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in situ hybridisation, and TUNEL assay.\n7.5 dpc decidual swellings were dissected away from maternal tissue and fixed in 4% paraformaldehyde/PBS overnight at 4 °C. After embryos were washed thoroughly in PBS, they were dehydrated through an ethanol series and xylene, embedded in paraffin, and sectioned at 5 μm. Sections were processed for immunohistochemistry using the ABC Staining System (Santa Cruz Biotechnology, Santa Cruz, California, United States) according to the manufacturer's instructions. Sections were stained with rabbit polyclonal antibodies against ATRX (H-300, Santa Cruz Biotechnology), Placental lactogen-I (AB1288, Chemicon International, Temecula, California, United States) and phospho (Ser10)-histone H3 (06–570, Upstate Biotechnology, Waltham, Massachusetts, United States). Where appropriate, adjacent sections were stained with haematoxylin. In some cases, adjacent sections were also analysed to detect apoptotic cells by TUNEL using the in situ cell death detection kit (Roche, Basel, Switzerland). After labelling, these slides were mounted in Vectashield containing DAPI (Vector Laboratories, Burlingame, California, United States) and visualised by fluorescence microscopy. Whole-mount in situ hybridisations were performed on 8.5 dpc embryos (dissected away from maternal and extraembryonic tissues) using a brachyury (T) riboprobe [16] and on bisected decidual implantation sites from which embryos (8.5 dpc) had been removed using a placental lactogen-1 (Pl-1) riboprobe (see Protocol S1 for details)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T12252","span":{"begin":30,"end":43},"obj":"GO:0097617"},{"id":"T12253","span":{"begin":70,"end":78},"obj":"UBERON:0002450"},{"id":"T12254","span":{"begin":123,"end":129},"obj":"UBERON:0000479"},{"id":"T12255","span":{"begin":146,"end":162},"obj":"CHEBI_EXT:paraformaldehye"},{"id":"T12256","span":{"begin":192,"end":199},"obj":"UBERON:0000922"},{"id":"T12257","span":{"begin":263,"end":270},"obj":"CHEBI:16236"},{"id":"T12258","span":{"begin":282,"end":288},"obj":"CHEBI:27338"},{"id":"T12259","span":{"begin":553,"end":559},"obj":"NCBITaxon:9986"},{"id":"T12260","span":{"begin":571,"end":581},"obj":"GO:0042571"},{"id":"T12261","span":{"begin":590,"end":594},"obj":"PR_EXT:000004503"},{"id":"T12262","span":{"begin":630,"end":639},"obj":"UBERON:0001987"},{"id":"T12263","span":{"begin":630,"end":648},"obj":"CHEBI:81588"},{"id":"T12264","span":{"begin":630,"end":650},"obj":"PR_EXT:000013543"},{"id":"T12265","span":{"begin":725,"end":732},"obj":"CHEBI:32958"},{"id":"T12266","span":{"begin":741,"end":748},"obj":"CHEBI:15358"},{"id":"T12267","span":{"begin":741,"end":751},"obj":"PR_EXT:000027594"},{"id":"T12268","span":{"begin":879,"end":891},"obj":"CHEBI:51686"},{"id":"T12269","span":{"begin":955,"end":964},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T12270","span":{"begin":955,"end":970},"obj":"CL:0000445"},{"id":"T12271","span":{"begin":965,"end":970},"obj":"CL_GO_EXT:cell"},{"id":"T12272","span":{"begin":998,"end":1002},"obj":"CL_GO_EXT:cell"},{"id":"T12273","span":{"begin":998,"end":1008},"obj":"GO:0008219"},{"id":"T12274","span":{"begin":1058,"end":1067},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T12275","span":{"begin":1121,"end":1125},"obj":"CHEBI:51231"},{"id":"T12276","span":{"begin":1127,"end":1133},"obj":"SO_EXT:0000440"},{"id":"T12277","span":{"begin":1250,"end":1264},"obj":"GO:0097617"},{"id":"T12278","span":{"begin":1291,"end":1298},"obj":"UBERON:0000922"},{"id":"T12279","span":{"begin":1333,"end":1355},"obj":"UBERON:0005292"},{"id":"T12280","span":{"begin":1365,"end":1374},"obj":"PR_EXT:000016001"},{"id":"T12281","span":{"begin":1376,"end":1377},"obj":"PR_EXT:000016001"},{"id":"T12282","span":{"begin":1379,"end":1388},"obj":"CHEBI_SO_EXT:riboprobe"},{"id":"T12283","span":{"begin":1410,"end":1418},"obj":"UBERON:0002450"},{"id":"T12284","span":{"begin":1419,"end":1431},"obj":"GO:0007566"},{"id":"T12285","span":{"begin":1449,"end":1456},"obj":"UBERON:0000922"},{"id":"T12286","span":{"begin":1492,"end":1501},"obj":"UBERON:0001987"},{"id":"T12287","span":{"begin":1492,"end":1510},"obj":"CHEBI:81588"},{"id":"T12288","span":{"begin":1492,"end":1512},"obj":"PR_EXT:000013543"},{"id":"T12289","span":{"begin":1514,"end":1516},"obj":"CHEBI:81588"},{"id":"T12290","span":{"begin":1514,"end":1518},"obj":"PR_EXT:000013543"},{"id":"T12291","span":{"begin":1520,"end":1529},"obj":"CHEBI_SO_EXT:riboprobe"}],"text":"Immunohistochemistry, in situ hybridisation, and TUNEL assay.\n7.5 dpc decidual swellings were dissected away from maternal tissue and fixed in 4% paraformaldehyde/PBS overnight at 4 °C. After embryos were washed thoroughly in PBS, they were dehydrated through an ethanol series and xylene, embedded in paraffin, and sectioned at 5 μm. Sections were processed for immunohistochemistry using the ABC Staining System (Santa Cruz Biotechnology, Santa Cruz, California, United States) according to the manufacturer's instructions. Sections were stained with rabbit polyclonal antibodies against ATRX (H-300, Santa Cruz Biotechnology), Placental lactogen-I (AB1288, Chemicon International, Temecula, California, United States) and phospho (Ser10)-histone H3 (06–570, Upstate Biotechnology, Waltham, Massachusetts, United States). Where appropriate, adjacent sections were stained with haematoxylin. In some cases, adjacent sections were also analysed to detect apoptotic cells by TUNEL using the in situ cell death detection kit (Roche, Basel, Switzerland). After labelling, these slides were mounted in Vectashield containing DAPI (Vector Laboratories, Burlingame, California, United States) and visualised by fluorescence microscopy. Whole-mount in situ hybridisations were performed on 8.5 dpc embryos (dissected away from maternal and extraembryonic tissues) using a brachyury (T) riboprobe [16] and on bisected decidual implantation sites from which embryos (8.5 dpc) had been removed using a placental lactogen-1 (Pl-1) riboprobe (see Protocol S1 for details)."}

{"project":"2_test","denotations":[{"id":"16628246-1689462-85799792","span":{"begin":1390,"end":1392},"obj":"1689462"},{"id":"T74395","span":{"begin":1390,"end":1392},"obj":"1689462"}],"text":"Immunohistochemistry, in situ hybridisation, and TUNEL assay.\n7.5 dpc decidual swellings were dissected away from maternal tissue and fixed in 4% paraformaldehyde/PBS overnight at 4 °C. After embryos were washed thoroughly in PBS, they were dehydrated through an ethanol series and xylene, embedded in paraffin, and sectioned at 5 μm. Sections were processed for immunohistochemistry using the ABC Staining System (Santa Cruz Biotechnology, Santa Cruz, California, United States) according to the manufacturer's instructions. Sections were stained with rabbit polyclonal antibodies against ATRX (H-300, Santa Cruz Biotechnology), Placental lactogen-I (AB1288, Chemicon International, Temecula, California, United States) and phospho (Ser10)-histone H3 (06–570, Upstate Biotechnology, Waltham, Massachusetts, United States). Where appropriate, adjacent sections were stained with haematoxylin. In some cases, adjacent sections were also analysed to detect apoptotic cells by TUNEL using the in situ cell death detection kit (Roche, Basel, Switzerland). After labelling, these slides were mounted in Vectashield containing DAPI (Vector Laboratories, Burlingame, California, United States) and visualised by fluorescence microscopy. Whole-mount in situ hybridisations were performed on 8.5 dpc embryos (dissected away from maternal and extraembryonic tissues) using a brachyury (T) riboprobe [16] and on bisected decidual implantation sites from which embryos (8.5 dpc) had been removed using a placental lactogen-1 (Pl-1) riboprobe (see Protocol S1 for details)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T12219","span":{"begin":30,"end":43},"obj":"GO:0097617"},{"id":"T12220","span":{"begin":70,"end":78},"obj":"UBERON:0002450"},{"id":"T12221","span":{"begin":123,"end":129},"obj":"UBERON:0000479"},{"id":"T12222","span":{"begin":192,"end":199},"obj":"UBERON:0000922"},{"id":"T12223","span":{"begin":263,"end":270},"obj":"CHEBI:16236"},{"id":"T12224","span":{"begin":282,"end":288},"obj":"CHEBI:27338"},{"id":"T12225","span":{"begin":553,"end":559},"obj":"NCBITaxon:9986"},{"id":"T12226","span":{"begin":571,"end":581},"obj":"GO:0042571"},{"id":"T12227","span":{"begin":590,"end":594},"obj":"PR:000004503"},{"id":"T12228","span":{"begin":630,"end":639},"obj":"UBERON:0001987"},{"id":"T12229","span":{"begin":630,"end":648},"obj":"CHEBI:81588"},{"id":"T12230","span":{"begin":630,"end":650},"obj":"PR:000013543"},{"id":"T12231","span":{"begin":725,"end":732},"obj":"CHEBI:32958"},{"id":"T12232","span":{"begin":741,"end":748},"obj":"CHEBI:15358"},{"id":"T12233","span":{"begin":741,"end":751},"obj":"PR:000027594"},{"id":"T12234","span":{"begin":879,"end":891},"obj":"CHEBI:51686"},{"id":"T12235","span":{"begin":955,"end":970},"obj":"CL:0000445"},{"id":"T12236","span":{"begin":998,"end":1008},"obj":"GO:0008219"},{"id":"T12237","span":{"begin":1121,"end":1125},"obj":"CHEBI:51231"},{"id":"T12238","span":{"begin":1127,"end":1133},"obj":"SO:0000440"},{"id":"T12239","span":{"begin":1250,"end":1264},"obj":"GO:0097617"},{"id":"T12240","span":{"begin":1291,"end":1298},"obj":"UBERON:0000922"},{"id":"T12241","span":{"begin":1333,"end":1355},"obj":"UBERON:0005292"},{"id":"T12242","span":{"begin":1365,"end":1374},"obj":"PR:000016001"},{"id":"T12243","span":{"begin":1376,"end":1377},"obj":"PR:000016001"},{"id":"T12244","span":{"begin":1410,"end":1418},"obj":"UBERON:0002450"},{"id":"T12245","span":{"begin":1419,"end":1431},"obj":"GO:0007566"},{"id":"T12246","span":{"begin":1449,"end":1456},"obj":"UBERON:0000922"},{"id":"T12247","span":{"begin":1492,"end":1501},"obj":"UBERON:0001987"},{"id":"T12248","span":{"begin":1492,"end":1510},"obj":"CHEBI:81588"},{"id":"T12249","span":{"begin":1492,"end":1512},"obj":"PR:000013543"},{"id":"T12250","span":{"begin":1514,"end":1516},"obj":"CHEBI:81588"},{"id":"T12251","span":{"begin":1514,"end":1518},"obj":"PR:000013543"}],"text":"Immunohistochemistry, in situ hybridisation, and TUNEL assay.\n7.5 dpc decidual swellings were dissected away from maternal tissue and fixed in 4% paraformaldehyde/PBS overnight at 4 °C. After embryos were washed thoroughly in PBS, they were dehydrated through an ethanol series and xylene, embedded in paraffin, and sectioned at 5 μm. Sections were processed for immunohistochemistry using the ABC Staining System (Santa Cruz Biotechnology, Santa Cruz, California, United States) according to the manufacturer's instructions. Sections were stained with rabbit polyclonal antibodies against ATRX (H-300, Santa Cruz Biotechnology), Placental lactogen-I (AB1288, Chemicon International, Temecula, California, United States) and phospho (Ser10)-histone H3 (06–570, Upstate Biotechnology, Waltham, Massachusetts, United States). Where appropriate, adjacent sections were stained with haematoxylin. In some cases, adjacent sections were also analysed to detect apoptotic cells by TUNEL using the in situ cell death detection kit (Roche, Basel, Switzerland). After labelling, these slides were mounted in Vectashield containing DAPI (Vector Laboratories, Burlingame, California, United States) and visualised by fluorescence microscopy. Whole-mount in situ hybridisations were performed on 8.5 dpc embryos (dissected away from maternal and extraembryonic tissues) using a brachyury (T) riboprobe [16] and on bisected decidual implantation sites from which embryos (8.5 dpc) had been removed using a placental lactogen-1 (Pl-1) riboprobe (see Protocol S1 for details)."}