SO:0000704 denotes gene
T1413 615-630 GO:0010467 denotes gene expression
T1414 687-694 SO:0000440 denotes vectors
T1415 710-714 PR:000004503 denotes Atrx
T1416 743-750 CL:0002322 denotes ES cell
T1417 897-901 SO:0000147 denotes exon
T1418 950-954 SO:0000147 denotes exon
T1419 967-974 SO:0000357 denotes flanked
T1420 978-1000 SO:0000346 denotes loxP recognition sites
T1421 1026-1030 PR:000004503 denotes Atrx
T1422 1031-1035 SO:0000359 denotes flox
T1423 1036-1042 SO:0001023 denotes allele
T1424 1075-1081 SO:0001023 denotes allele
T1425 1098-1110 SO:0000359 denotes loxP-flanked
T1426 1120-1128 SO:0005853 denotes cassette
T1427 1132-1138 SO:0000188 denotes intron
T1428 1228-1232 PR:000004503 denotes Atrx
T1429 1233-1237 SO:0000359 denotes flox
T1430 1258-1265 GO:0010467 denotes express
T1431 1283-1287 PR:000004503 denotes Atrx
T1432 1320-1327 SO:0001060 denotes isoform
T1433 3649-3657 CL:0002322 denotes ES cells
T1434 3663-3667 PR:000004503 denotes Atrx
T1435 3668-3672 SO:0000359 denotes flox
T1436 3715-3726 GO:0009294 denotes transfected
T1437 3750-3760 GO:0010467 denotes expression
T1438 3761-3768 SO:0000155 denotes plasmid
T1439 3781-3785 SO:0000243 denotes IRES
T1440 3832-3838 SO:0001023 denotes allele
T1441 3840-3844 PR:000004503 denotes Atrx
T1442 3881-3885 SO:0000147 denotes exon
T1443 3902-3910 SO:0005853 denotes cassette
T1444 4011-4015 PR:000004503 denotes Atrx
T1445 4016-4020 SO:0000359 denotes flox
T1446 4021-4027 SO:0001023 denotes allele
T1447 4145-4149 PR:000004503 denotes Atrx
T1448 4150-4160 SO:0000673 denotes transcript
T1449 4204-4208 PR:000004503 denotes Atrx
T1450 4330-4340 SO:0000673 denotes transcript
T1451 4375-4382 SO:0001060 denotes isoform
T1452 4388-4398 SO:0000673 denotes transcript
T1453 4429-4435 SO:0000188 denotes intron
T1454 4477-4481 SO:0000147 denotes exon
T1455 4549-4556 SO:0001060 denotes isoform
T1456 4586-4592 SO:0000417 denotes domain
T1457 4605-4612 GO:0016514 denotes SWI/SNF
T1458 4765-4773 CL:0002322 denotes ES cells
T1459 4804-4808 PR:000004503 denotes Atrx
R828 T1389 T1388 _lexicallyChainedTo Cells,Generation of