Id |
Subject |
Object |
Predicate |
Lexical cue |
T7420 |
0-8 |
JJ |
denotes |
Atrxnull |
T7421 |
9-11 |
NN |
denotes |
ES |
T7422 |
12-17 |
NNS |
denotes |
cells |
T7423 |
31-40 |
VBN |
denotes |
recovered |
T7424 |
18-23 |
MD |
denotes |
could |
T7425 |
24-27 |
RB |
denotes |
not |
T7426 |
28-30 |
VB |
denotes |
be |
T7427 |
41-43 |
IN |
denotes |
by |
T7428 |
44-50 |
JJ |
denotes |
direct |
T7429 |
51-60 |
NN |
denotes |
targeting |
T7430 |
61-64 |
CC |
denotes |
and |
T7431 |
65-69 |
VBD |
denotes |
were |
T7432 |
81-90 |
VBN |
denotes |
generated |
T7433 |
70-80 |
RB |
denotes |
eventually |
T7434 |
91-93 |
IN |
denotes |
by |
T7435 |
94-102 |
VBG |
denotes |
adopting |
T7436 |
103-104 |
DT |
denotes |
a |
T7437 |
127-135 |
NN |
denotes |
approach |
T7438 |
105-116 |
JJ |
denotes |
conditional |
T7439 |
117-126 |
NN |
denotes |
targeting |
T7440 |
135-136 |
. |
denotes |
. |
T7441 |
136-342 |
sentence |
denotes |
This is consistent with our observation that Atrx is highly expressed in ES cells, and that the absence of full-length Atrx imparts a growth disadvantage relative to cells bearing a functional Atrx allele. |
T7442 |
137-141 |
DT |
denotes |
This |
T7443 |
142-144 |
VBZ |
denotes |
is |
T7444 |
145-155 |
JJ |
denotes |
consistent |
T7445 |
156-160 |
IN |
denotes |
with |
T7446 |
161-164 |
PRP$ |
denotes |
our |
T7447 |
165-176 |
NN |
denotes |
observation |
T7448 |
177-181 |
IN |
denotes |
that |
T7449 |
187-189 |
VBZ |
denotes |
is |
T7450 |
182-186 |
NN |
denotes |
Atrx |
T7451 |
190-196 |
RB |
denotes |
highly |
T7452 |
197-206 |
JJ |
denotes |
expressed |
T7453 |
207-209 |
IN |
denotes |
in |
T7454 |
210-212 |
NN |
denotes |
ES |
T7455 |
213-218 |
NNS |
denotes |
cells |
T7456 |
218-220 |
, |
denotes |
, |
T7457 |
220-223 |
CC |
denotes |
and |
T7458 |
224-228 |
IN |
denotes |
that |
T7459 |
261-268 |
VBZ |
denotes |
imparts |
T7460 |
229-232 |
DT |
denotes |
the |
T7461 |
233-240 |
NN |
denotes |
absence |
T7462 |
241-243 |
IN |
denotes |
of |
T7463 |
244-248 |
JJ |
denotes |
full |
T7464 |
249-255 |
NN |
denotes |
length |
T7465 |
248-249 |
HYPH |
denotes |
- |
T7466 |
256-260 |
NN |
denotes |
Atrx |
T7467 |
269-270 |
DT |
denotes |
a |
T7468 |
278-290 |
NN |
denotes |
disadvantage |
T7469 |
271-277 |
NN |
denotes |
growth |
T7470 |
291-299 |
JJ |
denotes |
relative |
T7471 |
300-302 |
IN |
denotes |
to |
T7472 |
303-308 |
NNS |
denotes |
cells |
T7473 |
309-316 |
VBG |
denotes |
bearing |
T7474 |
317-318 |
DT |
denotes |
a |
T7475 |
335-341 |
NN |
denotes |
allele |
T7476 |
319-329 |
JJ |
denotes |
functional |
T7477 |
330-334 |
NN |
denotes |
Atrx |
T7478 |
341-342 |
. |
denotes |
. |
T7479 |
342-426 |
sentence |
denotes |
At present, the cause of the proliferative delay in Atrxnull ES cells is not known. |
T7480 |
343-345 |
IN |
denotes |
At |
T7481 |
413-415 |
VBZ |
denotes |
is |
T7482 |
346-353 |
JJ |
denotes |
present |
T7483 |
353-355 |
, |
denotes |
, |
T7484 |
355-358 |
DT |
denotes |
the |
T7485 |
359-364 |
NN |
denotes |
cause |
T7486 |
365-367 |
IN |
denotes |
of |
T7487 |
368-371 |
DT |
denotes |
the |
T7488 |
386-391 |
NN |
denotes |
delay |
T7489 |
372-385 |
JJ |
denotes |
proliferative |
T7490 |
392-394 |
IN |
denotes |
in |
T7491 |
395-403 |
JJ |
denotes |
Atrxnull |
T7492 |
407-412 |
NNS |
denotes |
cells |
T7493 |
404-406 |
NN |
denotes |
ES |
T7494 |
416-419 |
RB |
denotes |
not |
T7495 |
420-425 |
JJ |
denotes |
known |
T7496 |
425-426 |
. |
denotes |
. |
T7497 |
426-594 |
sentence |
denotes |
Interestingly, we demonstrated that apoptosis is not significantly up-regulated in ES cells lacking Atrx and is only mildly elevated in Atrxnull 7.5 dpc mouse embryos. |
T7498 |
427-440 |
RB |
denotes |
Interestingly |
T7499 |
445-457 |
VBD |
denotes |
demonstrated |
T7500 |
440-442 |
, |
denotes |
, |
T7501 |
442-444 |
PRP |
denotes |
we |
T7502 |
458-462 |
IN |
denotes |
that |
T7503 |
497-506 |
VBN |
denotes |
regulated |
T7504 |
463-472 |
NN |
denotes |
apoptosis |
T7505 |
473-475 |
VBZ |
denotes |
is |
T7506 |
476-479 |
RB |
denotes |
not |
T7507 |
480-493 |
RB |
denotes |
significantly |
T7508 |
494-496 |
RB |
denotes |
up |
T7509 |
496-497 |
HYPH |
denotes |
- |
T7510 |
507-509 |
IN |
denotes |
in |
T7511 |
510-512 |
NN |
denotes |
ES |
T7512 |
513-518 |
NNS |
denotes |
cells |
T7513 |
519-526 |
VBG |
denotes |
lacking |
T7514 |
527-531 |
NN |
denotes |
Atrx |
T7515 |
532-535 |
CC |
denotes |
and |
T7516 |
536-538 |
VBZ |
denotes |
is |
T7517 |
539-543 |
RB |
denotes |
only |
T7518 |
544-550 |
RB |
denotes |
mildly |
T7519 |
551-559 |
JJ |
denotes |
elevated |
T7520 |
560-562 |
IN |
denotes |
in |
T7521 |
563-571 |
JJ |
denotes |
Atrxnull |
T7522 |
586-593 |
NNS |
denotes |
embryos |
T7523 |
572-575 |
CD |
denotes |
7.5 |
T7524 |
576-579 |
NN |
denotes |
dpc |
T7525 |
580-585 |
NN |
denotes |
mouse |
T7526 |
593-594 |
. |
denotes |
. |
T7527 |
594-890 |
sentence |
denotes |
In contrast, it was recently shown that the loss of Atrx markedly increased the apoptotic population in the differentiating cells of the embryonic cortex and postnatal hippocampus, when Atrx expression was ablated in the developing mouse forebrain using the Atrx flox allele described here [20]. |
T7528 |
595-597 |
IN |
denotes |
In |
T7529 |
624-629 |
VBN |
denotes |
shown |
T7530 |
598-606 |
NN |
denotes |
contrast |
T7531 |
606-608 |
, |
denotes |
, |
T7532 |
608-610 |
PRP |
denotes |
it |
T7533 |
611-614 |
VBD |
denotes |
was |
T7534 |
615-623 |
RB |
denotes |
recently |
T7535 |
630-634 |
IN |
denotes |
that |
T7536 |
661-670 |
VBD |
denotes |
increased |
T7537 |
635-638 |
DT |
denotes |
the |
T7538 |
639-643 |
NN |
denotes |
loss |
T7539 |
644-646 |
IN |
denotes |
of |
T7540 |
647-651 |
NN |
denotes |
Atrx |
T7541 |
652-660 |
RB |
denotes |
markedly |
T7542 |
671-674 |
DT |
denotes |
the |
T7543 |
685-695 |
NN |
denotes |
population |
T7544 |
675-684 |
JJ |
denotes |
apoptotic |
T7545 |
696-698 |
IN |
denotes |
in |
T7546 |
699-702 |
DT |
denotes |
the |
T7547 |
719-724 |
NNS |
denotes |
cells |
T7548 |
703-718 |
VBG |
denotes |
differentiating |
T7549 |
725-727 |
IN |
denotes |
of |
T7550 |
728-731 |
DT |
denotes |
the |
T7551 |
742-748 |
NN |
denotes |
cortex |
T7552 |
732-741 |
JJ |
denotes |
embryonic |
T7553 |
749-752 |
CC |
denotes |
and |
T7554 |
753-762 |
JJ |
denotes |
postnatal |
T7555 |
763-774 |
NN |
denotes |
hippocampus |
T7556 |
774-776 |
, |
denotes |
, |
T7557 |
776-780 |
WRB |
denotes |
when |
T7558 |
801-808 |
VBN |
denotes |
ablated |
T7559 |
781-785 |
NN |
denotes |
Atrx |
T7560 |
786-796 |
NN |
denotes |
expression |
T7561 |
797-800 |
VBD |
denotes |
was |
T7562 |
809-811 |
IN |
denotes |
in |
T7563 |
812-815 |
DT |
denotes |
the |
T7564 |
833-842 |
NN |
denotes |
forebrain |
T7565 |
816-826 |
VBG |
denotes |
developing |
T7566 |
827-832 |
NN |
denotes |
mouse |
T7567 |
843-848 |
VBG |
denotes |
using |
T7568 |
849-852 |
DT |
denotes |
the |
T7569 |
863-869 |
NN |
denotes |
allele |
T7570 |
853-862 |
NN |
denotes |
Atrx flox |
T7571 |
870-879 |
VBN |
denotes |
described |
T7572 |
880-884 |
RB |
denotes |
here |
T7573 |
885-886 |
-LRB- |
denotes |
[ |
T7574 |
886-888 |
CD |
denotes |
20 |
T7575 |
888-889 |
-RRB- |
denotes |
] |
T7576 |
889-890 |
. |
denotes |
. |
T7577 |
890-1063 |
sentence |
denotes |
The human ATRX protein has been shown to associate in a complex with Daxx [8], a protein that has been implicated in multiple pathways for the regulation of apoptosis [21]. |
T7578 |
891-894 |
DT |
denotes |
The |
T7579 |
906-913 |
NN |
denotes |
protein |
T7580 |
895-900 |
JJ |
denotes |
human |
T7581 |
901-905 |
NN |
denotes |
ATRX |
T7582 |
923-928 |
VBN |
denotes |
shown |
T7583 |
914-917 |
VBZ |
denotes |
has |
T7584 |
918-922 |
VBN |
denotes |
been |
T7585 |
929-931 |
TO |
denotes |
to |
T7586 |
932-941 |
VB |
denotes |
associate |
T7587 |
942-944 |
IN |
denotes |
in |
T7588 |
945-946 |
DT |
denotes |
a |
T7589 |
947-954 |
NN |
denotes |
complex |
T7590 |
955-959 |
IN |
denotes |
with |
T7591 |
960-964 |
NN |
denotes |
Daxx |
T7592 |
965-966 |
-LRB- |
denotes |
[ |
T7593 |
966-967 |
CD |
denotes |
8 |
T7594 |
967-968 |
-RRB- |
denotes |
] |
T7595 |
968-970 |
, |
denotes |
, |
T7596 |
970-971 |
DT |
denotes |
a |
T7597 |
972-979 |
NN |
denotes |
protein |
T7598 |
980-984 |
WDT |
denotes |
that |
T7599 |
994-1004 |
VBN |
denotes |
implicated |
T7600 |
985-988 |
VBZ |
denotes |
has |
T7601 |
989-993 |
VBN |
denotes |
been |
T7602 |
1005-1007 |
IN |
denotes |
in |
T7603 |
1008-1016 |
JJ |
denotes |
multiple |
T7604 |
1017-1025 |
NNS |
denotes |
pathways |
T7605 |
1026-1029 |
IN |
denotes |
for |
T7606 |
1030-1033 |
DT |
denotes |
the |
T7607 |
1034-1044 |
NN |
denotes |
regulation |
T7608 |
1045-1047 |
IN |
denotes |
of |
T7609 |
1048-1057 |
NN |
denotes |
apoptosis |
T7610 |
1058-1059 |
-LRB- |
denotes |
[ |
T7611 |
1059-1061 |
CD |
denotes |
21 |
T7612 |
1061-1062 |
-RRB- |
denotes |
] |
T7613 |
1062-1063 |
. |
denotes |
. |
T7614 |
1063-1215 |
sentence |
denotes |
It is possible that disruption of the mouse Atrx-Daxx complex (by ablation of the Atrx protein) could have triggered a universal proapoptotic response. |
T7615 |
1064-1066 |
PRP |
denotes |
It |
T7616 |
1067-1069 |
VBZ |
denotes |
is |
T7617 |
1070-1078 |
JJ |
denotes |
possible |
T7618 |
1079-1083 |
IN |
denotes |
that |
T7619 |
1171-1180 |
VBN |
denotes |
triggered |
T7620 |
1084-1094 |
NN |
denotes |
disruption |
T7621 |
1095-1097 |
IN |
denotes |
of |
T7622 |
1098-1101 |
DT |
denotes |
the |
T7623 |
1118-1125 |
NN |
denotes |
complex |
T7624 |
1102-1107 |
NN |
denotes |
mouse |
T7625 |
1108-1112 |
NN |
denotes |
Atrx |
T7626 |
1113-1117 |
NN |
denotes |
Daxx |
T7627 |
1112-1113 |
HYPH |
denotes |
- |
T7628 |
1126-1127 |
-LRB- |
denotes |
( |
T7629 |
1127-1129 |
IN |
denotes |
by |
T7630 |
1130-1138 |
NN |
denotes |
ablation |
T7631 |
1139-1141 |
IN |
denotes |
of |
T7632 |
1142-1145 |
DT |
denotes |
the |
T7633 |
1151-1158 |
NN |
denotes |
protein |
T7634 |
1146-1150 |
NN |
denotes |
Atrx |
T7635 |
1158-1159 |
-RRB- |
denotes |
) |
T7636 |
1160-1165 |
MD |
denotes |
could |
T7637 |
1166-1170 |
VB |
denotes |
have |
T7638 |
1181-1182 |
DT |
denotes |
a |
T7639 |
1206-1214 |
NN |
denotes |
response |
T7640 |
1183-1192 |
JJ |
denotes |
universal |
T7641 |
1193-1205 |
JJ |
denotes |
proapoptotic |
T7642 |
1214-1215 |
. |
denotes |
. |
T7643 |
1215-1529 |
sentence |
denotes |
However, our observations in ES cells demonstrate that the induction of apoptosis is not an automatic response triggered by the removal of Atrx in all cell types, and suggest that the inappropriate apoptosis observed in the Atrx-mutant forebrain may reflect a requirement for Atrx during terminal differentiation. |
T7644 |
1216-1223 |
RB |
denotes |
However |
T7645 |
1254-1265 |
VBP |
denotes |
demonstrate |
T7646 |
1223-1225 |
, |
denotes |
, |
T7647 |
1225-1228 |
PRP$ |
denotes |
our |
T7648 |
1229-1241 |
NNS |
denotes |
observations |
T7649 |
1242-1244 |
IN |
denotes |
in |
T7650 |
1245-1247 |
NN |
denotes |
ES |
T7651 |
1248-1253 |
NNS |
denotes |
cells |
T7652 |
1266-1270 |
IN |
denotes |
that |
T7653 |
1298-1300 |
VBZ |
denotes |
is |
T7654 |
1271-1274 |
DT |
denotes |
the |
T7655 |
1275-1284 |
NN |
denotes |
induction |
T7656 |
1285-1287 |
IN |
denotes |
of |
T7657 |
1288-1297 |
NN |
denotes |
apoptosis |
T7658 |
1301-1304 |
RB |
denotes |
not |
T7659 |
1305-1307 |
DT |
denotes |
an |
T7660 |
1318-1326 |
NN |
denotes |
response |
T7661 |
1308-1317 |
JJ |
denotes |
automatic |
T7662 |
1327-1336 |
VBN |
denotes |
triggered |
T7663 |
1337-1339 |
IN |
denotes |
by |
T7664 |
1340-1343 |
DT |
denotes |
the |
T7665 |
1344-1351 |
NN |
denotes |
removal |
T7666 |
1352-1354 |
IN |
denotes |
of |
T7667 |
1355-1359 |
NN |
denotes |
Atrx |
T7668 |
1360-1362 |
IN |
denotes |
in |
T7669 |
1363-1366 |
DT |
denotes |
all |
T7670 |
1372-1377 |
NNS |
denotes |
types |
T7671 |
1367-1371 |
NN |
denotes |
cell |
T7672 |
1377-1379 |
, |
denotes |
, |
T7673 |
1379-1382 |
CC |
denotes |
and |
T7674 |
1383-1390 |
VBP |
denotes |
suggest |
T7675 |
1391-1395 |
IN |
denotes |
that |
T7676 |
1466-1473 |
VB |
denotes |
reflect |
T7677 |
1396-1399 |
DT |
denotes |
the |
T7678 |
1414-1423 |
NN |
denotes |
apoptosis |
T7679 |
1400-1413 |
JJ |
denotes |
inappropriate |
T7680 |
1424-1432 |
VBN |
denotes |
observed |
T7681 |
1433-1435 |
IN |
denotes |
in |
T7682 |
1436-1439 |
DT |
denotes |
the |
T7683 |
1452-1461 |
NN |
denotes |
forebrain |
T7684 |
1440-1444 |
NN |
denotes |
Atrx |
T7685 |
1445-1451 |
NN |
denotes |
mutant |
T7686 |
1444-1445 |
HYPH |
denotes |
- |
T7687 |
1462-1465 |
MD |
denotes |
may |
T7688 |
1474-1475 |
DT |
denotes |
a |
T7689 |
1476-1487 |
NN |
denotes |
requirement |
T7690 |
1488-1491 |
IN |
denotes |
for |
T7691 |
1492-1496 |
NN |
denotes |
Atrx |
T7692 |
1497-1503 |
IN |
denotes |
during |
T7693 |
1504-1512 |
JJ |
denotes |
terminal |
T7694 |
1513-1528 |
NN |
denotes |
differentiation |
T7695 |
1528-1529 |
. |
denotes |
. |
R4553 |
T7420 |
T7421 |
amod |
Atrxnull,ES |
R4554 |
T7421 |
T7422 |
compound |
ES,cells |
R4555 |
T7422 |
T7423 |
nsubjpass |
cells,recovered |
R4556 |
T7424 |
T7423 |
aux |
could,recovered |
R4557 |
T7425 |
T7423 |
neg |
not,recovered |
R4558 |
T7426 |
T7423 |
auxpass |
be,recovered |
R4559 |
T7427 |
T7423 |
agent |
by,recovered |
R4560 |
T7428 |
T7429 |
amod |
direct,targeting |
R4561 |
T7429 |
T7427 |
pobj |
targeting,by |
R4562 |
T7430 |
T7423 |
cc |
and,recovered |
R4563 |
T7431 |
T7432 |
auxpass |
were,generated |
R4564 |
T7432 |
T7423 |
conj |
generated,recovered |
R4565 |
T7433 |
T7432 |
advmod |
eventually,generated |
R4566 |
T7434 |
T7432 |
prep |
by,generated |
R4567 |
T7435 |
T7434 |
pcomp |
adopting,by |
R4568 |
T7436 |
T7437 |
det |
a,approach |
R4569 |
T7437 |
T7435 |
dobj |
approach,adopting |
R4570 |
T7438 |
T7439 |
amod |
conditional,targeting |
R4571 |
T7439 |
T7437 |
compound |
targeting,approach |
R4572 |
T7440 |
T7423 |
punct |
.,recovered |
R4573 |
T7442 |
T7443 |
nsubj |
This,is |
R4574 |
T7444 |
T7443 |
acomp |
consistent,is |
R4575 |
T7445 |
T7444 |
prep |
with,consistent |
R4576 |
T7446 |
T7447 |
poss |
our,observation |
R4577 |
T7447 |
T7445 |
pobj |
observation,with |
R4578 |
T7448 |
T7449 |
mark |
that,is |
R4579 |
T7449 |
T7447 |
advcl |
is,observation |
R4580 |
T7450 |
T7449 |
nsubj |
Atrx,is |
R4581 |
T7451 |
T7452 |
advmod |
highly,expressed |
R4582 |
T7452 |
T7449 |
acomp |
expressed,is |
R4583 |
T7453 |
T7449 |
prep |
in,is |
R4584 |
T7454 |
T7455 |
compound |
ES,cells |
R4585 |
T7455 |
T7453 |
pobj |
cells,in |
R4586 |
T7456 |
T7449 |
punct |
", ",is |
R4587 |
T7457 |
T7449 |
cc |
and,is |
R4588 |
T7458 |
T7459 |
mark |
that,imparts |
R4589 |
T7459 |
T7449 |
conj |
imparts,is |
R4590 |
T7460 |
T7461 |
det |
the,absence |
R4591 |
T7461 |
T7459 |
nsubj |
absence,imparts |
R4592 |
T7462 |
T7461 |
prep |
of,absence |
R4593 |
T7463 |
T7464 |
amod |
full,length |
R4594 |
T7464 |
T7466 |
compound |
length,Atrx |
R4595 |
T7465 |
T7464 |
punct |
-,length |
R4596 |
T7466 |
T7462 |
pobj |
Atrx,of |
R4597 |
T7467 |
T7468 |
det |
a,disadvantage |
R4598 |
T7468 |
T7459 |
dobj |
disadvantage,imparts |
R4599 |
T7469 |
T7468 |
compound |
growth,disadvantage |
R4600 |
T7470 |
T7459 |
advcl |
relative,imparts |
R4601 |
T7471 |
T7470 |
prep |
to,relative |
R4602 |
T7472 |
T7471 |
pobj |
cells,to |
R4603 |
T7473 |
T7472 |
acl |
bearing,cells |
R4604 |
T7474 |
T7475 |
det |
a,allele |
R4605 |
T7475 |
T7473 |
dobj |
allele,bearing |
R4606 |
T7476 |
T7475 |
amod |
functional,allele |
R4607 |
T7477 |
T7475 |
compound |
Atrx,allele |
R4608 |
T7478 |
T7443 |
punct |
.,is |
R4609 |
T7480 |
T7481 |
prep |
At,is |
R4610 |
T7482 |
T7480 |
amod |
present,At |
R4611 |
T7483 |
T7481 |
punct |
", ",is |
R4612 |
T7484 |
T7485 |
det |
the,cause |
R4613 |
T7485 |
T7481 |
nsubj |
cause,is |
R4614 |
T7486 |
T7485 |
prep |
of,cause |
R4615 |
T7487 |
T7488 |
det |
the,delay |
R4616 |
T7488 |
T7486 |
pobj |
delay,of |
R4617 |
T7489 |
T7488 |
amod |
proliferative,delay |
R4618 |
T7490 |
T7488 |
prep |
in,delay |
R4619 |
T7491 |
T7492 |
amod |
Atrxnull,cells |
R4620 |
T7492 |
T7490 |
pobj |
cells,in |
R4621 |
T7493 |
T7492 |
compound |
ES,cells |
R4622 |
T7494 |
T7481 |
neg |
not,is |
R4623 |
T7495 |
T7481 |
acomp |
known,is |
R4624 |
T7496 |
T7481 |
punct |
.,is |
R4625 |
T7498 |
T7499 |
advmod |
Interestingly,demonstrated |
R4626 |
T7500 |
T7499 |
punct |
", ",demonstrated |
R4627 |
T7501 |
T7499 |
nsubj |
we,demonstrated |
R4628 |
T7502 |
T7503 |
mark |
that,regulated |
R4629 |
T7503 |
T7499 |
ccomp |
regulated,demonstrated |
R4630 |
T7504 |
T7503 |
nsubjpass |
apoptosis,regulated |
R4631 |
T7505 |
T7503 |
auxpass |
is,regulated |
R4632 |
T7506 |
T7503 |
neg |
not,regulated |
R4633 |
T7507 |
T7503 |
advmod |
significantly,regulated |
R4634 |
T7508 |
T7503 |
advmod |
up,regulated |
R4635 |
T7509 |
T7503 |
punct |
-,regulated |
R4636 |
T7510 |
T7503 |
prep |
in,regulated |
R4637 |
T7511 |
T7512 |
compound |
ES,cells |
R4638 |
T7512 |
T7510 |
pobj |
cells,in |
R4639 |
T7513 |
T7512 |
acl |
lacking,cells |
R4640 |
T7514 |
T7513 |
dobj |
Atrx,lacking |
R4641 |
T7515 |
T7503 |
cc |
and,regulated |
R4642 |
T7516 |
T7503 |
conj |
is,regulated |
R4643 |
T7517 |
T7518 |
advmod |
only,mildly |
R4644 |
T7518 |
T7519 |
advmod |
mildly,elevated |
R4645 |
T7519 |
T7516 |
acomp |
elevated,is |
R4646 |
T7520 |
T7516 |
prep |
in,is |
R4647 |
T7521 |
T7522 |
amod |
Atrxnull,embryos |
R4648 |
T7522 |
T7520 |
pobj |
embryos,in |
R4649 |
T7523 |
T7524 |
nummod |
7.5,dpc |
R4650 |
T7524 |
T7522 |
compound |
dpc,embryos |
R4651 |
T7525 |
T7522 |
compound |
mouse,embryos |
R4652 |
T7526 |
T7499 |
punct |
.,demonstrated |
R4653 |
T7528 |
T7529 |
prep |
In,shown |
R4654 |
T7530 |
T7528 |
pobj |
contrast,In |
R4655 |
T7531 |
T7529 |
punct |
", ",shown |
R4656 |
T7532 |
T7529 |
nsubjpass |
it,shown |
R4657 |
T7533 |
T7529 |
auxpass |
was,shown |
R4658 |
T7534 |
T7529 |
advmod |
recently,shown |
R4659 |
T7535 |
T7536 |
mark |
that,increased |
R4660 |
T7536 |
T7529 |
ccomp |
increased,shown |
R4661 |
T7537 |
T7538 |
det |
the,loss |
R4662 |
T7538 |
T7536 |
nsubj |
loss,increased |
R4663 |
T7539 |
T7538 |
prep |
of,loss |
R4664 |
T7540 |
T7539 |
pobj |
Atrx,of |
R4665 |
T7541 |
T7536 |
advmod |
markedly,increased |
R4666 |
T7542 |
T7543 |
det |
the,population |
R4667 |
T7543 |
T7536 |
dobj |
population,increased |
R4668 |
T7544 |
T7543 |
amod |
apoptotic,population |
R4669 |
T7545 |
T7536 |
prep |
in,increased |
R4670 |
T7546 |
T7547 |
det |
the,cells |
R4671 |
T7547 |
T7545 |
pobj |
cells,in |
R4672 |
T7548 |
T7547 |
amod |
differentiating,cells |
R4673 |
T7549 |
T7547 |
prep |
of,cells |
R4674 |
T7550 |
T7551 |
det |
the,cortex |
R4675 |
T7551 |
T7549 |
pobj |
cortex,of |
R4676 |
T7552 |
T7551 |
amod |
embryonic,cortex |
R4677 |
T7553 |
T7551 |
cc |
and,cortex |
R4678 |
T7554 |
T7555 |
amod |
postnatal,hippocampus |
R4679 |
T7555 |
T7551 |
conj |
hippocampus,cortex |
R4680 |
T7556 |
T7536 |
punct |
", ",increased |
R4681 |
T7557 |
T7558 |
advmod |
when,ablated |
R4682 |
T7558 |
T7536 |
advcl |
ablated,increased |
R4683 |
T7559 |
T7560 |
compound |
Atrx,expression |
R4684 |
T7560 |
T7558 |
nsubjpass |
expression,ablated |
R4685 |
T7561 |
T7558 |
auxpass |
was,ablated |
R4686 |
T7562 |
T7558 |
prep |
in,ablated |
R4687 |
T7563 |
T7564 |
det |
the,forebrain |
R4688 |
T7564 |
T7562 |
pobj |
forebrain,in |
R4689 |
T7565 |
T7564 |
amod |
developing,forebrain |
R4690 |
T7566 |
T7564 |
compound |
mouse,forebrain |
R4691 |
T7567 |
T7536 |
advcl |
using,increased |
R4692 |
T7568 |
T7569 |
det |
the,allele |
R4693 |
T7569 |
T7567 |
dobj |
allele,using |
R4694 |
T7570 |
T7569 |
compound |
Atrx flox,allele |
R4695 |
T7571 |
T7569 |
acl |
described,allele |
R4696 |
T7572 |
T7571 |
advmod |
here,described |
R4697 |
T7573 |
T7574 |
punct |
[,20 |
R4698 |
T7574 |
T7529 |
parataxis |
20,shown |
R4699 |
T7575 |
T7574 |
punct |
],20 |
R4700 |
T7576 |
T7529 |
punct |
.,shown |
R4701 |
T7578 |
T7579 |
det |
The,protein |
R4702 |
T7579 |
T7582 |
nsubjpass |
protein,shown |
R4703 |
T7580 |
T7579 |
amod |
human,protein |
R4704 |
T7581 |
T7579 |
compound |
ATRX,protein |
R4705 |
T7583 |
T7582 |
aux |
has,shown |
R4706 |
T7584 |
T7582 |
auxpass |
been,shown |
R4707 |
T7585 |
T7586 |
aux |
to,associate |
R4708 |
T7586 |
T7582 |
xcomp |
associate,shown |
R4709 |
T7587 |
T7586 |
prep |
in,associate |
R4710 |
T7588 |
T7589 |
det |
a,complex |
R4711 |
T7589 |
T7587 |
pobj |
complex,in |
R4712 |
T7590 |
T7586 |
prep |
with,associate |
R4713 |
T7591 |
T7590 |
pobj |
Daxx,with |
R4714 |
T7592 |
T7593 |
punct |
[,8 |
R4715 |
T7593 |
T7591 |
parataxis |
8,Daxx |
R4716 |
T7594 |
T7593 |
punct |
],8 |
R4717 |
T7595 |
T7591 |
punct |
", ",Daxx |
R4718 |
T7596 |
T7597 |
det |
a,protein |
R4719 |
T7597 |
T7591 |
appos |
protein,Daxx |
R4720 |
T7598 |
T7599 |
dep |
that,implicated |
R4721 |
T7599 |
T7597 |
relcl |
implicated,protein |
R4722 |
T7600 |
T7599 |
aux |
has,implicated |
R4723 |
T7601 |
T7599 |
auxpass |
been,implicated |
R4724 |
T7602 |
T7599 |
prep |
in,implicated |
R4725 |
T7603 |
T7604 |
amod |
multiple,pathways |
R4726 |
T7604 |
T7602 |
pobj |
pathways,in |
R4727 |
T7605 |
T7599 |
prep |
for,implicated |
R4728 |
T7606 |
T7607 |
det |
the,regulation |
R4729 |
T7607 |
T7605 |
pobj |
regulation,for |
R4730 |
T7608 |
T7607 |
prep |
of,regulation |
R4731 |
T7609 |
T7608 |
pobj |
apoptosis,of |
R4732 |
T7610 |
T7611 |
punct |
[,21 |
R4733 |
T7611 |
T7582 |
parataxis |
21,shown |
R4734 |
T7612 |
T7611 |
punct |
],21 |
R4735 |
T7613 |
T7582 |
punct |
.,shown |
R4736 |
T7615 |
T7616 |
nsubj |
It,is |
R4737 |
T7617 |
T7616 |
acomp |
possible,is |
R4738 |
T7618 |
T7619 |
mark |
that,triggered |
R4739 |
T7619 |
T7616 |
ccomp |
triggered,is |
R4740 |
T7620 |
T7619 |
nsubj |
disruption,triggered |
R4741 |
T7621 |
T7620 |
prep |
of,disruption |
R4742 |
T7622 |
T7623 |
det |
the,complex |
R4743 |
T7623 |
T7621 |
pobj |
complex,of |
R4744 |
T7624 |
T7623 |
compound |
mouse,complex |
R4745 |
T7625 |
T7626 |
compound |
Atrx,Daxx |
R4746 |
T7626 |
T7623 |
compound |
Daxx,complex |
R4747 |
T7627 |
T7626 |
punct |
-,Daxx |
R4748 |
T7628 |
T7620 |
punct |
(,disruption |
R4749 |
T7629 |
T7620 |
prep |
by,disruption |
R4750 |
T7630 |
T7629 |
pobj |
ablation,by |
R4751 |
T7631 |
T7630 |
prep |
of,ablation |
R4752 |
T7632 |
T7633 |
det |
the,protein |
R4753 |
T7633 |
T7631 |
pobj |
protein,of |
R4754 |
T7634 |
T7633 |
compound |
Atrx,protein |
R4755 |
T7635 |
T7619 |
punct |
),triggered |
R4756 |
T7636 |
T7619 |
aux |
could,triggered |
R4757 |
T7637 |
T7619 |
aux |
have,triggered |
R4758 |
T7638 |
T7639 |
det |
a,response |
R4759 |
T7639 |
T7619 |
dobj |
response,triggered |
R4760 |
T7640 |
T7639 |
amod |
universal,response |
R4761 |
T7641 |
T7639 |
amod |
proapoptotic,response |
R4762 |
T7642 |
T7616 |
punct |
.,is |
R4763 |
T7644 |
T7645 |
advmod |
However,demonstrate |
R4764 |
T7646 |
T7645 |
punct |
", ",demonstrate |
R4765 |
T7647 |
T7648 |
poss |
our,observations |
R4766 |
T7648 |
T7645 |
nsubj |
observations,demonstrate |
R4767 |
T7649 |
T7648 |
prep |
in,observations |
R4768 |
T7650 |
T7651 |
compound |
ES,cells |
R4769 |
T7651 |
T7649 |
pobj |
cells,in |
R4770 |
T7652 |
T7653 |
mark |
that,is |
R4771 |
T7653 |
T7645 |
ccomp |
is,demonstrate |
R4772 |
T7654 |
T7655 |
det |
the,induction |
R4773 |
T7655 |
T7653 |
nsubj |
induction,is |
R4774 |
T7656 |
T7655 |
prep |
of,induction |
R4775 |
T7657 |
T7656 |
pobj |
apoptosis,of |
R4776 |
T7658 |
T7653 |
neg |
not,is |
R4777 |
T7659 |
T7660 |
det |
an,response |
R4778 |
T7660 |
T7653 |
attr |
response,is |
R4779 |
T7661 |
T7660 |
amod |
automatic,response |
R4780 |
T7662 |
T7660 |
acl |
triggered,response |
R4781 |
T7663 |
T7662 |
agent |
by,triggered |
R4782 |
T7664 |
T7665 |
det |
the,removal |
R4783 |
T7665 |
T7663 |
pobj |
removal,by |
R4784 |
T7666 |
T7665 |
prep |
of,removal |
R4785 |
T7667 |
T7666 |
pobj |
Atrx,of |
R4786 |
T7668 |
T7662 |
prep |
in,triggered |
R4787 |
T7669 |
T7670 |
det |
all,types |
R4788 |
T7670 |
T7668 |
pobj |
types,in |
R4789 |
T7671 |
T7670 |
compound |
cell,types |
R4790 |
T7672 |
T7645 |
punct |
", ",demonstrate |
R4791 |
T7673 |
T7645 |
cc |
and,demonstrate |
R4792 |
T7674 |
T7645 |
conj |
suggest,demonstrate |
R4793 |
T7675 |
T7676 |
mark |
that,reflect |
R4794 |
T7676 |
T7674 |
ccomp |
reflect,suggest |
R4795 |
T7677 |
T7678 |
det |
the,apoptosis |
R4796 |
T7678 |
T7676 |
nsubj |
apoptosis,reflect |
R4797 |
T7679 |
T7678 |
amod |
inappropriate,apoptosis |
R4798 |
T7680 |
T7678 |
acl |
observed,apoptosis |
R4799 |
T7681 |
T7680 |
prep |
in,observed |
R4800 |
T7682 |
T7683 |
det |
the,forebrain |
R4801 |
T7683 |
T7681 |
pobj |
forebrain,in |
R4802 |
T7684 |
T7685 |
compound |
Atrx,mutant |
R4803 |
T7685 |
T7683 |
compound |
mutant,forebrain |
R4804 |
T7686 |
T7685 |
punct |
-,mutant |
R4805 |
T7687 |
T7676 |
aux |
may,reflect |
R4806 |
T7688 |
T7689 |
det |
a,requirement |
R4807 |
T7689 |
T7676 |
dobj |
requirement,reflect |
R4808 |
T7690 |
T7689 |
prep |
for,requirement |
R4809 |
T7691 |
T7690 |
pobj |
Atrx,for |
R4810 |
T7692 |
T7689 |
prep |
during,requirement |
R4811 |
T7693 |
T7694 |
amod |
terminal,differentiation |
R4812 |
T7694 |
T7692 |
pobj |
differentiation,during |
R4813 |
T7695 |
T7645 |
punct |
.,demonstrate |